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  1. Article ; Online: Myeloma research on the move.

    Ludwig, Heinz

    Blood cancer journal

    2021  Volume 11, Issue 9, Page(s) 155

    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Antineoplastic Agents/therapeutic use ; Disease Management ; Humans ; Immunotherapy, Adoptive ; Lenalidomide/therapeutic use ; Multiple Myeloma/diagnosis ; Multiple Myeloma/pathology ; Multiple Myeloma/therapy ; Stem Cell Transplantation
    Chemical Substances Antibodies, Monoclonal ; Antineoplastic Agents ; daratumumab (4Z63YK6E0E) ; Lenalidomide (F0P408N6V4)
    Language English
    Publishing date 2021-09-17
    Publishing country United States
    Document type Editorial
    ZDB-ID 2600560-8
    ISSN 2044-5385 ; 2044-5385
    ISSN (online) 2044-5385
    ISSN 2044-5385
    DOI 10.1038/s41408-021-00550-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Beyond hemoglobin and quality of life

    Ludwig, Heinz

    exploring the spectrum of clinical benefits with rHuEpo

    (The oncologist ; 9, Suppl. 5)

    2004  

    Author's details guest ed. Heinz Ludwig
    Series title The oncologist ; 9, Suppl. 5
    Collection
    Language English
    Size 76 S. : Ill., graph. Darst.
    Publisher AlphaMed Press
    Publishing place Miamisburg, Ohio
    Publishing country United States
    Document type Book
    HBZ-ID HT014351358
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 4845 -9,Suppl.5- not available for loan Zeitschriften-Lesesaal

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  3. Article ; Online: Daratumumab: a game changer in myeloma therapy.

    Ludwig, Heinz

    The Lancet. Haematology

    2020  Volume 7, Issue 6, Page(s) e426–e427

    MeSH term(s) Antibodies, Monoclonal ; Humans ; Lenalidomide ; Multiple Myeloma
    Chemical Substances Antibodies, Monoclonal ; daratumumab (4Z63YK6E0E) ; Lenalidomide (F0P408N6V4)
    Language English
    Publishing date 2020-05-26
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(20)30105-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Prevention of infections including vaccination strategies in multiple myeloma.

    Ludwig, Heinz / Kumar, Shaji

    American journal of hematology

    2022  Volume 98 Suppl 2, Page(s) S46–S62

    Abstract: Infections are a major cause of morbidity and mortality in multiple myeloma. The increased risk for bacterial and viral infections results mainly from the disease-inherent and treatment-induced immunosuppression. Additional risk factors are older age ... ...

    Abstract Infections are a major cause of morbidity and mortality in multiple myeloma. The increased risk for bacterial and viral infections results mainly from the disease-inherent and treatment-induced immunosuppression. Additional risk factors are older age with immune senescence, T cell depletion, polymorbidity, and male gender. Hence, every effort should be taken to reduce the risk for infections by identifying patients at higher risk for these complications and by implementing prophylactic measures, including chemoprophylaxis and immunization against various relevant pathogens. Here, we review the available evidence and provide recommendations for medical prophylaxis and vaccination in clinical practice.
    MeSH term(s) Humans ; Male ; Multiple Myeloma/therapy ; Multiple Myeloma/drug therapy ; Vaccination ; Virus Diseases/complications ; Immunization ; Risk Factors
    Language English
    Publishing date 2022-11-24
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26766
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1251: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Early treatment for high-risk smouldering myeloma: has the time come?

    Ludwig, Heinz

    The Lancet. Oncology

    2016  Volume 17, Issue 8, Page(s) 1030–1032

    Language English
    Publishing date 2016-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(16)30151-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5696: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 460: Show issues

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  6. Article ; Online: SLiM CRAB criteria revisited: temporal trends in prognosis of patients with smoldering multiple myeloma who meet the definition of 'biomarker-defined early multiple myeloma'-a systematic review with meta-analysis.

    Ludwig, Heinz / Kainz, Sarah / Schreder, Martin / Zojer, Niklas / Hinke, Axel

    EClinicalMedicine

    2023  Volume 58, Page(s) 101910

    Abstract: Background: Biomarker-defined patients with smoldering multiple myeloma (SMM) were included in the diagnostic category of multiple myeloma (MM) by the International Myeloma Working Group (IMWG) in 2014. This includes ≥60% bone marrow plasma cells (BMPCs) ...

    Abstract Background: Biomarker-defined patients with smoldering multiple myeloma (SMM) were included in the diagnostic category of multiple myeloma (MM) by the International Myeloma Working Group (IMWG) in 2014. This includes ≥60% bone marrow plasma cells (BMPCs), free light chain ratio (FLCratio) ≥100, and >1 MRI-defined ≥5 mm focal lesion, also called SLiM CRAB MM. We examined whether the risk of progression of SLiM CRAB MM patients to CRAB positive MM described in recent studies differs from that reported in earlier studies published before the introduction of the new diagnostic criteria.
    Methods: We conducted a systematic review with meta-analysis, and included studies on Embase and PubMed (01/01/2010-01/11/2022), selecting studies with digitizable progression curves. Inconsistent studies were excluded. We created forest plots using random effects models from digitized and published data and Kaplan-Meier curves. Main outcomes were median time to progression (TTP), 2-year progression risk, and odds ratios (ORs) comparing 2-year progression risks.
    Findings: Our meta-analysis including 11 studies with 3482 patients found an approximately 3-fold longer TTP and 50% lower 2-year progression risk of SliM CRAB MM patients in recent (published after 2014) compared with earlier studies. Median TTP in patients with ≥60% BMPCs was 30.31 months [18.71-62.93] in recent compared with 9.20 months [6.02-15.56] in earlier studies; the 2-year progression risk was 45.45% [20.12-62.75] compared with 86.21% [65.74-94.45] in the respective time periods. In patients with a FLCratio ≥ 100, the median TTP was 48.06 months [40.51-64.91] vs. 15.33 months [9.38-19.10], and the 2-year progression risk was 31.61% [25.30-37.39] vs. 73.00% [62.39-80.62] in recent and earlier studies, respectively. Tests for heterogeneity showed that the two time periods differed significantly in their ORs when comparing patients who met the high-and low risk criteria. No appropriate recent studies on focal lesions have been published.
    Interpretation: Recent studies show significantly improved prognosis of biomarker-defined MM with ≥60% BMPCs and FLCratio ≥ 100. This warrants careful evaluation for signs of progression before treatment initiation.
    Funding: Funding was provided by the Austrian Forum against Cancer.
    Language English
    Publishing date 2023-03-20
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2023.101910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Convalescent plasma for patients with multiple myeloma and COVID-19; the European Myeloma Network consensus.

    Terpos, Evangelos / Musto, Pellegrino / Engelhardt, Monika / Ntanasis-Stathopoulos, Ioannis / Sonneveld, Pieter / Ludwig, Heinz

    Leukemia

    2023  Volume 37, Issue 9, Page(s) 1939–1940

    MeSH term(s) Humans ; COVID-19 ; Multiple Myeloma/therapy ; Consensus ; COVID-19 Serotherapy ; SARS-CoV-2
    Language English
    Publishing date 2023-07-28
    Publishing country England
    Document type Letter
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/s41375-023-01974-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2295: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Synergistic interaction between HDAC and MCL-1 inhibitors through downregulation of BCL-XL in multiple myeloma.

    Schneller, Anja / Zojer, Niklas / Bolomsky, Arnold / Ludwig, Heinz

    Haematologica

    2021  Volume 106, Issue 9, Page(s) 2516–2521

    MeSH term(s) Apoptosis ; Cell Line, Tumor ; Down-Regulation ; Humans ; Multiple Myeloma/drug therapy ; Myeloid Cell Leukemia Sequence 1 Protein/genetics ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; bcl-X Protein/genetics ; bcl-X Protein/metabolism
    Chemical Substances Myeloid Cell Leukemia Sequence 1 Protein ; Proto-Oncogene Proteins c-bcl-2 ; bcl-X Protein
    Language English
    Publishing date 2021-09-01
    Publishing country Italy
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2020.277152
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.76: Show issues Location:
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  9. Article ; Online: Compliance With Vaccination Recommendations Among Patients With Multiple Myeloma: A Real World Experience.

    Ludwig, Heinz / Meckl, Angela / Engelhardt, Monika

    HemaSphere

    2021  Volume 5, Issue 7, Page(s) e597

    Language English
    Publishing date 2021-06-25
    Publishing country United States
    Document type Journal Article
    ISSN 2572-9241
    ISSN (online) 2572-9241
    DOI 10.1097/HS9.0000000000000597
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: BMP-2: a culprit for anemia in myeloma.

    Ludwig, Heinz

    Blood

    2010  Volume 116, Issue 18, Page(s) 3383–3384

    Abstract: Maes and colleagues(1) have found increased BMP-2 in the blood of multiple myeloma patients as an important stimulator of hepcidin in addition to other well-known mediators of hepcidin induction. These findings were obtained by transfection of human ... ...

    Abstract Maes and colleagues(1) have found increased BMP-2 in the blood of multiple myeloma patients as an important stimulator of hepcidin in addition to other well-known mediators of hepcidin induction. These findings were obtained by transfection of human liver HuH7 cells with reporter constructs for the hepcidin promoter carrying either mutations in BMP-response elements or in STAT3-binding sites.
    Language English
    Publishing date 2010-11-04
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2010-09-302349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.140: Show issues Location:
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    Zs.MO 364: Show issues

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