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Article ; Online: Antidepressant effects of Kai-Xin-San in fluoxetine-resistant depression rats.

Dong, X Z / Wang, D X / Lu, Y P / Yuan, S / Liu, P / Hu, Y

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

2017 Volume 50, Issue 10, Page(s) e6161

Abstract: This study aimed to investigate the antidepressant effect and the mechanism of action of Kai-Xin-San (KXS) in fluoxetine-resistant depressive (FRD) rats. Two hundred male Wistar rats weighing 200±10 g were exposed to chronic and unpredictable mild ... ...

Abstract	This study aimed to investigate the antidepressant effect and the mechanism of action of Kai-Xin-San (KXS) in fluoxetine-resistant depressive (FRD) rats. Two hundred male Wistar rats weighing 200±10 g were exposed to chronic and unpredictable mild stresses (CUMS) for 4 weeks and given fluoxetine treatment simultaneously. The rats that did not show significant improvement in behavioral indexes were chosen as the FRD model rats. These rats were randomly divided into four groups: FRD model control; oral fluoxetine and aspirin; oral KXS at a dose of 338 mg·kg-1·day-1; and oral KXS at a dose of 676 mg·kg-1·day-1. Rats continued to be exposed to CUMS and underwent treatment once a day for 3 weeks, then cytokine (COX-2, IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-10, TGF-β, and TNF-α) levels in the hippocampus and serum, and organ coefficients were measured. Both doses of KXS improved the crossing and rearing frequencies, sucrose-preference index, and body weight in FRD rats. KXS at a dose of 338 mg·kg-1·day-1reduced COX-2, IL-2, IL-6, TNF-α levels, increased IL-10 level in the hippocampus, and reduced IL-2 and TNF-α levels in serum. KXS at a dose of 676 mg·kg-1·day-1reduced TNF-α level in the hippocampus, reduced IL-2 and TNF-α levels in serum, and increased IFN-γ and IL-10 levels in the hippocampus and serum. There were no significant differences in organ-coefficients of the spleen among and between groups. The results suggested that oral administration of KXS in FRD rats was effective in improving behavior disorders by influencing various inflammatory pathways.
Language	English
Publishing date	2017-08-17
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	786234-9
ISSN	1414-431X ; 0100-879X
ISSN (online)	1414-431X
ISSN	0100-879X
DOI	10.1590/1414-431X20176161
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Article: [Effects of lateral and medial points of thoracic paravertebral nerve block by ultrasound for rapid recovery after laparoscopic cholecystectomy].

Wu, Z W / Ni, H D / Hou, X M / Lu, Y P / Zhou, X Y / Yao, M

Zhonghua yi xue za zhi

2019 Volume 99, Issue 13, Page(s) 988–992

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Adolescent ; Adult ; Aged ; Anesthesia, General ; Cholecystectomy, Laparoscopic ; Humans ; Middle Aged ; Nerve Block ; Pain, Postoperative ; Ultrasonography ; Young Adult
Language	Chinese
Publishing date	2019-04-06
Publishing country	China
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	132513-9
ISSN	0376-2491
ISSN	0376-2491
DOI	10.3760/cma.j.issn.0376-2491.2019.13.006
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Article: [Study of genetic etiology in fetuses with severely short limbs in the first and second trimester using whole exome sequencing].

Zhang, X Y / You, Y Q / Zhou, H H / Wang, S J / Xie, X X / Zhang, M L / Wang, L X / Lu, Y P

Zhonghua fu chan ke za zhi

2019 Volume 54, Issue 4, Page(s) 221–225

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Congenital Abnormalities/diagnosis ; Congenital Abnormalities/genetics ; Cytoplasmic Dyneins ; DNA Copy Number Variations/genetics ; Female ; Fetal Development/genetics ; Fetus/abnormalities ; Fetus/diagnostic imaging ; Humans ; Karyotyping ; Pregnancy ; Pregnancy Trimester, First ; Pregnancy Trimester, Second ; Ultrasonography, Prenatal ; Whole Exome Sequencing/methods
Chemical Substances	Cytoplasmic Dyneins (EC 3.6.4.2) ; DYNC2LI1 protein, human (EC 3.6.4.2)
Language	Chinese
Publishing date	2019-04-21
Publishing country	China
Document type	Journal Article
ZDB-ID	604570-4
ISSN	0529-567X
ISSN	0529-567X
DOI	10.3760/cma.j.issn.0529-567x.2019.04.002
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Article ; Online: Association of single-nucleotide polymorphisms, rs2235371 and rs2013162, in the IRF6 gene with non-syndromic cleft palate in northeast China.

Xu, W / Han, W T / Lu, Y P / Feng, W H / Dai, M

Genetics and molecular research : GMR

2016 Volume 15, Issue 3

Abstract: The aim of this study was to determine the association between two SNPs (rs2235371 and rs2013162) in the interferon regulatory factor 6 (IRF6) gene and non-syndromic cleft palate (NSCP) in northeast China. We genotyped these two SNPs in 104 NSCP cases, ... ...

Abstract	The aim of this study was to determine the association between two SNPs (rs2235371 and rs2013162) in the interferon regulatory factor 6 (IRF6) gene and non-syndromic cleft palate (NSCP) in northeast China. We genotyped these two SNPs in 104 NSCP cases, as well as in 178 parents and 300 controls. Case-control and case-parent analyses were performed using χ2 tests and family-based association tests (FBAT). Results indicated that there were significant differences in both genotypic and allelic distributions between patients and controls at rs2235371 and rs2013162 in the IRF6 gene. Case-parent analysis revealed over-transmission of the C allele in rs2235371 and the A allele in rs2013162. Lastly, FBAT showed over-transmission of the CA haplotype. This study demonstrated that the two SNPs, rs2235371 and rs2013162, are strongly associated with NSCP in the northeast Chinese population.
MeSH term(s)	Adult ; Alleles ; Asian Continental Ancestry Group ; Asymptomatic Diseases ; Case-Control Studies ; Child ; Cleft Palate/diagnosis ; Cleft Palate/ethnology ; Cleft Palate/genetics ; Female ; Gene Expression ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Haplotypes ; Humans ; Interferon Regulatory Factors/genetics ; Male ; Phenotype ; Polymorphism, Single Nucleotide
Chemical Substances	IRF6 protein, human ; Interferon Regulatory Factors
Language	English
Publishing date	2016-09-02
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2114039-X
ISSN	1676-5680 ; 1676-5680
ISSN (online)	1676-5680
ISSN	1676-5680
DOI	10.4238/gmr.15038210
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Article: [Observation on the efficacy of CT-guided lumbar sympathetic chemical destructive block in the treatment of cold sensation of limbs].

Tao, J C / Huang, B / Wang, T T / Xie, K Y / He, Q L / Ni, H D / Zhu, J J / Lu, Y P / Zhang, L / Yao, M

Zhonghua yi xue za zhi

2020 Volume 100, Issue 33, Page(s) 2586–2590

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Autonomic Nerve Block ; Humans ; Lumbosacral Region ; Retrospective Studies ; Sensation ; Tomography, X-Ray Computed ; Treatment Outcome
Language	Chinese
Publishing date	2020-09-05
Publishing country	China
Document type	Journal Article
ZDB-ID	132513-9
ISSN	0376-2491
ISSN	0376-2491
DOI	10.3760/cma.j.cn112137-20200513-01525
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Article: Study on the electro‐transformation conditions of improving transformation efficiency for Bacillus subtilis

Lu, Y.‐P / Zhang, C / Lv, F.X / Bie, X.M / Lu, Z.‐X

Letters in applied microbiology. 2012 July, v. 55, no. 1

2012

Abstract: Aims: To optimize the transformation conditions and improve the transformation efficiency of Bacillus subtilis WB800 and DB104. Methods and Results: Trehalose, which could decrease the damage of electric shock to the cells, was added to the ... ...

Abstract	Aims: To optimize the transformation conditions and improve the transformation efficiency of Bacillus subtilis WB800 and DB104. Methods and Results: Trehalose, which could decrease the damage of electric shock to the cells, was added to the electroporation medium containing sorbitol and mannitol. The factors affecting the transformation efficiency, such as the growth phase of bacteria, cell concentration, electric field strength and plasmid variety, were examined and improved. The new method increased the transformation efficiency of B. subtilis by nearly 100‐fold compared with the conventional one. Conclusions: With the optimized method, the transformation efficiency came up to 3·64 × 105 transformants μg−1 DNA for WB800, and 2·10 × 105 transformants μg−1 DNA for DB104. Significance and Impact of the Study: This improvement in transformation efficiency will be largely attributed to the research of expression of exogenous genes in B. subtilis, gene library construction for directed evolution and transformation of wild‐type B. subtilis strains.
Keywords	Bacillus subtilis ; DNA libraries ; bacteria ; electric field ; electroporation ; evolution ; genes ; mannitol ; new methods ; plasmids ; sorbitol ; trehalose
Language	English
Dates of publication	2012-07
Size	p. 9-14.
Publishing place	Blackwell Publishing Ltd
Document type	Article
ZDB-ID	632584-1
ISSN	1472-765X ; 0266-8254
ISSN (online)	1472-765X
ISSN	0266-8254
DOI	10.1111/j.1472-765X.2012.03249.x
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Article ; Online: Urinary connective tissue growth factor is a biomarker in a rat model of chronic nephropathy.

Yue, L / Xia, Q / Luo, G H / Lu, Y P

Transplantation proceedings

2010 Volume 42, Issue 5, Page(s) 1875–1880

Abstract: Aim: This study sought to determine whether urinary connective tissue growth factor (CTGF) was a molecular marker for chronic allograft nephropathy (CAN).: Methods: F344 rat renal grafts orthotopically transplanted into Lewis rats following the ... ...

Abstract	Aim: This study sought to determine whether urinary connective tissue growth factor (CTGF) was a molecular marker for chronic allograft nephropathy (CAN). Methods: F344 rat renal grafts orthotopically transplanted into Lewis rats following the procedure of Kamada were harvested at 4,8,12, or 16 weeks. Morphological changes were studied using hematoxylin eosin (HE) and Masson trichrome stains. Serum creatinine (SCr) was measured. CAN grades were evaluated according to the Banff97 schema. Expressions of CTGF in the kidney and urine were determined using real-time polymerase chain reaction (PCR) Western blots, and competitive indirect enzyme-linked immunosorbent assay (ELISA). Spearman correlation analysis was used to compare urinary CTGF expression and CAN development. Results: SCr levels and Banff scores increased in a time-dependent manner. The expression of CTGF in the graft was markedly elevated compared with the control group. Urine CTGF increased by week 4, and maintained high levels up to week 16. The urinary levels correlated positively with the histological presence of CAN. Thus, urine CTGF concentrations reflected the course of CAN, especially at an early stage. Conclusion: CTGF plays a significant role in the pathological changes of CAN after kidney transplantation. Urinary CTGF has the potential to be a biomarker for CAN.
MeSH term(s)	Animals ; Biomarkers/urine ; Blotting, Western ; Connective Tissue Growth Factor/analysis ; Connective Tissue Growth Factor/genetics ; Connective Tissue Growth Factor/urine ; Creatinine/blood ; DNA Primers ; Kidney Diseases/diagnosis ; Kidney Diseases/urine ; Kidney Transplantation/pathology ; Kidney Transplantation/physiology ; Male ; RNA/genetics ; RNA/isolation & purification ; RNA, Messenger/genetics ; Rats ; Rats, Inbred F344 ; Rats, Inbred Lew ; Reverse Transcriptase Polymerase Chain Reaction ; Transplantation, Homologous/pathology ; Transplantation, Homologous/physiology
Chemical Substances	Biomarkers ; CCN2 protein, rat ; DNA Primers ; RNA, Messenger ; Connective Tissue Growth Factor (139568-91-5) ; RNA (63231-63-0) ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2010-06-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2009.11.041
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Article ; Online: Variations in WNT3 gene are associated with incidence of non-syndromic cleft lip with or without cleft palate in a northeast Chinese population.

Lu, Y P / Han, W T / Liu, Q / Li, J X / Li, Z J / Jiang, M / Xu, W

Genetics and molecular research : GMR

2015 Volume 14, Issue 4, Page(s) 12646–12653

Abstract: Non-syndromic cleft lip with or without cleft palate (NSCL/P) is a common birth defect. Several WNT genes are involved in craniofacial embryogenesis, and therefore may play an important role in the etiology of NSCL/P. Two SNPs (rs3809857 and rs9890413) ... ...

Abstract	Non-syndromic cleft lip with or without cleft palate (NSCL/P) is a common birth defect. Several WNT genes are involved in craniofacial embryogenesis, and therefore may play an important role in the etiology of NSCL/P. Two SNPs (rs3809857 and rs9890413) in the WNT3 gene were subjected to case-control and case-parent analysis by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 236 unrelated patients with NSCL/P, including 128 elementary families (185 mothers and 154 fathers), and 400 control individuals from northeast China. The rs3809857 SNP, under the assumption of a dominant model, was found to induce a 2-fold lower risk of NSCL/P ORGG vs GT + TT = 0.605, 95%CI = 0.436-0.839, P = 0.003). Moreover, the family-based association test revealed an under-transmission for the minor allele T. On the other hand, we observed a significant association in the case-control and case-parent analysis of the SNP rs9890413. In addition, the P values for the haplotype of rs3809857-rs9890413 were observed to be statistically significant (P = 0.004). In conclusion, our study confirmed the association between the WNT3 variant and NSCL/P in the population tested.
MeSH term(s)	Alleles ; Asian Continental Ancestry Group/genetics ; Brain/abnormalities ; Case-Control Studies ; China/epidemiology ; Cleft Lip/epidemiology ; Cleft Lip/genetics ; Cleft Palate/epidemiology ; Cleft Palate/genetics ; Female ; Gene Frequency ; Genetic Association Studies ; Haplotypes ; Humans ; Incidence ; Male ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide ; Wnt3 Protein/genetics
Chemical Substances	WNT3 protein, human ; Wnt3 Protein
Language	English
Publishing date	2015-10-19
Publishing country	Brazil
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2114039-X
ISSN	1676-5680 ; 1676-5680
ISSN (online)	1676-5680
ISSN	1676-5680
DOI	10.4238/2015.October.19.8
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Article ; Online: Study on the electro-transformation conditions of improving transformation efficiency for Bacillus subtilis.

Lu, Y-P / Zhang, C / Lv, F X / Bie, X M / Lu, Z-X

Letters in applied microbiology

2012 Volume 55, Issue 1, Page(s) 9–14

Abstract: Aims: To optimize the transformation conditions and improve the transformation efficiency of Bacillus subtilis WB800 and DB104.: Methods and results: Trehalose, which could decrease the damage of electric shock to the cells, was added to the ... ...

Abstract	Aims: To optimize the transformation conditions and improve the transformation efficiency of Bacillus subtilis WB800 and DB104. Methods and results: Trehalose, which could decrease the damage of electric shock to the cells, was added to the electroporation medium containing sorbitol and mannitol. The factors affecting the transformation efficiency, such as the growth phase of bacteria, cell concentration, electric field strength and plasmid variety, were examined and improved. The new method increased the transformation efficiency of B. subtilis by nearly 100-fold compared with the conventional one. Conclusions: With the optimized method, the transformation efficiency came up to 3.64 × 10(5) transformants μg(-1) DNA for WB800, and 2.10 × 10(5) transformants μg(-1) DNA for DB104. Significance and impact of the study: This improvement in transformation efficiency will be largely attributed to the research of expression of exogenous genes in B. subtilis, gene library construction for directed evolution and transformation of wild-type B. subtilis strains.
MeSH term(s)	Bacillus subtilis/genetics ; Bacillus subtilis/growth & development ; Culture Media/chemistry ; DNA/genetics ; Electroporation/methods ; Genetic Techniques ; Mannitol/chemistry ; Plasmids ; Sorbitol/chemistry ; Transformation, Genetic ; Trehalose/chemistry
Chemical Substances	Culture Media ; Mannitol (3OWL53L36A) ; Sorbitol (506T60A25R) ; DNA (9007-49-2) ; Trehalose (B8WCK70T7I)
Language	English
Publishing date	2012-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632584-1
ISSN	1472-765X ; 0266-8254
ISSN (online)	1472-765X
ISSN	0266-8254
DOI	10.1111/j.1472-765X.2012.03249.x
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Article: [Initial study of transthoracic echocardiography guided three-dimensional printing on the application of assessment of structural heart disease].

Zhu, Y B / Liu, J S / Wang, L Q / Guan, X / Luo, Y J / Geng, J / Geng, Q G / Lin, Y J / Zhang, L X / Li, X X / Lu, Y P

Zhonghua yi xue za zhi

2017 Volume 97, Issue 29, Page(s) 2280–2283

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Echocardiography ; Echocardiography, Three-Dimensional ; Female ; Heart Septal Defects, Atrial ; Heart Septal Defects, Ventricular ; Humans ; Male ; Middle Aged ; Printing, Three-Dimensional ; Young Adult
Language	Chinese
Publishing date	2017-08-05
Publishing country	China
Document type	Journal Article
ZDB-ID	132513-9
ISSN	0376-2491
ISSN	0376-2491
DOI	10.3760/cma.j.issn.0376-2491.2017.29.010
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