Article ; Online: Detection of non-alcoholic steatohepatitis in patients with morbid obesity before bariatric surgery: preliminary evaluation with acoustic radiation force impulse imaging.
2012 Volume 22, Issue 11, Page(s) 2525–2532
Abstract: Objective: To investigate the utility of acoustic radiation force impulse (ARFI) imaging, with the determination of shear wave velocity (SWV), to differentiate non-alcoholic fatty liver disease (NAFLD) from non-alcoholic steatohepatitis (NASH) in ... ...
| Abstract | Objective: To investigate the utility of acoustic radiation force impulse (ARFI) imaging, with the determination of shear wave velocity (SWV), to differentiate non-alcoholic fatty liver disease (NAFLD) from non-alcoholic steatohepatitis (NASH) in patients with morbid obesity before bariatric surgery. Methods: Thirty-two patients with morbid obesity were evaluated with ARFI and conventional ultrasound before bariatric surgery. The ARFI and ultrasound results were compared with liver biopsy findings, which is the reference standard. The patients were classed according to their histological findings into three groups: group A, simple steatosis; group B, inflammation; and group C, fibrosis. Results: The median SWV was 1.57 ± 0.79 m/s. Hepatic alterations were observed in the histopathological findings for all the patients in the study (100 %), with the results of the laboratory tests proving normal. Differences in SWV were also observed between groups A, B and C: 1.34 ± 0.90 m/s, 1.55 ± 0.79 m/s and 1.86 ± 0.75 m/s (P < 0.001), respectively. The Az for differentiating NAFLD from NASH or fibrosis was 0.899 (optimal cut-off value 1.3 m/s; sensitivity 85 %; specificity 83.3 %). Conclusion: The ARFI technique is a useful diagnostic tool for differentiating NAFLD from NASH in asymptomatic patients with morbid obesity. Key points : • Acoustic radiation force impulse imaging provides ultrasonic shear wave velocity measurements. • SWV measurements were higher in patients with inflammation or fibrosis than NAFLD. • ARFI differentiates NAFLD from NASH in patients with morbid obesity. • Results suggest that ARFI can detect NASH in asymptomatic morbidly obese patients. |
|---|---|
| MeSH term(s) | Acoustics ; Adult ; Bariatric Surgery/methods ; Biopsy ; Fatty Liver/complications ; Fatty Liver/diagnosis ; Female ; Humans ; Inflammation ; Liver/diagnostic imaging ; Liver/physiopathology ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease ; Obesity, Morbid/complications ; Prospective Studies ; ROC Curve ; Reference Standards ; Reproducibility of Results ; Shear Strength ; Stress, Mechanical ; Ultrasonography/methods |
| Language | English |
| Publishing date | 2012-06-01 |
| Publishing country | Germany |
| Document type | Journal Article |
| ZDB-ID | 1085366-2 |
| ISSN | 1432-1084 ; 0938-7994 ; 1613-3749 |
| ISSN (online) | 1432-1084 |
| ISSN | 0938-7994 ; 1613-3749 |
| DOI | 10.1007/s00330-012-2505-3 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 3300: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.