LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 8 of total 8

Search options

  1. Article ; Online: Impaired glucose tolerance with neurological manifestations in insulinoma

    Luis Geraldine Villanueva‐Rodríguez / Alfredo Adolfo Reza‐Albarrán / Enrique Cárdenas / Arturo Ángeles / Jacobo Lester

    Clinical Case Reports, Vol 9, Iss 9, Pp n/a-n/a (2021)

    2021  

    Abstract: Abstract Insulinoma may have an atypical presentation and it should be suspected in patients with neurological manifestations in spite of an atypical insulin and proinsulin levels associated with hypoglycemia. Fast test is an important tool to reach the ... ...

    Abstract Abstract Insulinoma may have an atypical presentation and it should be suspected in patients with neurological manifestations in spite of an atypical insulin and proinsulin levels associated with hypoglycemia. Fast test is an important tool to reach the diagnosis.
    Keywords hypoglycemia ; insulinoma ; neurological symptoms ; proinsulin ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article: Impaired glucose tolerance with neurological manifestations in insulinoma.

    Villanueva-Rodríguez, Luis Geraldine / Reza-Albarrán, Alfredo Adolfo / Cárdenas, Enrique / Ángeles, Arturo / Lester, Jacobo

    Clinical case reports

    2021  Volume 9, Issue 9, Page(s) e04532

    Abstract: Insulinoma may have an atypical presentation and it should be suspected in patients with neurological manifestations in spite of an atypical insulin and proinsulin levels associated with hypoglycemia. Fast test is an important tool to reach the diagnosis. ...

    Abstract Insulinoma may have an atypical presentation and it should be suspected in patients with neurological manifestations in spite of an atypical insulin and proinsulin levels associated with hypoglycemia. Fast test is an important tool to reach the diagnosis.
    Language English
    Publishing date 2021-09-12
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.4532
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells.

    Rademaker, Gilles / Boumahd, Yasmine / Peiffer, Raphaël / Anania, Sandy / Wissocq, Tom / Liégeois, Maude / Luis, Géraldine / Sounni, Nor Eddine / Agirman, Ferman / Maloujahmoum, Naïma / De Tullio, Pascal / Thiry, Marc / Bellahcène, Akeila / Castronovo, Vincent / Peulen, Olivier

    Redox biology

    2022  Volume 53, Page(s) 102324

    Abstract: Myoferlin, an emerging oncoprotein, has been associated with a low survival in several cancer types including pancreas ductal adenocarcinoma where it controls mitochondria structure and respiratory functions. Owing to the high susceptibility of KRAS- ... ...

    Abstract Myoferlin, an emerging oncoprotein, has been associated with a low survival in several cancer types including pancreas ductal adenocarcinoma where it controls mitochondria structure and respiratory functions. Owing to the high susceptibility of KRAS-mutated cancer cells to iron-dependent cell death, ferroptosis, and to the high iron content in mitochondria, we investigated the relation existing between mitochondrial integrity and iron-dependent cell death. We discovered that myoferlin targeting with WJ460 pharmacological compound triggered mitophagy and ROS accumulation culminating with lipid peroxidation and apoptosis-independent cell death. WJ460 caused a reduction of the abundance of ferroptosis core regulators x
    MeSH term(s) Ferroptosis ; Humans ; Iron/metabolism ; Lipid Peroxidation ; Mitophagy ; Pancreas ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Reactive Oxygen Species/metabolism
    Chemical Substances Reactive Oxygen Species ; Iron (E1UOL152H7)
    Language English
    Publishing date 2022-05-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2022.102324
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Novel Loss of Function Variant in BCKDK Causes a Treatable Developmental and Epileptic Encephalopathy.

    Boemer, François / Josse, Claire / Luis, Géraldine / Di Valentin, Emmanuel / Thiry, Jérôme / Cello, Christophe / Caberg, Jean-Hubert / Dadoumont, Caroline / Harvengt, Julie / Lumaka, Aimé / Bours, Vincent / Debray, François-Guillaume

    International journal of molecular sciences

    2022  Volume 23, Issue 4

    Abstract: Branched-chain amino acids (BCAA) are essential amino acids playing crucial roles in protein synthesis and brain neurotransmission. Branched-chain ketoacid dehydrogenase (BCKDH), the flux-generating step of BCAA catabolism, is tightly regulated by ... ...

    Abstract Branched-chain amino acids (BCAA) are essential amino acids playing crucial roles in protein synthesis and brain neurotransmission. Branched-chain ketoacid dehydrogenase (BCKDH), the flux-generating step of BCAA catabolism, is tightly regulated by reversible phosphorylation of its E1α-subunit. BCKDK is the kinase responsible for the phosphorylation-mediated inactivation of BCKDH. In three siblings with severe developmental delays, microcephaly, autism spectrum disorder and epileptic encephalopathy, we identified a new homozygous in-frame deletion (c.999_1001delCAC; p.Thr334del) of
    MeSH term(s) 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)/genetics ; Amino Acid Sequence ; Amino Acids, Branched-Chain/genetics ; Autism Spectrum Disorder/genetics ; Autism Spectrum Disorder/pathology ; Brain/pathology ; Brain Diseases/genetics ; Brain Diseases/pathology ; Cell Line ; Epilepsy, Generalized/genetics ; Female ; HEK293 Cells ; Humans ; Loss of Function Mutation/genetics ; Male ; Phosphorylation/genetics ; Retrospective Studies
    Chemical Substances Amino Acids, Branched-Chain ; 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) (EC 1.2.4.4)
    Language English
    Publishing date 2022-02-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23042253
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Tumor resistance to ferroptosis driven by Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells and Fatty Acid Biding Protein-4 (FABP4) in tumor microenvironment promote tumor recurrence.

    Luis, Géraldine / Godfroid, Adrien / Nishiumi, Shin / Cimino, Jonathan / Blacher, Silvia / Maquoi, Erik / Wery, Coline / Collignon, Alice / Longuespée, Rémi / Montero-Ruiz, Laetitia / Dassoul, Isabelle / Maloujahmoum, Naima / Pottier, Charles / Mazzucchelli, Gabriel / Depauw, Edwin / Bellahcène, Akeila / Yoshida, Masaru / Noel, Agnès / Sounni, Nor Eddine

    Redox biology

    2021  Volume 43, Page(s) 102006

    Abstract: Problem: Tumor recurrence is a major clinical issue that represents the principal cause of cancer-related deaths, with few targetable common pathways. Mechanisms by which residual tumors persist and progress under a continuous shift between hypoxia- ... ...

    Abstract Problem: Tumor recurrence is a major clinical issue that represents the principal cause of cancer-related deaths, with few targetable common pathways. Mechanisms by which residual tumors persist and progress under a continuous shift between hypoxia-reoxygenation after neoadjuvent-therapy are unknown. In this study, we investigated the role of lipid metabolism and tumor redox balance in tumor recurrence.
    Methods: Lipidomics, proteomics and mass spectrometry imaging approaches where applied to mouse tumor models of recurrence. Genetic and pharmacological inhibitions of lipid mediators in tumors were used in vivo and in functional assays in vitro.
    Results: We found that stearoyl-CoA desaturase-1 (SCD1) expressed by cancer cells and fatty acid binding protein-4 (FABP4) produced by tumor endothelial cells (TECs) and adipocytes in the tumor microenvironment (TME) are essential for tumor relapse in response to tyrosine kinase inhibitors (TKI) and chemotherapy. SCD1 and FABP4 were also found upregulated in recurrent human breast cancer samples and correlated with worse prognosis of cancer patients with different types of tumors. Mechanistically, SCD1 leads to fatty acid (FA) desaturation and FABP4 derived from TEM enhances lipid droplet (LD) in cancer cells, which cooperatively protect from oxidative stress-induced ferroptosis. We revealed that lipid mobilization and desaturation elicit tumor intrinsic antioxidant and anti-ferroptotic resources for survival and regrowth in a harsh TME. Inhibition of lipid transport from TME by FABP4 inhibitor reduced tumor regrowth and by genetic - or by pharmacological - targeting SCD1 in vivo, tumor regrowth was abolished completely.
    Conclusion: This finding unveils that it is worth taking advantage of tumor lipid addiction, as a tumor vulnerability to design novel treatment strategy to prevent cancer recurrence.
    MeSH term(s) Endothelial Cells/metabolism ; Fatty Acid-Binding Proteins ; Fatty Acids ; Ferroptosis ; Humans ; Neoplasm Recurrence, Local ; Stearoyl-CoA Desaturase/metabolism ; Tumor Microenvironment
    Chemical Substances FABP4 protein, human ; Fatty Acid-Binding Proteins ; Fatty Acids ; SCD1 protein, human (EC 1.14.19.1) ; Stearoyl-CoA Desaturase (EC 1.14.19.1)
    Language English
    Publishing date 2021-05-14
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2021.102006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Streptomyces lunaelactis sp. nov., a novel ferroverdin A-producing Streptomyces species isolated from a moonmilk speleothem.

    Maciejewska, Marta / Pessi, Igor Stelmach / Arguelles-Arias, Anthony / Noirfalise, Pauline / Luis, Géraldine / Ongena, Marc / Barton, Hazel / Carnol, Monique / Rigali, Sébastien

    Antonie van Leeuwenhoek

    2015  Volume 107, Issue 2, Page(s) 519–531

    Abstract: A novel actinobacterium, designated MM109(T), was isolated from a moonmilk deposit collected from the cave 'Grotte des Collemboles' located in Comblain-au-Pont, Belgium. Based on a polyphasic taxonomic approach comprising chemotaxonomic, phylogenetic, ... ...

    Abstract A novel actinobacterium, designated MM109(T), was isolated from a moonmilk deposit collected from the cave 'Grotte des Collemboles' located in Comblain-au-Pont, Belgium. Based on a polyphasic taxonomic approach comprising chemotaxonomic, phylogenetic, morphological, and physiological characterization, the isolate has been affiliated to the genus Streptomyces. Multilocus sequence analysis based on the 16S rRNA gene and five other house-keeping genes (atpD, gyrB, rpoB, recA and trpB) showed that the MM109(T) isolate is sufficiently distinct from its closest relative, Streptomyces peucetius strain AS 4.1799(T), as to represent a novel species. The phylogenetic distinctiveness of the taxon represented by isolate MM109(T) was supported by the isolation and identification of additional twelve moonmilk-derived isolates, which according to multilocus sequence analysis were clustered along with MM109(T). Scanning electron microscopy observations revealed complex and diversified structures within a MM109(T) colony, made from branching vegetative mycelia. The spore chains of the MM109(T) isolate undergo complete septation at the late stages of the morphological differentiation process, leading to the formation of packs of smooth cylindrical-shaped spores. Isolate MM109(T) produces several intracellular and diffusible pigments, particularly an intracellular green-pigmented secondary metabolite, which was identified through UPLC-ESI-MS analysis as ferroverdin A, an iron-chelating molecule formerly extracted and characterized from Streptomyces sp. strain WK-5344. The isolate MM109(T) is thus considered to represent a novel species of Streptomyces, for which the name Streptomyces lunaelactis sp. nov. is proposed with the type strain MM109(T) (=DSM 42149(T) = BCCM/LMG 28326(T)).
    MeSH term(s) Bacterial Proteins/genetics ; Bacterial Typing Techniques ; Belgium ; Cluster Analysis ; DNA, Bacterial/chemistry ; DNA, Bacterial/genetics ; DNA, Ribosomal/chemistry ; DNA, Ribosomal/genetics ; Environmental Microbiology ; Ferrous Compounds/metabolism ; Microscopy, Electron, Scanning ; Molecular Sequence Data ; Nitroso Compounds/metabolism ; Phylogeny ; Pigments, Biological/analysis ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA ; Streptomyces/classification ; Streptomyces/genetics ; Streptomyces/isolation & purification ; Streptomyces/metabolism
    Chemical Substances Bacterial Proteins ; DNA, Bacterial ; DNA, Ribosomal ; Ferrous Compounds ; Nitroso Compounds ; Pigments, Biological ; RNA, Ribosomal, 16S ; ferroverdin (26671-45-4)
    Language English
    Publishing date 2015-02
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 214861-4
    ISSN 1572-9699 ; 0003-6072
    ISSN (online) 1572-9699
    ISSN 0003-6072
    DOI 10.1007/s10482-014-0348-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.94: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Streptomyces lunaelactis sp. nov., a novel ferroverdin A-producing Streptomyces species isolated from a moonmilk speleothem

    Maciejewska, Marta / Pessi, Igor Stelmach / Arguelles-Arias, Anthony / Noirfalise, Pauline / Luis, Géraldine / Ongena, Marc / Barton, Hazel / Carnol, Monique / Rigali, Sébastien

    Antonie van Leeuwenhoek. 2015 Feb., v. 107, no. 2

    2015  

    Abstract: A novel actinobacterium, designated MM109ᵀ, was isolated from a moonmilk deposit collected from the cave ‘Grotte des Collemboles’ located in Comblain-au-Pont, Belgium. Based on a polyphasic taxonomic approach comprising chemotaxonomic, phylogenetic, ... ...

    Abstract A novel actinobacterium, designated MM109ᵀ, was isolated from a moonmilk deposit collected from the cave ‘Grotte des Collemboles’ located in Comblain-au-Pont, Belgium. Based on a polyphasic taxonomic approach comprising chemotaxonomic, phylogenetic, morphological, and physiological characterization, the isolate has been affiliated to the genus Streptomyces. Multilocus sequence analysis based on the 16S rRNA gene and five other house-keeping genes (atpD, gyrB, rpoB, recA and trpB) showed that the MM109ᵀisolate is sufficiently distinct from its closest relative, Streptomyces peucetius strain AS 4.1799ᵀ, as to represent a novel species. The phylogenetic distinctiveness of the taxon represented by isolate MM109ᵀwas supported by the isolation and identification of additional twelve moonmilk-derived isolates, which according to multilocus sequence analysis were clustered along with MM109ᵀ. Scanning electron microscopy observations revealed complex and diversified structures within a MM109ᵀcolony, made from branching vegetative mycelia. The spore chains of the MM109ᵀisolate undergo complete septation at the late stages of the morphological differentiation process, leading to the formation of packs of smooth cylindrical-shaped spores. Isolate MM109ᵀproduces several intracellular and diffusible pigments, particularly an intracellular green-pigmented secondary metabolite, which was identified through UPLC-ESI–MS analysis as ferroverdin A, an iron-chelating molecule formerly extracted and characterized from Streptomyces sp. strain WK-5344. The isolate MM109ᵀis thus considered to represent a novel species of Streptomyces, for which the name Streptomyces lunaelactis sp. nov. is proposed with the type strain MM109ᵀ(=DSM 42149ᵀ = BCCM/LMG 28326ᵀ).
    Keywords Streptomyces peucetius ; branching ; chemotaxonomy ; essential genes ; metabolites ; multilocus sequence typing ; mycelium ; new species ; phylogeny ; pigments ; ribosomal RNA ; scanning electron microscopy ; spores ; Belgium
    Language English
    Dates of publication 2015-02
    Size p. 519-531.
    Publishing place Springer-Verlag
    Document type Article
    ZDB-ID 214861-4
    ISSN 1572-9699 ; 0003-6072
    ISSN (online) 1572-9699
    ISSN 0003-6072
    DOI 10.1007/s10482-014-0348-4
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.94: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Streptomyces lunaelactis sp. nov., a novel ferroverdin A-producing Streptomyces species isolated from a moonmilk speleothem

    Maciejewska, Marta / Pessi, Igor Stelmach / Arguelles-Arias, Anthony / Noirfalise, Pauline / Luis, Géraldine / Ongena, Marc / Barton, Hazel / Carnol, Monique / Rigali, Sébastien

    Antonie van Leeuwenhoek

    Volume v. 107,, Issue no. 2

    Abstract: A novel actinobacterium, designated MM109ᵀ, was isolated from a moonmilk deposit collected from the cave ‘Grotte des Collemboles’ located in Comblain-au-Pont, Belgium. Based on a polyphasic taxonomic approach comprising chemotaxonomic, phylogenetic, ... ...

    Abstract A novel actinobacterium, designated MM109ᵀ, was isolated from a moonmilk deposit collected from the cave ‘Grotte des Collemboles’ located in Comblain-au-Pont, Belgium. Based on a polyphasic taxonomic approach comprising chemotaxonomic, phylogenetic, morphological, and physiological characterization, the isolate has been affiliated to the genus Streptomyces. Multilocus sequence analysis based on the 16S rRNA gene and five other house-keeping genes (atpD, gyrB, rpoB, recA and trpB) showed that the MM109ᵀisolate is sufficiently distinct from its closest relative, Streptomyces peucetius strain AS 4.1799ᵀ, as to represent a novel species. The phylogenetic distinctiveness of the taxon represented by isolate MM109ᵀwas supported by the isolation and identification of additional twelve moonmilk-derived isolates, which according to multilocus sequence analysis were clustered along with MM109ᵀ. Scanning electron microscopy observations revealed complex and diversified structures within a MM109ᵀcolony, made from branching vegetative mycelia. The spore chains of the MM109ᵀisolate undergo complete septation at the late stages of the morphological differentiation process, leading to the formation of packs of smooth cylindrical-shaped spores. Isolate MM109ᵀproduces several intracellular and diffusible pigments, particularly an intracellular green-pigmented secondary metabolite, which was identified through UPLC-ESI–MS analysis as ferroverdin A, an iron-chelating molecule formerly extracted and characterized from Streptomyces sp. strain WK-5344. The isolate MM109ᵀis thus considered to represent a novel species of Streptomyces, for which the name Streptomyces lunaelactis sp. nov. is proposed with the type strain MM109ᵀ(=DSM 42149ᵀ = BCCM/LMG 28326ᵀ).
    Keywords metabolites ; new species ; phylogeny ; pigments ; ribosomal RNA ; chemotaxonomy ; multilocus sequence typing ; spores ; Streptomyces peucetius ; branching ; essential genes ; scanning electron microscopy ; mycelium
    Language English
    Document type Article
    ISSN 0003-6072
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top