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  1. Article: Locally Advanced Glomus Tumor of the Stomach With Synchronous Liver Metastases: Case Report and Literature Review.

    Frosio, Fabio / Petruzziello, Carmine / Poiasina, Elia / Pisano, Michele / Lucianetti, Alessandro

    Cureus

    2023  Volume 15, Issue 12, Page(s) e51041

    Abstract: Gastric glomus tumors (GGTs) are usually rare mesenchymal neoplasms. They are typically benign, with very few metastatic cases reported and no specific guidelines on their management. Here, we present a patient with a locally advanced GGT with ... ...

    Abstract Gastric glomus tumors (GGTs) are usually rare mesenchymal neoplasms. They are typically benign, with very few metastatic cases reported and no specific guidelines on their management. Here, we present a patient with a locally advanced GGT with synchronous liver metastases. One month after resection of the GGT, emergency laparotomy was required for massive hemoperitoneum due to bleeding from the largest metastasis. Indeed, a dramatic progression of liver metastases was observed in just one month. A wide local excision is considered the treatment of choice for GGTs. In particular, this case report suggests that the resection of any liver metastases should possibly be performed at the same time as the GGT excision and not at a later stage.
    Language English
    Publishing date 2023-12-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.51041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Delayed-release oral mesalamine tablet mimicking a small jejunal gastrointestinal stromal tumor: A case report.

    Frosio, Fabio / Rausa, Emanuele / Marra, Paolo / Boutron-Ruault, Marie-Christine / Lucianetti, Alessandro

    World journal of clinical cases

    2022  Volume 10, Issue 19, Page(s) 6710–6715

    Abstract: Background: Enteric-coated medications are supposed to pass intact through the gastric environment and to release the drug content into the small intestine or the colon. Before dissolution of the enteric coating, they may appear hyperdense on computed ... ...

    Abstract Background: Enteric-coated medications are supposed to pass intact through the gastric environment and to release the drug content into the small intestine or the colon. Before dissolution of the enteric coating, they may appear hyperdense on computed tomography (CT). Unfortunately, few reports have been published on this topic so far. In this case report, the hyperdense appearance on contrast-enhanced CT of an enteric-coated mesalamine tablet was initially misinterpreted as a jejunal gastrointestinal stromal tumor (GIST).
    Case summary: An asymptomatic 81-year-old male patient, who had undergone laparoscopic right nephrectomy four years earlier for stage 1 renal carcinoma, was diagnosed with a jejunal GIST at the 4-year follow-up thoraco-abdominal CT scan. He was referred to our hub hospital for gastroenterological evaluation, and subsequently underwent 18-fluorodeoxyglucose positron emission tomography, abdominal magnetic resonance imaging, and video capsule endoscopy. None of these examinations detected any lesion of the small intestine. After reviewing all the CT images in a multidisciplinary setting, the panel estimated that the hyperdense jejunal image was consistent with a tablet rather than a GIST. The tablet was an 800 mg delayed-release enteric-coated oral mesalamine tablet (Asacol
    Conclusion: Delayed-release oral mesalamine (Asacol
    Language English
    Publishing date 2022-07-28
    Publishing country United States
    Document type Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v10.i19.6710
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Living Donor Lung Transplantation After Hematopoietic Stem Cell Transplantation From the Same Donor: A Risk Worth Taking.

    Camagni, Stefania / D'Antiga, Lorenzo / Di Marco, Fabiano / Grazioli, Lorenzo / Bonanomi, Ezio / Pinelli, Domenico / Beretta, Marta / Tintori, Veronica / Lucianetti, Alessandro / Colledan, Michele

    Chest

    2024  Volume 165, Issue 4, Page(s) e91–e93

    Abstract: Living donor (LD) lung transplantation (LT) represents an exceptional procedure in Western countries. However, in selected situations, it could be a source of unique advantages, besides addressing organ shortage. We report a successful case of father-to- ... ...

    Abstract Living donor (LD) lung transplantation (LT) represents an exceptional procedure in Western countries. However, in selected situations, it could be a source of unique advantages, besides addressing organ shortage. We report a successful case of father-to-child single-lobe LT, because of the complications of hematopoietic stem cell transplantation from the same donor, with initial low-dose immunosuppressive therapy and subsequent early discontinuation. Full donor chimerism was hypothesized to be a mechanism of transplant tolerance, and this postulated immunological benefit was deemed to outweigh the risks of living donation and the possible drawbacks of single compared with bilateral LT. Favorable size matching and donor's anatomy, accurate surgical planning, and specific expertise in pediatric transplantation also contributed to the optimal recipient and donor outcomes. Ten months after LD LT, the patient's steadily good lung function after withdrawal of immunosuppressive therapy seems to confirm the original hypothesis.
    MeSH term(s) Humans ; Child ; Living Donors ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Immunosuppression Therapy ; Lung Transplantation
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.12.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Endoluminal vacuum-assisted closure (E-Vac) therapy for postoperative esophageal fistula: successful case series and literature review.

    Rubicondo, Carolina / Lovece, Andrea / Pinelli, Domenico / Indriolo, Amedeo / Lucianetti, Alessandro / Colledan, Michele

    World journal of surgical oncology

    2020  Volume 18, Issue 1, Page(s) 301

    Abstract: Background: Treatment of esophageal perforations and postoperative anastomotic leaks of the upper gastrointestinal tract remains a challenge. Endoluminal vacuum-assisted closure (E-Vac) therapy has positively contributed, in recent years, to the ... ...

    Abstract Background: Treatment of esophageal perforations and postoperative anastomotic leaks of the upper gastrointestinal tract remains a challenge. Endoluminal vacuum-assisted closure (E-Vac) therapy has positively contributed, in recent years, to the management of upper gastrointestinal tract perforations by using the same principle of vacuum-assisted closure therapy of external wounds. The aim is to provide continuous wound drainage and to promote tissue granulation, decreasing the needed time to heal with a high rate of leakage closure.
    Cases presentation: A series of two different cases with clinical and radiological diagnosis of esophageal fistulas, recorded from 2018 to 2019 period at our institution, is presented. The first one is a case of anastomotic leak after esophagectomy for cancer complicated by pleuro-mediastinal abscess, while the second one is a leak of an esophageal suture, few days after resection of a bronchogenic cyst perforated into the esophageal lumen. Both cases were successfully treated with E-Vac therapy.
    Conclusion: Our experience shows the usefulness of E-Vac therapy in the management of anastomotic and non-anastomotic esophageal fistulas. Further research is needed to better define its indications, to compare it to traditional treatments and to evaluate its long-term efficacy.
    MeSH term(s) Anastomotic Leak/etiology ; Anastomotic Leak/surgery ; Esophageal Fistula/etiology ; Esophageal Fistula/surgery ; Humans ; Negative-Pressure Wound Therapy ; Prognosis
    Language English
    Publishing date 2020-11-14
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2118383-1
    ISSN 1477-7819 ; 1477-7819
    ISSN (online) 1477-7819
    ISSN 1477-7819
    DOI 10.1186/s12957-020-02073-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Laparoscopic Witzel jejunostomy.

    Lotti, Marco / Capponi, Michela Giulii / Ferrari, Denise / Carrara, Giulia / Campanati, Luca / Lucianetti, Alessandro

    Journal of minimal access surgery

    2020  Volume 17, Issue 1, Page(s) 127–130

    Abstract: The placement of a feeding jejunostomy can be indicated in malnourished patients with gastric and oesophagogastric junction cancer to allow for enteral nutritional support. In these patients, the jejunostomy tube can be suitably placed at the time of ... ...

    Abstract The placement of a feeding jejunostomy can be indicated in malnourished patients with gastric and oesophagogastric junction cancer to allow for enteral nutritional support. In these patients, the jejunostomy tube can be suitably placed at the time of staging laparoscopy. Several techniques of laparoscopic jejunostomy (LJ) have been described, yet the Witzel approach remains neglected, due to the perceived difficulty of suturing the bowel around the tube and securing them to the abdominal wall. Here, we describe a novel technique for LJ, using a single barbed suture for securing the bowel and tunnelling the jejunostomy catheter according to the Witzel approach.
    Language English
    Publishing date 2020-12-22
    Publishing country India
    Document type Journal Article
    ZDB-ID 2186884-0
    ISSN 1998-3921 ; 0972-9941
    ISSN (online) 1998-3921
    ISSN 0972-9941
    DOI 10.4103/jmas.JMAS_248_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Beware of the acute bowel disease in COVID-19 patients.

    Lotti, Marco / Giulii Capponi, Michela / Magnone, Stefano / Campanati, Luca / Lucianetti, Alessandro

    ANZ journal of surgery

    2020  Volume 90, Issue 12, Page(s) 2586–2588

    MeSH term(s) Acute Disease ; Aged, 80 and over ; COVID-19/epidemiology ; Cecal Diseases/diagnosis ; Cecal Diseases/epidemiology ; Cecum/diagnostic imaging ; Colonoscopy/methods ; Comorbidity ; Humans ; Male ; SARS-CoV-2 ; Tomography, X-Ray Computed/methods
    Keywords covid19
    Language English
    Publishing date 2020-10-08
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.16384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Impact of COVID-19 on attendances to a major emergency department: an Italian perspective.

    Rausa, Emanuele / Kelly, Michael E / Manfredi, Roberto / Riva, Ivano / Lucianetti, Alessandro

    Internal medicine journal

    2020  Volume 50, Issue 9, Page(s) 1159–1160

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Emergency Service, Hospital/statistics & numerical data ; Humans ; Italy/epidemiology ; Pandemics ; Patient Admission/statistics & numerical data ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-15
    Publishing country Australia
    Document type Letter
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/imj.14972
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Unsuspected clinical presentation of coronavirus disease 2019: acute bowel disease.

    Lotti, Marco / Giulii Capponi, Michela / Dokic, Dusanka / Bertoli, Paolo / Lucianetti, Alessandro

    ANZ journal of surgery

    2020  Volume 90, Issue 9, Page(s) 1772–1774

    MeSH term(s) Acute Disease ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Endoscopy, Digestive System/methods ; Humans ; Intestinal Diseases/diagnosis ; Intestinal Diseases/etiology ; Intestine, Small/diagnostic imaging ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Tomography, X-Ray Computed
    Keywords covid19
    Language English
    Publishing date 2020-08-08
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.16213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Outpatient Non-operative Management of Uncomplicated Acute Appendicitis: A Non-inferiority Study.

    Ceresoli, Marco / Fumagalli, Chiara / Fugazzola, Paola / Zanini, Nicola / Magnone, Stefano / Ravasi, Michela / Bonalumi, Jacopo / Morezzi, Daniele / Bova, Raffaele / Sargenti, Benedetta / Schiavone, Luca / Lucianetti, Alessandro / Catena, Fausto / Ansaloni, Luca / Braga, Marco

    World journal of surgery

    2023  Volume 47, Issue 10, Page(s) 2378–2385

    Abstract: Introduction: Non-operative management (NOM) of uncomplicated acute appendicitis is a well-established alternative to upfront surgery. The administration of intravenous broad-spectrum antibiotics is usually performed in hospital, and only one study ... ...

    Abstract Introduction: Non-operative management (NOM) of uncomplicated acute appendicitis is a well-established alternative to upfront surgery. The administration of intravenous broad-spectrum antibiotics is usually performed in hospital, and only one study described outpatient NOM. The aim of this multicentre retrospective non-inferiority study was to evaluate both safety and non-inferiority of outpatient compared to inpatient NOM in uncomplicated acute appendicitis.
    Methods: The study included 668 consecutive patients with uncomplicated acute appendicitis. Patients were treated according to the surgeon's preference: 364 upfront appendectomy, 157 inpatient NOM (inNOM), and 147 outpatient NOM (outNOM). The primary endpoint was the 30-day appendectomy rate, with a non-inferiority limit of 5%. Secondary endpoints were negative appendectomy rate, 30-day unplanned emergency department (ED) visits, and length of stay.
    Results: 30-day appendectomies were 16 (10.9%) in the outNOM group and 23 (14.6%) in the inNOM group (p = 0.327). OutNOM was non-inferior to inNOM with a risk difference of-3.80% 97.5% CI (- 12.57; 4.97). No difference was found between inNOM and outNOM groups for the number of complicated appendicitis (3 vs. 5) and negative appendectomy (1 vs. 0). Twenty-six (17.7%) outNOM patients required an unplanned ED visit after a median of 1 (1-4) days. In the outNOM group, the mean cumulative in-hospital stay was 0.89 (1.94) days compared with 3.94 (2.17) days in the inNOM group (p < 0.001).
    Conclusions: Outpatient NOM was non-inferior to inpatient NOM with regard to the 30-day appendectomy rate, while a shorter hospital stay was found in the outNOM group. Further, studies are required to confirm these findings.
    MeSH term(s) Humans ; Appendicitis/surgery ; Appendicitis/drug therapy ; Outpatients ; Retrospective Studies ; Treatment Outcome ; Anti-Bacterial Agents/therapeutic use ; Acute Disease
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-05-20
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-023-07065-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Hyperthermic intraperitoneal chemotherapy (HIPEC) as adjuvant and therapeutic options for patients with advanced gastric cancer at high risk of recurrence or established peritoneal metastases: a single-centre experience.

    Allievi, Niccolò / Bianco, Federica / Pisano, Michele / Montori, Giulia / Fugazzola, Paola / Coccolini, Federico / Lotti, Marco / Mosconi, Stefania / Merelli, Barbara / Campanati, Luca / Lucianetti, Alessandro / Ansaloni, Luca / Magnone, Stefano

    Updates in surgery

    2022  

    Abstract: Peritoneal metastases from gastric cancer (PM-GC) have a detrimental prognostic impact on survival and there is a lack of consensus regarding treatment. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) may offer a chance ... ...

    Abstract Peritoneal metastases from gastric cancer (PM-GC) have a detrimental prognostic impact on survival and there is a lack of consensus regarding treatment. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) may offer a chance for prolonged survival as compared to standard chemotherapy. This study aims to present our experience in the management of GC with CRS and HIPEC. This is a single-centre retrospective study. Patients were divided into two groups: patients with GC at high risk for developing PM-GC (adjuvant HIPEC group) and patients with PM-GC or positive peritoneal cytology (therapeutic CRS and HIPEC group). Overall survival (OS) and disease-free survival (DFS) were considered as outcome measures. A total of 41 patients with a GC primary received surgery and HIPEC: 14 patients (34.1%) were in the adjuvant HIPEC group, while 27 patients (65.9%) were in the therapeutic CRS and HIPEC group. In the adjuvant HIPEC group, the 1- and 3-year OS were 85.7% and 71.4%, while 1- and 3-year DFS were 71.4% and 64.3%, respectively. In the therapeutic CRS and HIPEC group, OS was 60.3% and 35.1% at 1 and 3 years, whereas 1- and 3-year DFS were 38% and 32.6%, respectively. Univariate survival analysis of patients in the therapeutic CRS and HIPEC group showed that the presence of lymph node metastasis and signet ring cell histology predicted worse OS, while PCI > 12 and lymph node metastasis were associated with decreased DFS. Treatment of highly selected patients with GC at high risk of peritoneal recurrence or established PM with CRS and HIPEC showed satisfactory results in terms of OS and DFS.
    Language English
    Publishing date 2022-11-12
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-022-01399-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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