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  1. Article ; Online: Leptomeningeal metastases-What outcomes should we measure and how?

    Lukas, Rimas V

    Neuro-oncology

    2022  Volume 24, Issue 10, Page(s) 1736–1737

    MeSH term(s) Diagnostic Imaging ; Humans ; Meningeal Carcinomatosis/diagnosis
    Language English
    Publishing date 2022-04-14
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/noac101
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    Zs.A 5307: Show issues Location:
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  2. Article ; Online: Introduction to the evolving landscape of the management of glioblastoma.

    Lukas, Rimas V

    Chinese clinical oncology

    2021  Volume 10, Issue 4, Page(s) 34

    MeSH term(s) Brain Neoplasms/therapy ; Glioblastoma/therapy ; Humans
    Language English
    Publishing date 2021-09-20
    Publishing country China
    Document type Editorial
    ZDB-ID 2828547-5
    ISSN 2304-3873 ; 2304-3873
    ISSN (online) 2304-3873
    ISSN 2304-3873
    DOI 10.21037/cco-21-106
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  3. Article ; Online: Commentary: Long-Term Outcomes of Intra-Arterial Chemotherapy for Progressive or Unresectable Pilocytic Astrocytomas: Case Studies.

    Lukas, Rimas V

    Neurosurgery

    2021  Volume 88, Issue 4, Page(s) E343–E344

    MeSH term(s) Astrocytoma/drug therapy ; Brain Neoplasms/drug therapy ; Humans
    Language English
    Publishing date 2021-01-29
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyab009
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  4. Article ; Online: Essential oils for blood-brain barrier disruption: Preclinical studies of NEO100 in breast cancer brain metastases.

    Lukas, Rimas V

    Neuro-oncology

    2021  Volume 23, Issue 10, Page(s) 1621–1622

    MeSH term(s) Blood-Brain Barrier/metabolism ; Brain Neoplasms/drug therapy ; Breast Neoplasms/drug therapy ; Female ; Humans ; Oils, Volatile ; Receptor, ErbB-2/metabolism
    Chemical Substances Oils, Volatile ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2021-07-07
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/noab167
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  5. Article ; Online: The kynurenine pathway implicated in patient delirium: possible indications for indoleamine 2,3 dioxygenase inhibitors.

    Heimberger, Amy B / Lukas, Rimas V

    The Journal of clinical investigation

    2023  Volume 133, Issue 2

    Abstract: Tryptophan (Trp) metabolism plays a central role in sleep, mood, and immune system regulation. The kynurenine pathway (KP), which is regulated by the enzymes tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3 dioxygenase (IDO), which catalyze the ... ...

    Abstract Tryptophan (Trp) metabolism plays a central role in sleep, mood, and immune system regulation. The kynurenine pathway (KP), which is regulated by the enzymes tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3 dioxygenase (IDO), which catalyze the conversion of Trp to kynurenine (Kyn), facilitates immune regulation and influences neurocognition. Notably, Kyn metabolites bind the N-methyl-d-aspartate receptor (NMDAR), essential for memory encoding, and in turn, cognition. Aberrant NMDAR activity through agonist binding influences excitability and cell death. In this issue of the JCI, Watne and authors demonstrate that KP pathway end products were elevated in the serum and the cerebrospinal fluid (CSF) of subjects with delirium. This observation provides insight regarding the basis of a variety of commonly observed clinical conditions including sundowning, abnormal sleep-wake cycles in hospitalized patients, neurodegenerative cognitive impairment, radiation-induced cognitive impairment, neurocognitive symptomatology related to COVID-19, and clinical outcomes observed in patients with CNS tumors, such as gliomas.
    MeSH term(s) Humans ; Delirium ; Indoleamine-Pyrrole 2,3,-Dioxygenase/antagonists & inhibitors ; Kynurenine/metabolism ; Tryptophan/metabolism
    Chemical Substances Indoleamine-Pyrrole 2,3,-Dioxygenase ; Kynurenine (343-65-7) ; Tryptophan (8DUH1N11BX)
    Language English
    Publishing date 2023-01-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI164577
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  6. Article ; Online: Glioma Response to IDH Inhibition: Real-World Experience.

    Lukas, Rimas V / Horbinski, Craig

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2023  Volume 29, Issue 23, Page(s) 4709–4710

    Abstract: Treatment of IDH-mutated non-enhancing grade 2 and 3 diffuse gliomas with ivosidenib leads to reduction of tumor size when assessed via volumetric MRI. Isocitrate dehydrogenase inhibition has a therapeutic benefit in patients with these tumors. See ... ...

    Abstract Treatment of IDH-mutated non-enhancing grade 2 and 3 diffuse gliomas with ivosidenib leads to reduction of tumor size when assessed via volumetric MRI. Isocitrate dehydrogenase inhibition has a therapeutic benefit in patients with these tumors. See related article by Kamson et al., p. 4863.
    MeSH term(s) Humans ; Brain Neoplasms/drug therapy ; Brain Neoplasms/pathology ; Mutation ; Glioma/drug therapy ; Glioma/genetics ; Glioma/pathology ; Magnetic Resonance Imaging ; Isocitrate Dehydrogenase/genetics
    Chemical Substances Isocitrate Dehydrogenase (EC 1.1.1.41)
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-23-2164
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  7. Article ; Online: Commentary: Immune Checkpoint Inhibitors for Brain Metastases: A Primer for Neurosurgeons.

    Lukas, Rimas V

    Neurosurgery

    2020  Volume 87, Issue 3, Page(s) E289–E290

    MeSH term(s) Brain Neoplasms/drug therapy ; Humans ; Melanoma ; Neurosurgeons
    Language English
    Publishing date 2020-04-17
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyaa100
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  8. Article ; Online: Commentary: BRAF V600 Mutation and BRAF Kinase Inhibitors in Conjunction with Stereotactic Radiosurgery for Intracranial Melanoma Metastases: A Multicenter Retrospective Study.

    Lukas, Rimas V

    Neurosurgery

    2018  Volume 84, Issue 4, Page(s) 881–882

    MeSH term(s) Brain Neoplasms/surgery ; Humans ; Melanoma/surgery ; Mutation ; Proto-Oncogene Proteins B-raf/genetics ; Radiosurgery ; Retrospective Studies
    Chemical Substances BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
    Language English
    Publishing date 2018-05-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyy241
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  9. Article ; Online: Neurosciences Continuing Education: An Adult With New-Onset Seizures.

    Lukas, Rimas V

    The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses

    2018  Volume 50, Issue 2, Page(s) 100–101

    Abstract: The case of a 43-year-old woman with new-onset seizures is presented within the context of a continuing education quiz. Details regarding the underlying etiology and contemporary advances in the literature are referenced. ...

    Abstract The case of a 43-year-old woman with new-onset seizures is presented within the context of a continuing education quiz. Details regarding the underlying etiology and contemporary advances in the literature are referenced.
    MeSH term(s) Adult ; Astrocytoma/diagnosis ; Astrocytoma/pathology ; Brain Neoplasms/diagnosis ; Brain Neoplasms/diagnostic imaging ; Education, Continuing ; Female ; Humans ; Isocitrate Dehydrogenase/genetics ; Magnetic Resonance Imaging ; Neurosciences ; Seizures/complications
    Chemical Substances Isocitrate Dehydrogenase (EC 1.1.1.41)
    Language English
    Publishing date 2018-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 632790-4
    ISSN 1945-2810 ; 0888-0395
    ISSN (online) 1945-2810
    ISSN 0888-0395
    DOI 10.1097/JNN.0000000000000351
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  10. Article ; Online: Reader response: Education Research: Difficult conversations in neurology: Lessons learned from medical students.

    Lukas, Rimas V

    Neurology

    2018  Volume 91, Issue 13, Page(s) 635–636

    MeSH term(s) Education, Medical ; Humans ; Neurology/education ; Students, Medical
    Language English
    Publishing date 2018-09-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000006236
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