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Artikel ; Online: Ultrasound changes in lower limb muscle architectural parameters and ambulatory outcomes in early stroke survivors.

Kong, Keng He / Tham, Shuen-Loong / Tay, Matthew Rong Jie / Lui, Wen Li / Rajeswaran, Deshan Kumar / Kim, Jongmoon

2023

Sprache	Englisch
Erscheinungsdatum	2023-07-26
Erscheinungsland	India
Dokumenttyp	Journal Article
ZDB-ID	604319-7
ISSN	2737-5935 ; 0037-5675
ISSN (online)	2737-5935
ISSN	0037-5675
DOI	10.4103/singaporemedj.SMJ-2022-210
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Apigenin delays postovulatory oocyte aging by reducing oxidative stress through SIRT1 upregulation.

Yao, Xuerui / Guo, Panpan / Li, Ying-Hua / Guo, Hao / Jin, Zhelong / Lui, Wen / Yuan, Jianbin / Gao, Qingshan / Wang, Lin / Li, Yunxiao / Shi, Jiabin / Zhang, Xiwei / Cao, Qilong / Xu, Yong-Nan / Kim, Nam-Hyung

Theriogenology

2024 Band 218, Seite(n) 89–98

Abstract: After ovulation, senescent oocytes inevitably experience reduced quality and defects in embryonic development. Apigenin (API) is a flavonoid with a wide range of pharmacological effects. Therefore, this study examined the protective effects of API on the ...

Abstract	After ovulation, senescent oocytes inevitably experience reduced quality and defects in embryonic development. Apigenin (API) is a flavonoid with a wide range of pharmacological effects. Therefore, this study examined the protective effects of API on the quality of porcine oocytes during in-vitro ageing and the underlying mechanisms. The results showed that API treatment could reduce the activation rate after aging for 48 h. In addition, API significantly reduced reactive oxygen species, abnormal distribution of mitochondria, early apoptosis in ageing oocytes, increased glutathione, and mitochondrial adenosine triphosphate levels in ageing oocytes. Importantly, API increased the embryonic development rate in aged oocytes. We also examined molecular changes, finding decreased sirtuin 1 expression in in-vitro postovulatory oocytes, but API reversed this effect. Our results suggest that API attenuates the deterioration of oocyte quality during in-vitro ageing, possibly by reducing oxidative stress through the upregulation of sirtuin 1.
Mesh-Begriff(e)	Female ; Animals ; Swine ; Sirtuin 1/genetics ; Sirtuin 1/metabolism ; Apigenin/pharmacology ; Apigenin/metabolism ; Up-Regulation ; Cellular Senescence/physiology ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Oocytes/physiology
Chemische Substanzen	Sirtuin 1 (EC 3.5.1.-) ; Apigenin (7V515PI7F6) ; Reactive Oxygen Species
Sprache	Englisch
Erscheinungsdatum	2024-01-07
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	189232-0
ISSN	1879-3231 ; 0093-691X
ISSN (online)	1879-3231
ISSN	0093-691X
DOI	10.1016/j.theriogenology.2024.01.007
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Ultrasound Assessment of Changes in Muscle Architecture of the Brachialis Muscle After Stroke-A Prospective Study.

Kong, Keng He / Shuen-Loong, Tham / Tay, Matthew Rong Jie / Lui, Wen Li / Rajeswaran, Deshan Kumar / Kim, Jongmoon

Archives of rehabilitation research and clinical translation

2022 Band 4, Heft 3, Seite(n) 100215

Abstract: Objective: To investigate changes in ultrasound-derived muscle architecture parameters of the brachialis and correlations in patients with subacute stroke.: Design: Prospective longitudinal observational study.: Setting: Tertiary inpatient ... ...

Abstract	Objective: To investigate changes in ultrasound-derived muscle architecture parameters of the brachialis and correlations in patients with subacute stroke. Design: Prospective longitudinal observational study. Setting: Tertiary inpatient rehabilitation center. Participants: Fifty adult patients (N=50) who were recruited within the first month poststroke. The patients had a mean age of 57.2±12.3 years and 68.0% were male. The majority of patients had significant upper limb weakness with a low mean Motricity Index of 18.5±24.7 and median elbow flexor strength of grade 0. Intervention: Not applicable. Main outcome measures: Ultrasound of the intact and hemiparetic brachialis was performed at 3-time intervals: within 1 month of stroke onset and at 1 and 6 months after first assessment. Clinical variables captured included upper limb motor power and elbow flexor spasticity. Results: Compared to the intact brachialis, there was reduced muscle thickness (1.93 cm vs 2.07 cm, 1.86 cm vs 2.08 cm, 1.85 cm vs 2.05 cm; Conclusions: Changes including decreased muscle thickness and increased echo intensity of the hemiparetic brachialis were noted over time. Elbow flexor spasticity at 1-month assessment interval appears to mitigate against these changes.
Sprache	Englisch
Erscheinungsdatum	2022-07-15
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	2590-1095
ISSN (online)	2590-1095
DOI	10.1016/j.arrct.2022.100215
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Changes in muscle architecture on ultrasound in patients early after stroke.

Kim, Jong Moon / Tay, Matthew Rong Jie / Rajeswaran, Deshan Kumar / Tham, Shuen-Loong / Lui, Wen Li / Kong, Keng He

NeuroRehabilitation

2021 Band 49, Heft 4, Seite(n) 565–572

Abstract: Background: Early muscle changes are believed to occur in patients with stroke. However, there are insufficient data on the changes in muscle mass and architecture of these patients.: Objectives: This study investigates differences in ultrasound- ... ...

Abstract	Background: Early muscle changes are believed to occur in patients with stroke. However, there are insufficient data on the changes in muscle mass and architecture of these patients. Objectives: This study investigates differences in ultrasound-derived muscle architecture parameters of the hemiplegic upper and lower limbs in patients with subacute stroke. Methods: This is a prospective observational study, which recruited 40 adult patients who had experienced a first ever unilateral stroke (ischemic or hemorrhagic), with a duration of < 1 month post stroke. The brachialis, vastus lateralis and medial gastrocnemius on both the hemiplegic and normal side were evaluated via ultrasound. We recorded clinical variables including Motricity Index, Modified Ashworth Scale (MAS) and Functional Independence Measure (FIM)-walk. Results: We found reduced mean muscle thickness (p < 0.001) and increased echo intensity (p < 0.001) in the brachialis muscle, increased echo intensity (p = 0.002) in the vastus lateralis muscle, and reduced muscle thickness (p < 0.001) with increased echo intensity (p < 0.001) in the medial gastrocnemius muscle compared to the normal side. There were no significant correlations between ultrasound findings and Motricity Index. Conclusions: We report changes in ultrasound-derived muscle architecture in the hemiplegic limbs of patients with subacute stroke, with consistent findings of decreased muscle mass and increased echo intensity.
Mesh-Begriff(e)	Adult ; Humans ; Lower Extremity ; Muscle Spasticity/diagnostic imaging ; Muscle Spasticity/etiology ; Muscle, Skeletal/diagnostic imaging ; Stroke/complications ; Stroke/diagnostic imaging ; Stroke Rehabilitation ; Ultrasonography
Sprache	Englisch
Erscheinungsdatum	2021-11-21
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article ; Observational Study
ZDB-ID	1087912-2
ISSN	1878-6448 ; 1053-8135
ISSN (online)	1878-6448
ISSN	1053-8135
DOI	10.3233/NRE-210257
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Covert Subclinical Neurocognitive Sequelae During the Rehabilitation Course of Severe Coronavirus Disease 2019.

Tay, Matthew Rong Jie / Low, Yee Hong / Lim, Choie Cheio Tchoyoson / Umapathi, Thirugnanam / Thio, Jocelyn Mei Lin / Lui, Wen Li / Chan, Wai Lim William / Chua, Karen Sui Geok

American journal of physical medicine & rehabilitation

2020 Band 100, Heft 1, Seite(n) 39–43

Abstract: Abstract: Apart from respiratory symptoms, encephalopathy and a range of central nervous system complications have been described in coronavirus disease 2019. However, there is a lack of published literature on the rehabilitative course and functional ... ...

Abstract	Abstract: Apart from respiratory symptoms, encephalopathy and a range of central nervous system complications have been described in coronavirus disease 2019. However, there is a lack of published literature on the rehabilitative course and functional outcomes of severe coronavirus disease 2019 with encephalopathy. In addition, the presence of subclinical neurocognitive sequelae during postacute rehabilitation has not been described and may be underrecognized by rehabilitation providers. We report the rehabilitative course of a middle-aged male patient with severe coronavirus disease 2019 who required intensive care and mechanical ventilation. During postacute inpatient rehabilitation for severe intensive care unit-related weakness, an abnormal cognitive screen prompted brain magnetic resonance imaging, which revealed destructive leukoencephalopathy. Subsequently, detailed psychometric evaluation revealed significant impairments in the domains of processing speed and executive function. After 40 days of intensive inpatient rehabilitation, he was discharged home with independent function. This report highlights the need for an increased awareness of covert subclinical neurocognitive sequelae, the role of comprehensive rehabilitation, and value of routine cognitive screening therein and describes the neurocognitive features in severe COVID-19.
Mesh-Begriff(e)	COVID-19/complications ; COVID-19/diagnosis ; COVID-19/rehabilitation ; Critical Care ; Humans ; Leukoencephalopathies/diagnosis ; Leukoencephalopathies/etiology ; Leukoencephalopathies/rehabilitation ; Male ; Middle Aged ; Patient Discharge
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2020-10-03
Erscheinungsland	United States
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	219390-5
ISSN	1537-7385 ; 0002-9491 ; 0894-9115
ISSN (online)	1537-7385
ISSN	0002-9491 ; 0894-9115
DOI	10.1097/PHM.0000000000001633
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A Malaysian Vehicle License Plate Localization and Recognition System

Ganapathy Velappa / Dennis LUI Wen Lik

Journal of Systemics, Cybernetics and Informatics, Vol 6, Iss 1, Pp 13-

2008 Band 20

Abstract: Technological intelligence is a highly sought after commodity even in traffic-based systems. These intelligent systems do not only help in traffic monitoring but also in commuter safety, law enforcement and commercial applications. In this paper, a ... ...

Abstract	Technological intelligence is a highly sought after commodity even in traffic-based systems. These intelligent systems do not only help in traffic monitoring but also in commuter safety, law enforcement and commercial applications. In this paper, a license plate localization and recognition system for vehicles in Malaysia is proposed. This system is developed based on digital images and can be easily applied to commercial car park systems for the use of documenting access of parking services, secure usage of parking houses and also to prevent car theft issues. The proposed license plate localization algorithm is based on a combination of morphological processes with a modified Hough Transform approach and the recognition of the license plates is achieved by the implementation of the feed-forward backpropagation artificial neural network. Experimental results show an average of 95% successful license plate localization and recognition in a total of 589 images captured from a complex outdoor environment.
Schlagwörter	Backpropagation ; recognition ; License plate ; localization ; Autoskew correction ; Character segmentation ; Hough Transform ; Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q ; DOAJ:Computer Science ; DOAJ:Technology and Engineering
Thema/Rubrik (Code)	629
Sprache	Englisch
Erscheinungsdatum	2008-02-01T00:00:00Z
Verlag	International Institute of Informatics and Cybernetics
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel: Covert Subclinical Neurocognitive Sequelae during the Rehabilitation Course of Severe Coronavirus Disease 2019: A Case Report

Tay, Matthew Rong Jie / Low, Yee Hong / Lim, Choie Cheio Tchoyoson / Umapathi, Thirugnanam / Thio, Jocelyn Mei Lin / Lui, Wen Li / Chan, Wai Lim William / Chua, Karen Sui Geok

Am. j. phys. med. rehabilit

Abstract: Apart from respiratory symptoms, encephalopathy and a range of central nervous system complications have been described in COVID-19 (Coronavirus Disease 2019). However, there is a lack of published literature on the rehabilitative course and functional ... ...

Abstract	Apart from respiratory symptoms, encephalopathy and a range of central nervous system complications have been described in COVID-19 (Coronavirus Disease 2019). However, there is a lack of published literature on the rehabilitative course and functional outcomes of severe COVID-19 with encephalopathy. Additionally, the presence of subclinical neurocognitive sequelae during post-acute rehabilitation has not been described and may be under-recognized by rehabilitation providers. We report the rehabilitative course of a middle-aged male patient with severe COVID-19 who required intensive care and mechanical ventilation. During post-acute inpatient rehabilitation for severe ICU-related weakness, an abnormal cognitive screen prompted brain MRI imaging which revealed destructive leukoencephalopathy. Subsequently, detailed psychometric evaluation revealed significant impairments in the domains of processing speed and executive function. After 40 days of intensive inpatient rehabilitation, he was discharged home with independent function. This report highlights the need for an increased awareness of covert subclinical neurocognitive sequalae, the role of comprehensive rehabilitation and value of routine cognitive screening therein; and describes the neurocognitive features in severe COVID-19.
Schlagwörter	covid19
Verlag	WHO
Dokumenttyp	Artikel
Anmerkung	WHO #Covidence: #894707
Datenquelle	COVID19

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Artikel ; Online: Transformative Reality: improving bionic vision with robotic sensing.

Lui, Wen Lik Dennis / Browne, Damien / Kleeman, Lindsay / Drummond, Tom / Li, Wai Ho

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2012 Band 2012, Seite(n) 304–307

Abstract: Implanted visual prostheses provide bionic vision with very low spatial and intensity resolution when compared against healthy human vision. Vision processing converts camera video to low resolution imagery for bionic vision with the aim of preserving ... ...

Abstract	Implanted visual prostheses provide bionic vision with very low spatial and intensity resolution when compared against healthy human vision. Vision processing converts camera video to low resolution imagery for bionic vision with the aim of preserving salient features such as edges. Transformative Reality extends and improves upon traditional vision processing in three ways. Firstly, a combination of visual and non-visual sensors are used to provide multi-modal data of a person's surroundings. This enables the sensing of features that are difficult to sense with only a camera. Secondly, robotic sensing algorithms construct models of the world in real time. This enables the detection of complex features such as navigable empty ground or people. Thirdly, models are visually rendered so that visually complex entities such as people can be effectively represented in low resolution. Preliminary simulated prosthetic vision trials, where a head mounted display is used to constrain a subject's vision to 25×25 binary phosphenes, suggest that Transformative Reality provides functional bionic vision for tasks such as indoor navigation, object manipulation and people detection in scenes where traditional processing is unusable.
Mesh-Begriff(e)	Algorithms ; Humans ; Models, Theoretical ; Prosthesis Design ; Robotics/instrumentation ; Robotics/methods ; Visual Prosthesis
Sprache	Englisch
Erscheinungsdatum	2012-08-06
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC.2012.6345929
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Folate-mediated chondroitin sulfate-Pluronic 127 nanogels as a drug carrier.

Huang, Shih-Jer / Sun, Shuo-Li / Feng, Tzu-Hua / Sung, Kuo-Hsun / Lui, Wen-Ling / Wang, Li-Fang

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2009 Band 38, Heft 1, Seite(n) 64–73

Abstract: Pluronic F127 (PF127), one of the polymers which can inhibit drug efflux transporters in cancer therapy, was used to produce amphiphilic nanocarriers for doxorubicin (DOX). In order to stabilize the nanocarriers, the hydroxyl groups on both termini of ... ...

Abstract	Pluronic F127 (PF127), one of the polymers which can inhibit drug efflux transporters in cancer therapy, was used to produce amphiphilic nanocarriers for doxorubicin (DOX). In order to stabilize the nanocarriers, the hydroxyl groups on both termini of PF127 were acrylated and reacted with methacrylated chondroitin sulfate (CSMA) to form CS-PF127 nanogel. The introducing CSMA has carboxylic acid groups which can be used to react with a folic acid-polyethylene glycol (FA-PEG). Folic acid, having high binding affinity to tumor-associated folate receptors (FR), provides a selective delivery of doxorubicin (DOX) to FR-positive tumor cells. DOX was loaded either in a cationic DOX.HCl form through the electrostatic interactions with the negative charges of chondroitin sulfate, or in a free DOX form by solubilization into the PPO core compartment of PF127. The loading efficiency and release behavior of DOX prepared from two different formulations are compared. The synthesis of CS-PF127 and FA-PEG grafted CS-PF127 (FA-CS-PF127) was characterized by nuclear magnetic resonance spectrometry (NMR), ultraviolet/visible spectroscopy (UV), and X-ray photoelectron spectroscopy (XPS). With a fluorescent probe technique, the critical aggregation concentrations (CAC) are 7.5 x 10(-2)mg/mL for CS-PF127 and 7.9 x 10(-2)mg/mL for FA-CS-PF127, respectively. The spherical images of nanogels were visualized with the use of the transmission electron microscope (TEM). The particle diameters measured by dynamic light scattering (DLS) are 299.6+/-8.2nm for CS-PF127 and 138.3+/-12.3 for FA-CS-PF127, neither aggregation nor change in sizes in double deionized (DD) water after 20 days. The better cellular uptake of FA-CS-PF127 in KB cells was evidenced by confocal laser scanning microscopy (CLSM) and flow cytometry upon loading Rhodamine123 as a probe.
Mesh-Begriff(e)	Acrylates/chemistry ; Binding, Competitive ; Biological Availability ; Cell Line, Tumor ; Cell Survival/drug effects ; Chondroitin Sulfates/chemical synthesis ; Chondroitin Sulfates/chemistry ; Chondroitin Sulfates/pharmacology ; Doxorubicin/administration & dosage ; Doxorubicin/pharmacokinetics ; Drug Carriers/chemistry ; Drug Carriers/pharmacology ; Endocytosis/drug effects ; Fluorescent Dyes/chemistry ; Folic Acid/analogs & derivatives ; Folic Acid/chemical synthesis ; Folic Acid/chemistry ; Folic Acid/pharmacology ; Humans ; Magnetic Resonance Spectroscopy ; Methacrylates/chemistry ; Microscopy, Electron, Transmission ; Molecular Structure ; Nanostructures/chemistry ; Particle Size ; Poloxamer/analogs & derivatives ; Poloxamer/chemical synthesis ; Poloxamer/chemistry ; Poloxamer/pharmacology ; Polyethylene Glycols/chemistry ; Pyrenes/chemistry ; Spectrometry, Fluorescence ; Spectrometry, X-Ray Emission ; Spectrophotometry, Ultraviolet
Chemische Substanzen	Acrylates ; Drug Carriers ; Fluorescent Dyes ; Methacrylates ; Pyrenes ; Poloxamer (106392-12-5) ; Polyethylene Glycols (30IQX730WE) ; Doxorubicin (80168379AG) ; Chondroitin Sulfates (9007-28-7) ; Folic Acid (935E97BOY8) ; pyrene (9E0T7WFW93)
Sprache	Englisch
Erscheinungsdatum	2009-08-12
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1154366-8
ISSN	1879-0720 ; 0928-0987
ISSN (online)	1879-0720
ISSN	0928-0987
DOI	10.1016/j.ejps.2009.06.002
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals

Riva, Laura / Yuan, Shuofeng / Yin, Xin / Martin-Sancho, Laura / Matsunaga, Naoko / Burgstaller, Sebastian / Pache, Lars / De Jesus, Paul / Hull, Mitchell V. / Chang, Max / Chan, Jasper F.W. / Cao, Jianli / Kwok-Man Poon, Vincent / Herbert, Kristina / Nguyen, Tu-Trinh / Pu, Yuan / Nguyen, Courtney / Rubanov, Andrey / Martinez-Sobrido, Luis /

Lui, Wen-Chun / Miorin, Lisa / White, Kris / Johnson, Jeffrey R / Benner, Christopher / Sun, Ren / Schultz, Peter / Su, Andrew I / Garcia-Sastre, Adolfo / Chatterjee, Arnab / Yuen, Kwok-Yung / Chanda, Sumit

bioRxiv

Abstract: The emergence of novel SARS coronavirus 2 (SARS-CoV-2) in 2019 has triggered an ongoing global pandemic of severe pneumonia-like disease designated as coronavirus disease 2019 (COVID-19). To date, more than 2.1 million confirmed cases and 139,500 deaths ... ...

Abstract	The emergence of novel SARS coronavirus 2 (SARS-CoV-2) in 2019 has triggered an ongoing global pandemic of severe pneumonia-like disease designated as coronavirus disease 2019 (COVID-19). To date, more than 2.1 million confirmed cases and 139,500 deaths have been reported worldwide, and there are currently no medical countermeasures available to prevent or treat the disease. As the development of a vaccine could require at least 12-18 months, and the typical timeline from hit finding to drug registration of an antiviral is >10 years, repositioning of known drugs can significantly accelerate the development and deployment of therapies for COVID-19. To identify therapeutics that can be repurposed as SARS-CoV-2 antivirals, we profiled a library of known drugs encompassing approximately 12,000 clinical-stage or FDAapproved small molecules. Here, we report the identification of 30 known drugs that inhibit viral replication. Of these, six were characterized for cellular dose-activity relationships, and showed effective concentrations likely to be commensurate with therapeutic doses in patients. These include the PIKfyve kinase inhibitor Apilimod, cysteine protease inhibitors MDL-28170, Z LVG CHN2, VBY-825, and ONO 5334, and the CCR1 antagonist MLN-3897. Since many of these molecules have advanced into the clinic, the known pharmacological and human safety profiles of these compounds will accelerate their preclinical and clinical evaluation for COVID-19 treatment.
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2020-04-17
Verlag	Cold Spring Harbor Laboratory
Dokumenttyp	Artikel ; Online
DOI	10.1101/2020.04.16.044016
Datenquelle	COVID19

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