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  1. Article ; Online: Research progress on SII in digestive system diseases

    Hang Hang, Jia Zhe, Zhu Jiali, Lu Sucai

    Xin yixue, Vol 53, Iss 6, Pp 400-

    2022  Volume 403

    Abstract: Hu et al. first proposed the systemic immune-inflammation index （SII） based on prognostic scoring of inflammation and immunity in 2014. The calculation formula is platelet count×neutrophil count/lymphocyte count, which is widely applied in clinical ... ...

    Abstract Hu et al. first proposed the systemic immune-inflammation index （SII） based on prognostic scoring of inflammation and immunity in 2014. The calculation formula is platelet count×neutrophil count/lymphocyte count, which is widely applied in clinical practice because it is non-invasive, easy to calculate and economical. Previous studies have shown that SII reflects the balance between host immunity and inflammatory status. High SII level can be utilized to predict poor outcome in malignancies, and it is correlated with the severity of some diseases. In this article, research progress on the predictive value of SII for the incidence and development of digestive system diseases was reviewed.
    Keywords |systemic immune-inflammation index|disease severity|prognosis|clinical utility ; Medicine ; R
    Language Chinese
    Publishing date 2022-06-01T00:00:00Z
    Publisher Editorial Office of Journal of New Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Rosmarinic Acid Protects Mice from Concanavalin A-Induced Hepatic Injury through AMPK Signaling.

    Wang, Yangyang / Meng, Jie / Men, Lu / An, Boran / Jin, Xiaoxu / He, Wenjuan / Lu, Sucai / Li, Na

    Biological & pharmaceutical bulletin

    2020  Volume 43, Issue 11, Page(s) 1749–1759

    Abstract: Rosmarinic acid (RA) is extensively utilized in herbal medicine in China. The AMP-activated protein kinase (AMPK) signaling can be activated by RA and inhibited by the synthetic, reversible AMP-competitive inhibitor, Compound C (CC). The objective of ... ...

    Abstract Rosmarinic acid (RA) is extensively utilized in herbal medicine in China. The AMP-activated protein kinase (AMPK) signaling can be activated by RA and inhibited by the synthetic, reversible AMP-competitive inhibitor, Compound C (CC). The objective of this study was to investigate the role of AMPK signaling involving the protective effects of RA on concanavalin A (Con A)-induced autoimmune hepatitis (AIH) in mice. BALB/c mice were treated with RA, with or without CC, followed by the pretreatment with Con A. Analysis of serum aminotransferases and cytokines were conducted and liver tissue histology was performed to evaluate hepatic injury. Cytokine levels in serum and hepatic tissue were respectively measured by enzyme-linked immunoassay (ELISA) and used quantitative (q)PCR. Levels of phosphorylated acetyl CoA carboxylase in the liver, representing AMPK activation, were detected by Western blotting. Compared with the Con A group, serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in RA group (100 and 150 mg/kg/d) were significantly reduced. RA also reduced hepatocyte swelling, cell death, and infiltration of leukocytes in the liver of Con A-treated mice. Serum levels of cytokines, such as interferon-γ (IFN-γ), interleukin-2 (IL-2) and interleukin-1β (IL-1β), were reduced by RA pretreatment, while the levels of serum interleukin-10 (IL-10), an anti-inflammatory cytokine, was elevated. These protective effects were reversed by treatment with CC. RA treatment reduced the hepatic damage via the activation of AMPK in the mice of Con A-induced. So RA acts as a potential part in the therapy of autoimmune hepatitis.
    MeSH term(s) AMP-Activated Protein Kinases/antagonists & inhibitors ; AMP-Activated Protein Kinases/metabolism ; Alanine Transaminase/blood ; Animals ; Aspartate Aminotransferases/blood ; Cinnamates/administration & dosage ; Concanavalin A/immunology ; Depsides/administration & dosage ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Hepatitis, Autoimmune/blood ; Hepatitis, Autoimmune/diagnosis ; Hepatitis, Autoimmune/immunology ; Hepatitis, Autoimmune/prevention & control ; Humans ; Liver/drug effects ; Liver/immunology ; Liver/pathology ; Male ; Mice ; Mice, Inbred BALB C ; Protective Agents/administration & dosage ; Pyrazoles/administration & dosage ; Pyrimidines/administration & dosage ; Signal Transduction/drug effects ; Rosmarinic Acid
    Chemical Substances Cinnamates ; Depsides ; Protective Agents ; Pyrazoles ; Pyrimidines ; dorsomorphin (10K52CIC1Z) ; Concanavalin A (11028-71-0) ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2) ; AMP-Activated Protein Kinases (EC 2.7.11.31)
    Language English
    Publishing date 2020-09-04
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1150271-x
    ISSN 1347-5215 ; 0918-6158
    ISSN (online) 1347-5215
    ISSN 0918-6158
    DOI 10.1248/bpb.b20-00477
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Study of the mechanism of anti-ulcer effects of virgin coconut oil on gastric ulcer-induced rat model.

    Meng, Jie / Chen, Taoping / Zhao, Yu / Lu, Sucai / Yu, Huiling / Chang, Ying / Chen, Dalei

    Archives of medical science : AMS

    2018  Volume 15, Issue 5, Page(s) 1329–1335

    Abstract: Introduction: This study aims to evaluate the gastro-protective effects of virgin coconut oil (VCO) on different ulcer models as compared to the standard drug (omeprazole).: Material and methods: Three groups of rats (6 rats per group for each ulcer ... ...

    Abstract Introduction: This study aims to evaluate the gastro-protective effects of virgin coconut oil (VCO) on different ulcer models as compared to the standard drug (omeprazole).
    Material and methods: Three groups of rats (6 rats per group for each ulcer model) were pre-treated with distilled water for the negative control group, 30 mg/kg of omeprazole for the positive control group and VCO (2 ml per rat) for the treatment group. Animals were pre-treated for 7 days and ulcers were induced with cold restraint stress, piroxicam, ethanol and pylorus ligation. On day eight, animals were sacrificed and ulcer scores were determined based on macroscopic evaluation. The gastric volume, pH, total acidity and mucus content were measured in the pylorus-ligated model. The levels of antioxidants were determined from the gastric tissue homogenates.
    Results: Virgin coconut oil significantly (
    Conclusions: Virgin coconut oil shows a possible association with antioxidant properties to control the regulation of prostaglandin synthesis and protect against reactive oxygen species damage.
    Language English
    Publishing date 2018-07-05
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2203781-0
    ISSN 1734-1922
    ISSN 1734-1922
    DOI 10.5114/aoms.2018.76943
    Database MEDical Literature Analysis and Retrieval System OnLINE

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