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  1. Article ; Online: Deep viral metagenomics in patients with haemophilia receiving plasma-derived coagulation factor concentrates.

    Valença, Ian Nunes / Bezerra, Rafael Dos Santos / de Oliveira, Luciana Correa Oliveira / Covas, Dimas Tadeu / Kashima, Simone / Slavov, Svetoslav Nanev

    Haemophilia : the official journal of the World Federation of Hemophilia

    2021  Volume 27, Issue 5, Page(s) e645–e648

    MeSH term(s) Blood Coagulation Factors/therapeutic use ; Factor VIII ; Hemophilia A/drug therapy ; Hemophilia B/genetics ; Humans ; Metagenomics ; Plasma
    Chemical Substances Blood Coagulation Factors ; Factor VIII (9001-27-8)
    Language English
    Publishing date 2021-07-27
    Publishing country England
    Document type Letter
    ZDB-ID 1229713-6
    ISSN 1365-2516 ; 1351-8216 ; 1355-0691
    ISSN (online) 1365-2516
    ISSN 1351-8216 ; 1355-0691
    DOI 10.1111/hae.14382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: High-Dose Convalescent Plasma for Treatment of Severe COVID-19

    Gil C. De Santis / Luciana Correa Oliveira / Pedro M.M. Garibaldi / Carlos E.L. Almado / Julio Croda / Ghislaine G.A. Arcanjo / Érika A.F. Oliveira / Adriana C. Tonacio / Dante M. Langhi / José O. Bordin / Renato N. Gilio / Leonardo C. Palma / Elaine V. Santos / Simone K. Haddad / Benedito P.A. Prado / Marjorie Cornejo Pontelli / Rogério Gomes / Carlos H. Miranda / Maria Auxiliadora Martins /
    Dimas T. Covas / Eurico Arruda / Benedito A.L. Fonseca / Rodrigo T. Calado

    Emerging Infectious Diseases, Vol 28, Iss 3, Pp 548-

    2022  Volume 555

    Abstract: To assess whether high-dose coronavirus disease (COVID-19) convalescent plasma (CCP) transfusion may benefit patients with severe COVID-19, we conducted a multicenter randomized trial in Brazil. Patients with severe COVID-19 who were within 10 days of ... ...

    Abstract To assess whether high-dose coronavirus disease (COVID-19) convalescent plasma (CCP) transfusion may benefit patients with severe COVID-19, we conducted a multicenter randomized trial in Brazil. Patients with severe COVID-19 who were within 10 days of initial symptom onset were eligible. Patients in the CCP group received 3 daily doses of CCP (600 mL/d) in addition to standard treatment; control patients received standard treatment only. Primary outcomes were death rates at days 30 and 60 of study randomization. Secondary outcomes were ventilator-free days and hospital-free days. We enrolled 107 patients: 36 CCP and 71 control. At day 30, death rates were 22% for CCP and 25% for the control group; at day 60, rates were 31% for CCP and 35% for control. Needs for invasive mechanical ventilation and durations of hospital stay were similar between groups. We conclude that high-dose CCP transfused within 10 days of symptom onset provided no benefit for patients with severe COVID-19.
    Keywords COVID-19 ; 2019 novel coronavirus disease ; coronavirus disease ; severe acute respiratory syndrome coronavirus 2 ; SARS-CoV-2 ; viruses ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Pathologic rupture of the spleen in a patient with acute myelogenous leukemia and leukostasis

    Gil Cunha De Santis / Luciana Correa Oliveira / Aline Fernanda Ramos / Nataly Dantas Fortes da Silva / Roberto Passetto Falcão

    Revista Brasileira de Hematologia e Hemoterapia, Vol 36, Iss 4, Pp 290-

    2014  Volume 292

    Abstract: Rupture of the spleen can be classified as spontaneous, traumatic, or pathologic. Pathologic rupture has been reported in infectious diseases such as infectious mononucleosis, and hematologic malignancies such as acute and chronic leukemias. Splenomegaly ...

    Abstract Rupture of the spleen can be classified as spontaneous, traumatic, or pathologic. Pathologic rupture has been reported in infectious diseases such as infectious mononucleosis, and hematologic malignancies such as acute and chronic leukemias. Splenomegaly is considered the most relevant factor that predisposes to splenic rupture. A 66-year-old man with acute myeloid leukemia evolved from an unclassified myeloproliferative neoplasm, complaining of fatigue and mild upper left abdominal pain. He was pale and presented fever and tachypnea. Laboratory analyses showed hemoglobin 8.3 g/dL, white blood cell count 278 × 109/L, platelet count 367 × 109/L, activated partial thromboplastin time (aPTT) ratio 2.10, and international normalized ratio (INR) 1.60. A blood smear showed 62% of myeloblasts. The immunophenotype of the blasts was positive for CD117, HLA-DR, CD13, CD56, CD64, CD11c and CD14. Lactate dehydrogenase was 2384 U/L and creatinine 2.4 mg/dL (normal range: 0.7-1.6 mg/dL). Two sessions of leukapheresis were performed. At the end of the second session, the patient presented hemodynamic instability that culminated in circulatory shock and death. The post-mortem examination revealed infiltration of the vessels of the lungs, heart, and liver, and massive infiltration of the spleen by leukemic blasts. Blood volume in the peritoneal cavity was 500 mL. Acute leukemia is a rare cause of splenic rupture. Male gender, old age and splenomegaly are factors associated with this condition. As the patient had leukostasis, we hypothesize that this, associated with other factors such as lung and heart leukemic infiltration, had a role in inducing splenic rupture. Finally, we do not believe that leukapheresis in itself contributed to splenic rupture, as it is essentially atraumatic.
    Keywords Splenomegaly ; Leukemia ; Myeloid ; Acute ; Leukostasis ; Internal medicine ; RC31-1245 ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2014-07-01T00:00:00Z
    Publisher Sociedade Brasileira de Hematologia e Hemoterapia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Hormônios femininos e hemostasia Female hormones and hemostasis

    Carolina Sales Vieira / Luciana Correa Oliveira de Oliveira / Marcos Felipe Silva de Sá

    Revista Brasileira de Ginecologia e Obstetrícia, Vol 29, Iss 10, Pp 538-

    2007  Volume 547

    Abstract: Os hormônios femininos exógenos utilizados para contracepção ou para terapia hormonal (TH) no climatério estão associados a aumento de risco para tromboembolismo venoso (TEV), principalmente por provocarem alterações pró-coagulantes na hemostasia. Este ... ...

    Abstract Os hormônios femininos exógenos utilizados para contracepção ou para terapia hormonal (TH) no climatério estão associados a aumento de risco para tromboembolismo venoso (TEV), principalmente por provocarem alterações pró-coagulantes na hemostasia. Este risco não é cumulativo e parece ser maior no primeiro ano de uso. A dose de estrogênio, o tipo de estrogênio e progestagênio utilizados, a via de administração hormonal e os fatores de risco hereditários para trombose venosa de cada paciente interferem no risco final para trombose venosa. O conhecimento dos efeitos na hemostasia inerentes a cada composto hormonal é essencial para uma prescrição adequada. Exogenous female hormones used for contraception or postmenopausal hormonal replacement therapy are associated with an increase of venous thromboembolism (VTE) risk, mainly because they cause a hypercoagulable state. The risk is highest during the first year of use and it is not cumulative. The dose of estrogen, the type of estrogen and progestogen, the route of administration of female sex steroid hormones, and the hereditary risk factors for VTE of each patient can interfere on the final risk for VTE. The knowledge of their effect on hemostasis is essential for a correct prescription.
    Keywords Tromboembolismo ; Hemostasia ; Contraceptivos orais ; Terapia de reposição hormonal ; Thromboembolism ; Hemostasis ; Contraceptives ; oral ; Hormone replacement therapy ; Gynecology and obstetrics ; RG1-991 ; Medicine ; R ; DOAJ:Gynecology and Obstetrics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language Portuguese
    Publishing date 2007-10-01T00:00:00Z
    Publisher Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Therapeutic leukapheresis in patients with leukostasis secondary to acute myelogenous leukemia.

    De Santis, Gil Cunha / de Oliveira, Luciana Correa Oliveira / Romano, Lucas Gabriel Maltoni / Almeida Prado, Benedito de Pina / Simoes, Belinda Pinto / Rego, Eduardo Magalhaes / Covas, Dimas Tadeu / Falcao, Roberto Passetto

    Journal of clinical apheresis

    2011  Volume 26, Issue 4, Page(s) 181–185

    Abstract: Leukostasis is a relatively uncommon but potentially catastrophic complication of acute myelogenous leukemia (AML). Prompt leukoreduction is considered imperative to reduce the high mortality rate in this condition. Leukapheresis, usually associated with ...

    Abstract Leukostasis is a relatively uncommon but potentially catastrophic complication of acute myelogenous leukemia (AML). Prompt leukoreduction is considered imperative to reduce the high mortality rate in this condition. Leukapheresis, usually associated with chemotherapy, is an established approach to diminish blast cell counts. We report a single center experience in managing leukostasis with leukapheresis. Fifteen patients with leukostasis of 187 patients with AML (8.02%) followed at our institution were treated with leukapheresis associated with chemotherapy. The procedures were scheduled to be performed on a daily basis until clinical improvement was achieved and WBC counts were significantly reduced. Overall and early mortalities, defined as that occurred in the first 7 days from diagnosis, were reported. A high proportion of our patients with leukostasis (46.66%) had a monocytic subtype AML (M4/M5, according to French-American-British classification). The median overall survival was 10 days, despite a significant WBC reduction after the first apheresis procedure (from 200.7 × 10⁹/L to 150.3 × 10⁹/L). Almost half of patients (7/15) had an early death. Therapeutic leukapheresis, associated or not to chemotherapy, is an effective approach to reduce WBC counts in patients with AML and leukostasis; however, this therapeutic procedure does not appear to change significantly the sombre prognosis observed in the majority of patients with this complication. Other forms of treatment must be found to reduce the high mortality rate related to leukostasis.
    MeSH term(s) Adult ; Aged ; Female ; Humans ; Leukapheresis ; Leukemia, Myeloid, Acute/blood ; Leukemia, Myeloid, Acute/complications ; Leukocyte Count ; Leukostasis/blood ; Leukostasis/etiology ; Leukostasis/mortality ; Leukostasis/therapy ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Treatment Failure ; Young Adult
    Language English
    Publishing date 2011
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604912-6
    ISSN 1098-1101 ; 0733-2459
    ISSN (online) 1098-1101
    ISSN 0733-2459
    DOI 10.1002/jca.20290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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