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  1. Article ; Online: Heavy metals chemical speciation and environmental risk of bottom slag during co-combustion of municipal solid waste and sewage sludge

    Chen, Limei / Liao, Yanfen / Ma, Xiaoqian / Lü, Shiguang

    Journal of cleaner production. 2020 July 20, v. 262 p.121318-

    2020  

    Abstract: Incineration of sewage sludge (SS) in waste incinerators is one of the main ways of SS disposal. In order to reuse the incineration bottom slag, chemical speciation and environmental risk of heavy metals of bottom slag during co-combustion of municipal ... ...

    Abstract Incineration of sewage sludge (SS) in waste incinerators is one of the main ways of SS disposal. In order to reuse the incineration bottom slag, chemical speciation and environmental risk of heavy metals of bottom slag during co-combustion of municipal solid waste (MSW) and SS should be evaluated. When co-combusted with SS, the proportion of mild acid-souble fraction of Cr, Cu and Zn in the bottom slag decreased, the proportion of reducible fraction and residual fraction increased. As for As, with the increase of sludge blending ratio, the proportion of mild acid-souble fraction increased, and the proportion of oxidizable fraction decreased rapidly. The degree of soil contamination by As and the ecological risk of As of MSW combustion bottom slag increased when co-combusted with SS, while that of Cr, Cu, and Zn decreased. Fitting formulas between environmental index of bottom slag and combustion condition were giving.
    Keywords arsenic ; chemical speciation ; chromium ; combustion ; copper ; heavy metals ; incinerators ; mixing ; municipal solid waste ; risk ; sewage sludge ; slags ; soil pollution ; zinc ; Heavy metals ; Municipal solid wastes ; Sewage sludge ; Combustion bottom slag ; Ecological risk
    Language English
    Dates of publication 2020-0720
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ISSN 0959-6526
    DOI 10.1016/j.jclepro.2020.121318
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Hangover headache and its behavioral changes in rats

    Lu Shiguang / Zhang Ying / Yang Yuejun / Zhang Yafang / Qin Guangcheng / Fu Qingqing / Shi Yingying / Zhang Fan / Wang Zhe / Chen Yanhe / Liu Yuancai / chen Lixue

    Iranian Journal of Basic Medical Sciences, Vol 26, Iss 3, Pp 326-

    2023  Volume 334

    Abstract: Objective(s): The present study aims to establish and evaluate a rat model for hangover headaches caused by alcoholic drinks.Materials and Methods: Chronic migraine (CM) model rats were divided into 3 groups, and intragastrically administered alcoholic ... ...

    Abstract Objective(s): The present study aims to establish and evaluate a rat model for hangover headaches caused by alcoholic drinks.Materials and Methods: Chronic migraine (CM) model rats were divided into 3 groups, and intragastrically administered alcoholic drinks (sample A, B, or C) to simulate hangover headache attacks. The withdrawal threshold for the hind paw/face and the thermal latency of hind paw withdrawal were detected after 24 hr. Serum was collected from the periorbital venous plexus of rats in each group, and enzymatic immunoassays were used to determine the serum levels of calcitonin gene-related peptide (CGRP), substance P (SP), and nitric oxide (NO).Results: Compared with the control group, the mechanical hind paw pain threshold was significantly lower in rats administered Samples A and B after 24 hr; however, no significant difference was observed across groups for the thermal pain threshold. The mechanical threshold for periorbital pain was only significantly reduced in rats administered Sample A. Immunoassays further indicated that serum levels of SP in the group administered Sample A were significantly higher than those in the control group; the serum levels of NO and CGRP were significantly higher in the group of rats receiving Sample B.Conclusion: We successfully developed an effective and safe rat model for investigating alcohol drink induced hangover headaches. This model could be used to investigate the mechanisms associated with hangover headaches for the development of novel and promising candidates for the future treatment or prophylaxis of hangover headaches.
    Keywords alcohol ; animal ; behavior ; central nervous system - sensitization ; disease models ; hangover ; headche ; Medicine ; R
    Subject code 630
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Mashhad University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Quercetin in Tartary Buckwheat Induces Autophagy against Protein Aggregations

    Ikari, Sumiko / Yang, Qiang / Lu, Shiou-Ling / Liu, Yuancai / Hao, Feike / Tong, Guoqiang / Lü, Shiguang / Noda, Takeshi

    Antioxidants. 2021 July 29, v. 10, no. 8

    2021  

    Abstract: Tartary buckwheat is used as an ingredient in flour and tea, as well as in traditional Chinese medicine for its antioxidant effects. Here, we found that an ethanol extract of tartary buckwheat (TBE) potently induced autophagy flux in HeLa cells by ... ...

    Abstract Tartary buckwheat is used as an ingredient in flour and tea, as well as in traditional Chinese medicine for its antioxidant effects. Here, we found that an ethanol extract of tartary buckwheat (TBE) potently induced autophagy flux in HeLa cells by suppressing mTORC1 activity, as revealed by dephosphorylation of the mTORC1 substrates Ulk1, S6K, and 4EBP, as well as by the nuclear translocation of transcriptional factor EB. In addition to non-selective bulk autophagy, TBE also induced aggrephagy, which is defined as autophagy against aggregated proteins. Quercetin is a flavonol found at high levels in TBE. We showed that quercetin induced both non-selective bulk autophagy and aggrephagy. These effects were also observed in Huh-7 cells derived from hepatocytes. Thus, aggrephagy induction by TBE and quercetin may relieve alcoholic hepatitis, which is closely linked to the accumulation of protein aggregations called Mallory–Denk bodies.
    Keywords Oriental traditional medicine ; alcoholic hepatitis ; antioxidants ; buckwheat ; dephosphorylation ; ethanol ; flour ; hepatocytes ; ingredients ; macroautophagy ; quercetin ; tea ; transcription factors
    Language English
    Dates of publication 2021-0729
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10081217
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Hangover headache and its behavioral changes in rats.

    Lu, Shiguang / Zhang, Ying / Yang, Yuejun / Zhang, Yafang / Qin, Guangcheng / Fu, Qingqing / Shi, Yingying / Zhang, Fan / Wang, Zhe / Chen, Yanhe / Liu, Yuancai / Chen, Lixue

    Iranian journal of basic medical sciences

    2023  Volume 26, Issue 3, Page(s) 326–334

    Abstract: Objectives: The present study aims to establish and evaluate a rat model for hangover headaches caused by alcoholic drinks.: Materials and methods: Chronic migraine (CM) model rats were divided into 3 groups, and intragastrically administered ... ...

    Abstract Objectives: The present study aims to establish and evaluate a rat model for hangover headaches caused by alcoholic drinks.
    Materials and methods: Chronic migraine (CM) model rats were divided into 3 groups, and intragastrically administered alcoholic drinks (sample A, B, or C) to simulate hangover headache attacks. The withdrawal threshold for the hind paw/face and the thermal latency of hind paw withdrawal were detected after 24 hr. Serum was collected from the periorbital venous plexus of rats in each group, and enzymatic immunoassays were used to determine the serum levels of calcitonin gene-related peptide (CGRP), substance P (SP), and nitric oxide (NO).
    Results: Compared with the control group, the mechanical hind paw pain threshold was significantly lower in rats administered Samples A and B after 24 hr; however, no significant difference was observed across groups for the thermal pain threshold. The mechanical threshold for periorbital pain was only significantly reduced in rats administered Sample A. Immunoassays further indicated that serum levels of SP in the group administered Sample A were significantly higher than those in the control group; the serum levels of NO and CGRP were significantly higher in the group of rats receiving Sample B.
    Conclusion: We successfully developed an effective and safe rat model for investigating alcohol drink induced hangover headaches. This model could be used to investigate the mechanisms associated with hangover headaches for the development of novel and promising candidates for the future treatment or prophylaxis of hangover headaches.
    Language English
    Publishing date 2023-02-14
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2500485-2
    ISSN 2008-3874 ; 2008-3866
    ISSN (online) 2008-3874
    ISSN 2008-3866
    DOI 10.22038/IJBMS.2023.66724.14644
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Therapeutic strategies of small molecules in the microbiota-gut-brain axis for alcohol use disorder.

    Xie, Lushuang / Rungratanawanich, Wiramon / Yang, Qiang / Tong, Guoqiang / Fu, Eric / Lu, Shiguang / Liu, Yuancai / Akbar, Mohammed / Song, Byoung-Joon / Wang, Xin

    Drug discovery today

    2023  Volume 28, Issue 5, Page(s) 103552

    Abstract: The microbiota-gut-brain axis (MGBA) is important in maintaining the structure and function of the central nervous system (CNS) and is regulated by the CNS environment and signals from the peripheral tissues. However, the mechanism and function of the ... ...

    Abstract The microbiota-gut-brain axis (MGBA) is important in maintaining the structure and function of the central nervous system (CNS) and is regulated by the CNS environment and signals from the peripheral tissues. However, the mechanism and function of the MGBA in alcohol use disorder (AUD) are still not completely understood. In this review, we investigate the underlying mechanisms involved in the onset of AUD and/or associated neuronal deficits and create a foundation for better treatment (and prevention) strategies. We summarize recent reports focusing on the alteration of the MGBA in AUD. Importantly, we highlight the properties of small-molecule short-chain fatty acids (SCFAs), neurotransmitters, hormones, and peptides in the MGBA and discusses their usage as therapeutic agents against AUD.
    MeSH term(s) Humans ; Alcoholism/drug therapy ; Brain-Gut Axis ; Brain ; Central Nervous System
    Chemical Substances methylglyoxal bis(3-aminopropylamidinohydrazone) (121496-63-7)
    Language English
    Publishing date 2023-03-11
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1324988-5
    ISSN 1878-5832 ; 1359-6446
    ISSN (online) 1878-5832
    ISSN 1359-6446
    DOI 10.1016/j.drudis.2023.103552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Quercetin in Tartary Buckwheat Induces Autophagy against Protein Aggregations.

    Ikari, Sumiko / Yang, Qiang / Lu, Shiou-Ling / Liu, Yuancai / Hao, Feike / Tong, Guoqiang / Lu, Shiguang / Noda, Takeshi

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 8

    Abstract: Tartary buckwheat is used as an ingredient in flour and tea, as well as in traditional Chinese medicine for its antioxidant effects. Here, we found that an ethanol extract of tartary buckwheat (TBE) potently induced autophagy flux in HeLa cells by ... ...

    Abstract Tartary buckwheat is used as an ingredient in flour and tea, as well as in traditional Chinese medicine for its antioxidant effects. Here, we found that an ethanol extract of tartary buckwheat (TBE) potently induced autophagy flux in HeLa cells by suppressing mTORC1 activity, as revealed by dephosphorylation of the mTORC1 substrates Ulk1, S6K, and 4EBP, as well as by the nuclear translocation of transcriptional factor EB. In addition to non-selective bulk autophagy, TBE also induced aggrephagy, which is defined as autophagy against aggregated proteins. Quercetin is a flavonol found at high levels in TBE. We showed that quercetin induced both non-selective bulk autophagy and aggrephagy. These effects were also observed in Huh-7 cells derived from hepatocytes. Thus, aggrephagy induction by TBE and quercetin may relieve alcoholic hepatitis, which is closely linked to the accumulation of protein aggregations called Mallory-Denk bodies.
    Language English
    Publishing date 2021-07-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10081217
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A Traditional Chinese Medicine Plant Extract Prevents Alcohol-Induced Osteopenia.

    Qian, Dongyang / Zhou, Hui / Fan, Pan / Yu, Tao / Patel, Anish / O'Brien, Morgan / Wang, Zhe / Lu, Shiguang / Tong, Guoqiang / Shan, Yimin / Wang, Lei / Gao, Yuan / Xiong, Yuan / Zhang, Lily / Wang, Xin / Liu, Yuancai / Zhou, Shuanhu

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 754088

    Abstract: Traditional Chinese medicine (TCM) has been practiced in the treatment of bone diseases and alcoholism. Chronic excessive alcohol use results in alcohol-induced bone diseases, including osteopenia and osteoporosis, which increases fracture risk, ... ...

    Abstract Traditional Chinese medicine (TCM) has been practiced in the treatment of bone diseases and alcoholism. Chronic excessive alcohol use results in alcohol-induced bone diseases, including osteopenia and osteoporosis, which increases fracture risk, deficient bone repair, and osteonecrosis. This preclinical study investigated the therapeutic effects of TCM herbal extracts in animal models of chronic excessive alcohol consumption-induced osteopenia. TCM herbal extracts (Jing extracts) were prepared from nine Chinese herbal medicines, a combinative herbal formula for antifatigue and immune regulation, including
    Language English
    Publishing date 2021-12-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.754088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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