LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 9 of total 9

Search options

  1. Article ; Online: T memory stem cell formation

    Daniel H. Fowler / Luca Gattinoni

    EBioMedicine, Vol 4, Iss C, Pp 3-

    Caveat mTOR

    2016  Volume 4

    Keywords Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2016-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8+ T cell fate

    Yun Ji / Jessica Fioravanti / Wei Zhu / Hongjun Wang / Tuoqi Wu / Jinhui Hu / Neal E. Lacey / Sanjivan Gautam / John B. Le Gall / Xia Yang / James D. Hocker / Thelma M. Escobar / Shan He / Stefania Dell’Orso / Nga V. Hawk / Veena Kapoor / William G. Telford / Luciano Di Croce / Stefan A. Muljo /
    Yi Zhang / Vittorio Sartorelli / Luca Gattinoni

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 12

    Abstract: The inability of T cells to properly mount anti-tumour immunity underlies failed cancer immune surveillance or therapy. Here the authors show that a microRNA, miR-155, suppresses Ship1 phosphatase expression to modulate epigenetic reprogramming of CD8 T ... ...

    Abstract The inability of T cells to properly mount anti-tumour immunity underlies failed cancer immune surveillance or therapy. Here the authors show that a microRNA, miR-155, suppresses Ship1 phosphatase expression to modulate epigenetic reprogramming of CD8 T cell differentiation via the Phf19/PRC2 axis, thereby implicating a novel aspect of cancer immunity regulation.
    Keywords Science ; Q
    Language English
    Publishing date 2019-05-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8+ T cell fate

    Yun Ji / Jessica Fioravanti / Wei Zhu / Hongjun Wang / Tuoqi Wu / Jinhui Hu / Neal E. Lacey / Sanjivan Gautam / John B. Le Gall / Xia Yang / James D. Hocker / Thelma M. Escobar / Shan He / Stefania Dell’Orso / Nga V. Hawk / Veena Kapoor / William G. Telford / Luciano Di Croce / Stefan A. Muljo /
    Yi Zhang / Vittorio Sartorelli / Luca Gattinoni

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 12

    Abstract: The inability of T cells to properly mount anti-tumour immunity underlies failed cancer immune surveillance or therapy. Here the authors show that a microRNA, miR-155, suppresses Ship1 phosphatase expression to modulate epigenetic reprogramming of CD8 T ... ...

    Abstract The inability of T cells to properly mount anti-tumour immunity underlies failed cancer immune surveillance or therapy. Here the authors show that a microRNA, miR-155, suppresses Ship1 phosphatase expression to modulate epigenetic reprogramming of CD8 T cell differentiation via the Phf19/PRC2 axis, thereby implicating a novel aspect of cancer immunity regulation.
    Keywords Science ; Q
    Language English
    Publishing date 2019-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity

    Shan He / Yongnian Liu / Lijun Meng / Hongxing Sun / Ying Wang / Yun Ji / Janaki Purushe / Pan Chen / Changhong Li / Jozef Madzo / Jean-Pierre Issa / Jonathan Soboloff / Ran Reshef / Bethany Moore / Luca Gattinoni / Yi Zhang

    Nature Communications, Vol 8, Iss 1, Pp 1-

    2017  Volume 14

    Abstract: During an immune response naive CD8+ T cells can differentiate into either effector or memory T cells. Here the authors show that Akt-mediated phosphorylation of the epigenetic regulator Ezh2 is critical for the generation of an anti-tumor CD8 T cell ... ...

    Abstract During an immune response naive CD8+ T cells can differentiate into either effector or memory T cells. Here the authors show that Akt-mediated phosphorylation of the epigenetic regulator Ezh2 is critical for the generation of an anti-tumor CD8 T cell response and promotes the expansion of memory-precursors.
    Keywords Science ; Q
    Language English
    Publishing date 2017-12-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity

    Shan He / Yongnian Liu / Lijun Meng / Hongxing Sun / Ying Wang / Yun Ji / Janaki Purushe / Pan Chen / Changhong Li / Jozef Madzo / Jean-Pierre Issa / Jonathan Soboloff / Ran Reshef / Bethany Moore / Luca Gattinoni / Yi Zhang

    Nature Communications, Vol 8, Iss 1, Pp 1-

    2017  Volume 14

    Abstract: During an immune response naive CD8+ T cells can differentiate into either effector or memory T cells. Here the authors show that Akt-mediated phosphorylation of the epigenetic regulator Ezh2 is critical for the generation of an anti-tumor CD8 T cell ... ...

    Abstract During an immune response naive CD8+ T cells can differentiate into either effector or memory T cells. Here the authors show that Akt-mediated phosphorylation of the epigenetic regulator Ezh2 is critical for the generation of an anti-tumor CD8 T cell response and promotes the expansion of memory-precursors.
    Keywords Science ; Q
    Language English
    Publishing date 2017-12-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection

    Tuoqi Wu / Hyun Mu Shin / E. Ashley Moseman / Yun Ji / Bonnie Huang / Christelle Harly / Jyoti M. Sen / Leslie J. Berg / Luca Gattinoni / Dorian B. McGavern / Pamela L. Schwartzberg

    Cell Reports, Vol 12, Iss 12, Pp 2099-

    2015  Volume 2110

    Abstract: T follicular helper (TFH) and T helper 1 (Th1) cells generated after viral infections are critical for the control of infection and the development of immunological memory. However, the mechanisms that govern the differentiation and maintenance of these ... ...

    Abstract T follicular helper (TFH) and T helper 1 (Th1) cells generated after viral infections are critical for the control of infection and the development of immunological memory. However, the mechanisms that govern the differentiation and maintenance of these two distinct lineages during viral infection remain unclear. We found that viral-specific TFH and Th1 cells showed reciprocal expression of the transcriptions factors TCF1 and Blimp1 early after infection, even before the differential expression of the canonical TFH marker CXCR5. Furthermore, TCF1 was intrinsically required for the TFH cell response to viral infection; in the absence of TCF1, the TFH cell response was severely compromised, and the remaining TCF1-deficient TFH cells failed to maintain TFH-associated transcriptional and metabolic signatures, which were distinct from those in Th1 cells. Mechanistically, TCF1 functioned through forming negative feedback loops with IL-2 and Blimp1. Our findings demonstrate an essential role of TCF1 in TFH cell responses to viral infection.
    Keywords Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2015-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Identification of the genomic insertion site of Pmel-1 TCR α and β transgenes by next-generation sequencing.

    Yun Ji / Natalie Abrams / Wei Zhu / Eddie Salinas / Zhiya Yu / Douglas C Palmer / Parthav Jailwala / Zulmarie Franco / Rahul Roychoudhuri / Eric Stahlberg / Luca Gattinoni / Nicholas P Restifo

    PLoS ONE, Vol 9, Iss 5, p e

    2014  Volume 96650

    Abstract: The pmel-1 T cell receptor transgenic mouse has been extensively employed as an ideal model system to study the mechanisms of tumor immunology, CD8+ T cell differentiation, autoimmunity and adoptive immunotherapy. The 'zygosity' of the transgene affects ... ...

    Abstract The pmel-1 T cell receptor transgenic mouse has been extensively employed as an ideal model system to study the mechanisms of tumor immunology, CD8+ T cell differentiation, autoimmunity and adoptive immunotherapy. The 'zygosity' of the transgene affects the transgene expression levels and may compromise optimal breeding scheme design. However, the integration sites for the pmel-1 mouse have remained uncharacterized. This is also true for many other commonly used transgenic mice created before the modern era of rapid and inexpensive next-generation sequencing. Here, we show that whole genome sequencing can be used to determine the exact pmel-1 genomic integration site, even with relatively 'shallow' (8X) coverage. The results were used to develop a validated polymerase chain reaction-based genotyping assay. For the first time, we provide a quick and convenient polymerase chain reaction method to determine the dosage of pmel-1 transgene for this freely and publically available mouse resource. We also demonstrate that next-generation sequencing provides a feasible approach for mapping foreign DNA integration sites, even when information of the original vector sequences is only partially known.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: In vitro generated anti-tumor T lymphocytes exhibit distinct subsets mimicking in vivo antigen-experienced cells.

    Yang, Shicheng / Gattinoni, Luca / Luca, Gattinoni / Liu, Fang / Ji, Yun / Yu, Zhiya / Restifo, Nicholas P / Rosenberg, Steven A / Morgan, Richard A

    Cancer immunology, immunotherapy : CII

    2011  Volume 60, Issue 5, Page(s) 739–749

    Abstract: The T-lymphocyte pool can be subdivided into naïve (Tn), effector memory (Tem), and central memory (Tcm) T cells. In this study, we characterized in vitro short-term cultured anti-tumor human T lymphocytes generated by lentiviral transduction with an ... ...

    Abstract The T-lymphocyte pool can be subdivided into naïve (Tn), effector memory (Tem), and central memory (Tcm) T cells. In this study, we characterized in vitro short-term cultured anti-tumor human T lymphocytes generated by lentiviral transduction with an anti-tumor antigen TCR vector. Within 2 weeks of in vitro culture, the cultured T cells showed a Tcm-like phenotype illustrated by a high percentage of CD62L and CD45RO cells. When the cells were sorted into populations that were CD45RO+/CD62L-(Tem), CD45RO+/CD62L+(Tcm), or CD45RO(low)/CD62L+(Tn) and co-cultured with antigen-matched tumor lines, the magnitude of cytokine release from these populations for IFNγ (Tn < Tcm < Tem) and IL-2 (Tn > Tcm > Tem) mimicked the types of immune cell responses observed in vivo. In comparing cell-mediated effector function, Tn were found to be deficient (relative to Tcm and Tem) in the ability to form conjugates with tumor cells and subsequent lytic activity. Moreover, analysis of the gene expression profiles of the in vitro cultured and sorted T-cell populations also demonstrated patterns consistent with their in vivo counterparts. When Tcm and Tem were tested for the ability to survive in vivo, Tcm displayed significantly increased engraftment and persistence in NOD/SCID/γc(-/-) mice. In general, a large percentage of in vitro generated anti-tumor T lymphocytes mimic a Tcm-like phenotype (based on phenotype, effector function, and increased persistence in vivo), which suggests that these Tcm-like cultured T cells may be optimal for adoptive immunotherapy.
    MeSH term(s) Animals ; Antigens, Neoplasm/immunology ; Cells, Cultured ; Coculture Techniques ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Gene Expression ; Genes, T-Cell Receptor ; Humans ; Immunologic Memory ; Immunotherapy, Adoptive ; Interferon-gamma/metabolism ; Interleukin-2/metabolism ; L-Selectin/analysis ; Leukocyte Common Antigens/analysis ; Lymphocyte Activation ; Mice ; Mice, SCID ; Neoplasms/immunology ; Polymerase Chain Reaction ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocyte Subsets/immunology ; Transduction, Genetic
    Chemical Substances Antigens, Neoplasm ; Interleukin-2 ; Receptors, Antigen, T-Cell ; L-Selectin (126880-86-2) ; Interferon-gamma (82115-62-6) ; Leukocyte Common Antigens (EC 3.1.3.48)
    Language English
    Publishing date 2011-02-09
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 195342-4
    ISSN 1432-0851 ; 0340-7004
    ISSN (online) 1432-0851
    ISSN 0340-7004
    DOI 10.1007/s00262-011-0977-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1237: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche

    Clever, David / Rahul Roychoudhuri / Michael G. Constantinides / Michael H. Askenase / Madhusudhanan Sukumar / Christopher A. Klebanoff / Robert L. Eil / Heather D. Hickman / Zhiya Yu / Jenny H. Pan / Douglas C. Palmer / Anthony T. Phan / John Goulding / Luca Gattinoni / Ananda W. Goldrath / Yasmine Belkaid / Nicholas P. Restifo

    Cell. 2016 Aug. 25, v. 166

    2016  

    Abstract: Cancer cells must evade immune responses at distant sites to establish metastases. The lung is a frequent site for metastasis. We hypothesized that lung-specific immunoregulatory mechanisms create an immunologically permissive environment for tumor ... ...

    Abstract Cancer cells must evade immune responses at distant sites to establish metastases. The lung is a frequent site for metastasis. We hypothesized that lung-specific immunoregulatory mechanisms create an immunologically permissive environment for tumor colonization. We found that T-cell-intrinsic expression of the oxygen-sensing prolyl-hydroxylase (PHD) proteins is required to maintain local tolerance against innocuous antigens in the lung but powerfully licenses colonization by circulating tumor cells. PHD proteins limit pulmonary type helper (Th)-1 responses, promote CD4+-regulatory T (Treg) cell induction, and restrain CD8+ T cell effector function. Tumor colonization is accompanied by PHD-protein-dependent induction of pulmonary Treg cells and suppression of IFN-γ-dependent tumor clearance. T-cell-intrinsic deletion or pharmacological inhibition of PHD proteins limits tumor colonization of the lung and improves the efficacy of adoptive cell transfer immunotherapy. Collectively, PHD proteins function in T cells to coordinate distinct immunoregulatory programs within the lung that are permissive to cancer metastasis.[Display omitted]
    Keywords CD8-positive T-lymphocytes ; antigens ; immune response ; immunotherapy ; metastasis ; neoplasm cells ; neoplasms ; oxygen ; proteins
    Language English
    Dates of publication 2016-0825
    Size p. 1117-1131.e14.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2016.07.032
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 75/702: Show issues
    Z 93: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top