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  1. Article: Peanut allergy and oral immunotherapy.

    Lee, T H / Chan, J K C / Lau, P C / Luk, W P / Fung, L H

    Hong Kong medical journal = Xianggang yi xue za zhi

    2019  Volume 25, Issue 3, Page(s) 228–234

    Abstract: Peanut allergy is the commonest cause of food-induced anaphylaxis in the world, and it can be fatal. There have been many recent improvements to achieve safe methods of peanut desensitisation, one of which is to use a combination of anti-immunoglobulin E ...

    Abstract Peanut allergy is the commonest cause of food-induced anaphylaxis in the world, and it can be fatal. There have been many recent improvements to achieve safe methods of peanut desensitisation, one of which is to use a combination of anti-immunoglobulin E and oral immunotherapy. We have treated 27 patients with anti-immunoglobulin E and oral immunotherapy, and report on the outcomes and incidence of adverse reactions encountered during treatment. The dose of peanut protein tolerated increased from a median baseline of 5 to 2000 mg after desensitisation, which is substantially more than would be encountered through accidental ingestion. The incidence of adverse reactions during the escalation phase of oral immunotherapy was 1.8%, and that during the maintenance phase was 0.6%. Most adverse reactions were mild; three episodes were severe enough to warrant withdrawal from oral immunotherapy, but none required epinephrine injection. Preliminary data suggest that unresponsiveness is lost when daily ingestion of peanuts is stopped after the maintenance period.
    MeSH term(s) Administration, Oral ; Adolescent ; Allergens/administration & dosage ; Allergens/immunology ; Arachis/immunology ; Child ; Desensitization, Immunologic/adverse effects ; Desensitization, Immunologic/methods ; Epinephrine/therapeutic use ; Female ; Histamine H1 Antagonists/therapeutic use ; Humans ; Immunologic Factors/adverse effects ; Male ; Peanut Hypersensitivity/immunology ; Peanut Hypersensitivity/therapy
    Chemical Substances Allergens ; Histamine H1 Antagonists ; Immunologic Factors ; Epinephrine (YKH834O4BH)
    Language English
    Publishing date 2019-06-10
    Publishing country China
    Document type Journal Article
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
    DOI 10.12809/hkmj187743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4347: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Serological response to mRNA and inactivated COVID-19 vaccine in healthcare workers in Hong Kong: decline in antibodies 12 weeks after two doses.

    Zee, J S T / Lai, K T W / Ho, M K S / Leung, A C P / Fung, L H / Luk, W P / Kwok, L F / Kee, K M / Chan, Q W L / Tang, S F / Ma, E S K / Lee, K H / Lau, C C / Yung, R W H

    Hong Kong medical journal = Xianggang yi xue za zhi

    2021  Volume 27, Issue 5, Page(s) 380–383

    MeSH term(s) Adult ; Antibodies, Neutralizing/blood ; BNT162 Vaccine ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/immunology ; Female ; Health Personnel/statistics & numerical data ; Hong Kong/epidemiology ; Humans ; Immunogenicity, Vaccine ; Immunoglobulin G/blood ; Logistic Models ; Male ; Middle Aged ; SARS-CoV-2 ; Serologic Tests/methods ; Serologic Tests/statistics & numerical data ; Spike Glycoprotein, Coronavirus/immunology ; Vaccines, Inactivated/administration & dosage ; Vaccines, Inactivated/immunology ; Vaccines, Synthetic/administration & dosage ; Vaccines, Synthetic/immunology ; mRNA Vaccines
    Chemical Substances Antibodies, Neutralizing ; COVID-19 Vaccines ; Immunoglobulin G ; Spike Glycoprotein, Coronavirus ; Vaccines, Inactivated ; Vaccines, Synthetic ; BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2021-10-18
    Publishing country China
    Document type Comparative Study ; Letter
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
    DOI 10.12809/hkmj219744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4347: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Decomposing rhythmic hippocampal data to obtain neuronal correlates.

    Gillis, J A / Luk, W P / Zhang, L / Skinner, F K

    Journal of neuroscience methods

    2005  Volume 147, Issue 2, Page(s) 99–113

    Abstract: Characterizing hippocampal electrical rhythmic activities requires a broadly applicable methodology that lends itself to physiological interpretation. In the intact hippocampal preparation, spontaneous rhythmic field potentials are exhibited in the 3--4 ... ...

    Abstract Characterizing hippocampal electrical rhythmic activities requires a broadly applicable methodology that lends itself to physiological interpretation. In the intact hippocampal preparation, spontaneous rhythmic field potentials are exhibited in the 3--4 Hz range which evidence suggests is due to discharges in the inhibitory interneuron population. Because field rhythms arise as a network effect and models must be built from the neuron up, we focus on developing a methodology to de-construct the non-stationary rhythms into its important constituents. This study uses 50 CA1/CA3 local field potentials to determine the important constituents, and an additional field recording and two intracellular recordings are examined subsequently. We determine the suitability of several time-frequency techniques. Distinct regions in the time-frequency domain which account for the signal behaviour are then characterized in terms of duration and frequency. These characteristics are interpreted as arising from a statistical mixture distribution. The decomposition of the 50 recordings yields three components whose patterns of activity match those of the intracellular recordings. We suggest that the statistical variability of the local field data can be linked to the variability of neuronal activities seen in intracellular data.
    MeSH term(s) Action Potentials/physiology ; Animals ; Animals, Newborn ; Electrophysiology/methods ; Fourier Analysis ; Hippocampus/cytology ; Hippocampus/physiology ; Mice ; Neural Inhibition/physiology ; Neurons/physiology ; Periodicity ; Spectrum Analysis/methods ; Time Factors
    Language English
    Publishing date 2005-09-30
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 282721-9
    ISSN 1872-678X ; 0165-0270
    ISSN (online) 1872-678X
    ISSN 0165-0270
    DOI 10.1016/j.jneumeth.2005.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1486: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Adenosine: a mediator of interleukin-1beta-induced hippocampal synaptic inhibition.

    Luk, W P / Zhang, Y / White, T D / Lue, F A / Wu, C / Jiang, C G / Zhang, L / Moldofsky, H

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    1999  Volume 19, Issue 11, Page(s) 4238–4244

    Abstract: Interleukin-1 (IL-1) is a pleotrophic cytokine implicated in a variety of central activities, including fever, sleep, ischemic injury, and neuromodulatory responses, such as neuroimmune, and neuroendocrine interactions. Although accumulating evidence is ... ...

    Abstract Interleukin-1 (IL-1) is a pleotrophic cytokine implicated in a variety of central activities, including fever, sleep, ischemic injury, and neuromodulatory responses, such as neuroimmune, and neuroendocrine interactions. Although accumulating evidence is available regarding the expression pattern of this cytokine, its receptors in the CNS, and its mechanistic profile under pathological levels, it is unclear whether this substance modulates central neurons under physiological concentrations. Further, in light of the functional and spatial overlap between the adenosine and IL-1 systems, it is not known whether these two systems are coupled. We report here that, in rat brain slices, brief application of sub-femtomolar IL-1beta causes a profound decrease of glutamate transmission, but not GABAergic inhibition, in hippocampal CA1 pyramidal neurons. This decrease by IL-1beta is prevented by pharmacological blockade of adenosine A1 receptors. In addition, we show that IL-1beta failed to suppress glutamate transmission at room temperature. Because the production and release of adenosine in the CNS is thought to be metabolically dependent, this observation suggests that one of the functions of IL-1beta is to increase the endogenous production of adenosine. Together, these data suggest for the first time that sub-femtomolar levels of IL-1 can effectively modulate glutamate excitation in hippocampal neurons via an adenosine-dependent mechanism.
    MeSH term(s) Adenosine/physiology ; Animals ; Excitatory Postsynaptic Potentials/drug effects ; Hippocampus/drug effects ; Interleukin-1/pharmacology ; Male ; Neural Inhibition/drug effects ; Rats ; Rats, Wistar ; Synaptic Transmission/drug effects
    Chemical Substances Interleukin-1 ; Adenosine (K72T3FS567)
    Language English
    Publishing date 1999-06-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1668: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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