LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Lucia Landoni"
  2. AU="Singh, Pawan"
  3. AU=Bevan D R
  4. AU="Arobindu Dash"
  5. AU="Xu, Boqi"
  6. AU="Minako Kamimoto"
  7. AU="Akinwunmi, Adebowale F"
  8. AU="Luo, Dong Dong"
  9. AU=Cao Jun
  10. AU="Lauren A Holt"
  11. AU="Nathalie Turgeon"
  12. AU="Santos, Bryan" AU="Santos, Bryan"
  13. AU="Platanios, Emmanouil Antonios"
  14. AU="Havva Keskin"
  15. AU="Gomis, Susantha"
  16. AU="Castro, Vanda"
  17. AU="Josiah, S M"
  18. AU="Yanjun Guo"
  19. AU="Klapp, Sabine H L"
  20. AU="Cipolat, Lauriane"
  21. AU="Rhee, Hwanseok"
  22. AU="El-Khatabi, K"
  23. AU="Lee, Seung Hee"
  24. AU=Torres Antoni
  25. AU="Baldacini, Mathieu"
  26. AU="Stahl, Alexander"
  27. AU="Karimbumkara, Seena Narayanan"
  28. AU="Welz Mirosław"
  29. AU="Jintao Ding"
  30. AU="Mei-Fang Chen"

Suchergebnis

Treffer 1 - 2 von insgesamt 2

Suchoptionen

  1. Artikel ; Online: Blood Thiol Redox State in Chronic Kidney Disease

    Maria Lisa Garavaglia / Daniela Giustarini / Graziano Colombo / Francesco Reggiani / Silvia Finazzi / Marta Calatroni / Lucia Landoni / Nicola Marcello Portinaro / Aldo Milzani / Salvatore Badalamenti / Ranieri Rossi / Isabella Dalle-Donne

    International Journal of Molecular Sciences, Vol 23, Iss 2853, p

    2022  Band 2853

    Abstract: Thiols (sulfhydryl groups) are effective antioxidants that can preserve the correct structure of proteins, and can protect cells and tissues from damage induced by oxidative stress. Abnormal levels of thiols have been measured in the blood of patients ... ...

    Abstract Thiols (sulfhydryl groups) are effective antioxidants that can preserve the correct structure of proteins, and can protect cells and tissues from damage induced by oxidative stress. Abnormal levels of thiols have been measured in the blood of patients with moderate-to-severe chronic kidney disease (CKD) compared to healthy subjects, as well as in end-stage renal disease (ESRD) patients on haemodialysis or peritoneal dialysis. The levels of protein thiols (a measure of the endogenous antioxidant capacity inversely related to protein oxidation) and S -thiolated proteins (mixed disulphides of protein thiols and low molecular mass thiols), and the protein thiolation index (the molar ratio of the S -thiolated proteins to free protein thiols in plasma) have been investigated in the plasma or red blood cells of CKD and ESRD patients as possible biomarkers of oxidative stress. This type of minimally invasive analysis provides valuable information on the redox status of the less-easily accessible tissues and organs, and of the whole organism. This review provides an overview of reversible modifications in protein thiols in the setting of CKD and renal replacement therapy. The evidence suggests that protein thiols, S -thiolated proteins, and the protein thiolation index are promising biomarkers of reversible oxidative stress that could be included in the routine monitoring of CKD and ESRD patients.
    Schlagwörter chronic kidney disease ; end-stage renal disease ; haemodialysis ; peritoneal dialysis ; protein thiols ; S -thiolated proteins ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2022-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  2. Artikel ; Online: Effects of Physiological and Pathological Urea Concentrations on Human Microvascular Endothelial Cells

    Graziano Colombo / Alessandra Altomare / Emanuela Astori / Lucia Landoni / Maria Lisa Garavaglia / Ranieri Rossi / Daniela Giustarini / Maria Chiara Lionetti / Nicoletta Gagliano / Aldo Milzani / Isabella Dalle-Donne

    International Journal of Molecular Sciences, Vol 24, Iss 1, p

    2022  Band 691

    Abstract: Urea is the uremic toxin accumulating with the highest concentration in the plasma of chronic kidney disease (CKD) patients, not being completely cleared by dialysis. Urea accumulation is reported to exert direct and indirect side effects on the ... ...

    Abstract Urea is the uremic toxin accumulating with the highest concentration in the plasma of chronic kidney disease (CKD) patients, not being completely cleared by dialysis. Urea accumulation is reported to exert direct and indirect side effects on the gastrointestinal tract, kidneys, adipocytes, and cardiovascular system (CVS), although its pathogenicity is still questioned since studies evaluating its side effects lack homogeneity. Here, we investigated the effects of physiological and pathological urea concentrations on a human endothelial cell line from the microcirculation (Human Microvascular Endothelial Cells-1, HMEC-1). Urea (5 g/L) caused a reduction in the proliferation rate after 72 h of exposure and appeared to be a potential endothelial-to-mesenchymal transition (EndMT) stimulus. Moreover, urea induced actin filament rearrangement, a significant increase in matrix metalloproteinases 2 (MMP-2) expression in the medium, and a significant up- or down-regulation of other EndMT biomarkers (keratin, fibrillin-2, and collagen IV), as highlighted by differential proteomic analysis. Among proteins whose expression was found to be significantly dysregulated following exposure of HMEC-1 to urea, dimethylarginine dimethylaminohydrolase (DDAH) and vasorin turned out to be down-regulated. Both proteins have been directly linked to cardiovascular diseases (CVD) by in vitro and in vivo studies. Future experiments will be needed to deepen their role and investigate the signaling pathways in which they are involved to clarify the possible link between CKD and CVD.
    Schlagwörter urea ; HMEC-1 ; CVD ; CKD ; vasorin ; differential proteomics ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 570 ; 610
    Sprache Englisch
    Erscheinungsdatum 2022-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Zum Seitenanfang