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Book ; Online: O Português Afro-Brasileiro

Lucchesi, Dante / Baxter, Alan N. / Ribeiro, Ilza

2009

Abstract: Organizado pelos professores Dante Lucchesi e Ilza Ribeiro, da Universidade Federal da Bahia, e pelo professor Allan Baxter, da Universidade de Macau, teve a colaboração de vários autores, professores de outras universidades do mesmo Estado, além de ... ...

Abstract	Organizado pelos professores Dante Lucchesi e Ilza Ribeiro, da Universidade Federal da Bahia, e pelo professor Allan Baxter, da Universidade de Macau, teve a colaboração de vários autores, professores de outras universidades do mesmo Estado, além de mestres, doutores e pós-graduandos, em geral oriundos daquela mesma universidade, integrantes do grupo de pesquisa ali constituído, e que vêm se dedicando ao estudo da realidade lingüística brasileira. Baseado na análise de amostras da fala de algumas comunidades rurais afro-brasileiras isoladas, no caso, quatro comunidades do Estado da Bahia - Helvécia, Cinzento, Rio de Contas e Sapé -, o livro apresenta os resultados obtidos pela aplicação de modelos teóricos que transitam da gerativa, de princípios e parâmetros, à sociolingüística variacionista, dentro daquela linha fecunda inaugurada pelo Prof. Tarallo nos anos oitenta.Dividido em duas partes, são apresentados, na primeira, os fundamentos teóricos e metodológicos nos quais se baseou a pesquisa e também o contexto sócio histórico das comunidades analisadas. Na segunda parte, são isolados dezesseis pontos-diagnósticos (apropriando-me da expressão utilizada pelo Professor Aryon Rodrigues em sua análise comparativa das línguas tupi-guarani), pelos quais se pode tanto esboçar um retrato das variedades vernáculas das comunidades pesquisadas, quanto levantar hipóteses, já mais bem fundadas, sobre a história do contato do português com as línguas africanas em território brasileiro
Keywords	Language and Literature
Size	1 electronic resource (576 p.)
Publisher	SciELO Books - EDUFBA
Document type	Book ; Online
Note	Portuguese ; Open Access
HBZ-ID	HT020089608
ISBN	9788523208752 ; 8523208755
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: An Italian MODY family with proband and son carrying variants in GCK and HFN1A: is it a true case of digenic MODY?

Lucchesi, Daniela / Randazzo, Emioli / Del Prato, Stefano / Bianchi, Cristina

Acta diabetologica

2023 Volume 61, Issue 1, Page(s) 131–134

Abstract: Maturity Onset Diabetes of the Young (MODY) is a monogenic autosomal dominant disorder affecting 1-5 % of all patients with diabetes mellitus. In Caucasians, GCK and HNF1A mutations are the most common cause of MODY. Here, we report two family members ... ...

Abstract	Maturity Onset Diabetes of the Young (MODY) is a monogenic autosomal dominant disorder affecting 1-5 % of all patients with diabetes mellitus. In Caucasians, GCK and HNF1A mutations are the most common cause of MODY. Here, we report two family members carrying a genetic variant of both GCK and HNF1A gene and their nine year clinical follow-up. Our report urges physicians to be cautious when variants in two genes are found in a single patient and suggests that collaboration with MODY genetics experts is necessary for correct diagnosis and treatment.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/drug therapy ; Family ; Glucokinase/genetics ; Hepatocyte Nuclear Factor 1-alpha/genetics ; Italy ; Mutation ; Nuclear Family
Chemical Substances	Glucokinase (EC 2.7.1.2) ; Hepatocyte Nuclear Factor 1-alpha ; HNF1A protein, human ; MAP4K2 protein, human
Language	English
Publishing date	2023-09-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1097676-0
ISSN	1432-5233 ; 0940-5429
ISSN (online)	1432-5233
ISSN	0940-5429
DOI	10.1007/s00592-023-02171-3
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Article: Stepwise changes in the murine salivary gland immune response during virally-induced ectopic lymphoid structure formation.

Coleby, Rachel / Lucchesi, Davide / Pontarini, Elena / Pitzalis, Costantino / Bombardieri, Michele

Clinical and experimental rheumatology

2021 Volume 39 Suppl 133, Issue 6, Page(s) 39–48

Abstract: Objectives: Sjögren's syndrome (SS) is a chronic autoimmune disease characterised by lymphocytic infiltration into the salivary glands (SG) and, in a subset of patients, formation of ectopic lymphoid structures (ELS) in the glands. However, the ... ...

Abstract	Objectives: Sjögren's syndrome (SS) is a chronic autoimmune disease characterised by lymphocytic infiltration into the salivary glands (SG) and, in a subset of patients, formation of ectopic lymphoid structures (ELS) in the glands. However, the mechanisms of how ELS form ectopically are not fully elucidated. Here we used a viral inducible murine model of ELS formation in the SG to elucidate the key immunological steps regulating the formation of ELS in the SG. Methods: We have utilised an inducible murine model of sialadenitis whereby retrograde cannulation of the submandibular SG with a replication-deficient adenovirus 5 leads to the formation of ELS. Flow cytometry, immunofluorescence and gene expression was performed on the SGs at regular time points after cannulation to follow the organisation of ELS. Results: Innate immune cells (neutrophils, eosinophils and monocytes) rapidly infiltrated the SG by 3 days post cannulation (dpc) whereby monocytes started to differentiate into resident macrophages. Myeloid dendritic cells accumulated inside leukocytic aggregates whereas macrophages were excluded from the developing ELS. Meanwhile, CD11b+ cells upregulated Il18, Cxcl13, Ltb, April and other lymphoid genes stimulating the influx of T cells by 12 days and B cells shortly after. Infiltration of T-follicular helper (Tfh) cells correlated with an increase in GL7+ germinal centre B cells, which peaked at 19 dpc. Conclusions: Immune cell infiltration in virally-infected murine SG follows a highly reproducible step-wise process whereby early innate immune cells reshape the SG myeloid compartment leading to upregulation of genes involved in the ectopic lymphoid neogenesis process. This in turns leads to T and B cell recruitment, differentiation and activation, culminating in the organization of ELS and localised germinal centres responses.
MeSH term(s)	Animals ; Humans ; Immunity ; Mice ; Salivary Glands ; Sialadenitis ; Sjogren's Syndrome ; Up-Regulation
Language	English
Publishing date	2021-09-30
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
DOI	10.55563/clinexprheumatol/gb7pfc
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Article ; Online: Fatty liver index is an independent risk factor for all-cause mortality and major cardiovascular events in type 1 diabetes: an 11-year observational study.

Garofolo, Monia / Lucchesi, Daniela / Giambalvo, Massimo / Aragona, Michele / Bertolotto, Alessandra / Campi, Fabrizio / Bianchi, Cristina / Francesconi, Paolo / Marchetti, Piero / Del Prato, Stefano / Penno, Giuseppe

Cardiovascular diabetology

2024 Volume 23, Issue 1, Page(s) 85

Abstract: Background: Non-alcoholic fatty liver disease (NAFLD), identified by the Fatty Liver Index (FLI), is associated with increased mortality and cardiovascular (CV) outcomes. Whether this also applies to type 1 diabetes (T1D) has not been yet reported.: ... ...

Abstract	Background: Non-alcoholic fatty liver disease (NAFLD), identified by the Fatty Liver Index (FLI), is associated with increased mortality and cardiovascular (CV) outcomes. Whether this also applies to type 1 diabetes (T1D) has not been yet reported. Methods: We prospectively observed 774 subjects with type 1 diabetes (males 52%, 30.3 ± 11.1 years old, diabetes duration (DD) 18.5 ± 11.6 years, HbA1c 7.8 ± 1.2%) to assess the associations between FLI (based on BMI, waist circumference, gamma-glutamyl transferase and triglycerides) and all-cause death and first CV events. Results: Over a median 11-year follow-up, 57 subjects died (7.4%) and 49 CV events (6.7%) occurred among 736 individuals with retrievable incidence data. At baseline, FLI was < 30 in 515 subjects (66.5%), 30-59 in 169 (21.8%), and ≥ 60 in 90 (11.6%). Mortality increased steeply with FLI: 3.9, 10.1, 22.2% (p < 0.0001). In unadjusted Cox analysis, compared to FLI < 30, risk of death increased in FLI 30-59 (HR 2.85, 95% CI 1.49-5.45, p = 0.002) and FLI ≥ 60 (6.07, 3.27-11.29, p < 0.0001). Adjusting for Steno Type 1 Risk Engine (ST1-RE; based on age, sex, DD, systolic BP, LDL cholesterol, HbA1c, albuminuria, eGFR, smoking and exercise), HR was 1.52 (0.78-2.97) for FLI 30-59 and 3.04 (1.59-5.82, p = 0.001) for FLI ≥ 60. Inclusion of prior CV events slightly modified HRs. FLI impact was confirmed upon adjustment for EURODIAB Risk Engine (EURO-RE; based on age, HbA1c, waist-to-hip ratio, albuminuria and HDL cholesterol): FLI 30-59: HR 1.24, 0.62-2.48; FLI ≥ 60: 2.54, 1.30-4.95, p = 0.007), even after inclusion of prior CVD. CV events incidence increased with FLI: 3.5, 10.5, 17.2% (p < 0.0001). In unadjusted Cox, HR was 3.24 (1.65-6.34, p = 0.001) for FLI 30-59 and 5.41 (2.70-10.83, p < 0.0001) for FLI ≥ 60. After adjustment for ST1-RE or EURO-RE, FLI ≥ 60 remained statistically associated with risk of incident CV events, with trivial modification with prior CVD inclusion. Conclusions: This observational prospective study shows that FLI is associated with higher all-cause mortality and increased risk of incident CV events in type 1 diabetes.
MeSH term(s)	Male ; Humans ; Young Adult ; Adult ; Diabetes Mellitus, Type 1/diagnosis ; Diabetes Mellitus, Type 1/epidemiology ; Diabetes Mellitus, Type 1/complications ; Prospective Studies ; Glycated Hemoglobin ; Albuminuria/diagnosis ; Albuminuria/epidemiology ; Albuminuria/complications ; Risk Factors ; Non-alcoholic Fatty Liver Disease/epidemiology ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/complications
Chemical Substances	Glycated Hemoglobin
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2093769-6
ISSN	1475-2840 ; 1475-2840
ISSN (online)	1475-2840
ISSN	1475-2840
DOI	10.1186/s12933-024-02171-9
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Article ; Online: The Impact of the Even Zonal Harmonics Secular Variations on the Lense-Thirring Effect Measurement with the Two LAGEOS Satellites

Lucchesi, D.

International Journal of Modern Physics D

2005

Publishing country	de
Document type	Article ; Online
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Article ; Online: Current views on the pathogenesis of Sjögren's syndrome.

Pontarini, Elena / Lucchesi, Davide / Bombardieri, Michele

Current opinion in rheumatology

2018 Volume 30, Issue 2, Page(s) 215–221

Abstract: Purpose of review: The purpose of this review is to provide an insight into the pathophysiological mechanisms involved in the pathogenesis of primary Sjögren's Syndrome (pSS), highlighting recent findings with potential therapeutic repercussions.: ... ...

Abstract	Purpose of review: The purpose of this review is to provide an insight into the pathophysiological mechanisms involved in the pathogenesis of primary Sjögren's Syndrome (pSS), highlighting recent findings with potential therapeutic repercussions. Recent findings: In the last 2 years, epigenetic analyses provided new insights into pSS pathogenesis. Characterization of DNA methylation patterns, chromatin structures and microRNA confirmed the importance of aberrant interferon and B-cell responses in the development of the disease. The formation of ectopic B-cell follicles with germinal centers is now a well recognized pathogenic mechanism within salivary glands of pSS. In the context of ectopic germinal centers reaction, T/B-cell interactions, that is regarding T-helper 17 and T-follicular helper cells, and their respective counterparts, T-regulatory and T-follicular regulatory cells, appear particularly relevant in pSS pathogenesis as their imbalance is associated with a dysregulation of B-cell dynamics and the production of autoantibodies. Summary: Advances in the understanding of pSS pathogenesis have paved the way for clinical trials with novel biologic agents targeting immune pathways regulating T/B-cell interactions and downstream B-cell activation. Reverse translation from these studies provides invaluable novel information of the mechanisms sustaining autoimmunity and chronic inflammation in pSS.
MeSH term(s)	CD4-Positive T-Lymphocytes/immunology ; Epigenesis, Genetic/genetics ; Epigenesis, Genetic/immunology ; Genetic Predisposition to Disease ; Germinal Center ; Humans ; Salivary Glands/immunology ; Sjogren's Syndrome/genetics ; Sjogren's Syndrome/immunology ; Sjogren's Syndrome/physiopathology ; T-Lymphocyte Subsets/immunology
Language	English
Publishing date	2018-02-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1045317-9
ISSN	1531-6963 ; 1040-8711
ISSN (online)	1531-6963
ISSN	1040-8711
DOI	10.1097/BOR.0000000000000473
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Article ; Online: Type 2 diabetes albuminuric and non-albuminuric phenotypes have different morphological and functional ultrasound features of diabetic kidney disease.

Garofolo, Monia / Napoli, Vinicio / Lucchesi, Daniela / Accogli, Sandra / Mazzeo, Maria Letizia / Rossi, Piercarlo / Neri, Emanuele / Del Prato, Stefano / Penno, Giuseppe

Diabetes/metabolism research and reviews

2022 Volume 39, Issue 1, Page(s) e3585

Abstract: Aims: Whether different diabetic kidney disease (DKD) phenotypes recognise differences in morphological and vascular properties of the kidney is still unexplored. We evaluated the potential role of kidney ultrasonography in differentiating DKD ... ...

Abstract	Aims: Whether different diabetic kidney disease (DKD) phenotypes recognise differences in morphological and vascular properties of the kidney is still unexplored. We evaluated the potential role of kidney ultrasonography in differentiating DKD phenotypes in subjects with type 2 diabetes. Materials and methods: This is a cross-sectional, single-centre study. Total (TRV) and parenchymal renal volumes (PRV) were calculated by applying the ellipsoid formula for conventional (2D) ultrasonography and with manual segmentation for 3D ultrasonography, and then adjusted for body surface area (aTRV, aPRV). Renal resistive index (RI) was contextually determined. DKD phenotypes have been defined based on increased urinary albumin-to-creatinine ratio (ACR >30 mg/g) and/or reduced eGFR (<60 ml/min/1.73 m Results: Among 256 subjects, 26.2% had No-DKD, 24.6% increased albuminuria only (Alb Conclusions: As a novel information, we reported that, in type 2 diabetes, the emerging normoalbuminuric DKD phenotype showed reduced TRVs and PRVs even when compared, at similarly reduced eGFR levels, with Alb
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/complications ; Diabetic Nephropathies/etiology ; Diabetic Nephropathies/complications ; Cross-Sectional Studies ; Phenotype ; Ultrasonography ; Glomerular Filtration Rate ; Albuminuria
Language	English
Publishing date	2022-11-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1470192-3
ISSN	1520-7560 ; 1520-7552
ISSN (online)	1520-7560
ISSN	1520-7552
DOI	10.1002/dmrr.3585
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Article ; Online: SIRT1 rs7896005 polymorphism affects major vascular outcomes, not all-cause mortality, in Caucasians with type 2 diabetes: A 13-year observational study.

Dardano, Angela / Lucchesi, Daniela / Garofolo, Monia / Gualdani, Elisa / Falcetta, Pierpaolo / Sancho Bornez, Veronica / Francesconi, Paolo / Del Prato, Stefano / Penno, Giuseppe

Diabetes/metabolism research and reviews

2022 Volume 38, Issue 4, Page(s) e3523

Abstract: Aims: SIRT1 exerts effects on ageing and lifespan, as well cardiovascular (CV) disease risk. SIRT1 gene is very polymorph with a few tagging single nucleotide polymorphisms (SNPs) so far identified. Some SNPs, including rs7896005, were associated with ... ...

Abstract	Aims: SIRT1 exerts effects on ageing and lifespan, as well cardiovascular (CV) disease risk. SIRT1 gene is very polymorph with a few tagging single nucleotide polymorphisms (SNPs) so far identified. Some SNPs, including rs7896005, were associated with type 2 diabetes (T2DM). We aimed to ascertain whether this SNP may be associated with CV disease at baseline as well with these same outcomes and all-cause mortality over a 13-year follow-up. Materials and methods: Genotypes of SIRT1 gene were determined using TaqMan SNP assay. Results: Out of 905 T2DM, 9.1% had the AA genotype, 43.2% the AG, and 47.7% the GG. Hardy-Weinberg Equilibrium was met (minor allele frequency 0.306; p = 0.8899). At baseline, there was no difference across genotypes for sex, age, diabetes duration, CV risk factors, treatments, and microangiopathy. Major CV outcomes, myocardial infarction (MI), any coronary heart disease (CHD), and peripheral artery disease (PAD) were more frequent in GG than in AA/AG (p from 0.013 to 0.027), with no association with cerebrovascular events. By fully adjusted regression, GG remained independently related to major CV outcomes, MI, CHD, and PAD. Over follow-up, we recorded 258 major CV events (28.5%; AA/AG 25.2%, GG 32.2%; p = 0.014) with an adjusted hazard ratio (HR) of GG versus AA/AG of 1.296 (95% CI 1.007-1.668, p = 0.044); 169 coronary events (18.7%; AA/AG 15.4%, GG 22.2%; p = 0.006) with HR 1.522 (1.113-2.080, p = 0.008); 79 (8.7%) hospitalisation for heart failure (AA/AG 7.0%, GG 10.6%; p = 0.045) and HR 1.457 (0.919-2.309, p = 0.109); 36 PAD (4.0%; AA/AG 2.3%, GG 5.8%; p = 0.007) with HR 2.225 (1.057-4.684, p = 0.035). No association was found with cerebrovascular events, end stage renal disease, and all-cause mortality. Conclusions: The rs7896005 SNP of SIRT1 might play a role in cardiovascular disease, mainly CHD risk in T2DM. Results call for larger association studies as well as studies to ascertain mechanisms by which this variant confers increased risk.
MeSH term(s)	Cardiovascular Diseases/genetics ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/genetics ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Polymorphism, Single Nucleotide ; Sirtuin 1/genetics
Chemical Substances	SIRT1 protein, human (EC 3.5.1.-) ; Sirtuin 1 (EC 3.5.1.-)
Language	English
Publishing date	2022-02-07
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	1470192-3
ISSN	1520-7560 ; 1520-7552
ISSN (online)	1520-7560
ISSN	1520-7552
DOI	10.1002/dmrr.3523
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Book ; Online: Crilin

Ceravolo, S. / Colao, F. / Curatolo, C. / Di Meco, E. / Diociaiuti, E. / Lucchesi, D. / Paesani, D. / Pastrone, N. / Saputi, A. / Sarra, I. / Sestini, L. / Tagnani, D.

A CRystal calorImeter with Longitudinal InformatioN for a future Muon Collider

2022

Abstract: The measurement of physics processes at new energy frontier experiments requires excellent spatial, time, and energy resolutions to resolve the structure of collimated high-energy jets. In a future Muon Collider, the beam-induced backgrounds (BIB) ... ...

Abstract	The measurement of physics processes at new energy frontier experiments requires excellent spatial, time, and energy resolutions to resolve the structure of collimated high-energy jets. In a future Muon Collider, the beam-induced backgrounds (BIB) represent the main challenge in the design of the detectors and of the event reconstruction algorithms. The technology and the design of the calorimeters should be chosen to reduce the effect of the BIB, while keeping good physics performance. Several requirements can be inferred: i) high granularity to reduce the overlap of BIB particles in the same calorimeter cell; ii) excellent timing (of the order of 100 ps) to reduce the out-of-time component of the BIB; iii) longitudinal segmentation to distinguish the signal showers from the fake showers produced by the BIB; iv) good energy resolution (less than 10%/sqrt(E)) to obtain good physics performance, as has been already demonstrated for conceptual particle flow calorimeters. Our proposal consists of a semi-homogeneous electromagnetic calorimeter based on Lead Fluoride Crystals (PbF2) readout by surface-mount UV-extended Silicon Photomultipliers (SiPMs): the Crilin calorimeter. In this paper, the performances of the Crilin calorimeter in the Muon Collider framework for hadron jets reconstruction have been analyzed. We report the single components characterizations together with the development of a small-scale prototype, consisting of 2 layers of 3x3 crystals each.
Keywords	Physics - Instrumentation and Detectors ; High Energy Physics - Experiment
Subject code	621
Publishing date	2022-06-12
Publishing country	us
Document type	Book ; Online
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Article ; Online: The role of viruses in autoreactive B cell activation within tertiary lymphoid structures in autoimmune diseases.

Lucchesi, Davide / Bombardieri, Michele

Journal of leukocyte biology

2013 Volume 94, Issue 6, Page(s) 1191–1199

Abstract: TLS, characterized by the formation of ectopic B/T cell follicles with FDCs supporting an ectopic GC response, have been described in the target organs of several autoimmune diseases, including MS, RA, SS, and autoimmune thyroiditis. These structures ... ...

Abstract	TLS, characterized by the formation of ectopic B/T cell follicles with FDCs supporting an ectopic GC response, have been described in the target organs of several autoimmune diseases, including MS, RA, SS, and autoimmune thyroiditis. These structures represent functional niches, whereby autoreactive B cells undergo in situ affinity maturation and differentiation to autoantibody-producing cells, thus contributing to the progression and persistence of autoimmunity. Increasing evidence demonstrates that TLS can also develop in the context of cancer, as well as chronic infections. In this review, we collect recent evidences that highlights the relationship between persistent viral infection and the development of ectopic lymphoid structures in animal models and patients. Furthermore, we shall discuss the concept that whereas in physiological conditions, inducible TLS are critical for viral clearance and the establishment of protective immunity, but in the context of susceptible individuals, persistent viral infections may contribute, directly or indirectly, to the development of breach of tolerance against self-antigens and the development of autoimmunity through the formation of TLS.
MeSH term(s)	Animals ; Antigens, Viral/immunology ; Autoantigens/immunology ; Autoimmune Diseases/etiology ; Autoimmune Diseases/immunology ; Autoimmune Diseases/pathology ; Autoimmune Diseases/virology ; B-Lymphocytes/immunology ; B-Lymphocytes/pathology ; Disease Models, Animal ; Humans ; Immune Tolerance ; Lymphocyte Activation ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology ; Virus Diseases/complications ; Virus Diseases/immunology ; Virus Diseases/pathology ; Viruses/immunology
Chemical Substances	Antigens, Viral ; Autoantigens
Language	English
Publishing date	2013-06-28
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	605722-6
ISSN	1938-3673 ; 0741-5400
ISSN (online)	1938-3673
ISSN	0741-5400
DOI	10.1189/jlb.0413240
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