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  1. Article ; Online: The Importance of Subjectivity in Assessing the Efficiency of Surgery for Obstructive Sleep Apnea. Comment on Kuik et al. Subjective Efficiency Evaluation after Maxillomandibular Advancement Surgery in Obstructive Sleep Apnea Patients. J. Clin. Med. 2023, 12 , 4023

    Antonino Maniaci / Salvatore Cocuzza / Giovanni Cammaroto / Claudio Vicini / Luigi La Via

    Journal of Clinical Medicine, Vol 12, Iss 21, p

    2023  Volume 6761

    Abstract: We recently read with interest the study by Kuik et al. [.] ...

    Abstract We recently read with interest the study by Kuik et al. [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Intraoperative Bleeding in Pediatric Otolaryngology

    Antonino Maniaci / Salvatore Cocuzza / Ron B. Mitchell / Ignazio La Mantia / Luigi La Via

    Pediatric Reports, Vol 15, Iss 4, Pp 707-

    Trends and Future Perspectives

    2023  Volume 709

    Abstract: A significant challenge that ENT surgeons often encounter is managing intraoperative bleeding, a task that requires precision, adept judgment, and a thorough knowledge of the latest techniques and procedures [.] ...

    Abstract A significant challenge that ENT surgeons often encounter is managing intraoperative bleeding, a task that requires precision, adept judgment, and a thorough knowledge of the latest techniques and procedures [.]
    Keywords n/a ; Medicine ; R ; Pediatrics ; RJ1-570
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Caution Is Warranted When Assessing Diastolic Function Using Transesophageal Echocardiography. Comment on Kyle et al. Consensus Defined Diastolic Dysfunction and Cardiac Postoperative Morbidity Score

    Filippo Sanfilippo / Luigi La Via / Simone Messina / Bruno Lanzafame / Veronica Dezio / Marinella Astuto

    Journal of Clinical Medicine, Vol 11, Iss 3105, p

    A Prospective Observational Study. J. Clin. Med. 2021, 10 , 5198

    2022  Volume 3105

    Abstract: Kyle et al. [.] ...

    Abstract Kyle et al. [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Non-Invasive Monitoring during Caesarean Delivery

    Francesco Vasile / Luigi La Via / Paolo Murabito / Stefano Tigano / Federica Merola / Tiziana Nicosia / Giuseppe De Masi / Andrea Bruni / Eugenio Garofalo / Filippo Sanfilippo

    Journal of Clinical Medicine, Vol 12, Iss 23, p

    Prevalence of Hypotension and Impact on the Newborn

    2023  Volume 7295

    Abstract: Background: The aim of our study was to investigate the prevalence of perioperative hypotension after spinal anesthesia for cesarean section using non-invasive continuous hemodynamic monitoring and its correlation with neonatal well-being. Methods: We ... ...

    Abstract Background: The aim of our study was to investigate the prevalence of perioperative hypotension after spinal anesthesia for cesarean section using non-invasive continuous hemodynamic monitoring and its correlation with neonatal well-being. Methods: We included 145 patients. Spinal anesthesia was performed with a combination of hyperbaric bupivacaine 0.5% (according to a weight/height scheme) and fentanyl 20 μg. Hypotension was defined as a mean arterial pressure (MAP) < 65 mmHg or <60 mmHg. We also evaluated the impact of hypotension on neonatal well-being. Results: Perioperative maternal hypotension occurred in 54.5% of cases considering a MAP < 65 mmHg and in 42.1% with the more conservative cut-off (<60 mmHg). Severe neonatal acidosis occurred in 1.4% of neonates, while an Apgar score ≥ 9 was observed in 95.9% at 1 min and 100% at 5 min. Conclusions: Continuous non-invasive hemodynamic monitoring allowed an early detection of maternal hypotension leading to a prompt treatment with satisfactory results considering neonatal well-being.
    Keywords caesarean section ; maternal hypotension ; neonatal well-being ; hemodynamic monitoring ; blood pressure ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Targeted Temperature Management after Cardiac Arrest

    Filippo Sanfilippo / Luigi La Via / Bruno Lanzafame / Veronica Dezio / Diana Busalacchi / Antonio Messina / Giuseppe Ristagno / Paolo Pelosi / Marinella Astuto

    Journal of Clinical Medicine, Vol 10, Iss 3943, p

    A Systematic Review and Meta-Analysis with Trial Sequential Analysis

    2021  Volume 3943

    Abstract: Target temperature management (TTM) in cardiac arrest (CA) survivors is recommended after hospital admission for its possible beneficial effects on survival and neurological outcome. Whether a lower target temperature (i.e., 32–34 °C) improves outcomes ... ...

    Abstract Target temperature management (TTM) in cardiac arrest (CA) survivors is recommended after hospital admission for its possible beneficial effects on survival and neurological outcome. Whether a lower target temperature (i.e., 32–34 °C) improves outcomes is unclear. We conducted a systematic review and meta-analysis on Pubmed and EMBASE to evaluate the effects on mortality and neurologic outcome of TTM at 32–34 °C as compared to controls (patients cared with “actively controlled” or “uncontrolled” normothermia). Results were analyzed via risk ratios (RR) and 95% confidence intervals (CI). Eight randomized controlled trials (RCTs) were included. TTM at 32–34 °C was compared to “actively controlled” normothermia in three RCTs and to “uncontrolled” normothermia in five RCTs. TTM at 32–34 °C does not improve survival as compared to normothermia (RR:1.06 (95%CI 0.94, 1.20), p = 0.36; I 2 = 39%). In the subgroup analyses, TTM at 32–34 °C is associated with better survival when compared to “uncontrolled” normothermia (RR: 1.31 (95%CI 1.07, 1.59), p = 0.008) but shows no beneficial effects when compared to “actively controlled” normothermia (RR: 0.97 (95%CI 0.90, 1.04), p = 0.41). TTM at 32–34 °C does not improve neurological outcome as compared to normothermia (RR: 1.17 (95%CI 0.97, 1.41), p = 0.10; I 2 = 60%). TTM at 32–34 °C increases the risk of arrhythmias (RR: 1.35 (95%CI 1.16, 1.57), p = 0.0001, I 2 = 0%). TTM at 32–34 °C does not improve survival nor neurological outcome after CA and increases the risk of arrhythmias.
    Keywords cardiac arrest ; hospital discharge ; neurological outcome ; cerebral performance category ; mortality ; Medicine ; R
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Proactive Management of Intraoperative Hypotension Reduces Biomarkers of Organ Injury and Oxidative Stress during Elective Non-Cardiac Surgery

    Paolo Murabito / Marinella Astuto / Filippo Sanfilippo / Luigi La Via / Francesco Vasile / Francesco Basile / Alessandro Cappellani / Lucia Longhitano / Alfio Distefano / Giovanni Li Volti

    Journal of Clinical Medicine, Vol 11, Iss 392, p

    A Pilot Randomized Controlled Trial

    2022  Volume 392

    Abstract: Background: Intraoperative hypotension is associated with increased postoperative morbidity and mortality. Methods: We randomly assigned patients undergoing major general surgery to early warning system (EWS) and hemodynamic algorithm (intervention group, ...

    Abstract Background: Intraoperative hypotension is associated with increased postoperative morbidity and mortality. Methods: We randomly assigned patients undergoing major general surgery to early warning system (EWS) and hemodynamic algorithm (intervention group, n = 20) or standard care ( n = 20). The primary outcome was the difference in hypotension (defined as mean arterial pressure < 65 mmHg) and as secondary outcome surrogate markers of organ injury and oxidative stress. Results: The median number of hypotensive episodes was lower in the intervention group (−5.0 (95% CI: −9.0, −0.5); p < 0.001), with lower time spent in hypotension (−12.8 min (95% CI: −38.0, −2.3 min); p = 0.048), correspondent to −4.8% of total surgery time (95% CI: −12.7, 0.01%; p = 0.048).The median time-weighted average of hypotension was 0.12 mmHg (0.35) in the intervention group and 0.37 mmHg (1.11) in the control group, with a median difference of −0.25 mmHg (95% CI: −0.85, −0.01; p = 0.025). Neutrophil Gelatinase-Associated Lipocalin (NGAL) correlated with time-weighted average of hypotension (R = 0.32; p = 0.038) and S100B with number of hypotensive episodes, absolute time of hypotension, relative time of hypotension and time-weighted average of hypotension ( p < 0.001 for all). The intervention group showed lower Neuronal Specific Enolase (NSE) and higher reduced glutathione when compared to the control group. Conclusions: The use of an EWS coupled with a hemodynamic algorithm resulted in reduced intraoperative hypotension, reduced NSE and oxidative stress.
    Keywords hypotension ; organ injury ; surgery ; biomarkers ; oxidative stress ; Medicine ; R
    Subject code 796
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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