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  1. Article ; Online: Caveats for Interpreting the Results of Up-and-Down Dose-Finding Studies for Prophylactic Oxytocin at Cesarean Delivery.

    Bamber, James H / Lucas, Dominique N

    Anesthesia and analgesia

    2024  Volume 138, Issue 5, Page(s) e25

    MeSH term(s) Pregnancy ; Female ; Humans ; Oxytocin/adverse effects ; Oxytocics/adverse effects ; Cesarean Section/methods ; Postpartum Hemorrhage/prevention & control
    Chemical Substances Oxytocin (50-56-6) ; Oxytocics
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000006675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ethnic inequalities in how care is given, not just in access and outcomes.

    Bamber, James H / Lucas, Dominique N

    BMJ (Clinical research ed.)

    2023  Volume 382, Page(s) 1589

    Language English
    Publishing date 2023-07-11
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.p1589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Long-term effects of neuraxial analgesia.

    Kearns, Rachel J / Broom, Malcolm A / Lucas, Dominique N

    Current opinion in anaesthesiology

    2024  Volume 37, Issue 3, Page(s) 227–233

    Abstract: Purpose of review: This review article explores the potential longer-term implications of neuraxial analgesia in labour for both the mother and her child.: Recent findings: Neuraxial techniques for labour analgesia are well tolerated and effective, ... ...

    Abstract Purpose of review: This review article explores the potential longer-term implications of neuraxial analgesia in labour for both the mother and her child.
    Recent findings: Neuraxial techniques for labour analgesia are well tolerated and effective, and long-term adverse sequelae are rare. Labour epidural analgesia is not independently associated with long-term headache, backache, postnatal depression or anal sphincter injury, and evidence supports that epidurals may offer protection against severe maternal morbidity, particularly in women at a higher risk of complications. However, there is an increasing awareness that postdural puncture headache may be associated with chronic headache, back pain and postnatal depression, emphasizing the need for adequate follow-up until symptoms resolve.For the neonate, a growing body of evidence refutes any association between epidural analgesia in labour and the later development of autism spectrum disorder. The clinical significance of epidural related maternal fever remains uncertain and is a research priority.
    Summary: Women should continue to access the significant benefits of neuraxial analgesia in labour without undue concern about adverse sequelae for themselves or their offspring. Measures to prevent, appropriately manage and adequately follow-up women who have suffered complications of neuraxial analgesia, such as postdural puncture headache, are good practice and can mitigate the development of long-term sequelae.
    MeSH term(s) Humans ; Pregnancy ; Analgesia, Epidural/adverse effects ; Analgesia, Epidural/methods ; Female ; Analgesia, Obstetrical/adverse effects ; Analgesia, Obstetrical/methods ; Infant, Newborn ; Post-Dural Puncture Headache/prevention & control ; Post-Dural Puncture Headache/etiology ; Post-Dural Puncture Headache/diagnosis ; Post-Dural Puncture Headache/epidemiology ; Depression, Postpartum/prevention & control ; Autism Spectrum Disorder
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645203-6
    ISSN 1473-6500 ; 0952-7907
    ISSN (online) 1473-6500
    ISSN 0952-7907
    DOI 10.1097/ACO.0000000000001365
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Obstetric anaesthetic practice in the UK: a descriptive analysis of the National Obstetric Anaesthetic Database 2009-14.

    Bamber, James H / Lucas, Dominique N / Plaat, Felicity / Russell, Robin

    British journal of anaesthesia

    2020  Volume 125, Issue 4, Page(s) 580–587

    Abstract: Background: Data on UK obstetric anaesthetic practice between 2009 and 2014 were collected by the Obstetric Anaesthetists' Association's National Obstetric Anaesthetic Database. This database provides information on workload, variation in practice, and ... ...

    Abstract Background: Data on UK obstetric anaesthetic practice between 2009 and 2014 were collected by the Obstetric Anaesthetists' Association's National Obstetric Anaesthetic Database. This database provides information on workload, variation in practice, and complication rates.
    Methods: During 2009-14, data were submitted by 190 UK hospitals. The number of hospitals that submitted data each year ranged between 114 and 145. During this 6 yr period, between 27 and 35 data items were requested, although not all hospitals submitted information on all data items. The dataset was assessed for quality and only those data items with acceptable quality were analysed.
    Results: The dataset contains information on 3 030 493 deliveries, 770 545 Caesarean sections, 623 050 women with labour neuraxial analgesia, and 61 121 general anaesthetics for Caesarean section. There was increased use of patient-controlled regimens for labour neuraxial analgesia over the 6 yr period. The mean rate of general anaesthesia used for Caesarean section was 8.75% (95% confidence interval, 8.26-9.24%). The rate of failed intubation for general anaesthesia for Caesarean section was one in 379. Inadvertent dural puncture rates varied between hospitals with a mean of 1.2% (95% confidence interval, 1.02-1.37%). The rate of a high neuraxial block causing unconsciousness was one in 6667 for all blocks.
    Conclusions: This unique large dataset provides a valuable insight of obstetric anaesthetic activity in the UK. Although missing data may place limitations on interpretation, it provides comparative estimates for the rates of rare complications and highlights variations in practice in time and place.
    MeSH term(s) Analgesia, Obstetrical ; Anesthesia, General ; Anesthesia, Obstetrical/adverse effects ; Anesthesia, Obstetrical/methods ; Cesarean Section ; Data Analysis ; Databases, Factual ; Datasets as Topic ; Female ; Humans ; Intensive Care Units ; Nerve Block/adverse effects ; Nerve Block/methods ; Pregnancy ; United Kingdom
    Language English
    Publishing date 2020-07-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2020.06.053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Massive bilateral breast reduction in an 11-year-old girl: 24% ablation of body weight.

    Fiumara, Linda / Gault, David T / Nel, Mark R / Lucas, Dominique N / Courtauld, Elizabeth

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2009  Volume 62, Issue 8, Page(s) e263–6

    Abstract: An 11-year-old girl with massive virginal breast hypertrophy is presented. The breasts had begun to grow rapidly at puberty and had reached an enormous size within a year, to the point of causing physical impairment and respiratory compromise. Routine ... ...

    Abstract An 11-year-old girl with massive virginal breast hypertrophy is presented. The breasts had begun to grow rapidly at puberty and had reached an enormous size within a year, to the point of causing physical impairment and respiratory compromise. Routine blood chemistry and endocrine investigation was normal, as was an MRI scan of the pituitary fossa. A bilateral reduction mammaplasty with free nipple grafts was performed, removing 12.5 kg of tissue in all (24% of the total body weight). There was no recurrence at a 2 year follow up, and no requirement for additional surgery. A review of the literature reveals that breast regrowth is less frequent when free nipple grafting is used, and this technique is recommended for these extraordinary cases.
    MeSH term(s) Body Weight ; Breast/pathology ; Breast/surgery ; Child ; Female ; Humans ; Hypertrophy/pathology ; Hypertrophy/surgery ; Mammaplasty/methods ; Nipples/pathology ; Nipples/surgery ; Secondary Prevention ; Treatment Outcome
    Language English
    Publishing date 2009-08
    Publishing country Netherlands
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2007.10.053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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