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  1. Article ; Online: Multilevel ecological compensation policy design based on ecosystem service flow: A case study of carbon sequestration services in the Qinghai-Tibet Plateau.

    Wu, Chunsheng / Lu, Rongrong / Zhang, Peng / Dai, Erfu

    The Science of the total environment

    2024  Volume 921, Page(s) 171093

    Abstract: Ecological compensation is an effective means to reconcile the imbalance of eco-social development between regions and promote enthusiasm for ecological environmental protection. There is some conformity between the theory of ecosystem service flow and ... ...

    Abstract Ecological compensation is an effective means to reconcile the imbalance of eco-social development between regions and promote enthusiasm for ecological environmental protection. There is some conformity between the theory of ecosystem service flow and ecological compensation, which provides new technical support for the formulation of ecological compensation policy. This study took the Qinghai-Tibet Plateau as the research area, adopted the breaking point model to obtain the spatial characteristics of carbon sequestration flow, and formulated a multilevel ecological compensation policy with Tibet as the design object. The results showed that most of the Qinghai-Tibet Plateau has a carbon sequestration surplus; the central and eastern Qinghai-Tibet Plateau, western Sichuan are successively carbon sequestration supply areas; the Chengdu Plain and Xinjiang were listed as carbon sequestration benefit areas; and the carbon sequestration tended to flow more closely between supply and benefit areas in proximity to each other. Nyingchi, Chamdo, Naqu and Shannan in Tibet need to receive a total ecological compensation of 393.21 million USD, of which 93.71 % is from the national level, 6.02 % is from carbon sequestration benefit areas in other provinces; furthermore, Lhasa and Shigatse in Tibet need to provide the remaining ecological compensation. This study offers innovations for the formulation of ecological compensation policies and provide a new theory for ecological environment management.
    Language English
    Publishing date 2024-02-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.171093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Analysis of post-market adverse events of istradefylline: a real-world study base on FAERS database.

    Jiang, Ying / Lu, Rongrong / Zhou, Qin / Shen, Yuan / Zhu, Haohao

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 7659

    Abstract: Analyze the adverse event (AE) signals of istradefylline based on the FAERS database. By extracting large-scale data from the FAERS database, this study used various signal quantification techniques such as ROR, PRR, BCPNN, and MGPS to calculate and ... ...

    Abstract Analyze the adverse event (AE) signals of istradefylline based on the FAERS database. By extracting large-scale data from the FAERS database, this study used various signal quantification techniques such as ROR, PRR, BCPNN, and MGPS to calculate and evaluate the ratio and association between istradefylline and specific AEs. In the FAERS database, this study extracted data from the third quarter of 2019 to the first quarter of 2023, totaling 6,749,750 AE reports. After data cleansing and drug screening, a total of 3633 AE reports related to istradefylline were included for analysis. Based on four calculation methods, this study unearthed 25 System Organ Class (SOC) AE signals and 82 potential preferred terms (PTs) related to istradefylline. The analysis revealed new AEs during istradefylline treatment, including reports of Parkinsonism hyperpyrexia syndrome (n = 3, ROR 178.70, PRR 178.63, IC 1.97, EBGM 165.63), Compulsions (n = 5, ROR 130.12, PRR 130.04, IC 2.53, EBGM 123.02), Deep brain stimulation (n = 10, ROR 114.42, PRR 114.27, IC 3.33, EBGM 108.83), and Freezing phenomenon (n = 60, ROR 97.52, PRR 96.76, IC 5.21, EBGM 92.83). This study provides new risk signals and important insights into the use of istradefylline, but further research and validation are needed, especially for those AE that may occur in actual usage scenarios but are not yet explicitly described in the instructions.
    MeSH term(s) United States ; Compulsive Behavior ; Databases, Factual ; Drug Evaluation, Preclinical ; Purines/adverse effects ; United States Food and Drug Administration
    Chemical Substances istradefylline (2GZ0LIK7T4) ; Purines
    Language English
    Publishing date 2024-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-58460-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Disitamab Vedotin (RC48) combined with bevacizumab for treatment of HR-negative/HER2-positive metastatic breast cancer with liver and brain involvement: A case report.

    Qu, Fei / Liu, Qian / Lu, Rongrong / Li, Wei

    Frontiers in oncology

    2023  Volume 13, Page(s) 1245701

    Abstract: Background: The overexpression of human epidermal growth factor receptor 2 (HER2) is strongly correlated with an elevated risk of developing distant metastases, particularly brain metastases, in breast cancer (BC) cases. RC48 (also known as Disitamab ... ...

    Abstract Background: The overexpression of human epidermal growth factor receptor 2 (HER2) is strongly correlated with an elevated risk of developing distant metastases, particularly brain metastases, in breast cancer (BC) cases. RC48 (also known as Disitamab vedotin), represents a promising antibody-drug conjugate (ADC), that comprises three well-defined components: hertuzumab against the prominent tumor target-HER2, monomethyl auristatin E (MMAE) and a cleavable linker. Preclinical studies have demonstrated its robust antitumor activity in BC patient-derived xenograft models with HER2-positive or HER2-low expression. Additionally, antiangiogenic drugs like bevacizumab have shown potential efficacy on advanced BC
    Case presentation: Here, we will share our experience in treating a 49-year-old woman initially diagnosed with stage IV breast cancer characterized by hormone receptor (HR)-negativity and HER2-positivity. This complex case entailed brain and liver metastases, and the patient exhibited resistance to various HER2-targeted treatment regimens. Finally, the patient received RC48 plus bevacizumab as the advanced forth-line treatment, which was well tolerated with no observed toxicities. Subsequent radiological assessments revealed remarkable regression in the brain metastatic lesions, classified as having partial response based on the RECIST 1.1 system. The period of progression-free survival (PFS) was 7 months.
    Conclusion: The present study underscores the efficacy of systemic treatment with RC48 in conjunction, showcasing substantial enhancement in both radiographic indicators and clinical symptomatology among patients with brain metastatic breast cancer (BMBC). More specifically, the sequential application of ADCs in combination with antiangiogenics presents a novel avenue for advancing the treatment landscape of metastatic BC.
    Language English
    Publishing date 2023-08-28
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1245701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pickering emulsion stabilized by casein-caffeic acid covalent nanoparticles to enhance the bioavailability of curcumin in vitro and in vivo.

    Zhang, Bingyan / Wang, Yunping / Lu, Rongrong

    Journal of the science of food and agriculture

    2023  Volume 103, Issue 7, Page(s) 3579–3591

    Abstract: Background: In recent years, the design of food-grade Pickering emulsion delivery systems has become an effective strategy for improving the low bioavailability of bioactive substances. Protein-based Pickering emulsions have received extensive attention ...

    Abstract Background: In recent years, the design of food-grade Pickering emulsion delivery systems has become an effective strategy for improving the low bioavailability of bioactive substances. Protein-based Pickering emulsions have received extensive attention because of a high biocompatibility and loading capacity. The bioavailability of active substances is mainly evaluated by simulating in vitro gastrointestinal digestion. As a model organism for antioxidation and anti-aging, Caenorhabditis elegans can provide additional biological information for the in vivo utilization of active substances.
    Results: After the introduction of caffeic acid, the average particle size and Zeta potential of the casein-caffeic acid covalent complex nanoparticles (CCP) were 171.11 nm and - 37.73 mV, respectively. The three-phase contact angle was also increased to 89.8°. By using CCP to stabilize Pickering emulsion (CCE), the retention quantity of the embedded curcumin increased by 2.19-fold after 28 days. In the simulated gastric digestion, curcumin degradation in CCE was reduced by 61.84%, released slowly in the intestinal environment, and the final bioaccessibility was increased by 1.90-fold. In C. elegans, CCE significantly reduced ROS accumulation, increased SOD activity by 2.01-fold and CAT activity by 2.30-fold, decreased MDA content by 36.76%, prolonging the lifespan of nematodes by 13.33% under H
    Conclusion: The results indictae that CCP-stabilized Pickering emulsion can efficiently implement the physiological activities of bioactive compounds in vitro digestion and C. elegans, and thus it can be regarded as a reliable delivery system for food and medicine. © 2023 Society of Chemical Industry.
    MeSH term(s) Animals ; Curcumin/chemistry ; Emulsions/chemistry ; Caseins/metabolism ; Biological Availability ; Caenorhabditis elegans/metabolism ; Nanoparticles/chemistry ; Particle Size
    Chemical Substances Curcumin (IT942ZTH98) ; Emulsions ; Caseins ; caffeic acid (U2S3A33KVM)
    Language English
    Publishing date 2023-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 184116-6
    ISSN 1097-0010 ; 0022-5142
    ISSN (online) 1097-0010
    ISSN 0022-5142
    DOI 10.1002/jsfa.12447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pickering emulsion stabilized by casein–caffeic acid covalent nanoparticles to enhance the bioavailability of curcumin in vitro and in vivo

    Zhang, Bingyan / Wang, Yunping / Lu, Rongrong

    Journal of the Science of Food and Agriculture. 2023 May, v. 103, no. 7 p.3579-3591

    2023  

    Abstract: BACKGROUND: In recent years, the design of food‐grade Pickering emulsion delivery systems has become an effective strategy for improving the low bioavailability of bioactive substances. Protein‐based Pickering emulsions have received extensive attention ... ...

    Abstract BACKGROUND: In recent years, the design of food‐grade Pickering emulsion delivery systems has become an effective strategy for improving the low bioavailability of bioactive substances. Protein‐based Pickering emulsions have received extensive attention because of a high biocompatibility and loading capacity. The bioavailability of active substances is mainly evaluated by simulating in vitro gastrointestinal digestion. As a model organism for antioxidation and anti‐aging, Caenorhabditis elegans can provide additional biological information for the in vivo utilization of active substances. RESULTS: After the introduction of caffeic acid, the average particle size and Zeta potential of the casein–caffeic acid covalent complex nanoparticles (CCP) were 171.11 nm and − 37.73 mV, respectively. The three‐phase contact angle was also increased to 89.8°. By using CCP to stabilize Pickering emulsion (CCE), the retention quantity of the embedded curcumin increased by 2.19‐fold after 28 days. In the simulated gastric digestion, curcumin degradation in CCE was reduced by 61.84%, released slowly in the intestinal environment, and the final bioaccessibility was increased by 1.90‐fold. In C. elegans, CCE significantly reduced ROS accumulation, increased SOD activity by 2.01‐fold and CAT activity by 2.30‐fold, decreased MDA content by 36.76%, prolonging the lifespan of nematodes by 13.33% under H₂O₂ stimulation and improving bioavailability in vivo. CONCLUSION: The results indictae that CCP‐stabilized Pickering emulsion can efficiently implement the physiological activities of bioactive compounds in vitro digestion and C. elegans, and thus it can be regarded as a reliable delivery system for food and medicine. © 2023 Society of Chemical Industry.
    Keywords Caenorhabditis elegans ; agriculture ; bioavailability ; biocompatibility ; caffeic acid ; contact angle ; curcumin ; digestion ; emulsions ; intestines ; longevity ; medicine ; nanoparticles ; particle size ; zeta potential
    Language English
    Dates of publication 2023-05
    Size p. 3579-3591.
    Publishing place John Wiley & Sons, Ltd.
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 184116-6
    ISSN 1097-0010 ; 0022-5142
    ISSN (online) 1097-0010
    ISSN 0022-5142
    DOI 10.1002/jsfa.12447
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: The current application and research progress of vitamin D in improving the efficacy of tuberculosis treatment.

    Dai, Yaoyao / Wei, Ye / Fu, Jian / Han, Yingying / Yang, Juan / Mao, Jiamin / Lu, Rongrong

    Minerva surgery

    2024  

    Language English
    Publishing date 2024-01-24
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3067899-7
    ISSN 2724-5438
    ISSN (online) 2724-5438
    DOI 10.23736/S2724-5691.23.10201-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Safety, Accuracy, and Efficacy of Robot-Assisted Stereo Electroencephalography in Children of Different Ages.

    Lu, Rongrong / Wang, Min / Zhang, Yi / Li, Hao / Zhou, Yuanfeng / Wang, Yi / Zhao, Rui

    Neurosurgery

    2024  

    Abstract: Background and objectives: Aimed to investigate the safety, accuracy, and efficacy of stereo electroencephalography (SEEG) in children of various ages, with particular emphasis on those younger than 3 years. There is limited guidance regarding whether ... ...

    Abstract Background and objectives: Aimed to investigate the safety, accuracy, and efficacy of stereo electroencephalography (SEEG) in children of various ages, with particular emphasis on those younger than 3 years. There is limited guidance regarding whether SEEG can conducted on very young children.
    Methods: This retrospective study was conducted between July 2018 and August 2022. It involved 88 patients who underwent 99 robot-assisted SEEG procedures at our center. The patients were categorized into 3 groups based on their age at the time of the robot-assisted SEEG procedures: group 1 (3 years and younger, n = 28), group 2 (age 3-6 years, n = 27), and group 3 (older than 6 years, n = 44). Clinical data, SEEG demographics, complications, and seizure outcomes were analyzed.
    Results: A total of 675 electrodes were implanted, with an average of 6.82 ± 3.47 (2.00-16.00) electrodes per patient (P = .052). The average target point error for the 675 electrodes was 1.93 ± 1.11 mm, and the average entry point error was 1.30 ± 0.97 mm (P = .536 and P = .549, respectively). The overall percentage of complications was 6.06% (P = .879). No severe or long-term neurologic impairment was observed. Of the total 99 procedures included in this study, 78 were admitted for epilepsy surgery for the first time, while 9 patients were treated twice and 1 patient was treated 3 times. There were 21 radiofrequency thermocoagulation and 78 second-stage resective procedures performed after SEEG. There was no statistically significant difference in Engel class I outcomes among the patients who underwent SEEG in the 3 age groups (P = .621).
    Conclusion: Robot-assisted SEEG were demonstrated to be safe, accurate, and efficient across different age groups of children. This technique is suitable for children younger than 3 years who have indications for SEEG placement.
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/neu.0000000000002853
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Causal relationship between diabetes and depression: A bidirectional Mendelian randomization study.

    Wang, Zhe / Du, Zhiqiang / Lu, Rongrong / Zhou, Qin / Jiang, Ying / Zhu, Haohao

    Journal of affective disorders

    2024  Volume 351, Page(s) 956–961

    Abstract: Objective: This study explores the causal relationship between diabetes and depression using a two-sample Mendelian Randomization (TSMR) method.: Methods: The study selected single nucleotide polymorphisms (SNPs) closely associated with diabetes and ... ...

    Abstract Objective: This study explores the causal relationship between diabetes and depression using a two-sample Mendelian Randomization (TSMR) method.
    Methods: The study selected single nucleotide polymorphisms (SNPs) closely associated with diabetes and depression in European populations from the Genome-Wide Association Study (GWAS) database, to serve as instrumental variables (IVs). The main evaluation method was inverse variance weighted analysis (IVW), supplemented by verification using Weighted median, Weighted mode, and MR Egger methods. The Odds Ratio (OR) and 95 % Confidence Interval (CI) were used as the main evaluation indicators, along with sensitivity analysis.
    Results: This study found a negative correlation between diabetes and depression, suggesting that diabetes may reduce the risk of depression [IVW(FE): OR: 0.901, 95 % CI: 0.823 to 0.987; P = 0.025 < 0.05]. This finding was further confirmed by the Weighted median [OR: 0.844, 95 % CI: 0.730 to 0.974; P = 0.021 < 0.05] and Weighted mode method [OR: 0.766, 95 % CI: 0.637 to 0.921; P = 0.006 < 0.05]. However, the reverse showed no causal relationship between depression and diabetes (P > 0.05). Sensitivity analysis found no pleiotropy, and there were no large influences from individual SNPs on the result's robustness; the results are stable and reliable.
    Conclusion: For the first time, this study using TSMR analysis found a negative correlation between diabetes and the risk of depression onset in European populations, suggesting that diabetes might reduce the risk of depression. But as the mechanisms are still unclear, these findings warrant further study.
    MeSH term(s) Humans ; Depression/epidemiology ; Depression/genetics ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/genetics ; Analysis of Variance
    Language English
    Publishing date 2024-02-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2024.02.031
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  9. Article ; Online: Antibody-drug conjugates transform the outcome of individuals with low-HER2-expression advanced breast cancer.

    Qu, Fei / Lu, Rongrong / Liu, Qian / Wu, Xuefang / Huang, Xiang / Yin, Yongmei / Li, Wei

    Cancer

    2024  Volume 130, Issue S8, Page(s) 1392–1402

    Abstract: Antibody-drug conjugates (ADCs)-a groundbreaking class of agents for targeted oncological therapies-consist of monoclonal antibodies with strong antigenic specificity coupled with highly active cytotoxic agents (also referred to as "payloads"). Over the ... ...

    Abstract Antibody-drug conjugates (ADCs)-a groundbreaking class of agents for targeted oncological therapies-consist of monoclonal antibodies with strong antigenic specificity coupled with highly active cytotoxic agents (also referred to as "payloads"). Over the past 2 decades, breast cancer research has evolved into a focal point for the research and development of ADCs, leading to several recent landmark publications. These advancements are ushering in a transformative era in breast cancer treatment and redefining conventional classifications by introducing a prospective subtype termed "HER2-low." The latest iterations of ADCs have demonstrated enhanced efficacy in disease management through the optimization of various factors, notably the incorporation of the bystander effect. These conjugates are no longer limited to the oncogenic driver human epidermal growth factor receptor 2 (HER2). Other antigens, including human epidermal growth factor receptor 3 (HER3), trophoblast cell surface antigen 2 (Trop-2), zinc transporter ZIP6 (LIV-1), and folate receptor α (FRα), have recently emerged as intriguing tumor cell surface nondriver gene targets for ADCs, each with one or more specific ADCs that showed encouraging results in the breast cancer field. This article reviews recent advances in the application of ADCs in the treatment of HER2-low breast cancer. Additionally, this review explores the underlying factors contributing to the impact of target selection on ADC efficacy to provide new insights for optimizing the clinical application of ADCs in individuals with low HER2 expression in advanced breast cancer.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Immunoconjugates/therapeutic use ; Prospective Studies ; Antibodies, Monoclonal/therapeutic use ; Medical Oncology ; Antineoplastic Agents/therapeutic use
    Chemical Substances Immunoconjugates ; Antibodies, Monoclonal ; Antineoplastic Agents
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.35205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Investigating the Mechanism of Chufan Yishen Formula in Treating Depression through Network Pharmacology and Experimental Verification.

    Zhu, Haohao / Du, Zhiqiang / Lu, Rongrong / Zhou, Qin / Shen, Yuan / Jiang, Ying

    ACS omega

    2024  Volume 9, Issue 11, Page(s) 12698–12710

    Abstract: ... ...

    Abstract Objective
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c08350
    Database MEDical Literature Analysis and Retrieval System OnLINE

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