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Book ; Online: Recent Advances of Spectrometric and Spectroscopic Techniques in Food Quality and Safety

Lu, Weiying / Chen, Yanping

2023

Keywords	Research & information: general ; Chemistry ; Analytical chemistry ; surface-enhanced Raman spectroscopy ; carbendazim ; probability of detection model ; semi-quantitative analysis ; rapid detection method evaluation ; Raman spectroscopy ; digital farming ; harvest maturity assessment ; fruit and seeds quality diagnostics ; non-invasive phenotyping ; non-centrifugal cane sugar (NCS) ; GC-O-MS ; fingerprint ; orthogonal partial least squares discriminant analysis (OPLS-DA) ; tetrodotoxin ; Takifugu obscurus ; solid-phase microextraction ; ultrahigh-performance liquid chromatography-tandem mass spectrometry ; aflatoxin B1 ; edible oil ; chromatographic technology ; spectroscopic technology ; biosensor technology ; recognition elements ; fish scraps ; fish soup ; GC × GC-O-MS ; AEDA ; r-OAV ; coffee ; E-nose ; GC-IMS ; volatile organic components ; hypoglycemic activity ; hypolipidemic activity ; Angelica keiskei ; flavonoid ; function evaluation ; black garlic ; S-allyl-cysteine ; sensory quality ; polyphenol ; freezing ; high hydrostatic pressure ; medicine and food homology ; spectroscopy ; pesticides ; analytical methods ; grapes and wines ; sustainable viticulture ; pasteurized yogurt ; dynamic headspace sampling (DHS) ; odor-active compounds ; PLS-DA ; Chihuahua cheese ; histamine ; tyramine ; hdc and tdc genes ; HDC and TDC proteins ; seafood ; molecular species ; mass spectrum ; quantification ; identification ; lipid
Language	English
Size	1 electronic resource (260 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030381814
ISBN	9783036582306 ; 3036582304
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Evaluating the causality between skin tanning, radiated disorders, and basal cell carcinoma: a multivariable Mendelian randomization analysis.

Chen, Chunli / Wan, Bangbei / Lu, Weiying / Lu, Jianyun

Environmental science and pollution research international

2023 Volume 30, Issue 27, Page(s) 71001–71006

Abstract: The causality of ease of skin tanning and radiation-related disorders of the skin and subcutaneous tissue with basal cell carcinoma (BCC) remains unclear. Our objective was to investigate whether ease of skin tanning and radiation-related disorders of ... ...

Abstract	The causality of ease of skin tanning and radiation-related disorders of the skin and subcutaneous tissue with basal cell carcinoma (BCC) remains unclear. Our objective was to investigate whether ease of skin tanning and radiation-related disorders of the skin and subcutaneous tissue have a relation with the occurrence and development of BCCs. In this work, independent genetic variants strongly associated (P < 5e-08) with ease of skin tanning and radiation-related disorders of the skin and subcutaneous tissue were selected as instrumental variables from corresponding genome-wide association studies (GWASs). Summary-level data for BCC was obtained from the European Bioinformatics Institute (EBI). Two-sample univariable and multivariable Mendelian randomization (MR) were performed. Sensitivity analyses were preformed via MR-Egger regression, heterogeneity test, pleiotropy test, and leave-one-out sensitivity test. We observed positive causal effect both for ease of skin tanning [odds ratio (OR) = 2.102, 95% confidence interval (CI) = 1.915-2.306, P = 2.71e-55] and radiation-related disorders of the skin and subcutaneous (OR = 1.603, 95% CI = 1.483-1.734, P = 3.41e-32) on occurrence of BCCs based on univariable MR analyses. In the multivariable mendelian randomization (MVMR) analysis of BCC risk, we also observed a direct causal effect of ease of skin tanning (ORMVMR = 1.623, 95% CI = 1.445-1.824, PMVMR =3.41e-16) and radiation-related disorders of the skin and subcutaneous (ORMVMR = 1.208, 95% CI = 1.107-1.319, PMVMR = 2.46e-05) on BCCs. The findings suggest that the high risk of BCCs can be attributed to ease of skin tanning and radiation-related disorders of the skin and subcutaneous tissue.
MeSH term(s)	Humans ; Mendelian Randomization Analysis ; Genome-Wide Association Study ; Carcinoma, Basal Cell/genetics ; Skin ; Skin Neoplasms/genetics
Language	English
Publishing date	2023-05-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-27420-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Modifiable risk factors that mediate the effect of educational attainment on the risk of stroke: a network Mendelian randomization study.

Wan, Bangbei / Ma, Ning / Zhou, Zhi / Lu, Weiying

Molecular brain

2023 Volume 16, Issue 1, Page(s) 39

Abstract: Background: Stroke is a common cerebrovascular disease with great danger to public health. Educational inequality is a universal issue that influences populations' stroke risk. This study aimed to investigate the causal relationship between education ... ...

Abstract	Background: Stroke is a common cerebrovascular disease with great danger to public health. Educational inequality is a universal issue that influences populations' stroke risk. This study aimed to investigate the causal relationship between education and stroke risk and the contributions of effects mediated by four modifiable factors. Materials and methods: Public large-scale genome-wide association study (GWAS) summary data associated with educational attainment, hypertensive diseases, body mass index (BMI), smoking behavior, time spent on watching the television (TV), and stroke were obtained from European ancestry. The data were used to investigate the causal relationship among educational attainment, hypertensive disease, BMI, smoking, watching TV, and stroke risk. Inverse variance weighted (IVW) method was used as a primary algorithm for estimating causal direction and effect size in univariable and multivariable Mendelian randomization (MR) analyses. Results: Higher educational attainment was a causal protective factor, while hypertensive diseases, higher BMI, smoking, and longer time spent on watching the TV were all causal risk factors for the risk of stroke. Hypertensive disease, BMI, smoking, and watching TV were all mediators for linking the causal relationship between educational attainment and stroke risk. Hypertensive disease, BMI, smoking, and watching TV explained 47.35%, 24.74%, 15.72%, and 2.29% of the variance in educational attainment's effect on stroke risk, respectively. The explained proportion reached 69.32% after integrating the four factors. Conclusions: These findings support the causal effect of educational attainment on the risk of stroke, with a substantial proportion mediated by modifiable risk factors. Interventions on these modifiable factors would lead to substantial reductions in stroke cases attributable to educational inequality.
MeSH term(s)	Humans ; Mendelian Randomization Analysis ; Genome-Wide Association Study ; Risk Factors ; Educational Status ; Stroke/genetics ; Hypertension/complications ; Hypertension/genetics ; Polymorphism, Single Nucleotide
Language	English
Publishing date	2023-05-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2436057-0
ISSN	1756-6606 ; 1756-6606
ISSN (online)	1756-6606
ISSN	1756-6606
DOI	10.1186/s13041-023-01030-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Non-targeted metabolomics of moldy wheat by ultra-performance liquid chromatography - quadrupole time-of-flight mass spectrometry.

Gao, Boyan / Lu, Weiying / Jin, Mengchu / Chen, Yumei

Frontiers in microbiology

2023 Volume 14, Page(s) 1136516

Abstract: Introduction: As one of the staple foods for the world's major populations, the safety of wheat is critical in ensuring people's wellbeing. However, mildew is one of the prevalent safety issues that threatens the quality of wheat during growth, ... ...

Abstract	Introduction: As one of the staple foods for the world's major populations, the safety of wheat is critical in ensuring people's wellbeing. However, mildew is one of the prevalent safety issues that threatens the quality of wheat during growth, production, and storage. Due to the complex nature of the microbial metabolites, the rapid identification of moldy wheat is challenging. Methods: In this research, identification of moldy wheat samples was studied using ultra-performance liquid chromatography - quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) coupled with chemometrics. The non-targeted PCA model for identifying moldy wheat from normal wheat was established by using previously established compounds database of authentic wheat samples. The partial least squares-discriminant analysis (PLS-DA) was performed. Results and discussion: By optimizing the model parameters, correct discrimination of the moldy wheat as low as 5% (w/w) adulteration level could be achieved. Differential biomarkers unique to moldy wheat were also extracted to identify between the moldy and authentic wheat samples. The results demonstrated that the chemical information of wheat combined with the existing PCA model could efficiently discriminate between the constructed moldy wheat samples. The study offered an effective method toward screening wheat safety.
Language	English
Publishing date	2023-04-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1136516
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Article ; Online: Pressure injury prevalence and characteristics in patients with COVID-19 admitted to acute inpatient rehabilitation unit.

Lu, Weiying / Bloom, Ona / Rathgeber, Melissa / Maltser, Susan

Frontiers in rehabilitation sciences

2023 Volume 4, Page(s) 1058982

Abstract: Objective: To investigate the incidence and severity of pressure injuries among COVID-19 patients who required acute hospitalization and subsequent acute inpatient rehabilitation (AIR).: Design: Data was collected retrospectively from medical charts ... ...

Abstract	Objective: To investigate the incidence and severity of pressure injuries among COVID-19 patients who required acute hospitalization and subsequent acute inpatient rehabilitation (AIR). Design: Data was collected retrospectively from medical charts of COVID-19 patients who were admitted to AIR during April 2020-April 2021. Setting: Acute Inpatient Rehabilitation at a single hospital in the greater New York metropolitan area. Participants: Subjects included COVID-19 patients ( Interventions: Not applicable. Main outcome measures: The incidence, location, and severity of pressure injuries in COVID-19 patients, as well as demographic and clinical characteristics of the acute hospitalization. Results: Among patients who developed pressure injuries, more patients received mechanical ventilation (59% vs. 33%, Conclusion: Pressure injuries were more common in COVID-19 patients who had longer lengths of stay, received mechanical ventilation or tracheostomy, during acute hospitalization. This supports the use of protocols to prioritize pressure offloading in this patient population.
Language	English
Publishing date	2023-04-03
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-6861
ISSN (online)	2673-6861
DOI	10.3389/fresc.2023.1058982
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Article ; Online: Evaluating the causal relationship between five modifiable factors and the risk of spinal stenosis: a multivariable Mendelian randomization analysis.

Wan, Bangbei / Ma, Ning / Lu, Weiying

PeerJ

2023 Volume 11, Page(s) e15087

Abstract: Background: Spinal stenosis is a neurological disorder related to the compression of the spinal cord or nerve roots, and its incidence increases yearly. We aimed to use Mendelian randomization (MR) to investigate the causal relationship between several ... ...

Abstract	Background: Spinal stenosis is a neurological disorder related to the compression of the spinal cord or nerve roots, and its incidence increases yearly. We aimed to use Mendelian randomization (MR) to investigate the causal relationship between several modifiable risk factors and the risk of spinal stenosis. Methods: We obtained genome-wide association study summary data of large-sample projects (more than 100,000 individuals) from public databases. The data were associated with traits, including years of schooling (educational attainment) from the IEU OpenGWAS Project, smoking behavior (never Results: Univariable MR analyses showed that genetically predicted higher educational attainment (IVW; odds ratio (OR) = 0.606; 95% confidence interval (CI): 0.507-0.724; Conclusion: Our findings supported the potential causal associations of the five factors (educational attainment, smoking behavior, BMI, length of mobile phone use, and watching TV) with the risk for spinal stenosis. While replication studies are essential, these findings may provide a new perspective on prevention and intervention strategies directed toward spinal stenosis.
MeSH term(s)	Humans ; Spinal Stenosis ; Mendelian Randomization Analysis ; Genome-Wide Association Study ; Reproducibility of Results ; Causality
Language	English
Publishing date	2023-03-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.15087
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mendelian randomization investigation identified the causal relationship between body fat indexes and the risk of bladder cancer.

Wan, Bangbei / Ma, Ning / Lu, Weiying

PeerJ

2023 Volume 11, Page(s) e14739

Abstract: Background: Observational studies have suggested that obesity is associated with the risk of bladder cancer (BCa). However, their causal relationship remains unclear. This study aimed to prove the causal relationship between obesity and the risk of BCa ... ...

Abstract	Background: Observational studies have suggested that obesity is associated with the risk of bladder cancer (BCa). However, their causal relationship remains unclear. This study aimed to prove the causal relationship between obesity and the risk of BCa by using Mendelian randomization. Methods: Single-nucleotide polymorphisms (SNPs) correlated with body fat indexes were screened from several genome-wide association studies (GWAS) with more than 300,000 individuals. Summary-level genetic data of BCa-related GWAS were obtained from a European cohort with a sample size of 218,792. An inverse-variance-weighted (IVW) method was used as the major MR analysis. The MR-Egger regression, IVW regression, leave-one-out test, and MR-Pleiotropy Residual Sum and Outlier methods were used to test the reliability and stability of MR results. Results: Genetically predicted per 1-SD increase in body fat indexes (whole body fat mass, and the right leg, left leg, right arm, left arm, and trunk fat mass) were associated with increased BCa risk with values of 51.8%, 77.9%, 75.1%, 67.2%, 59.7%, and 36.6%, respectively. Sensitivity analyses suggested that the genetically determined risk effect of obesity on BCa was stable and reliable. Conclusions: Our study provided powerful evidence to support the causal hypothesis that the genetically predicted high body fat mass was associated with a risk increase for BCa. The finding is a new idea for drawing up prevention strategies for BCa.
MeSH term(s)	Humans ; Adipose Tissue ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Obesity/epidemiology ; Reproducibility of Results ; Urinary Bladder Neoplasms/epidemiology
Language	English
Publishing date	2023-01-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.14739
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Article ; Online: Four modifiable factors that mediate the effect of educational time on major depressive disorder risk: A network Mendelian randomization study.

Wan, Bangbei / Wu, Yamei / Ma, Ning / Zhou, Zhi / Lu, Weiying

PloS one

2023 Volume 18, Issue 7, Page(s) e0288034

Abstract: Background: Major depressive disorder (MDD) is a mental illness, which is a notable public health problem that aggravates the global economic burden. This study aimed to investigate the causal relationship between education and MDD risk and the ... ...

Abstract	Background: Major depressive disorder (MDD) is a mental illness, which is a notable public health problem that aggravates the global economic burden. This study aimed to investigate the causal relationship between education and MDD risk and the contributions of effects mediated by four modifiable factors. Materials and methods: Instrumental variables were screened from several large-scale genome-wide association study (GWAS) data (years of schooling with 766,345 participants, MDD with 59,851 cases and 113,154 controls, neuroticism with 329,821 individuals, smoking behavior with 195,068 cases and 164,638 controls, body mass index [BMI] with 336,107 individuals, and household income with 397,751 individuals). The data were used to evaluate the association of the four modifiable factors (neuroticism, smoking behavior, BMI, and household income) that mediate the effect of education on MDD risk via Mendelian randomization (MR) analysis. Results: Each standard deviation increase in years of schooling could reduce the risk for MDD by 30.70%. Higher neuroticism and BMI were associated with a higher risk of MDD. Non-smoking status and increased household income were protective factors for MDD. Notably, the mediator neuroticism, BMI, smoking behavior, and household income explained 52.92%, 15.54%, 31.86%, and 81.30% of the effect of years of schooling on MDD risk, respectively. Conclusions: Longer years of schooling have a protective effect on MDD risk. Reasonable interventions to reduce neuroticism, BMI, smoking, and increasing household income are beneficial for MDD prevention. Our work provides new ideas for the development of prevention strategies for MDD.
MeSH term(s)	Humans ; Depressive Disorder, Major/epidemiology ; Depressive Disorder, Major/genetics ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Educational Status ; Body Mass Index
Language	English
Publishing date	2023-07-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0288034
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of UBE3A on the insulin resistance in polycystic ovary syndrome through the ubiquitination of AMPK.

Ma, Ning / Zhou, Jing / Zhou, Zhi / Wan, Bangbei / Lu, Weiying

BMC endocrine disorders

2023 Volume 23, Issue 1, Page(s) 152

Abstract: Background: Polycystic ovary syndrome (PCOS) is a reproductive hormonal abnormality and a metabolic disorder, which is frequently associated with insulin resistance (IR). We aim to investigate the potential therapeutic effects of Ubiquitin-protein ... ...

Abstract	Background: Polycystic ovary syndrome (PCOS) is a reproductive hormonal abnormality and a metabolic disorder, which is frequently associated with insulin resistance (IR). We aim to investigate the potential therapeutic effects of Ubiquitin-protein ligase E3A (UBE3A) on IR in the PCOS rats via Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) activation. Methods: The PCOS and IR rats model was established by dehydroepiandrosterone (DHEA) and high fat diet (HFD) treatment, and the fat rate, glucose tolerance and insulin tolerance were measured. The IR rats numbers were calculated. Besides, the mRNA levels of glucose transporter 4 (GLUT4) and UBE3A were detected by RT-qPCR. Furthermore, the relationship between was demonstrated by co-IP assay. The phosphorylation and ubiquitination of AMPK were analyzed by western blot. Results: UBE3A was up-regulated in the PCOS rats. UBE3A knockdown significantly decreased the fat rate, glucose tolerance and insulin tolerance in the PCOS and IR rats. Additionally, the GLUT4 levels were significantly increased in PCOS + IR rats. Besides, after UBE3A knockdown, the IR rats were decreased, the p-IRS1 and p-AKT levels were significantly up-regulated. Furthermore, UBE3A knockdown enhanced phosphorylation of AMPK through decreasing the ubiquitination of AMPK. AMPK knockdown reversed the role of UBE3A knockdown in the PCOS + IR rats. Conclusions: UBE3A knockdown inhibited the IR in PCOS rats through targeting AMPK. Our study indicated that UBE3A might become a potential biological target for the clinical treatment of PCOS.
MeSH term(s)	Animals ; Female ; Rats ; AMP-Activated Protein Kinases/metabolism ; Glucose ; Insulin Resistance/physiology ; Insulins/genetics ; Insulins/metabolism ; Insulins/therapeutic use ; Polycystic Ovary Syndrome/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitin-Protein Ligases/therapeutic use ; Ubiquitination
Chemical Substances	AMP-Activated Protein Kinases (EC 2.7.11.31) ; Glucose (IY9XDZ35W2) ; Insulins ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Ube3a protein, rat (EC 2.3.2.26)
Language	English
Publishing date	2023-07-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2091323-0
ISSN	1472-6823 ; 1472-6823
ISSN (online)	1472-6823
ISSN	1472-6823
DOI	10.1186/s12902-023-01400-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Gut fungi differentially response to the antipyretic (heat-clearing) and diaphoretic (exterior-releasing) traditional Chinese medicines in

Yang, Yanan / Lu, Weiying / Zhang, Xiaopo / Wu, Chongming

Frontiers in pharmacology

2022 Volume 13, Page(s) 1032919

Abstract: Antipyretic (heat-clearing) and diaphoretic (exterior-releasing) drugs are two main groups of traditional Chinese medicines (TCMs) possessing anti-microbes and anti-inflammation effects, with the former mainly through clearing pyrogens while the latter ... ...

Abstract	Antipyretic (heat-clearing) and diaphoretic (exterior-releasing) drugs are two main groups of traditional Chinese medicines (TCMs) possessing anti-microbes and anti-inflammation effects, with the former mainly through clearing pyrogens while the latter through promoting diaphoresis. Although anti-microorganism is a common action of these two kinds of TCMs, their difference in antimicrobial spectrums and their interactions when combinedly used remain unclear. Herein, we prepared aqueous extracts from
Language	English
Publishing date	2022-11-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.1032919
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