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  1. Book ; Online: Towards a molecular classification of colorectal cancer

    Lugli, Alessandro

    2015  

    Abstract: In 2007, Jeremy Jass proposed a molecular classification of colorectal cancer including KRAS, BRAF, Mismatch Repair, CIMP and MGMT Status. Since then, many prognostic and predictive studies have been published on this topic, mainly focusing on one single ...

    Abstract In 2007, Jeremy Jass proposed a molecular classification of colorectal cancer including KRAS, BRAF, Mismatch Repair, CIMP and MGMT Status. Since then, many prognostic and predictive studies have been published on this topic, mainly focusing on one single molecular marker. The aim of the e-book is to summarize the knowledge in 2014 from a multidisciplinary point of view that can potentially be used as a manual by CRC researchers in every field
    Keywords Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; Medicine (General)
    Size 1 electronic resource (62 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020090876
    ISBN 9782889195671 ; 2889195678
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Towards a molecular classification of colorectal cancer.

    Lugli, Alessandro

    Frontiers in oncology

    2015  Volume 5, Page(s) 46

    Language English
    Publishing date 2015-02-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2015.00046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The battle for prognosis at the invasive front of colorectal cancer.

    Lugli, Alessandro / Zlobec, Inti

    EBioMedicine

    2020  Volume 58, Page(s) 102918

    MeSH term(s) Colorectal Neoplasms ; Humans ; Prognosis
    Language English
    Publishing date 2020-07-22
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2020.102918
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Standards der histopathologischen und molekularen Diagnostik des kolorektalen Karzinoms.

    Dawson, Heather / Lugli, Alessandro

    Therapeutische Umschau. Revue therapeutique

    2019  Volume 75, Issue 10, Page(s) 615–621

    Abstract: Current standards of pathological and molecular diagnostics in colorectal ... ...

    Title translation Current standards of pathological and molecular diagnostics in colorectal cancer.
    Abstract Current standards of pathological and molecular diagnostics in colorectal cancer
    MeSH term(s) Biomarkers, Tumor ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/genetics ; Humans ; Pathology, Molecular ; Prognosis
    Chemical Substances Biomarkers, Tumor
    Language German
    Publishing date 2019-03-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 82044-1
    ISSN 1664-2864 ; 0040-5930
    ISSN (online) 1664-2864
    ISSN 0040-5930
    DOI 10.1024/0040-5930/a001048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Tumor Budding beim kolorektalen Karzinom – Informationen zur klinischen Anwendung und Anleitung zur praktischen Bestimmung.

    Müller, Felix / Lugli, Alessandro / Dawson, Heather

    Der Pathologe

    2021  Volume 43, Issue 1, Page(s) 45–50

    Abstract: Background: Some patients with high-risk colorectal cancer show a worse prognosis within the same UICC stage. Therefore, the identification of additional risk factors is necessary to find the best treatment for these patients.: Objective: In which ... ...

    Title translation Tumor budding in colorectal cancer-Information for clinical use and instructions for practical evaluation.
    Abstract Background: Some patients with high-risk colorectal cancer show a worse prognosis within the same UICC stage. Therefore, the identification of additional risk factors is necessary to find the best treatment for these patients.
    Objective: In which settings can tumor budding help the clinical decision-making process for treatment planning and how should scoring be performed?
    Material and methods: Evaluation of current publications on tumor budding with an emphasis on practical grading and potential problems in the determination of tumor budding.
    Results: Tumor budding is a significant risk factor for worse clinical outcome of colorectal cancer and can influence clinical decision-making in pT1 and stage II colorectal cancer. A scoring method was standardized by the ITBCC 2016 and is feasible in everyday practice. Challenges in assessment can be addressed by increasing awareness of potential problem cases.
    MeSH term(s) Colorectal Neoplasms/pathology ; Humans ; Lymphatic Metastasis ; Neoplasm Staging ; Prognosis ; Risk Factors
    Language German
    Publishing date 2021-11-01
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 135954-x
    ISSN 1432-1963 ; 0172-8113
    ISSN (online) 1432-1963
    ISSN 0172-8113
    DOI 10.1007/s00292-021-01016-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1543: Show issues Location:
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  6. Article ; Online: Tumour budding in colorectal cancer: molecular rationale for clinical translation.

    Zlobec, Inti / Lugli, Alessandro

    Nature reviews. Cancer

    2018  Volume 18, Issue 4, Page(s) 203–204

    MeSH term(s) Biomarkers, Tumor/analysis ; Biomarkers, Tumor/metabolism ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Epithelial-Mesenchymal Transition ; Gene Expression Regulation, Neoplastic ; Humans ; Lymphatic Metastasis
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2018-01-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2062767-1
    ISSN 1474-1768 ; 1474-175X
    ISSN (online) 1474-1768
    ISSN 1474-175X
    DOI 10.1038/nrc.2018.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5563: Show issues Location:
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  7. Article: Standards der histopathologischen und molekularen Diagnostik des kolorektalen Karzinoms

    Dawson, Heather / Lugli, Alessandro

    Therapeutische Umschau

    2018  Volume 75, Issue 10, Page(s) 615–621

    Abstract: Die pathologische Aufarbeitung von Biopsie- und Operationspräparaten spielt beim kolorektalen Karzinom für das Patientenmanagement eine wichtige Rolle. ...

    Abstract Die pathologische Aufarbeitung von Biopsie- und Operationspräparaten spielt beim kolorektalen Karzinom für das Patientenmanagement eine wichtige Rolle.
    Keywords Biopsie ; Patientenmanagement ; Biomarker
    Language German
    Document type Article
    ZDB-ID 82044-1
    ISSN 1664-2864 ; 0040-5930
    ISSN (online) 1664-2864
    ISSN 0040-5930
    Database bibnet.org

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  8. Article ; Online: Tumour budding and its clinical implications in gastrointestinal cancers.

    Zlobec, Inti / Berger, Martin D / Lugli, Alessandro

    British journal of cancer

    2020  Volume 123, Issue 5, Page(s) 700–708

    Abstract: Tumour budding in colorectal cancer has become an important prognostic factor. Represented by single cells or small tumour cell clusters at the invasion front of the tumour mass, these tumour buds seem to reflect cells in a 'hybrid' state of epithelial- ... ...

    Abstract Tumour budding in colorectal cancer has become an important prognostic factor. Represented by single cells or small tumour cell clusters at the invasion front of the tumour mass, these tumour buds seem to reflect cells in a 'hybrid' state of epithelial-mesenchymal transition, and evidence indicates that the presence of these entities is associated with lymph node metastasis, local recurrence and distant metastatic disease. The International Tumour Budding Consensus Conference (ITBCC) has highlighted a scoring system for the reporting of tumour budding in colorectal cancer, as well as different clinical scenarios that could affect patient management. Other organs are not spared: tumour budding has been described in numerous gastrointestinal and non-gastrointestinal cancers. Here, we give an update on ITBCC validation studies in the context of colorectal cancer and the clinical implications of tumour budding throughout the upper gastrointestinal and pancreatico-biliary tract.
    MeSH term(s) Gastrointestinal Neoplasms/pathology ; Humans ; Neoplasm Invasiveness ; Neoplasm Staging ; Practice Guidelines as Topic
    Language English
    Publishing date 2020-06-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-020-0954-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Archaeology dig into the duodenal biopsy.

    Lugli, Alessandro

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2010  Volume 42, Issue 7, Page(s) 470–471

    MeSH term(s) Biopsy/statistics & numerical data ; Biopsy/utilization ; Duodenal Diseases/diagnosis ; Duodenal Diseases/pathology ; Endoscopy, Digestive System/statistics & numerical data ; Female ; Humans ; Interdisciplinary Communication ; Male ; Retrospective Studies ; Sex Factors
    Language English
    Publishing date 2010-07
    Publishing country Netherlands
    Document type Comment ; Journal Article
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2010.04.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [No title information]

    Dawson, Heather / Lugli, Alessandro

    Therapeutische Umschau. Revue therapeutique

    2017  Volume 74, Issue 4, Page(s) 151–155

    Title translation Tumor Budding beim kolorektalen Karzinom: Ein morphologischer Biomarker für die Praxis.
    Language German
    Publishing date 2017-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 82044-1
    ISSN 1664-2864 ; 0040-5930
    ISSN (online) 1664-2864
    ISSN 0040-5930
    DOI 10.1024/0040-5930/a000898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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