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  1. Article ; Online: The hidden cost of genetic resistance to HIV-1.

    Luban, Jeremy

    publication RETRACTED

    Nature medicine

    2019  Volume 25, Issue 6, Page(s) 878–879

    MeSH term(s) HIV Infections ; HIV Seropositivity ; HIV-1/genetics ; Homozygote ; Humans ; Receptors, CCR5/genetics
    Chemical Substances CCR5 protein, human ; Receptors, CCR5
    Language English
    Publishing date 2019-06-03
    Publishing country United States
    Document type Journal Article ; Comment ; Retracted Publication
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-019-0481-8
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  2. Article ; Online: Retraction Note: The hidden cost of genetic resistance to HIV-1.

    Luban, Jeremy

    Nature medicine

    2019  Volume 25, Issue 11, Page(s) 1796

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Language English
    Publishing date 2019-10-05
    Publishing country United States
    Document type Journal Article ; Retraction of Publication
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-019-0636-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: SARS-CoV-2

    Luban, Jeremy

    Coronavirus COVID-19 Publications by UMMS Authors

    2020  

    Abstract: This presentation about the biology of Coronaviruses was presented virtually to the RNA Biology Journal Club at the University of Massachusetts Medical School on April 7, 2020. ...

    Abstract This presentation about the biology of Coronaviruses was presented virtually to the RNA Biology Journal Club at the University of Massachusetts Medical School on April 7, 2020.
    Keywords 2019-nCoV ; COVID-19 ; SARS-2-CoV ; SARS-2 ; 2019 novel coronavirus disease ; coronaviruses ; Immunology and Infectious Disease ; Infectious Disease ; Virology ; Virus Diseases ; covid19
    Publishing date 2020-04-07T07:00:00Z
    Publisher eScholarship@UMMS
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Lessons from a local effort to screen for SARS-CoV-2.

    Silverstein, Noah J / Luban, Jeremy

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 26

    MeSH term(s) Asymptomatic Infections ; COVID-19/diagnosis ; Colorado ; Humans ; Mass Screening ; SARS-CoV-2/isolation & purification ; Viral Load
    Language English
    Publishing date 2021-06-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2108044118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Consulting the Oracle of SARS-CoV-2 Infection.

    Lemieux, Jacob E / Luban, Jeremy

    The Journal of infectious diseases

    2021  Volume 225, Issue 7, Page(s) 1115–1117

    MeSH term(s) COVID-19 ; Humans ; Referral and Consultation ; SARS-CoV-2
    Language English
    Publishing date 2021-12-23
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiab623
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    Zs.MO 445: Show issues

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  6. Article ; Online: Closing the net on retroviruses.

    Luban, Jeremy

    eLife

    2016  Volume 5

    Abstract: Structural studies reveal how an antiviral factor forms a molecular net to restrict retroviruses including HIV-1. ...

    Abstract Structural studies reveal how an antiviral factor forms a molecular net to restrict retroviruses including HIV-1.
    MeSH term(s) Animals ; Capsid ; Carrier Proteins ; HIV-1 ; Macaca mulatta ; Retroviridae ; Retroviridae Proteins
    Chemical Substances Carrier Proteins ; Retroviridae Proteins
    Language English
    Publishing date 2016-07-07
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.18243
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  7. Article: Regulation of Ebola GP conformation and membrane binding by the chemical environment of the late endosome.

    Jain, Aastha / Govindan, Ramesh / Berkman, Alex / Luban, Jeremy / Durham, Natasha D / Munro, James

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Interaction between the Ebola virus envelope glycoprotein (GP) and the endosomal membrane is an essential step during virus entry into the cell. Acidic pH and Ca2+ have been implicated in mediating the GP-membrane interaction. However, the molecular ... ...

    Abstract Interaction between the Ebola virus envelope glycoprotein (GP) and the endosomal membrane is an essential step during virus entry into the cell. Acidic pH and Ca2+ have been implicated in mediating the GP-membrane interaction. However, the molecular mechanism by which these environmental factors regulate the conformational changes that enable engagement of GP with the target membrane is unknown. Here, we apply fluorescence correlation spectroscopy (FCS) and single-molecule Forster resonance energy transfer (smFRET) imaging to elucidate how the acidic pH, Ca2+ and anionic phospholipids in the late endosome promote GP-membrane interaction, thereby facilitating virus entry. We find that bis(monoacylglycero)phosphate (BMP), which is specific to the late endosome, is especially critical in determining the Ca2+-dependence of the GP-membrane interaction. Molecular dynamics (MD) simulations suggested residues in GP that sense pH and induce conformational changes that make the fusion loop available for insertion into the membrane. We similarly confirm residues in the fusion loop that mediate GPs interaction with Ca2+, which likely promotes local conformational changes in the fusion loop and mediates electrostatic interactions with the anionic phospholipids. Collectively, our results provide a mechanistic understanding of how the environment of the late endosome regulates the timing and efficiency of virus entry.
    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.01.18.524651
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: IFIH1 (MDA5) is required for innate immune detection of intron-containing RNA expressed from the HIV-1 provirus.

    Guney, Mehmet Hakan / Nagalekshmi, Karthika / McCauley, Sean Matthew / Carbone, Claudia / Aydemir, Ozkan / Luban, Jeremy

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Antiretroviral therapy (ART) suppresses HIV-1 viremia and prevents progression to AIDS. Nonetheless, chronic inflammation is a common problem for people living with HIV-1 on ART. One possible cause of inflammation is ongoing transcription from HIV-1 ... ...

    Abstract Antiretroviral therapy (ART) suppresses HIV-1 viremia and prevents progression to AIDS. Nonetheless, chronic inflammation is a common problem for people living with HIV-1 on ART. One possible cause of inflammation is ongoing transcription from HIV-1 proviruses, whether or not the sequences are competent for replication. Previous work has shown that intron-containing RNA expressed from the HIV-1 provirus in primary human blood cells, including CD4
    Language English
    Publishing date 2023-12-12
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.17.567619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Emerging role of cyclophilin A in HIV-1 infection: from producer cell to the target cell nucleus.

    Padron, Adrian / Prakash, Prem / Pandhare, Jui / Luban, Jeremy / Aiken, Chris / Balasubramaniam, Muthukumar / Dash, Chandravanu

    Journal of virology

    2023  Volume 97, Issue 11, Page(s) e0073223

    Abstract: The HIV-1 genome encodes a small number of proteins with structural, enzymatic, regulatory, and accessory functions. These viral proteins interact with a number of host factors to promote the early and late stages of HIV-1 infection. During the early ... ...

    Abstract The HIV-1 genome encodes a small number of proteins with structural, enzymatic, regulatory, and accessory functions. These viral proteins interact with a number of host factors to promote the early and late stages of HIV-1 infection. During the early stages of infection, interactions between the viral proteins and host factors enable HIV-1 to enter the target cell, traverse the cytosol, dock at the nuclear pore, gain access to the nucleus, and integrate into the host genome. Similarly, the viral proteins recruit another set of host factors during the late stages of infection to orchestrate HIV-1 transcription, translation, assembly, and release of progeny virions. Among the host factors implicated in HIV-1 infection, Cyclophilin A (CypA) was identified as the first host factor to be packaged within HIV-1 particles. It is now well established that CypA promotes HIV-1 infection by directly binding to the viral capsid. Mechanistic models to pinpoint CypA's role have spanned from an effect in the producer cell to the early steps of infection in the target cell. In this review, we will describe our understanding of the role(s) of CypA in HIV-1 infection, highlight the current knowledge gaps, and discuss the potential role of this host factor in the post-nuclear entry steps of HIV-1 infection.
    MeSH term(s) Humans ; Capsid Proteins/genetics ; Cell Nucleus/metabolism ; Cyclophilin A/genetics ; Cyclophilin A/metabolism ; HIV Infections/metabolism ; HIV-1/genetics ; HIV-1/metabolism ; Viral Proteins/metabolism ; Host-Pathogen Interactions
    Chemical Substances Capsid Proteins ; Cyclophilin A (EC 5.2.1.-) ; Viral Proteins
    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.00732-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 609: Show issues Location:
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  10. Article ; Online: TRIM5 and the Regulation of HIV-1 Infectivity.

    Luban, Jeremy

    Molecular biology international

    2012  Volume 2012, Page(s) 426840

    Abstract: The past ten years have seen an explosion of information concerning host restriction factors that inhibit the replication of HIV-1 and other retroviruses. Among these factors is TRIM5, an innate immune signaling molecule that recognizes the capsid ... ...

    Abstract The past ten years have seen an explosion of information concerning host restriction factors that inhibit the replication of HIV-1 and other retroviruses. Among these factors is TRIM5, an innate immune signaling molecule that recognizes the capsid lattice as soon as the retrovirion core is released into the cytoplasm of otherwise susceptible target cells. Recognition of the capsid lattice has several consequences that include multimerization of TRIM5 into a complementary lattice, premature uncoating of the virion core, and activation of TRIM5 E3 ubiquitin ligase activity. Unattached, K63-linked ubiquitin chains are generated that activate the TAK1 kinase complex and downstream inflammatory mediators. Polymorphisms in the capsid recognition domain of TRIM5 explain the observed species-specific differences among orthologues and the relatively weak anti-HIV-1 activity of human TRIM5. Better understanding of the complex interaction between TRIM5 and the retrovirus capsid lattice may someday lead to exploitation of this interaction for the development of potent HIV-1 inhibitors.
    Language English
    Publishing date 2012-05-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573919-0
    ISSN 2090-2190 ; 2090-2190
    ISSN (online) 2090-2190
    ISSN 2090-2190
    DOI 10.1155/2012/426840
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