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  1. Book ; Thesis: Funktionelle Charakterisierung des Faktor-H-verwandten Proteins CFHR-3

    Ludwig, Mirko

    2010  

    Author's details von Mirko Ludwig
    Language German
    Size 120 S., Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Jena, Univ., Diss., 2010
    HBZ-ID HT016880687
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 D 842 order for loan Magazin

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  2. Article: Prüfen Sie Vorsysteme?

    Ludwig, Mirko

    WPg Vol. 70, No. 12 , p. 675-681

    Hinweise für kleinere und mittelgroße Wirtschaftsprüfungsgesellschaften

    2017  Volume 70, Issue 12, Page(s) 675–681

    Author's details von WP StB CISA Mirko Ludwig
    Keywords Vorsystem ; Schnittstelle ; IT-Audit ; IKS ; IDW PH 9.33.3
    Language German
    Publisher IdW-Verl
    Publishing place Düsseldorf
    Document type Article
    ZDB-ID 202848-7
    ISSN 0043-6313
    Database ECONomics Information System

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  3. Article ; Online: Cell-specific RNA interference by peptide-inhibited-peptidase-activated siRNAs.

    Koehn, Sandra / Schaefer, Hendrik W / Ludwig, Mirko / Haag, Natja / Schubert, Ulrich S / Seyfarth, Lydia / Imhof, Diana / Markert, Udo R / Poehlmann, Tobias G

    Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research

    2010  Volume 6, Issue 2, Page(s) 422–430

    Abstract: The use of chemically-synthesized short interfering RNAs (siRNAs) is the key method of choice to manipulate gene expression in mammalian cell cultures and in vivo. Several previous studies have aimed at inducing cell-specific RNA interference (RNAi) in ... ...

    Abstract The use of chemically-synthesized short interfering RNAs (siRNAs) is the key method of choice to manipulate gene expression in mammalian cell cultures and in vivo. Several previous studies have aimed at inducing cell-specific RNA interference (RNAi) in order to use siRNA molecules as therapeutic reagents. Here, we used peptide-inhibited siRNAs that were activated after cleavage by cell-specific peptidases. We show that siRNAs with bound peptide at the antisense strand could be activated in target cells and were able to induce RNAi in a cell-specific manner. Green Fluorescent Protein (GFP) and Signal Transducer and Activator of Transcription (STAT)-3 gene expression were selectively reduced in a JEG-3 human choriocarcinoma cell line expressing the activating enzyme caspase-4, whereas the effect was absent in HEK cells which lacked the enzyme. In JEG-3 cells, reduction of STAT3 gene expression by conventional and peptide-inhibited siRNA led to a decrease in cell proliferation. This suggests that peptide-inhibited siRNAs provide improved cell specificity and offers new opportunities for their therapeutic use.
    Language English
    Publishing date 2010-12-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2205263-X
    ISSN 1747-0854 ; 1747-0854
    ISSN (online) 1747-0854
    ISSN 1747-0854
    Database MEDical Literature Analysis and Retrieval System OnLINE

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