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Article ; Online: Active stabilization of a pseudoheterodyne scattering scanning near field optical microscope.

Becerril, David / Cesca, Tiziana / Mattei, Giovanni / Noguez, Cecilia / Pirruccio, Giuseppe / Luce, Marco / Cricenti, Antonio

The Review of scientific instruments

2023 Volume 94, Issue 2, Page(s) 23704

Abstract: Scattering scanning near-field optical microscopes (s-SNOMs) based on pseudoheterodyne detection and operating at ambient conditions typically suffer from instabilities related to the variable optical path length of the interferometer arms. These cause ... ...

Abstract	Scattering scanning near-field optical microscopes (s-SNOMs) based on pseudoheterodyne detection and operating at ambient conditions typically suffer from instabilities related to the variable optical path length of the interferometer arms. These cause strong oscillations in the measured optical amplitude and phase comparable with those of the signal and, thus, resulting in dramatic artifacts. Besides hampering the comparison between the topography and the optical measurements, such oscillations may lead to misinterpretations of the physical phenomena occurring at the sample surface, especially for nanostructured materials. Here, we propose a stabilizing method based on interferometer phase control, which improves substantially the image quality and allows the correct extraction of optical phase and amplitude for both micro- and nanostructures. This stabilization method expands the measurement capabilities of s-SNOM to any slowly time-dependent phenomena that require long-term stability of the system. We envisage that active stabilization will increase the technological significance of s-SNOMs and will have far-reaching applications in the field of heat transfer and nanoelectronics.
Language	English
Publishing date	2023-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0133488
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Article ; Online: Semitransparent Perovskite Solar Cells with Ultrathin Protective Buffer Layers.

Magliano, Erica / Mariani, Paolo / Agresti, Antonio / Pescetelli, Sara / Matteocci, Fabio / Taheri, Babak / Cricenti, Antonio / Luce, Marco / Di Carlo, Aldo

ACS applied energy materials

2023 Volume 6, Issue 20, Page(s) 10340–10353

Abstract: Semitransparent perovskite solar cells (ST-PSCs) are increasingly important in a range of applications, including top cells in tandem devices and see-through photovoltaics. Transparent conductive oxides (TCOs) are commonly used as transparent electrodes, ...

Abstract	Semitransparent perovskite solar cells (ST-PSCs) are increasingly important in a range of applications, including top cells in tandem devices and see-through photovoltaics. Transparent conductive oxides (TCOs) are commonly used as transparent electrodes, with sputtering being the preferred deposition method. However, this process can damage exposed layers, affecting the electrical performance of the devices. In this study, an indium tin oxide (ITO) deposition process that effectively suppresses sputtering damage was developed using a transition metal oxides (TMOs)-based buffer layer. An ultrathin (<10 nm) layer of evaporated vanadium oxide or molybdenum oxide was found to be effective in protecting against sputtering damage in ST-PSCs for tandem applications, as well as in thin perovskite-based devices for building-integrated photovoltaics. The identification of minimal parasitic absorption, the high work function and the analysis of oxygen vacancies denoted that the TMO layers are suitable for use in ST-PSCs. The highest fill factor (FF) achieved was 76%, and the efficiency (16.4%) was reduced by less than 10% when compared with the efficiency of gold-based PSCs. Moreover, up-scaling to 1 cm
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Journal Article
ISSN	2574-0962
ISSN (online)	2574-0962
DOI	10.1021/acsaem.3c00735
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Article ; Online: Cyclic Stretch-Induced Mechanical Stress Applied at 1 Hz Frequency Can Alter the Metastatic Potential Properties of SAOS-2 Osteosarcoma Cells.

Alloisio, Giulia / Rodriguez, David Becerril / Luce, Marco / Ciaccio, Chiara / Marini, Stefano / Cricenti, Antonio / Gioia, Magda

International journal of molecular sciences

2023 Volume 24, Issue 9

Abstract: Recently, there has been an increasing focus on cellular morphology and mechanical behavior in order to gain a better understanding of the modulation of cell malignancy. This study used uniaxial-stretching technology to select a mechanical regimen able ... ...

Abstract	Recently, there has been an increasing focus on cellular morphology and mechanical behavior in order to gain a better understanding of the modulation of cell malignancy. This study used uniaxial-stretching technology to select a mechanical regimen able to elevate SAOS-2 cell migration, which is crucial in osteosarcoma cell pathology. Using confocal and atomic force microscopy, we demonstrated that a 24 h 0.5% cyclic elongation applied at 1 Hz induces morphological changes in cells. Following mechanical stimulation, the cell area enlarged, developing a more elongated shape, which disrupted the initial nuclear-to-cytoplasm ratio. The peripheral cell surface also increased its roughness. Cell-based biochemical assays and real-time PCR quantification showed that these morphologically induced changes are unrelated to the osteoblastic differentiative grade. Interestingly, two essential cell-motility properties in the modulation of the metastatic process changed following the 24 h 1 Hz mechanical stimulation. These were cell adhesion and cell migration, which, in fact, were dampened and enhanced, respectively. Notably, our results showed that the stretch-induced up-regulation of cell motility occurs through a mechanism that does not depend on matrix metalloproteinase (MMP) activity, while the inhibition of ion-stretch channels could counteract it. Overall, our results suggest that further research on mechanobiology could represent an alternative approach for the identification of novel molecular targets of osteosarcoma cell malignancy.
MeSH term(s)	Humans ; Stress, Mechanical ; Osteosarcoma/genetics ; Cell Movement ; Cell Differentiation ; Ion Channels ; Bone Neoplasms/genetics
Chemical Substances	Ion Channels
Language	English
Publishing date	2023-04-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24097686
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Article: Oxidized Alginate Dopamine Conjugate: A Study to Gain Insight into Cell/Particle Interactions.

Trapani, Adriana / Corbo, Filomena / Stefàno, Erika / Capobianco, Loredana / Muscella, Antonella / Marsigliante, Santo / Cricenti, Antonio / Luce, Marco / Becerril, David / Bellucci, Stefano

Journal of functional biomaterials

2022 Volume 13, Issue 4

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2022-10-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2648525-4
ISSN	2079-4983
ISSN	2079-4983
DOI	10.3390/jfb13040201
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Article: Oxidized Alginate Dopamine Conjugate: In Vitro Characterization for Nose-to-Brain Delivery Application.

Trapani, Adriana / Corbo, Filomena / Agrimi, Gennaro / Ditaranto, Nicoletta / Cioffi, Nicola / Perna, Filippo / Quivelli, Andrea / Stefàno, Erika / Lunetti, Paola / Muscella, Antonella / Marsigliante, Santo / Cricenti, Antonio / Luce, Marco / Mormile, Cristina / Cataldo, Antonino / Bellucci, Stefano

Materials (Basel, Switzerland)

2021 Volume 14, Issue 13

Abstract: Background: The blood-brain barrier (BBB) bypass of dopamine (DA) is still a challenge for supplying it to the neurons of : Methods: A Schiff base was designed to connect oxidized polymeric backbone to DA and both AlgOX and AlgOX-DA were ... ...

Abstract	Background: The blood-brain barrier (BBB) bypass of dopamine (DA) is still a challenge for supplying it to the neurons of Methods: A Schiff base was designed to connect oxidized polymeric backbone to DA and both AlgOX and AlgOX-DA were characterized in terms of Raman, XPS, FT-IR, and Results: Data demonstrated that AlgOX-DA was the most mucoadhesive material among the tested ones and it released the neurotransmitter in simulated nasal fluid and in low amounts in phosphate buffer saline. Results also demonstrated the capability of scanning near-field optical microscopy to study the structural and fluorescence properties of AlgOX, fluorescently labeled with fluorescein isothiocyanate microstructures. Interestingly, in SH-SY5Y neuroblastoma cell line up to 100 μg/mL, no toxic effect was derived from AlgOX and AlgOX-DA in 24 h. Conclusions: Overall, the in vitro performances of AlgOX and AlgOX-DA conjugates seem to encourage further ex vivo and in vivo studies in view of nose-to-brain administration.
Language	English
Publishing date	2021-06-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma14133495
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Article ; Online: Tissue degeneration in ALS affected spinal cord evaluated by Raman spectroscopy.

Picardi, Gennaro / Spalloni, Alida / Generosi, Amanda / Paci, Barbara / Mercuri, Nicola Biagio / Luce, Marco / Longone, Patrizia / Cricenti, Antonio

Scientific reports

2018 Volume 8, Issue 1, Page(s) 13110

Abstract: The Raman spectral features from spinal cord tissue sections of transgenic, ALS model mice and non-transgenic mice were compared using 457 nm excitation line, profiting from the favourable signal intensity obtained in the molecular fingerprint region at ... ...

Abstract	The Raman spectral features from spinal cord tissue sections of transgenic, ALS model mice and non-transgenic mice were compared using 457 nm excitation line, profiting from the favourable signal intensity obtained in the molecular fingerprint region at this wavelength. Transverse sections from four SOD1G93A mice at 75 days and from two at 90 days after birth were analysed and compared with sections of similarly aged control mice. The spectra acquired within the grey matter of tissue sections from the diseased mice is markedly different from the grey matter signature of healthy mice. In particular, we observe an intensity increase in the spectral windows 450-650 cm
MeSH term(s)	Amyotrophic Lateral Sclerosis/diagnostic imaging ; Amyotrophic Lateral Sclerosis/pathology ; Animals ; Gray Matter/pathology ; Mice, Inbred C57BL ; Mice, Transgenic ; Signal Processing, Computer-Assisted ; Spectrum Analysis, Raman ; Spinal Cord/diagnostic imaging ; Spinal Cord/pathology ; Superoxide Dismutase/genetics ; White Matter/pathology
Chemical Substances	Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2018-08-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-31469-4
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Article ; Online: Conjugates of Gold Nanoparticles and Antitumor Gold(III) Complexes as a Tool for Their AFM and SERS Detection in Biological Tissue.

Bondžić, Aleksandra M / Leskovac, Andreja R / Petrović, Sandra Ž / Vasić Anićijević, Dragana D / Luce, Marco / Massai, Lara / Generosi, Amanda / Paci, Barbara / Cricenti, Antonio / Messori, Luigi / Vasić, Vesna M

International journal of molecular sciences

2019 Volume 20, Issue 24

Abstract: Citrate-capped gold nanoparticles (AuNPs) were functionalized with three distinct antitumor gold(III) complexes, e.g., [Au(N,N)(OH) ...

Abstract	Citrate-capped gold nanoparticles (AuNPs) were functionalized with three distinct antitumor gold(III) complexes, e.g., [Au(N,N)(OH)
MeSH term(s)	Antineoplastic Agents/chemistry ; Gold/chemistry ; Humans ; Metal Nanoparticles/chemistry ; Metal Nanoparticles/ultrastructure ; Microscopy, Atomic Force ; Spectrum Analysis, Raman
Chemical Substances	Antineoplastic Agents ; Gold (7440-57-5)
Language	English
Publishing date	2019-12-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms20246306
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Article ; Online: Detection and localization of gold nanoshells inside cells: near-field approximation.

D'Acunto, Mario / Cricenti, Antonio / Danti, Serena / Dinarelli, Simone / Luce, Marco / Moroni, Davide / Salvetti, Ovidio

Applied optics

2016 Volume 55, Issue 34, Page(s) D11–D16

Abstract: The optical properties of metal nanoparticles play a fundamental role for their use in a wide range of applications. In hyperthermia treatment, for example, gold nanoshells (NSs, dielectric core+gold shell) pre-embedded in a cancer cell absorb energy ... ...

Abstract	The optical properties of metal nanoparticles play a fundamental role for their use in a wide range of applications. In hyperthermia treatment, for example, gold nanoshells (NSs, dielectric core+gold shell) pre-embedded in a cancer cell absorb energy when exposed to appropriate wavelengths of a laser beam and heat up, thereby destroying the cancer cell. In this process, nevertheless, healthy tissues (not targeted by the NSs) along the laser path are not affected; this is because most biological soft tissues have a relatively low light absorption coefficient in the near-infrared (NIR) regions-a characteristic known as the tissue optical window. Over such a window, NIR light transmits through the tissues with scattering-limited attenuation and minimal heating, thereby avoiding damage to healthy tissues. As a consequence, the identification of NSs assumed a fundamental role for the further development of such cancer treatment. Recently, we have demonstrated the possibility to identify 100-150 nm diameter gold NSs inside mouse cells using a scanning near-optical microscope (SNOM). In this paper, we provide a numerical demonstration that the SNOM is able to locate NSs inside the cell with a particle-aperture distance of about 100 nm. This result was obtained by developing an analytical approach based on the calculation of the dyadic Green function in the near-field approximation. The implications of our findings will remarkably affect further investigations on the interaction between NSs and biological systems.
Language	English
Publishing date	2016-12-01
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.55.000D11
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Article ; Online: An imaging dataset of cervical cells using scanning near-field optical microscopy coupled to an infrared free electron laser.

Halliwell, Diane E / Morais, Camilo L M / Lima, Kássio M G / Trevisan, Júlio / Siggel-King, Michele R F / Craig, Tim / Ingham, James / Martin, David S / Heys, Kelly / Kyrgiou, Maria / Mitra, Anita / Paraskevaidis, Evangelos / Theophilou, Georgios / Martin-Hirsch, Pierre L / Cricenti, Antonio / Luce, Marco / Weightman, Peter / Martin, Francis L

Scientific data

2017 Volume 4, Page(s) 170084

Abstract: Using a scanning near-field optical microscope coupled to an infrared free electron laser (SNOM-IR-FEL) in low-resolution transmission mode, we collected chemical data from whole cervical cells obtained from 5 pre-menopausal, non-pregnant women of ... ...

Abstract	Using a scanning near-field optical microscope coupled to an infrared free electron laser (SNOM-IR-FEL) in low-resolution transmission mode, we collected chemical data from whole cervical cells obtained from 5 pre-menopausal, non-pregnant women of reproductive age, and cytologically classified as normal or with different grades of cervical cell dyskaryosis. Imaging data are complemented by demography. All samples were collected before any treatment. Spectra were also collected using attenuated total reflection, Fourier-transform (ATR-FTIR) spectroscopy, to investigate the differences between the two techniques. Results of this pilot study suggests SNOM-IR-FEL may be able to distinguish cervical abnormalities based upon changes in the chemical profiles for each grade of dyskaryosis at designated wavelengths associated with DNA, Amide I/II, and lipids. The novel data sets are the first collected using SNOM-IR-FEL in transmission mode at the ALICE facility (UK), and obtained using whole cells as opposed to tissue sections, thus providing an 'intact' chemical profile. These data sets are suited to complementing future work on image analysis, and/or applying the newly developed algorithm to other datasets collected using the SNOM-IR-FEL approach.
Language	English
Publishing date	2017--11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/sdata.2017.84
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Article ; Online: Imaging cervical cytology with scanning near-field optical microscopy (SNOM) coupled with an IR-FEL.

Halliwell, Diane E / Morais, Camilo L M / Lima, Kássio M G / Trevisan, Julio / Siggel-King, Michele R F / Craig, Tim / Ingham, James / Martin, David S / Heys, Kelly A / Kyrgiou, Maria / Mitra, Anita / Paraskevaidis, Evangelos / Theophilou, Georgios / Martin-Hirsch, Pierre L / Cricenti, Antonio / Luce, Marco / Weightman, Peter / Martin, Francis L

Scientific reports

2016 Volume 6, Page(s) 29494

Abstract: Cervical cancer remains a major cause of morbidity and mortality among women, especially in the developing world. Increased synthesis of proteins, lipids and nucleic acids is a pre-condition for the rapid proliferation of cancer cells. We show that ... ...

Abstract	Cervical cancer remains a major cause of morbidity and mortality among women, especially in the developing world. Increased synthesis of proteins, lipids and nucleic acids is a pre-condition for the rapid proliferation of cancer cells. We show that scanning near-field optical microscopy, in combination with an infrared free electron laser (SNOM-IR-FEL), is able to distinguish between normal and squamous low-grade and high-grade dyskaryosis, and between normal and mixed squamous/glandular pre-invasive and adenocarcinoma cervical lesions, at designated wavelengths associated with DNA, Amide I/II and lipids. These findings evidence the promise of the SNOM-IR-FEL technique in obtaining chemical information relevant to the detection of cervical cell abnormalities and cancer diagnosis at spatial resolutions below the diffraction limit (≥0.2 μm). We compare these results with analyses following attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy; although this latter approach has been demonstrated to detect underlying cervical atypia missed by conventional cytology, it is limited by a spatial resolution of ~3 μm to 30 μm due to the optical diffraction limit.
MeSH term(s)	Adenocarcinoma/diagnostic imaging ; Adenocarcinoma/pathology ; Adolescent ; Adult ; Algorithms ; Biomarkers/metabolism ; Cell Proliferation ; Cervical Intraepithelial Neoplasia/diagnostic imaging ; Cervical Intraepithelial Neoplasia/pathology ; Cohort Studies ; Computer Simulation ; DNA/chemistry ; Electrons ; Female ; Humans ; Lipids/chemistry ; Microscopy/methods ; Microscopy, Atomic Force ; Middle Aged ; Models, Statistical ; Principal Component Analysis ; Spectroscopy, Fourier Transform Infrared ; Uterine Cervical Neoplasms/diagnostic imaging ; Uterine Cervical Neoplasms/pathology ; Young Adult
Chemical Substances	Biomarkers ; Lipids ; DNA (9007-49-2)
Language	English
Publishing date	2016-07-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep29494
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