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  1. Article ; Online: Protective Effect of the Total Triterpenes of Euscaphis konishii Hayata Pericarp on Bacillus Calmette-Guérin Plus Lipopolysaccharide-Induced Liver Injury

    Wei Huang / Hui Ding / Lu-yao Chen / Lin Ni / Yi-fang Ruan / Xiao-xing Zou / Min Ye / Shuang-quan Zou

    Evidence-Based Complementary and Alternative Medicine, Vol

    2019  Volume 2019

    Abstract: Background. Liver injury has been recognized as a primary cause of hepatic morbidity and mortality. Euscaphis konishii Hayata, also called Euscaphis fukienensis Hsu, is usually used as a detumescent and analgesic agent to improve liver function in South ... ...

    Abstract Background. Liver injury has been recognized as a primary cause of hepatic morbidity and mortality. Euscaphis konishii Hayata, also called Euscaphis fukienensis Hsu, is usually used as a detumescent and analgesic agent to improve liver function in South China, but its mechanism of action and chemical composition are unclear. Objective. The main aim of the study was to investigate the constituent and potential hepatoprotective mechanism of the total triterpenes of E. konishii pericarp (TTEP). Methods. The constituent of TTEP was analyzed by a series of silica gel column to get single compounds and then identified by NMR and MS. In vitro assays were conducted to test the free radical scavenging activity of TTEP. The BCG/LPS-induced immunological livery injury mice model was established to clarify the hepatoprotective effect of TTEP in vivo. Results. 8 pentacyclic triterpene acids were separated and identified by NMR and MS. TTEP treatment (50, 100, and 200 mg/Kg) improved the immune function of the BCG/LPS-infected mice, dose-dependently alleviated the BCG/LPS-induced inflammation and oxidative stress, and ameliorated the hepatocyte apoptosis in the liver tissue. Conclusion. The pericarp of E. konishii may be further considered as a potent natural food for liver disease treatment.
    Keywords Other systems of medicine ; RZ201-999
    Subject code 630
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Inferring spatial patterns and drivers of population divergence of Neolitsea sericea (Lauraceae), based on molecular phylogeography and landscape genomics

    Cao, Ya-Nan / Ian J. Wang / Lu-Xian Liu / Lu-Yao Chen / Yan-Qian Ding / Ying-Xiong Qiu

    Elsevier Inc. Molecular phylogenetics and evolution. 2018 Sept., v. 126

    2018  

    Abstract: The relative roles of geography, climate and ecology in driving population divergence and (incipient) speciation has so far been largely neglected in studies addressing the evolution of East Asia’s island flora. Here, we employed chloroplast and ... ...

    Abstract The relative roles of geography, climate and ecology in driving population divergence and (incipient) speciation has so far been largely neglected in studies addressing the evolution of East Asia’s island flora. Here, we employed chloroplast and ribosomal DNA sequences and restriction site-associated DNA sequencing (RADseq) loci to investigate the phylogeography and drivers of population divergence of Neolitsea sericea. These data sets support the subdivision of N. sericea populations into the Southern and Northern lineages across the ‘Tokara gap’. Two distinct sublineages were further identified for the Northern lineage of N. sericea from the RADseq data. RADseq was also used along with approximate Bayesian computation to show that the current distribution and differentiation of N. sericea populations resulted from a combination of relatively ancient migration and successive vicariant events that likely occurred during the mid to late Pleistocene. Landscape genomic analyses showed that, apart from geographic barriers, barrier, potentially local adaptation to different climatic conditions appears to be one of the major drivers for lineage diversification of N. sericea.
    Keywords Bayesian theory ; chloroplasts ; climatic factors ; data collection ; ecology ; evolution ; flora ; genomics ; islands ; loci ; Neolitsea sericea ; nucleotide sequences ; phylogeography ; East Asia
    Language English
    Dates of publication 2018-09
    Size p. 162-172.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 33610-5
    ISSN 1095-9513 ; 1055-7903
    ISSN (online) 1095-9513
    ISSN 1055-7903
    DOI 10.1016/j.ympev.2018.04.010
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3644: Show issues Location:
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  3. Article ; Online: The present scenario, challenges, and future anticipation of traditional mongolian medicine in China

    Hai-Ying Tong / Shao-Qian Zhang / Ghulam Murtaza / Hui-Hui Zhao / Xian-Ju Huang / Hu-Rilebagen / Wu-Lanqiqige / Wu-Ye Bao / Wu-Jisiguleng / Wu-Yunsiriguleng / Lu-Yao Chen

    World Journal of Traditional Chinese Medicine, Vol 5, Iss 4, Pp 187-

    2019  Volume 192

    Abstract: The objective was to study the present scenario, challenges, and future anticipation of traditional Mongolian medicine (TMM) in China. The literature was retrieved using various sources of information such as meetings with TMM experts, research and ... ...

    Abstract The objective was to study the present scenario, challenges, and future anticipation of traditional Mongolian medicine (TMM) in China. The literature was retrieved using various sources of information such as meetings with TMM experts, research and review articles, national health databases, and government websites and authoritative papers. Health care using TMM, TMM education and research, and the pharmaceutical industry of TMM has been improved by implementing TMM growth policies. TMM has been extensively used for health care in Mongolia and in various regions of China including Beijing. The national education system of China contains a stream of TMM education. There is a yearly increase in research productivity in the field of TMM due to extensive research funding by the government. The rapidly growing pharmaceutical industry of TMM has provided more availability of TMM to more patients. The literature search revealed good preservation and development of TMM in China, urging the need to take steps for the promotion of its spread and development in China and worldwide.
    Keywords health care ; pharmaceutical industry ; research productivity ; traditional mongolian medicine ; Medicine (General) ; R5-920
    Subject code 950
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Visualization of the activation of the histamine H3 receptor (H3R) using novel fluorescence resonance energy transfer biosensors and their potential application to the study of H3R pharmacology

    Liu, Ying / Hong Zeng / John D. Pediani / Li Ma / Lu‐Yao Chen / Mei Tang / Nan Wu / Qian Hao / Richard J. Ward / Su An / Tian‐Rui Xu / Xiao‐Xi Guo / Yang Yang

    FEBS journal. 2018 June, v. 285, no. 12

    2018  

    Abstract: Activation of the histamine‐3 receptor (H3R) is involved in memory processes and cognitive action, while blocking H3R activation can slow the progression of neurological disorders, such as Alzheimer's disease, schizophrenia and narcolepsy. To date, ... ...

    Abstract Activation of the histamine‐3 receptor (H3R) is involved in memory processes and cognitive action, while blocking H3R activation can slow the progression of neurological disorders, such as Alzheimer's disease, schizophrenia and narcolepsy. To date, however, no direct way to examine the activation of H3R has been utilized. Here, we describe a novel biosensor that can visualize the activation of H3R through an intramolecular fluorescence resonance energy transfer (FRET) signal. To achieve this, we constructed an intramolecular H3R FRET sensor with cyan fluorescent protein (CFP) attached at the C terminus and yellow fluorescent protein (YFP) inserted into the third intracellular loop. The sensor was found to internalize normally on agonist treatment. We measured FRET signals between the donor CFP and the acceptor YFP in living cells in real time, the results of which indicated that H3R agonist treatment (imetit or histamine) increases the FRET signal in a time‐ and concentration‐dependent manner with Kon and Koff values consistent with published data and which maybe correlated with decreasing cAMP levels and the promotion of ERK1/2 phosphorylation. The FRET signal was inhibited by H3R antagonists, and the introduction of mutations at F419A, F423A, L426A and L427A, once again, the promotion of ERK1/2 phosphorylation, was diminished. Thus, we have built a H3R biosensor which can visualize the activation of receptor through real‐time structure changes and which can obtain pharmacological kinetic data at the same time. The FRET signals may allow the sensor to become a useful tool for screening compounds and optimizing useful ligands.
    Keywords agonists ; Alzheimer disease ; antagonists ; biosensors ; cognition ; cyclic AMP ; energy transfer ; histamine ; ligands ; memory ; mutation ; narcolepsy ; pharmacology ; phosphorylation ; schizophrenia ; screening ; yellow fluorescent protein
    Language English
    Dates of publication 2018-06
    Size p. 2319-2336.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.14484
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2006/704: Show issues

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  5. Article: iTRAQ-based proteomics screen for potential regulators of wheat (Triticum aestivum L.) root cell wall component response to Al stress

    Yang, Ye / Cai-Xia Li / Chun-Yan Dai / Hong Zeng / Hui-Lin Guan / Li Ma / Lu-Yao Chen / Nan Wu / Xi Mu / Xiu-Ming Cui / Ying Liu / Yun Zheng / Ze-Ping Yang

    Gene. 2018,

    2018  

    Abstract: The inhibition of Aluminum (Al)-induced root tip cell elongation is a major cause of plant root elongation suppression. The inhibition of root tip cell elongation is caused by a disruption of cell wall component metabolism, growth signaling, or cellular ... ...

    Abstract The inhibition of Aluminum (Al)-induced root tip cell elongation is a major cause of plant root elongation suppression. The inhibition of root tip cell elongation is caused by a disruption of cell wall component metabolism, growth signaling, or cellular damage. The aim of this study was to identify the proteins involved in the metabolism of the root cell wall components under Al stress in the Al-tolerant wheat (Triticum aestivum L.) cultivar ET8.Differentially expressed proteins of Al-tolerant wheat roots were screened via isobaric tags for relative and absolute quantification (iTRAQ). Furthermore, their expression changes were detected via RT-PCR analysis. The contents of major components of the cell wall and their changes in metabolic enzyme activities were also investigated.A total of 97 differentially expressed proteins from Al-tolerant wheat roots were screened and nine of these 97 proteins were root cell wall component related. The known nucleic acid sequences of proteins were 14-3-3 protein, the plasm membrane (PM) H+-ATPase, phospholipase D, peroxidase, and glycosyltransferase. For 14-3-3 protein, phospholipase D and peroxidase, the protein expression and mRNA expression were consistent with Al-treatment; however, for PM H+-ATPase and glycosyltransferase, the protein expression and mRNA expression were inconsistent under Al-stress. Furthermore, both cellulase activity and callase activity were down-regulated by Al stress, while the phenylalanineammonialyase (PAL), cinnamyl alcohol dehydrogenase (CAD), and peroxidase (POD) activities were up-regulated. Furthermore, the PM H+-ATPase activity was decreased in response to Al stress. In addition, the contents of callose, cellulose, lignin, and H2O2 varied significantly.The cell wall components, relative metabolism enzymes activity, and gene expression also changed followed by protein expression changed in response to Al stress. The results suggest that Al stress leads to marked variations in metabolic enzyme activity, carbohydrate content, followed by changes of root cell components in wheat roots.
    Keywords aluminum ; callose ; carbohydrate content ; cell growth ; cell wall components ; cellulose ; cinnamyl alcohol dehydrogenase ; cultivars ; endo-1,4-beta-glucanase ; enzyme activity ; gene expression ; glycosyltransferases ; H-transporting ATP synthase ; hydrogen peroxide ; lignin ; messenger RNA ; nucleotide sequences ; peroxidase ; phospholipase D ; protein synthesis ; proteins ; proteomics ; reverse transcriptase polymerase chain reaction ; root growth ; root tips ; Triticum aestivum ; wheat
    Language English
    Size p. .
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2018.07.008
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 79/715: Show issues

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