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  1. Article ; Online: Roles of circRNAs in the progression of colorectal cancer: novel strategies for detection and therapy.

    Mao, Jun / Lu, Ying

    Cancer gene therapy

    2024  

    Abstract: Endogenous noncoding RNAs with a covalently closed loop are known as circular RNAs (circRNAs). Recently, published works have revealed that circRNAs, which act as microRNA sponges, are critical for the biological behavior of several kinds of malignancies, ...

    Abstract Endogenous noncoding RNAs with a covalently closed loop are known as circular RNAs (circRNAs). Recently, published works have revealed that circRNAs, which act as microRNA sponges, are critical for the biological behavior of several kinds of malignancies, including tumor cell proliferation, apoptosis, invasion, and metastasis. Additionally, there is a significant correlation between circRNAs and tumor resistance, stage, prognosis, and size. At present, colorectal cancer (CRC) is one of the most serious malignant tumors for human health. CircRNAs could represent potential targets to use in the prevention, diagnosis, and therapy of CRC, according to many studies. To fully comprehend the role of circRNAs in the incidence and progression of CRC, this review outlines the regulatory role and mechanisms of circRNAs in CRC and assesses their potential relevance as diagnostic and treatment possibilities for CRC. Our goal is to offer meaningful biological information for clinical evaluation and decision-making process for CRC treatment.
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1212513-1
    ISSN 1476-5500 ; 0929-1903
    ISSN (online) 1476-5500
    ISSN 0929-1903
    DOI 10.1038/s41417-024-00739-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4125: Show issues Location:
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  2. Article: Transmission efficiency of one tooth difference sine tooth profile planetary reducer.

    Lu, Ying / Xu, Lizhong

    Heliyon

    2024  Volume 10, Issue 4, Page(s) e26300

    Abstract: The structural size of space exploration and unmanned aerial vehicle manipulator is required to be as small as possible, and the weight must be as light as possible. However, the existing reducers have difficulties in achieving lightweight robot joint ... ...

    Abstract The structural size of space exploration and unmanned aerial vehicle manipulator is required to be as small as possible, and the weight must be as light as possible. However, the existing reducers have difficulties in achieving lightweight robot joint drive systems. For it, this paper proposes a single tooth difference continuous sine tooth profile K-H-V type planetary reducer in which pin type equi-speed output mechanism is used. Concerning the reducer, its structural composition and meshing characteristics are analyzed. Based on the findings, the meshing pair's force, the friction coefficient, and the meshing efficiency are investigated. The force and bearing efficiency of the planetary gear are studied, and the efficiency of the equi-speed output mechanism in addition to the total efficiency of the reducer are determined. Moreover, the efficiency of the reducer prototype is measured and compared to the calculated efficiencies. The results show that the gear modulus, the input speed, the surface roughness, and the lubricating oil viscosity have a significant effect on the meshing efficiency. Furthermore, the efficiency of the eccentric bearings is significantly lower than that of the non-eccentric bearings. Therefore, it can be increased by tuning the pressure angle, the tooth number of planetary gear, the tooth height, and the distribution circle radius of the pinhole. In addition, the power loss of the output mechanism has the greatest effect on transmission efficiency. Reducing the center distance, the inner diameter of the rotating arm bearing, and the tooth number of planetary gear, as well as increasing the outer diameter of the pin shaft can reduce the power loss of the output mechanism. The experimental efficiency of the reducer prototype is 82.47%, its computational efficiency is 83.72%, and its error is 1.25%, verifying the correctness of the efficiency calculation method.
    Language English
    Publishing date 2024-02-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e26300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The mechanism of photodegradation reaction of different dissociation forms of tetrabromobisphenol S in water with free radicals and the ecotoxicity evaluation of related products.

    Lu, Ying / Wang, Se

    Chemosphere

    2024  Volume 350, Page(s) 141136

    Abstract: Tetrabromobisphenol S (TBBPS) is a widely used brominated flame retardant that has attracted environmental concern due to its abundant presence in water. The objective of this study is to systematically analyze the direct photolysis and degradation ... ...

    Abstract Tetrabromobisphenol S (TBBPS) is a widely used brominated flame retardant that has attracted environmental concern due to its abundant presence in water. The objective of this study is to systematically analyze the direct photolysis and degradation mechanisms of TBBPS in two different dissociation forms in water, as well as to evaluate their toxicological effects induced by •OH,
    MeSH term(s) Water ; Photolysis ; Nitrogen Dioxide ; Free Radicals ; Kinetics ; Water Pollutants, Chemical/toxicity ; Water Pollutants, Chemical/chemistry ; Polybrominated Biphenyls
    Chemical Substances Water (059QF0KO0R) ; tetrabromobisphenol S ; Nitrogen Dioxide (S7G510RUBH) ; Free Radicals ; Water Pollutants, Chemical ; Polybrominated Biphenyls
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2024.141136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2540: Show issues Location:
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  4. Article ; Online: Theoretical explanation of direct photolysis and indirect photolysis of bendazone with •OH, •SO

    Lu, Ying / Wang, Se

    Environmental science and pollution research international

    2024  Volume 31, Issue 12, Page(s) 18982–18992

    Abstract: Bendazone (BNTE) is an herbicide and a highly concerned pollutant in aquatic environments. Understanding the photochemical behavior of BNTE in water is crucial for evaluating its photochemical conversion process in aquatic environments. This study ... ...

    Abstract Bendazone (BNTE) is an herbicide and a highly concerned pollutant in aquatic environments. Understanding the photochemical behavior of BNTE in water is crucial for evaluating its photochemical conversion process in aquatic environments. This study analyzed the direct photolysis and indirect photolysis pathways of two dissociated forms of BNTE in water through density functional theory and time-dependent density functional theory method. The results show that the reaction types of indirect photolysis of BNTE with free radicals (•OH, •SO
    MeSH term(s) Photolysis ; Water/chemistry ; Water Pollutants, Chemical/analysis ; Kinetics ; Free Radicals
    Chemical Substances Water (059QF0KO0R) ; Water Pollutants, Chemical ; Free Radicals
    Language English
    Publishing date 2024-02-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-024-32315-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

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  5. Book: Advanced medical statistics

    Lu, Ying

    2003  

    Author's details ed. Ying Lu
    Language English
    Size XV, 1101 S. : Ill., graph. Darst.
    Publisher World Scientific
    Publishing place River Edge, NJ u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013441472
    ISBN 981-02-4800-8 ; 981-02-4799-0 ; 978-981-02-4800-0 ; 978-981-02-4799-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 314 order for loan Magazin

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  6. Article ; Online: Panax notoginseng saponins reverse steroid resistance in lupus nephritis: Involvement of the suppression of exosomal P-gp levels from lymphocytes to glomerular endothelial cells.

    Pan, Feng / Lu, Ying

    Biochemistry and biophysics reports

    2023  Volume 36, Page(s) 101568

    Abstract: Microangiopathy is the most basic pathological manifestation of lupus nephritis (LN), and glomerular endothelial cells (GECs) injury is an important pathological mechanism. LN patients with microangiopathy are prone to steroid resistance (SR). Our ... ...

    Abstract Microangiopathy is the most basic pathological manifestation of lupus nephritis (LN), and glomerular endothelial cells (GECs) injury is an important pathological mechanism. LN patients with microangiopathy are prone to steroid resistance (SR). Our previous studies confirmed that Panax notoginseng saponins (PNS) could reverse SR by downregulating the expression of P-gp in SR lymphocytes of LN mice (SLCsL/S). However, the mechanism of how circulating lymphocytes transmit SR information to GECs and thus affect the efficacy of kidney treatment is not clear. Recent studies have found that exosomes (exos) are an important carrier for intercellular bioactive substance communication. But whether exosomes derived from SLCsL/S mediate SR in GECs and PNS interventions. To solve this problem, Exosomes isolated from SLCsL/S were characterized, and in vitro cell coculture was further conducted to investigate the effect of SLCsL/S-derived exosomes in the SR of GECs and PNS intervention. Sequencing was used to define the exosomal miRNA expression profiling of SR GECs. Moreover, the in vivo experiments were performed through the injection of exosomes extracted from SLCsL/S into the tail vein of mice. Our research results indicate that exosomes derived from SLCsL/S could transmit SR information to GECs and lead to the aggravation of inflammatory injury through conferring P-gp, which were negated by a P-gp inhibitor. Further, we identified higher levels of exosomal miR-125b-5p from SR GECs were associated with SR in LN and could serve as biomarker for the risk of developing SR. PNS could reverse the SR of GECs and alleviate inflammatory injury by suppressing exosomal P-gp levels from lymphocytes to GECs in vitro and in vivo. However, the specific molecular mechanism by which PNS regulates exosomes has not yet been elucidated, and we need to conduct more in-depth research in the future. Overall, Our findings suggest that exosomal transfer of SLCsL/S derived P-gp confer SR to GECs, and PNS can target exosome communication to reverse SR in LN, which provides new ideas and a scientific basis for improving the clinical efficacy of traditional Chinese medicine in the treatment of refractory LN.
    Language English
    Publishing date 2023-11-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2831046-9
    ISSN 2405-5808 ; 2405-5808
    ISSN (online) 2405-5808
    ISSN 2405-5808
    DOI 10.1016/j.bbrep.2023.101568
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The outcome of prolonged postoperative antibiotics on wound healing in orthognathic surgery: A meta-analysis.

    Lu, Ying / Li, Jian

    International wound journal

    2023  Volume 20, Issue 6, Page(s) 2233–2240

    Abstract: We conducted a meta-analysis to assess the outcome of prolonged postoperative antibiotics (PA) on wound healing in orthognathic surgery (OS). A systematic literature search up to January 2023 was performed and 1021 related studies were evaluated. The ... ...

    Abstract We conducted a meta-analysis to assess the outcome of prolonged postoperative antibiotics (PA) on wound healing in orthognathic surgery (OS). A systematic literature search up to January 2023 was performed and 1021 related studies were evaluated. The chosen studies comprised 1057 OS subjects who participated in the selected studies' baseline, 446 of them used short-term PA, and 611 used long-term PA. Odds ratio (OR) with 95% confidence intervals (CIs) were calculated to assess the effect of prolonged PA on wound infection after OS by the dichotomous methods with a random or fixed effect model. The short-term PA resulted in significantly higher wound infection (OR, 4.27; 95% CI, 2.97-6.14, P < 0.001) with low heterogeneity (I
    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Orthognathic Surgery ; Orthopedic Procedures ; Surgical Wound Infection/drug therapy ; Wound Healing ; Wound Infection
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-03-14
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2170920-8
    ISSN 1742-481X ; 1742-4801
    ISSN (online) 1742-481X
    ISSN 1742-4801
    DOI 10.1111/iwj.14104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6006: Show issues Location:
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  8. Article ; Online: Simulating the conformational dynamics of the ATPase complex on proteasome using its free-energy landscape.

    Fang, Rui / Lu, Ying

    STAR protocols

    2023  Volume 4, Issue 4, Page(s) 102182

    Abstract: The AAA+ ATPase complex on proteasome powers its functions through a series of intricate conformational transitions. Here, we describe a procedure to simulate the conformational dynamics of the proteasomal ATPase complex. We first empirically determined ... ...

    Abstract The AAA+ ATPase complex on proteasome powers its functions through a series of intricate conformational transitions. Here, we describe a procedure to simulate the conformational dynamics of the proteasomal ATPase complex. We first empirically determined the free-energy landscape (FEL) of proteasome and then simulated proteasome's conformational changes as stochastic transitions on its FEL. We compared the FEL-predicted proteasomal behaviors with experimental measurements and analyzed the map of the ATPase's global dynamics to gain mechanistic insights into proteasomal degradation. For complete details on the use and execution of this protocol, please refer to Fang et al. (2022).
    MeSH term(s) Proteasome Endopeptidase Complex/metabolism ; Molecular Conformation ; Adenosine Triphosphatases/metabolism
    Chemical Substances Proteasome Endopeptidase Complex (EC 3.4.25.1) ; Adenosine Triphosphatases (EC 3.6.1.-)
    Language English
    Publishing date 2023-09-26
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2023.102182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Two new species of Amaurobius C. L. Koch, 1837 (Araneae, Amaurobiidae) from Sichuan Province, China.

    Lu, Ying / Lin, Yejie / Li, Shuqiang

    Zootaxa

    2024  Volume 5397, Issue 1, Page(s) 116–126

    Abstract: In this paper, two new species of the genus Amaurobius C. L. Koch, 1837 of the family Amaurobiidae Thorell, 1869 are reported from Sichuan Province, China: A. danba Lin & Li, sp. nov. () and A. yaan Lin & Li, sp. nov. (). Photos and morphological ... ...

    Abstract In this paper, two new species of the genus Amaurobius C. L. Koch, 1837 of the family Amaurobiidae Thorell, 1869 are reported from Sichuan Province, China: A. danba Lin & Li, sp. nov. () and A. yaan Lin & Li, sp. nov. (). Photos and morphological descriptions of the new species are presented; the type specimens of the new species are deposited in the Institute of Zoology, Chinese Academy of Sciences (IZCAS), Beijing.
    MeSH term(s) Animals ; China ; Spiders
    Language English
    Publishing date 2024-01-03
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.5397.1.6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Study on the Direct and Indirect Photolysis of Antibacterial Florfenicol in Water Using DFT/TDDFT Method and Comparison of Its Reactivity with Hydroxyl Radical under the Effect of Metal Ions.

    Kang, Yue / Lu, Ying / Wang, Se

    Toxics

    2024  Volume 12, Issue 2

    Abstract: Florfenicol (FLO) is a widely used antibacterial drug, which is often detected in the environment. In this paper, the photolysis mechanism of FLO in water was investigated using density functional theory (DFT) and time-dependent density functional theory ...

    Abstract Florfenicol (FLO) is a widely used antibacterial drug, which is often detected in the environment. In this paper, the photolysis mechanism of FLO in water was investigated using density functional theory (DFT) and time-dependent density functional theory (TDDFT). The focus of the study is to elucidate the direct photolysis mechanism of FLO in the water environment and the indirect photolysis of free radicals (·OH, ·NO
    Language English
    Publishing date 2024-02-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics12020127
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