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  1. AU="Luck, Jennifer N"
  2. AU="Min Soo Kim"
  3. AU="Piotr Dylewicz"
  4. AU="Mankel, A"
  5. AU="Lia, Andrea"
  6. AU=Wang Yong
  7. AU="Mckay, Victoria"
  8. AU="Yanqun Liu"
  9. AU="Doyon, Yannick"
  10. AU=Ho-Yen Colan M
  11. AU="Tarnawski, Miroslaw"
  12. AU="Mark Pickering"
  13. AU=Felson Marcus
  14. AU="Antje Garten"
  15. AU="Pijpers, Judith"
  16. AU=Ciacchini Benedetta AU=Ciacchini Benedetta

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  1. Artikel ; Online: Sugar-Coated Killer: Serotype 3 Pneumococcal Disease.

    Luck, Jennifer N / Tettelin, Hervé / Orihuela, Carlos J

    Frontiers in cellular and infection microbiology

    2020  Band 10, Seite(n) 613287

    Abstract: Capsular polysaccharide (CPS), which surrounds the bacteria, is one of the most significant and multifaceted contributors ... ...

    Abstract Capsular polysaccharide (CPS), which surrounds the bacteria, is one of the most significant and multifaceted contributors to
    Mesh-Begriff(e) Humans ; Pneumococcal Infections/prevention & control ; Pneumococcal Vaccines ; Serogroup ; Streptococcus pneumoniae ; Sugars
    Chemische Substanzen Pneumococcal Vaccines ; Sugars
    Sprache Englisch
    Erscheinungsdatum 2020-12-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2020.613287
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Anatomical Site-Specific Carbohydrate Availability Impacts Streptococcus pneumoniae Virulence and Fitness during Colonization and Disease.

    Im, Hansol / Kruckow, Katherine L / D'Mello, Adonis / Ganaie, Feroze / Martinez, Eriel / Luck, Jennifer N / Cichos, Kyle H / Riegler, Ashleigh N / Song, Xiuhong / Ghanem, Elie / Saad, Jamil S / Nahm, Moon H / Tettelin, Hervé / Orihuela, Carlos J

    Infection and immunity

    2021  Band 90, Heft 1, Seite(n) e0045121

    Abstract: Streptococcus pneumoniae colonizes the nasopharynx asymptomatically but can also cause severe life-threatening disease. Importantly, stark differences in carbohydrate availability exist between the nasopharynx and invasive disease sites, such as the ... ...

    Abstract Streptococcus pneumoniae colonizes the nasopharynx asymptomatically but can also cause severe life-threatening disease. Importantly, stark differences in carbohydrate availability exist between the nasopharynx and invasive disease sites, such as the bloodstream, which most likely impact S. pneumoniae's behavior. Herein, using chemically defined medium (CDM) supplemented with physiological levels of carbohydrates, we examined how anatomical site-specific carbohydrate availability impacted S. pneumoniae physiology and virulence. S. pneumoniae cells grown in CDM modeling the nasopharynx (CDM-N) had reduced metabolic activity and a lower growth rate, demonstrated mixed acid fermentation with marked H
    Mesh-Begriff(e) Adaptation, Physiological ; Animals ; Bacterial Adhesion ; Carbohydrate Metabolism ; Female ; Male ; Mice ; Organ Specificity ; Pneumococcal Infections/microbiology ; Streptococcus pneumoniae/physiology ; Virulence ; Virulence Factors
    Chemische Substanzen Virulence Factors
    Sprache Englisch
    Erscheinungsdatum 2021-11-08
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/IAI.00451-21
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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