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Article: Clinical evaluation of maxillary sinus floor elevation with or without bone grafts: a systematic review and meta-analysis of randomised controlled trials with trial sequential analysis.

Chen, Jiayi / Lu, Yiping / Xu, Jin / Hua, Zhen

2024 Volume 20, Issue 2, Page(s) 384–401

Abstract: Introduction: Our goal was to systematically review the current evidence comparing the relative effectiveness of two maxillary sinus floor elevation (MSFE) approaches (internal and external) without bone grafts with that of conventional/grafted MSFE in ... ...

Abstract	Introduction: Our goal was to systematically review the current evidence comparing the relative effectiveness of two maxillary sinus floor elevation (MSFE) approaches (internal and external) without bone grafts with that of conventional/grafted MSFE in patients undergoing implantation in the posterior maxilla. Material and methods: Medical databases (PubMed/Medline, Embase, Web of Science, and Cochrane Library) were searched for randomised controlled trials published between January 1980 and May 2023. A manual search of implant-related journals was also performed. Studies published in English that reported the clinical outcomes of MSFE with or without bone material were included. The risk of bias was assessed using the Cochrane Handbook Risk Assessment Tool. Meta-analyses and trial sequence analyses were performed on the included trials. Meta-regression analysis was performed using pre-selected covariates to account for substantial heterogeneity. The certainty of evidence for clinical outcomes was assessed using GRADEpro GDT online (Guideline Development Tool). Results: Seventeen studies, including 547 sinuses and 696 implants, were pooled for the meta-analysis. The meta-analysis showed no statistically significant difference between MSFE without bone grafts and conventional MSFE in terms of the implant survival rate in the short term ( Conclusions: This systematic review revealed that both non-graft and grafted MSFE had high implant survival rates. Owing to the moderate strength of the evidence and short-term follow-up, the results should be interpreted with caution.
Language	English
Publishing date	2024-03-20
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	2203781-0
ISSN	1734-1922
ISSN	1734-1922
DOI	10.5114/aoms/174648
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Article ; Online: The Use of Tricaine Methanesulfonate (MS-222) in Asian Seabass (

Hsu, Julia Chu-Ning / Rairat, Tirawat / Lu, Yi-Ping / Chou, Chi-Chung

Veterinary sciences

2023 Volume 10, Issue 9

Abstract: This study was conducted to determine the optimal doses and minimum effective concentrations (MECs) of tricaine methanesulfonate (MS-222) in marketable-size Asian seabass reared at two temperatures (22 and 28 °C). Serum biochemical parameters, ... ...

Abstract	This study was conducted to determine the optimal doses and minimum effective concentrations (MECs) of tricaine methanesulfonate (MS-222) in marketable-size Asian seabass reared at two temperatures (22 and 28 °C). Serum biochemical parameters, pharmacokinetics, and tissue distributions of MS-222 following immersion at the determined optimal doses were also evaluated in order to delineate possible mechanisms dictating the temperature difference. The definition of optimal dose is set as the dose when fish attain stage III anesthesia within 5 min, sustain this stage for 3 min, and re-attain equilibrium within 5 min. The MEC is the fish serum MS-222 concentration when stage III anesthesia is reached. The results showed that water temperature exerted no or minimal impact on the designated parameters. The optimal doses at 22 and 28 °C were 140 and 150 µg/mL, while the MECs were 70.48 and 78.27 µg/mL, respectively. Fish exposed to the optimal doses of MS-222 had significantly elevated blood concentrations of lactate, glucose, calcium, magnesium, and sodium, while the blood pH was significantly decreased. The fish eliminated MS-222 faster at 28 °C than at 22 °C, with serum half-lives of 18.43 and 37.01 h, respectively. Tissue-specific distribution patterns were evident. Irrespective of water temperature, MS-222 peaked at 5 min for the brain and gill but peaked slightly later at 10-20 min for the liver and kidney. Most tissues exhibit a gradual decline of drug concentration except for the gill, which was maintained at a steady level. Muscle is the least perfused tissue with the lowest drug concentration throughout the 90 min period. This study provided physiological and pharmacokinetic evidence contributing to a better understanding of the actions of MS-222 in Asian seabass at different temperatures.
Language	English
Publishing date	2023-08-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2768971-2
ISSN	2306-7381 ; 2306-7381
ISSN (online)	2306-7381
ISSN	2306-7381
DOI	10.3390/vetsci10090539
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Article: [Darolutamide: A new drug for non-metastatic castration-resistant prostate cancer].

Zhang, Fan / Lu, Yi-Ping

Zhonghua nan ke xue = National journal of andrology

2020 Volume 26, Issue 4, Page(s) 364–368

Abstract: Prostate cancer (PCa) is one of the most common tumors in male. Castration-resistant PCa (CRPC) refers to the prostate malignancy with a PSA increase or imaging progression after androgen-deprivation therapy (ADT), which is divided into metastatic CRPC ( ... ...

Abstract	Prostate cancer (PCa) is one of the most common tumors in male. Castration-resistant PCa (CRPC) refers to the prostate malignancy with a PSA increase or imaging progression after androgen-deprivation therapy (ADT), which is divided into metastatic CRPC (mCRPC) and non-metastatic CRPC (nmCRPC) based on the presence or absence of imaging metastasis. Two second-generation antiandrogens, enzuramide and abiraterone, were approved for the treatment of nmCRPC in 2018. A recently completed three-stage large-scale clinical ARAMIS trial shows that the new drug, darolutamide, compared with the placebo, could prolong the metastasis-free survival (MFS) of nmCRPC patients. Darolutamide is now an anti-androgen drug available for patients with nmCRPC. This review focuses on the clinical trial of darolutamide and comparison of its therapeutic effect with that of another two second-generation antiandrogens.
MeSH term(s)	Androgen Antagonists/therapeutic use ; Androgen Receptor Antagonists/therapeutic use ; Humans ; Male ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Pyrazoles/therapeutic use ; Randomized Controlled Trials as Topic
Chemical Substances	Androgen Antagonists ; Androgen Receptor Antagonists ; Pyrazoles ; darolutamide
Language	Chinese
Publishing date	2020-12-22
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2267480-9
ISSN	1009-3591
ISSN	1009-3591
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Book ; Online: When can Regression-Adjusted Control Variates Help? Rare Events, Sobolev Embedding and Minimax Optimality

Blanchet, Jose / Chen, Haoxuan / Lu, Yiping / Ying, Lexing

2023

Abstract: This paper studies the use of a machine learning-based estimator as a control variate for mitigating the variance of Monte Carlo sampling. Specifically, we seek to uncover the key factors that influence the efficiency of control variates in reducing ... ...

Abstract	This paper studies the use of a machine learning-based estimator as a control variate for mitigating the variance of Monte Carlo sampling. Specifically, we seek to uncover the key factors that influence the efficiency of control variates in reducing variance. We examine a prototype estimation problem that involves simulating the moments of a Sobolev function based on observations obtained from (random) quadrature nodes. Firstly, we establish an information-theoretic lower bound for the problem. We then study a specific quadrature rule that employs a nonparametric regression-adjusted control variate to reduce the variance of the Monte Carlo simulation. We demonstrate that this kind of quadrature rule can improve the Monte Carlo rate and achieve the minimax optimal rate under a sufficient smoothness assumption. Due to the Sobolev Embedding Theorem, the sufficient smoothness assumption eliminates the existence of rare and extreme events. Finally, we show that, in the presence of rare and extreme events, a truncated version of the Monte Carlo algorithm can achieve the minimax optimal rate while the control variate cannot improve the convergence rate.
Keywords	Mathematics - Statistics Theory ; Computer Science - Information Theory ; Mathematics - Numerical Analysis ; Statistics - Machine Learning
Subject code	510
Publishing date	2023-05-25
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Thesis: Untersuchung der Caseinkinase II bei menschlichen urologischen Tumoren

Lu, Yi-Ping

1991

Author's details	vorgelegt von Yi-Ping Lu
Size	2 Mikrofiches : 24x
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Saarbrücken, Univ., Diss., 1991
Note	Mikroreprod. eines Ms. Getr. Zählung: Ill., graph. Darst.
HBZ-ID	HT004222483
Database	Catalogue ZB MED Medicine, Health

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1992 MB 1930	order for loan	Magazin

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Article ; Online: Synergistic Amelioration of Osseointegration and Osteoimmunomodulation with a Microarc Oxidation-Treated Three-Dimensionally Printed Ti-24Nb-4Zr-8Sn Scaffold via Surface Activity and Low Elastic Modulus.

Yang, Xinyue / Wu, Lijun / Li, Cheng / Li, Shujun / Hou, Wentao / Hao, Yulin / Lu, Yiping / Li, Lei

ACS applied materials & interfaces

2024 Volume 16, Issue 3, Page(s) 3171–3186

Abstract: Biomaterial scaffolds, including bone substitutes, have evolved from being primarily a biologically passive structural element to one in which material properties such as surface topography and chemistry actively direct bone regeneration by influencing ... ...

Abstract	Biomaterial scaffolds, including bone substitutes, have evolved from being primarily a biologically passive structural element to one in which material properties such as surface topography and chemistry actively direct bone regeneration by influencing stem cells and the immune microenvironment. Ti-6Al-4V(Ti6Al4V) implants, with a significantly higher elastic modulus than human bone, may lead to stress shielding, necessitating improved stability at the bone-titanium alloy implant interface. Ti-24Nb-4Zr-8Sn (Ti2448), a low elastic modulus β-type titanium alloy devoid of potentially toxic elements, was utilized in this study. We employed 3D printing technology to fabricate a porous scaffold structure to further decrease the structural stiffness of the implant to approximate that of cancellous bone. Microarc oxidation (MAO) surface modification technology is then employed to create a microporous structure and a hydrophilic oxide ceramic layer on the surface and interior of the scaffold. In vitro studies demonstrated that MAO treatment enhances the proliferation, adhesion, and osteogenesis capabilities on the scaffold surface. The chemical composition of the MAO-Ti2448 oxide layer is found to enhance the transcription and expression of osteogenic genes in bone mesenchymal stem cells (BMSCs), potentially related to the enrichment of Nb
MeSH term(s)	Animals ; Humans ; Rabbits ; Osseointegration ; Osteogenesis ; Elastic Modulus ; Titanium/pharmacology ; Alloys/pharmacology ; Alloys/chemistry ; Oxides ; Printing, Three-Dimensional ; Surface Properties
Chemical Substances	beta titanium ; Titanium (D1JT611TNE) ; Alloys ; Oxides
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c16459
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Article: Enhanced Surface Properties of the Al

Miao, Junwei / Li, Tianxin / Li, Qiang / Chen, Xiaohu / Ren, Zheng / Lu, Yiping

Materials (Basel, Switzerland)

2023 Volume 16, Issue 3

Abstract: The laser remelting technique was applied to the surface modification of the ... ...

Abstract	The laser remelting technique was applied to the surface modification of the Al
Language	English
Publishing date	2023-01-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16031085
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Article: Polymorphism of E6 and E7 Genes in Human Papillomavirus Types 31 and 33 in Northeast China.

Yu, Miao / Wu, Si / Wang, Shuang / Cui, Changwan / Lu, Yiping / Sun, Zhengrong

The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale

2023 Volume 2023, Page(s) 9338294

Abstract: Persistent infection with human papillomavirus (HPV) types 31 and 33 is an important causative factor for cervical cancer. The E6/E7 genes are key oncogenes involved in the immortalization and transformation of human epithelial cells. Genetic ... ...

Abstract	Persistent infection with human papillomavirus (HPV) types 31 and 33 is an important causative factor for cervical cancer. The E6/E7 genes are key oncogenes involved in the immortalization and transformation of human epithelial cells. Genetic polymorphism may lead to differences in the virus' carcinogenic potential, the immune reaction of the host, and the potencies of vaccines. Few studies on HPV31/33 E6/E7 genetic polymorphism have been carried out. To study the genetic polymorphism of HPV31 and HPV33 E6/E7 genes in northeast China, these genes (HPV31 E6/E7,
Language	English
Publishing date	2023-03-13
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	1057056-1
ISSN	1712-9532 ; 1180-2332
ISSN	1712-9532 ; 1180-2332
DOI	10.1155/2023/9338294
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Zs.A 3099: Show issues

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Article ; Online: Prediction of human epidermal growth factor receptor 2 (HER2) status in breast cancer by mammographic radiomics features and clinical characteristics: a multicenter study.

Deng, Yalan / Lu, Yiping / Li, Xuanxuan / Zhu, Yuqi / Zhao, Yajing / Ruan, Zhuoying / Mei, Nan / Yin, Bo / Liu, Li

European radiology

2024

Abstract: Objectives: To preoperatively evaluate the human epidermal growth factor 2 (HER2) status in breast cancer using mammographic radiomics features and clinical characteristics on a multi-vendor and multi-center basis.: Methods: This multi-center study ... ...

Abstract	Objectives: To preoperatively evaluate the human epidermal growth factor 2 (HER2) status in breast cancer using mammographic radiomics features and clinical characteristics on a multi-vendor and multi-center basis. Methods: This multi-center study included a cohort of 1512 Chinese female with invasive ductal carcinoma of no special type (IDC-NST) from two different hospitals and five devices (1332 from Institution A, used for training and testing the models, and 180 women from Institution B, as the external validation cohort). The Gradient Boosting Machine (GBM) was employed to establish radiomics and multiomics models. Model efficacy was evaluated by the area under the curve (AUC). Results: The number of HER2-positive patients in the training, testing, and external validation cohort were 245(26.3%), 105 (26.3.8%), and 51(28.3%), respectively, with no statistical differences among the three cohorts (p = 0.842, chi-square test). The radiomics model, based solely on the radiomics features, achieved an AUC of 0.814 (95% CI, 0.784-0.844) in the training cohort, 0.776 (95% CI, 0.727-0.825) in the testing cohort, and 0.702 (95% CI, 0.614-0.790) in the external validation cohort. The multiomics model, incorporated radiomics features with clinical characteristics, consistently outperformed the radiomics model with AUC values of 0.838 (95% CI, 0.810-0.866) in the training cohort, 0.788 (95% CI, 0.741-0.835) in the testing cohort, and 0.722 (95% CI, 0.637-0.811) in the external validation cohort. Conclusions: Our study demonstrates that a model based on radiomics features and clinical characteristics has the potential to accurately predict HER2 status of breast cancer patients across multiple devices and centers. Clinical relevance statement: By predicting the HER2 status of breast cancer reliably, the presented model built upon radiomics features and clinical characteristics on a multi-vendor and multi-center basis can help in bolstering the model's applicability and generalizability in real-world clinical scenarios. Key points: • The mammographic presentation of breast cancer is closely associated with the status of human epidermal growth factor receptor 2 (HER2). • The radiomics model, based solely on radiomics features, exhibits sub-optimal performance in the external validation cohort. • By combining radiomics features and clinical characteristics, the multiomics model can improve the prediction ability in external data.
Language	English
Publishing date	2024-01-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-024-10607-9
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Zs.A 3300: Show issues

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Article ; Online: Bacteria-Based Nanoprobes for Cancer Therapy.

Lu, Yiping / Mei, Nan / Ying, Yinwei / Wang, Dongdong / Li, Xuanxuan / Zhao, Yajing / Zhu, Yuqi / Shen, Shun / Yin, Bo

International journal of nanomedicine

2024 Volume 19, Page(s) 759–785

Abstract: Surgical removal together with chemotherapy and radiotherapy has used to be the pillars of cancer treatment. Although these traditional methods are still considered as the first-line or standard treatments, non-operative situation, systemic toxicity or ... ...

Abstract	Surgical removal together with chemotherapy and radiotherapy has used to be the pillars of cancer treatment. Although these traditional methods are still considered as the first-line or standard treatments, non-operative situation, systemic toxicity or resistance severely weakened the therapeutic effect. More recently, synthetic biological nanocarriers elicited substantial interest and exhibited promising potential for combating cancer. In particular, bacteria and their derivatives are omnipotent to realize intrinsic tumor targeting and inhibit tumor growth with anti-cancer agents secreted and immune response. They are frequently employed in synergistic bacteria-mediated anticancer treatments to strengthen the effectiveness of anti-cancer treatment. In this review, we elaborate on the development, mechanism and advantage of bacterial therapy against cancer and then systematically introduce the bacteria-based nanoprobes against cancer and the recent achievements in synergistic treatment strategies and clinical trials. We also discuss the advantages as well as the limitations of these bacteria-based nanoprobes, especially the questions that hinder their application in human, exhibiting this novel anti-cancer endeavor comprehensively.
MeSH term(s)	Humans ; Neoplasms/drug therapy ; Neoplasms/pathology ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/pharmacology ; Bacteria
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2024-01-23
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S438164
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Zs.A 6606: Show issues

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