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Book ; Online: Immune-Modulatory Effects of Vitamin D

Zughaier, Susu M. / Lubberts, Erik / Bener, Abdulbari

2020

Keywords	Medicine ; Immunology ; vitamin D ; immune modulation ; monocytes ; T cells ; infection
Size	1 electronic resource (177 pages)
Publisher	Frontiers Media SA
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021230904
ISBN	9782889661749 ; 2889661741
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: A Mechanistic Insight into the Pathogenic Role of Interleukin 17A in Systemic Autoimmune Diseases.

Bisoendial, Radjesh / Lubberts, Erik

Mediators of inflammation

2022 Volume 2022, Page(s) 6600264

Abstract: Interleukin 17A (IL-17A) has been put forward as a strong ally in our fight against invading pathogens across exposed epithelial surfaces by serving an antimicrobial immunosurveillance role in these tissues to protect the barrier integrity. Amongst other ...

Abstract	Interleukin 17A (IL-17A) has been put forward as a strong ally in our fight against invading pathogens across exposed epithelial surfaces by serving an antimicrobial immunosurveillance role in these tissues to protect the barrier integrity. Amongst other mechanisms that prevent tissue injury mediated by potential microbial threats and promote restoration of epithelial homeostasis, IL-17A attracts effector cells to the site of inflammation and support the host response by driving the development of ectopic lymphoid structures. Accumulating evidence now underscores an integral role of IL-17A in driving the pathophysiology and clinical manifestations in three potentially life-threatening autoimmune diseases, namely, systemic lupus erythematosus, Sjögren's syndrome, and systemic sclerosis. Available studies provide convincing evidence that the abundance of IL-17A in target tissues and its prime source, which is T helper 17 cells (Th17) and double negative T cells (DNT), is not an innocent bystander but in fact seems to be prerequisite for organ pathology. In this regard, IL-17A has been directly implicated in critical steps of autoimmunity. This review reports on the synergistic interactions of IL-17A with other critical determinants such as B cells, neutrophils, stromal cells, and the vasculature that promote the characteristic immunopathology of these autoimmune diseases. The summary of observations provided by this review may have empowering implications for IL-17A-based strategies to prevent clinical manifestations in a broad spectrum of autoimmune conditions.
MeSH term(s)	Autoimmune Diseases ; Autoimmunity ; Humans ; Inflammation ; Interleukin-17 ; Th17 Cells
Chemical Substances	Interleukin-17
Language	English
Publishing date	2022-05-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1137605-3
ISSN	1466-1861 ; 0962-9351
ISSN (online)	1466-1861
ISSN	0962-9351
DOI	10.1155/2022/6600264
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Basic Science Session 2. Recent Advances in Our Understanding of Psoriatic Arthritis Pathogenesis.

Lubberts, Erik / Scher, Jose U / FitzGerald, Oliver

The Journal of rheumatology

2022 Volume 49, Issue 6 Suppl 1, Page(s) 16–19

Abstract: The second basic science session at the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) annual meeting focused on 2 recent publications that have increased our understanding of the pathogenesis of psoriatic arthritis (PsA). ...

Abstract	The second basic science session at the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) annual meeting focused on 2 recent publications that have increased our understanding of the pathogenesis of psoriatic arthritis (PsA). Data from the first publication, presented by Prof. Erik Lubberts, showed that interleukin (IL)-17A is produced by CD4+ and not CD8+ T cells in PsA synovial fluid following T cell receptor activation. These findings contrast with previously published data, which had suggested that CD8+ T cells are a prominent source of IL-17A. In further experiments, they showed that when CD8+ T cells were stimulated with paramethoxyamphetamine/ionomycin, relatively high levels of IL-17A were detected. Prof. Jose Scher presented work on the role of the microbiome in PsA and more specifically, on pharmacomicrobiomics. He demonstrated the baseline collection of genomes and genes from the microbiota community (the metagenome) can be used as predictor for future treatment response in early rheumatoid arthritis and also likely in PsA.
MeSH term(s)	Arthritis, Psoriatic/pathology ; Arthritis, Rheumatoid ; Humans ; Interleukin-17 ; Male ; Psoriasis/pathology ; Synovial Fluid
Chemical Substances	Interleukin-17
Language	English
Publishing date	2022-02-15
Publishing country	Canada
Document type	Journal Article
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
DOI	10.3899/jrheum.211321
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Article ; Online: The IL-23-IL-17 axis in inflammatory arthritis.

Lubberts, Erik

Nature reviews. Rheumatology

2015 Volume 11, Issue 7, Page(s) 415–429

Abstract: The discovery that the IL-23-IL-17 immune pathway is involved in many models of autoimmune disease has changed the concept of the role of T-helper cell subsets in the development of autoimmunity. In addition to TH17 cells, IL-17 is also produced by other ...

Abstract	The discovery that the IL-23-IL-17 immune pathway is involved in many models of autoimmune disease has changed the concept of the role of T-helper cell subsets in the development of autoimmunity. In addition to TH17 cells, IL-17 is also produced by other T cell subsets and innate immune cells; which of these IL-17-producing cells have a role in tissue inflammation, and the timing, location and nature of their role(s), is incompletely understood. The current view is that innate and adaptive immune cells expressing the IL-23 receptor become pathogenic after exposure to IL-23, but further investigation into the role of IL-23 and IL-17 at different stages in the development and progression of chronic (destructive) inflammatory diseases is needed. Rheumatoid arthritis (RA) and spondyloarthritis (SpA) are the two most common forms of chronic immune-mediated inflammatory arthritis, and the IL-23-IL-17 axis is thought to have a critical role in both. This Review discusses the basic mechanisms of these cytokines in RA and SpA on the basis of findings from disease-specific animal models as well as human ex vivo studies. Promising therapeutic applications to modulate this immune pathway are in development or have already been approved. Blockade of IL-17 and/or TH17-cell activity in combination with anti-TNF therapy might be a successful approach to achieving stable remission or even prevention of chronic immune-mediated inflammatory diseases.
MeSH term(s)	Animals ; Arthritis, Rheumatoid/immunology ; Disease Models, Animal ; Humans ; Interleukin-17/immunology ; Interleukin-23/immunology
Chemical Substances	IL17A protein, human ; Interleukin-17 ; Interleukin-23
Language	English
Publishing date	2015-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2491532-4
ISSN	1759-4804 ; 1759-4790
ISSN (online)	1759-4804
ISSN	1759-4790
DOI	10.1038/nrrheum.2015.53
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Article ; Online: The IL-23-IL-17 axis in inflammatory arthritis.

Lubberts, Erik

Nature reviews. Rheumatology

2015 Volume 11, Issue 10, Page(s) 562

Abstract: The IL-23-IL-17 axis in inflammatory arthritis. Erik Lubberts. Nat. Rev. Rheumatol. 11, 415-429 (2015); published online 28 April 2015; doi:10.1038/nrrheum.2015.53. In Figure 2a of this Review, full protection against CIA was incorrectly stated as an ... ...

Abstract	The IL-23-IL-17 axis in inflammatory arthritis. Erik Lubberts. Nat. Rev. Rheumatol. 11, 415-429 (2015); published online 28 April 2015; doi:10.1038/nrrheum.2015.53. In Figure 2a of this Review, full protection against CIA was incorrectly stated as an effect of IL-17 deficiency instead of IL-17RA deficiency.
Language	English
Publishing date	2015-10
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2491532-4
ISSN	1759-4804 ; 1759-4790
ISSN (online)	1759-4804
ISSN	1759-4790
DOI	10.1038/nrrheum.2015.128
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Article ; Online: Role of T lymphocytes in the development of rheumatoid arthritis. Implications for treatment.

Lubberts, Erik

Current pharmaceutical design

2014 Volume 21, Issue 2, Page(s) 142–146

Abstract: T cells play a role in the initiation and perpetuation of tissue inflammation that can lead to tissue destruction. With the discovery of a number of T helper subsets and their potential plasticity during disease it became clear that the T cell behaviour ... ...

Abstract	T cells play a role in the initiation and perpetuation of tissue inflammation that can lead to tissue destruction. With the discovery of a number of T helper subsets and their potential plasticity during disease it became clear that the T cell behaviour in autoimmune diseases is much more complex than the first Th1/Th2 concept. From experimental autoimmune arthritis models it became clear that the IL-23/IL-17 immune pathway is critical in the development of autoimmune arthritis and IL-17A has been recognized to be a key cytokine involved in initiation and perpetuation of chronic destructive arthritis. Functional studies using T cells and stromal cells from patients with RA revealed improvement of anti-TNF effects when combined with agents neutralizing IL-17A or agents suppressing Th17 cytokines production. Clinic trials will be needed to test whether these data from experimental settings can be translated to human arthritis. Different approaches are available or under investigation to target: (1) pathogenic T cell activity by inhibiting RORc or STAT3 or the costimulator pathway by CTLA4-Ig; (2) Th17 cytokine production by anti-IL-17A, anti-IL-22, or combination of anti-IL-17A/anti-TNF approaches; (3) Th17 polarization by neutralizing IL-23 using an anti-IL-23 specific antibody, IL-12/IL-23 by an anti-p40 antibody, or the IL-6 signaling pathway; (4) Th17 migration by interfering the CCR6-CCL20 interaction. The challenge is to bring the best to the clinic to further improve current therapy for patients with RA and to reach stable remission or even prevent the development of this disabling disease.
MeSH term(s)	Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/therapy ; Humans ; T-Lymphocytes/immunology
Language	English
Publishing date	2014-05-30
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612820666140825122247
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Article ; Online: How to Prepare Spectral Flow Cytometry Datasets for High Dimensional Data Analysis: A Practical Workflow.

den Braanker, Hannah / Bongenaar, Margot / Lubberts, Erik

Frontiers in immunology

2021 Volume 12, Page(s) 768113

Abstract: Spectral flow cytometry is an upcoming technique that allows for extensive multicolor panels, enabling simultaneous investigation of a large number of cellular parameters in a single experiment. To fully explore the resulting high-dimensional single cell ...

Abstract	Spectral flow cytometry is an upcoming technique that allows for extensive multicolor panels, enabling simultaneous investigation of a large number of cellular parameters in a single experiment. To fully explore the resulting high-dimensional single cell datasets, high-dimensional analysis is needed, as opposed to the common practice of manual gating in conventional flow cytometry. However, preparing spectral flow cytometry data for high-dimensional analysis can be challenging, because of several technical aspects. In this article, we will give insight into the pitfalls of handling spectral flow cytometry datasets. Moreover, we will describe a workflow to properly prepare spectral flow cytometry data for high dimensional analysis and tools for integrating new data at later time points. Using healthy control data as example, we will go through the concepts of quality control, data cleaning, transformation, correcting for batch effects, subsampling, clustering and data integration. This methods article provides an R-based pipeline based on previously published packages, that are readily available to use. Application of our workflow will aid spectral flow cytometry users to obtain valid and reproducible results.
MeSH term(s)	Data Analysis ; Datasets as Topic ; Flow Cytometry/methods ; Flow Cytometry/standards ; Humans ; Quality Control ; Workflow
Language	English
Publishing date	2021-11-19
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.768113
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Editorial: Immune-Modulatory Effects of Vitamin D.

Zughaier, Susu M / Lubberts, Erik / Bener, Abdulbari

Frontiers in immunology

2020 Volume 11, Page(s) 596611

MeSH term(s)	Disease Susceptibility ; Host-Pathogen Interactions/immunology ; Humans ; Immunity, Innate ; Immunomodulation/drug effects ; Vitamin D/metabolism ; Vitamin D/pharmacology ; Vitamin D Deficiency/complications
Chemical Substances	Vitamin D (1406-16-2)
Keywords	covid19
Language	English
Publishing date	2020-09-29
Publishing country	Switzerland
Document type	Editorial ; Introductory Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.596611
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Article ; Online: Th17 cytokines and arthritis.

Lubberts, Erik

Seminars in immunopathology

2010 Volume 32, Issue 1, Page(s) 43–53

Abstract: Th17 cells are implicated in human autoimmune diseases, such as rheumatoid arthritis (RA), although it has not been established whether this persistent destructive arthritis is driven by Th1 and/or Th17 cells. Interleukin-17A (IL-17A) contributes to the ... ...

Abstract	Th17 cells are implicated in human autoimmune diseases, such as rheumatoid arthritis (RA), although it has not been established whether this persistent destructive arthritis is driven by Th1 and/or Th17 cells. Interleukin-17A (IL-17A) contributes to the pathogenesis of arthritis as has been shown in several experimental arthritis models. Importantly, recent data from first clinical trials with anti-IL-17A antibody treatment in psoriatic arthritis patients and RA patients looks promising. This review summarizes the findings about the role of Th17 cells in arthritis and discusses the impact of the different Th17 cytokines in the pathogenesis of this disease. However, further studies are needed to unravel the interplay between IL-17A and other Th17 cytokines such as IL-17F, IL-22, and IL-21 in the pathoimmunological process of this crippling disease, in particular, whether regulating Th17 cell activity or specific combinations of Th17 cytokines will have additional value compared to neutralizing IL-17A activity alone. Moreover, tumor necrosis factor-positive Th17 cells are discussed as potential dangerous cells in driving persistent arthritis in human early RA.
MeSH term(s)	Animals ; Arthritis, Experimental/immunology ; Arthritis, Rheumatoid/immunology ; Autoimmunity/immunology ; Humans ; Interleukin-17/immunology ; Interleukins/immunology ; T-Lymphocyte Subsets/immunology ; T-Lymphocytes, Helper-Inducer/immunology ; Interleukin-22
Chemical Substances	Interleukin-17 ; Interleukins
Language	English
Publishing date	2010-02-04
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2316828-6
ISSN	1863-2300 ; 1863-2297
ISSN (online)	1863-2300
ISSN	1863-2297
DOI	10.1007/s00281-009-0189-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: BCL11B

Parsa, Sara / Soheili, Zahra-Soheila / Alizadeh Otaghvar, Hamidreza / Behrangi, Elham / Mansouri, Parvin / Lubberts, Erik / Mowla, Seyed Javad

Cell journal

2023 Volume 25, Issue 5, Page(s) 300–306

Abstract: Objective: Psoriasis is a common, auto-immune skin disease characterized by abnormal proliferation and differentiation of keratinocytes. Studies revealed the role of stress stimulators in the pathogenesis of psoriasis. Oxidative stress and heat shock ... ...

Abstract	Objective: Psoriasis is a common, auto-immune skin disease characterized by abnormal proliferation and differentiation of keratinocytes. Studies revealed the role of stress stimulators in the pathogenesis of psoriasis. Oxidative stress and heat shock are two important stress factors tuning differentiation and proliferation of keratinocytes, regarding to psoriasis disease. BCL11B is a transcription factor with critical role in embryonic keratinocyte differentiation and proliferation. Given this, in keratinocytes we have investigated potential role of Materials and methods: In this experimental study, data sets of psoriatic and healthy skin samples were downloaded in silico and Results: Quantitative reverse transcription polymerase chain reaction (qRT-PCR) data revealed a significant upregulation of Conclusion: Results indicated a remarkable role of BCL11B in differentiation and proliferation of HaCaT keratinocytes. This data along with the results of flow cytometer suggested a probable role for BCL11B in stress-induced differentiation, which is similar to what is happening during initiation and progression of normal differentiation.
Language	English
Publishing date	2023-05-28
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2647430-X
ISSN	2228-5814 ; 2228-5806
ISSN (online)	2228-5814
ISSN	2228-5806
DOI	10.22074/cellj.2023.558003.1090
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