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  1. Article ; Online: Aortic Valve Repair of a Stenotic Unicuspid Aortic Valve in Young Patients.

    Kolesar, Adrian / Toporcer, Tomas / Bajmoczi, Milan / Luczy, Jan / Candik, Peter / Sabol, Frantisek

    The Annals of thoracic surgery

    2018  Volume 105, Issue 5, Page(s) 1351–1356

    Abstract: Background: The unicuspid aortic valve (UAV) is a well-described pediatric congenital abnormality, with incidence of 0.02% in the general population. Bicuspidization has been described as a potential surgical option to repair this defect.: Methods: ... ...

    Abstract Background: The unicuspid aortic valve (UAV) is a well-described pediatric congenital abnormality, with incidence of 0.02% in the general population. Bicuspidization has been described as a potential surgical option to repair this defect.
    Methods: Seventeen symptomatic young patients with a unicuspid valve combined with either valve insufficiency or valve stenosis underwent aortic valve (AV) bicuspidization procedure by using an equine pericardium. In addition to bicuspidization, 8 patients underwent aortic ring implantation and 5 patients underwent supracoronary replacement of the aorta.
    Results: Our results show safety of the bicuspidization procedure. No deaths occurred during our average follow-up period of 26 months. Freedom from reoperation for any valve-related reason was 100% during this follow-up period. We observed a statistically significant increase in the AV area from 0.8 ± 0.1 cm
    Conclusions: From our study, bicuspidization is an attractive surgical option to repair UAV, particularly in young patients who do not want to be subjected to long-term anticoagulation therapy or who refuse a more traditional surgical approach, such as Ross procedure, for reasons described previously.
    MeSH term(s) Adult ; Age Factors ; Animals ; Aortic Valve/surgery ; Aortic Valve Insufficiency/etiology ; Aortic Valve Insufficiency/surgery ; Aortic Valve Stenosis/etiology ; Aortic Valve Stenosis/surgery ; Bicuspid Aortic Valve Disease ; Bioprosthesis ; Cohort Studies ; Female ; Heart Defects, Congenital/complications ; Heart Defects, Congenital/surgery ; Heart Valve Diseases/complications ; Heart Valve Diseases/surgery ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation ; Horses ; Humans ; Male ; Pericardium ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2018-01-31
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2017.12.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 252: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Should open excisions and sutured incisions be treated differently? A review and meta-analysis of animal wound models following low-level laser therapy.

    Gál, Peter / Stausholm, Martin Bjørn / Kováč, Ivan / Dosedla, Erik / Luczy, Ján / Sabol, František / Bjordal, Jan Magnus

    Lasers in medical science

    2018  Volume 33, Issue 6, Page(s) 1351–1362

    Abstract: Although low-level laser therapy (LLLT) was discovered already in the 1960s of the twentieth century, it took almost 40 years to be widely used in clinical dermatology/surgery. It has been demonstrated that LLLT is able to increase collagen production/ ... ...

    Abstract Although low-level laser therapy (LLLT) was discovered already in the 1960s of the twentieth century, it took almost 40 years to be widely used in clinical dermatology/surgery. It has been demonstrated that LLLT is able to increase collagen production/wound stiffness and/or improve wound contraction. In this review, we investigated whether open and sutured wounds should be treated with different LLLT parameters. A PubMed search was performed to identify controlled studies with LLLT applied to wounded animals (sutured incisions-tensile strength measurement and open excisions-area measurement). Final score random effects meta-analyses were conducted. Nineteen studies were included. The overall result of the tensile strength analysis (eight studies) was significantly in favor of LLLT (SMD = 1.06, 95% CI 0.66-1.46), and better results were seen with 30-79 mW/cm
    MeSH term(s) Animals ; Diabetes Mellitus/pathology ; Disease Models, Animal ; Low-Level Light Therapy/methods ; Surgical Wound/therapy ; Sutures ; Tensile Strength ; Wound Healing ; Wounds and Injuries/radiotherapy
    Language English
    Publishing date 2018-03-30
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 632808-8
    ISSN 1435-604X ; 0268-8921
    ISSN (online) 1435-604X
    ISSN 0268-8921
    DOI 10.1007/s10103-018-2496-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2148: Show issues Location:
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  3. Article ; Online: Human galectin‑3: Molecular switch of gene expression in dermal fibroblasts in vitro and of skin collagen organization in open wounds and tensile strength in incisions

    Gál, Peter / Vasilenko, Tomáš / Kováč, Ivan / Čoma, Matúš / Jakubčo, Ján / Jakubčová, Martina / Peržeľová, Vlasta / Urban, Lukáš / Kolář, Michal / Sabol, František / Luczy, Ján / Novotný, Martin / Majerník, Jaroslav / Gabius, Hans-Joachim / Smetana, Karel Jr

    Molecular medicine reports

    2020  Volume 23, Issue 2

    Abstract: Understanding the molecular and cellular processes in skin wound healing can pave the way for devising innovative concepts by turning the identified natural effectors into therapeutic tools. Based on the concept of broad‑scale engagement of members of ... ...

    Abstract Understanding the molecular and cellular processes in skin wound healing can pave the way for devising innovative concepts by turning the identified natural effectors into therapeutic tools. Based on the concept of broad‑scale engagement of members of the family of galactoside‑binding lectins (galectins) in pathophysiological processes, such as cancer or tissue repair/regeneration, the present study investigated the potential of galectins‑1 (Gal‑1) and ‑3 (Gal‑3) in wound healing. Human dermal fibroblasts, which are key cells involved in skin wound healing, responded to galectin exposure (Gal‑1 at 300 or Gal‑3 at 600 ng/ml) with selective changes in gene expression among a panel of 84 wound‑healing‑related genes, as well as remodeling of the extracellular matrix. In the case of Gal‑3, positive expression of Ki67 and cell number increased when using a decellularized matrix produced by Gal‑3‑treated fibroblasts as substrate for culture of interfollicular keratinocytes.
    MeSH term(s) Blood Proteins/biosynthesis ; Collagen/biosynthesis ; Dermis/metabolism ; Dermis/pathology ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Galectins/biosynthesis ; Gene Expression Regulation ; Humans ; Tensile Strength ; Wounds and Injuries/metabolism ; Wounds and Injuries/pathology
    Chemical Substances Blood Proteins ; Galectins ; LGALS3 protein, human ; Collagen (9007-34-5)
    Language English
    Publishing date 2020-12-10
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2469505-1
    ISSN 1791-3004 ; 1791-2997
    ISSN (online) 1791-3004
    ISSN 1791-2997
    DOI 10.3892/mmr.2020.11738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: "V" aortoplasty of the proximal descending aorta in the elephant trunk procedure.

    Kolesar, Adrian / Bily, Boris / Spak, Lubomir / Luczy, Jan / Artemiou, Panagiotis / Sabol, Frantisek

    Journal of cardiothoracic surgery

    2015  Volume 10, Page(s) 13

    Abstract: Complex pathology of the aorta, especially in patients presenting an aneurysm involving the entire aortic arch and proximal descending aorta has been approached in one or two stages. Surgical management of those with an extremely wide diameter of the ... ...

    Abstract Complex pathology of the aorta, especially in patients presenting an aneurysm involving the entire aortic arch and proximal descending aorta has been approached in one or two stages. Surgical management of those with an extremely wide diameter of the proximal descending aorta is not yet well defined. The patient in this case was an asymptomatic 47-year-old female with systemic lupus erythematosus (SLE) associated with aneurysm of the ascending aorta, whose aortic arch and descending aorta had presented only overall weakness (examination by inspection and palpation without histological verification). The imaging identified a giant aorta arising at the level of the sinotubular junction (STJ), ending up immediately below the diaphragm. In the first stage she underwent surgical replacement of the entire ascending aorta, aortic arch and proximal part of the descending aorta by combining the elephant trunk with a new type of aortoplasty. In the second stage an endovascular stent graft was inserted into the elephant trunk in the descending aorta. The patient continues to do well 20 months following the repair. In this manuscript type we describe a novel technique of "V" aortoplasty of the proximal descending aorta in order to facilitate the performing of anastomosis between the Dacron graft and aortic aneurysm.
    MeSH term(s) Aorta/surgery ; Aorta, Thoracic/diagnostic imaging ; Aorta, Thoracic/surgery ; Aortic Aneurysm/diagnostic imaging ; Aortic Aneurysm/surgery ; Female ; Humans ; Middle Aged ; Stents ; Tomography, X-Ray Computed ; Vascular Surgical Procedures/methods
    Language English
    Publishing date 2015-01-31
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1749-8090
    ISSN (online) 1749-8090
    DOI 10.1186/s13019-015-0217-x
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  5. Article ; Online: Use of left ventricle assist device in a pregnant woman with acute aortic and coronary dissections.

    Kolesar, Adrian / Sabol, Frantisek / Luczy, Jan / Bajmoczi, Milan

    Interactive cardiovascular and thoracic surgery

    2010  Volume 11, Issue 2, Page(s) 194–195

    Abstract: We report the case of a 31-year-old female in her 32nd week of pregnancy, who experienced an acute type A aortic dissection resulting in severe aortic insufficiency, dissection of the left anterior descending coronary artery, and left ventricular infarct ...

    Abstract We report the case of a 31-year-old female in her 32nd week of pregnancy, who experienced an acute type A aortic dissection resulting in severe aortic insufficiency, dissection of the left anterior descending coronary artery, and left ventricular infarct with ejection fraction of 20%. After a successful cesarean section, she underwent a Bentall operation and three-vessel coronary artery bypass grafting. Despite maximal inotropic support, her cardiovascular indices deteriorated postoperatively. On the first postoperative day she was started on mechanical circulatory support with the Levitronix CentriMag left ventricular assist device. Her myocardial function improved and she was successfully weaned from this mechanical support on post-implant day 14. She remains alive and well to date.
    MeSH term(s) Acute Disease ; Aneurysm, Dissecting/physiopathology ; Aneurysm, Dissecting/surgery ; Aortic Aneurysm/physiopathology ; Aortic Aneurysm/surgery ; Blood Vessel Prosthesis Implantation/adverse effects ; Cesarean Section ; Coronary Aneurysm/physiopathology ; Coronary Aneurysm/surgery ; Coronary Artery Bypass/adverse effects ; Female ; Heart-Assist Devices ; Hemodynamics ; Humans ; Live Birth ; Myocardial Infarction/physiopathology ; Myocardial Infarction/surgery ; Pregnancy ; Pregnancy Complications, Cardiovascular/physiopathology ; Pregnancy Complications, Cardiovascular/surgery ; Pregnancy Trimester, Third ; Shock, Cardiogenic/etiology ; Shock, Cardiogenic/therapy ; Treatment Outcome
    Language English
    Publishing date 2010-08
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2095298-3
    ISSN 1569-9285 ; 1569-9293
    ISSN (online) 1569-9285
    ISSN 1569-9293
    DOI 10.1510/icvts.2010.238501
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5730: Show issues Location:
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  6. Article: The possible role of machine learning in detection of increased cardiovascular risk patients - KSC MR Study (design).

    Pella, Daniel / Toth, Stefan / Paralic, Jan / Gonsorcik, Jozef / Fedacko, Jan / Jarcuska, Peter / Pella, Dominik / Pella, Zuzana / Sabol, Frantisek / Jankajova, Monika / Valocik, Gabriel / Putrya, Alina / Kirschová, Andrea / Plachy, Lukas / Rabajdova, Miroslava / Hunavy, Mikulas / Kafkova, Bibiana / Doci, Ivan / Timkova, Silvia /
    Dvorožňáková, Mariana / Babic, Frantisek / Butka, Peter / Dimunova, Lucia / Marekova, Maria / Paralicova, Zuzana / Majernik, Jaroslav / Luczy, Jan / Janosik, Jakub / Kmec, Martin

    Archives of medical science : AMS

    2020  Volume 18, Issue 4, Page(s) 991–997

    Abstract: Introduction: Currently, just a few major parameters are used for cardiovascular (CV) risk quantification to identify many of the high-risk subjects; however, they leave a lot of them with an underestimated level of CV risk which does not reflect the ... ...

    Abstract Introduction: Currently, just a few major parameters are used for cardiovascular (CV) risk quantification to identify many of the high-risk subjects; however, they leave a lot of them with an underestimated level of CV risk which does not reflect the reality.
    Material and methods: The submitted study design of the Kosice Selective Coronarography Multiple Risk (KSC MR) Study will use computer analysis of coronary angiography results of admitted patients along with broad patients' characteristics based on questionnaires, physical findings, laboratory and many other examinations.
    Results: Obtained data will undergo machine learning protocols with the aim of developing algorithms which will include all available parameters and accurately calculate the probability of coronary artery disease.
    Conclusions: The KSC MR study results, if positive, could establisha base for development of proper software for revealing high-risk patients, as well as patients with suggested positive coronary angiography findings, based on the principles of personalised medicine.
    Language English
    Publishing date 2020-09-21
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2203781-0
    ISSN 1734-1922
    ISSN 1734-1922
    DOI 10.5114/aoms.2020.99156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Genistein Improves Skin Flap Viability in Rats: A Preliminary In Vivo and In Vitro Investigation.

    Fáber, Lenka / Kováč, Ivan / Mitrengová, Petra / Novotný, Martin / Varinská, Lenka / Vasilenko, Tomáš / Kello, Martin / Čoma, Matúš / Kuruc, Tomáš / Petrová, Klaudia / Miláčková, Ivana / Kuczmannová, Anika / Peržeľová, Vlasta / Mižáková, Štefánia / Dosedla, Erik / Sabol, František / Luczy, Ján / Nagy, Milan / Majerník, Jaroslav /
    Koščo, Martin / Mučaji, Pavel / Gál, Peter

    Molecules (Basel, Switzerland)

    2018  Volume 23, Issue 7

    Abstract: Selective estrogen receptor modulators (SERMs) have been developed to achieve beneficial effects of estrogens while minimizing their side effects. In this context, we decided to evaluate the protective effect of genistein, a natural SERM, on skin flap ... ...

    Abstract Selective estrogen receptor modulators (SERMs) have been developed to achieve beneficial effects of estrogens while minimizing their side effects. In this context, we decided to evaluate the protective effect of genistein, a natural SERM, on skin flap viability in rats and in a series of in vitro experiments on endothelial cells (migration, proliferation, antioxidant properties, and gene expression profiling following genistein treatment). Our results showed that administration of genistein increased skin flap viability, but importantly, the difference is only significant when treatment is started 3 days prior the flap surgery. Based on our in vitro experiments, it may be hypothesized that the underlying mechanism may rather by mediated by increasing SOD activity and Bcl-2 expression. The gene expression profiling further revealed 9 up-regulated genes (angiogenesis/inflammation promoting: CTGF, CXCL5, IL-6, ITGB3, MMP-14, and VEGF-A; angiogenesis inhibiting: COL18A1, TIMP-2, and TIMP-3). In conclusion, we observed a protective effect of genistein on skin flap viability which could be potentially applied in plastic surgery to women undergoing a reconstructive and/or plastic intervention. Nevertheless, further research is needed to explain the exact underlying mechanism and to find the optimal treatment protocol.
    MeSH term(s) Animals ; Cell Survival ; Endothelial Cells/cytology ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Gene Expression Profiling ; Gene Expression Regulation/drug effects ; Genistein/administration & dosage ; Genistein/pharmacology ; Human Umbilical Vein Endothelial Cells ; Humans ; Models, Animal ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats ; Superoxide Dismutase/metabolism ; Surgical Flaps/physiology ; Time Factors ; Up-Regulation
    Chemical Substances Proto-Oncogene Proteins c-bcl-2 ; Genistein (DH2M523P0H) ; Superoxide Dismutase (EC 1.15.1.1)
    Language English
    Publishing date 2018-07-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules23071637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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