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  1. Book ; Thesis: Die Auswirkungen von viral/bakteriellen Infektionen auf die alveoläre Homöostase

    Deinhardt-Emmer, Stefanie / Löffler, Bettina / Pletz, Mathias / Ludwig, Stephan

    2023  

    Institution Friedrich-Schiller-Universität Jena
    Author's details von Dr. med. Stefanie Deinhardt-Emmer
    Keywords Lungenentzündung ; Atemwegsinfektion ; Lungenbläschen
    Subject Alveolus pulmonis ; Lungenalveole ; Respiratorische Infektionskrankheit ; Pneumonie
    Language German ; English
    Size 145 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Jena
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Habilitationsschrift, Friedrich-Schiller-Universität Jena, 2023
    Note Zeitschriftenaufsätze in englischer Sprache ; Kumulative Habilitationsschrift, enthält Zeitschriftenaufsätze. - Erteilung der Lehrbefähigung: 14.02.2023
    HBZ-ID HT030016945
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 809 order for loan Magazin

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  2. Article: Zur Zulässigkeit von mündlichen Verwaltungsakten bei Kontrollen vor Ort. Behördliche Anordnungen zur Gefahrenabwehr nach Art. 138 der Verordnung (EU) 2017/625 über amtliche Kontrollen

    Ludwig, Stephan

    Amtstierärztlicher Dienst und Lebensmittelkontrolle

    2021  Volume 28, Issue 4, Page(s) 206

    Language German
    Document type Article
    ZDB-ID 1191273-X
    ISSN 0945-3296
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Z 6083: Show issues

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  3. Article ; Online: MEK inhibitors as novel host-targeted antivirals with a dual-benefit mode of action against hyperinflammatory respiratory viral diseases.

    Ludwig, Stephan / Pleschka, Stephan / Planz, Oliver

    Current opinion in virology

    2023  Volume 59, Page(s) 101304

    Abstract: Acute hyperinflammatory virus infections, such as influenza or coronavirus disease-19, are still a major health burden worldwide. In these diseases, a massive overproduction of pro-inflammatory cytokines and chemokines (cytokine storm syndrome) determine ...

    Abstract Acute hyperinflammatory virus infections, such as influenza or coronavirus disease-19, are still a major health burden worldwide. In these diseases, a massive overproduction of pro-inflammatory cytokines and chemokines (cytokine storm syndrome) determine the severity of the disease, especially in late stages. Direct-acting antivirals against these pathogens have to be administered very early after infection to be effective and may induce viral resistance. Here, we summarize data on a host-targeted strategy using inhibitors of the cellular Raf/MEK/ERK kinase cascade that not only block replication of different RNA viruses but also suppress the hyperinflammatory cytokine response upon infection. In the first phase-II clinical trial of that approach, the MEK inhibitor Zapnometinib shows evidence of clinical benefit.
    MeSH term(s) Humans ; Antiviral Agents/therapeutic use ; COVID-19 ; Hepatitis C, Chronic ; Influenza, Human/drug therapy ; Cytokines ; Mitogen-Activated Protein Kinase Kinases/therapeutic use
    Chemical Substances Antiviral Agents ; Cytokines ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2)
    Language English
    Publishing date 2023-02-24
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2611378-8
    ISSN 1879-6265 ; 1879-6257
    ISSN (online) 1879-6265
    ISSN 1879-6257
    DOI 10.1016/j.coviro.2023.101304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: "Topf Secret" - Vereinfachte Transparenz für die Verbraucher oder datenschutzwidrige Verfolgung eigener Interessen?

    Ludwig, Stephan

    Amtstierärztlicher Dienst und Lebensmittelkontrolle

    2019  Volume 26, Issue 4, Page(s) 176

    Language German
    Document type Article
    ZDB-ID 1191273-x
    ISSN 0945-3296
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

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  5. Article: Qualitätsmanagement und amtliche Kontrollen: Das Audit als Überprüfung mit zunehmender Bedeutung

    Ludwig, Stephan

    Amtstierärztlicher Dienst und Lebensmittelkontrolle

    2019  Volume 26, Issue 2, Page(s) 54

    Language German
    Document type Article
    ZDB-ID 1191273-x
    ISSN 0945-3296
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

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  6. Article ; Online: Small Spleen Peptides (SSPs) Shape Dendritic Cell Differentiation through Modulation of Extracellular ATP Synthesis Profile.

    Wixler, Viktor / Leite Dantas, Rafael / Varga, Georg / Boergeling, Yvonne / Ludwig, Stephan

    Biomolecules

    2024  Volume 14, Issue 4

    Abstract: Restoring peripheral immune tolerance is crucial for addressing autoimmune diseases. An ancient mechanism in maintaining the balance between inflammation and tolerance is the ratio of extracellular ATP (exATP) and adenosine. Our previous research ... ...

    Abstract Restoring peripheral immune tolerance is crucial for addressing autoimmune diseases. An ancient mechanism in maintaining the balance between inflammation and tolerance is the ratio of extracellular ATP (exATP) and adenosine. Our previous research demonstrated the effectiveness of small spleen peptides (SSPs) in inhibiting psoriatic arthritis progression, even in the presence of the pro-inflammatory cytokine TNFα, by transforming dendritic cells (DCs) into tolerogenic cells and fostering regulatory Foxp3
    MeSH term(s) Dendritic Cells/metabolism ; Dendritic Cells/drug effects ; Dendritic Cells/immunology ; Adenosine Triphosphate/metabolism ; Adenosine Triphosphate/pharmacology ; Animals ; Cell Differentiation/drug effects ; Spleen/cytology ; Spleen/metabolism ; Spleen/drug effects ; Spleen/immunology ; Mice ; Thymosin/pharmacology ; Thymosin/metabolism ; Peptides/pharmacology ; Arthritis, Psoriatic/drug therapy ; Arthritis, Psoriatic/metabolism ; Arthritis, Psoriatic/immunology ; Humans ; Mice, Inbred C57BL ; Immune Tolerance/drug effects
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE) ; Thymosin (61512-21-8) ; Peptides ; thymosin beta(4) (549LM7U24W)
    Language English
    Publishing date 2024-04-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14040469
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Coronaviruses and SARS-CoV-2: A Brief Overview.

    Ludwig, Stephan / Zarbock, Alexander

    Anesthesia and analgesia

    2020  Volume 131, Issue 1, Page(s) 93–96

    Abstract: In late December 2019, several cases of pneumonia of unknown origin were reported from China, which in early January 2020 were announced to be caused by a novel coronavirus. The virus was later denominated severe acute respiratory syndrome coronavirus 2 ( ...

    Abstract In late December 2019, several cases of pneumonia of unknown origin were reported from China, which in early January 2020 were announced to be caused by a novel coronavirus. The virus was later denominated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and defined as the causal agent of coronavirus disease 2019 (COVID-19). Despite massive attempts to contain the disease in China, the virus has spread globally, and COVID-19 was declared a pandemic by the World Health Organization (WHO) in March 2020. Here we provide a short background on coronaviruses, and describe in more detail the novel SARS-CoV-2 and attempts to identify effective therapies against COVID-19.
    MeSH term(s) Anesthesiologists ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/therapy ; Coronavirus Infections/transmission ; Critical Care ; Humans ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/therapy ; Pneumonia, Viral/transmission ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000004845
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.78: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 149: Show issues

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  8. Article ; Online: Will omics help to cure the flu?

    Ludwig, Stephan

    Trends in microbiology

    2014  Volume 22, Issue 5, Page(s) 232–233

    Abstract: Influenza virus infections are still a major burden to mankind and our antiviral arsenal against these pathogens is limited. The cellular responses to infection might provide novel targets for intervention strategies. Josset et al. combined comparative ... ...

    Abstract Influenza virus infections are still a major burden to mankind and our antiviral arsenal against these pathogens is limited. The cellular responses to infection might provide novel targets for intervention strategies. Josset et al. combined comparative transcriptome analysis with literature-based prediction tools for in silico identification of novel host-directed drugs.
    MeSH term(s) Epithelial Cells/virology ; Host-Pathogen Interactions ; Humans ; Influenza A Virus, H7N9 Subtype/genetics ; Transcriptome
    Language English
    Publishing date 2014-05
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2014.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3738: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Book ; Online: Molecular signatures determining pathogenicity and species transmission of influenza A viruses

    Ludwig, Stephan

    FluResearchNet ; Abschlussbericht des Vorhabens ; Berichtszeitraum: 01.10.2010 - 31.12.2013

    2014  

    Institution Institut für Molekulare Virologie
    Author's details Institut für Molekulare Virologie, Westfälische Wilhelms-Universität Münster ... [Autoren des Berichts]/Koordinator: Stephan Ludwig
    Language German
    Size Online-Ressource (145 S., 2,00 MB), Ill., graph. Darst.
    Publisher Technische Informationsbibliothek u. Universitätsbibliothek
    Publishing place Hannover ; Münster u.a.
    Document type Book ; Online
    Note Förderkennzeichen BMBF 01KI1006 A-F - 01KI1006 H-L - 01KI1006N - 01061531. - Verbund-Nr. 01061531 ; Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Book: Molecular signatures determining pathogenicity and species transmission of influenza A viruses

    Ludwig, Stephan

    FluResearchNet ; Abschlussbericht des Vorhabens ; Berichtszeitraum: 01.10.2010 - 31.12.2013

    2014  

    Institution Institut für Molekulare Virologie
    Author's details Institut für Molekulare Virologie, Westfälische Wilhelms-Universität Münster ... [Autoren des Berichts]/Koordinator: Stephan Ludwig
    Language German
    Size 111, [34] Bl., Ill., graph. Darst.
    Publishing place Münster u.a.
    Document type Book
    Note Förderkennzeichen BMBF 01KI1006 A-F - 01KI1006 H-L - 01KI1006N - 01061531. - Verbund-Nr. 01061531 ; Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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