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  1. Book ; Online ; E-Book: Diagnostic imgaging: pediatrics

    Merrow, A. Carlson / Aquino, Michael R. / Linscott, Luke L. / Koch, Bernadette L.

    (Diagnostic imaging)

    2022  

    Title variant Pediatrics
    Author's details A. Carlson Merrow, Michael R. Aquino, Luke L. Linscott, Bernadette L. Koch
    Series title Diagnostic imaging
    Keywords Pediatric diagnostic imaging
    Subject code 618.9200754
    Language English
    Size 1 Online-Ressource (xxiii, 1245, lxxvi Seiten), Illustrationen
    Edition Fourth edition
    Publisher Elsevier
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021307538
    ISBN 978-0-323-77739-1 ; 9780323777384 ; 0-323-77739-2 ; 0323777384
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Editorial overview: Modality, discovery, and class.

    Lairson, Luke L

    Current opinion in chemical biology

    2022  Volume 72, Page(s) 102251

    MeSH term(s) Drug Discovery ; Therapeutics
    Language English
    Publishing date 2022-12-24
    Publishing country England
    Document type Editorial
    ZDB-ID 1439176-4
    ISSN 1879-0402 ; 1367-5931
    ISSN (online) 1879-0402
    ISSN 1367-5931
    DOI 10.1016/j.cbpa.2022.102251
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  3. Article ; Online: Ependymal cells SCOre sweet cerebrospinal fluid.

    Liu, Luke L / Fame, Ryann M

    PLoS biology

    2023  Volume 21, Issue 9, Page(s) e3002323

    Abstract: The subcommissural organ (SCO) is a secretory tissue located on the roof of the brain's third ventricle. A new study published in PLOS Biology finds that the SCO responds to glucose by secreting signaling molecules into the cerebrospinal fluid (CSF), ... ...

    Abstract The subcommissural organ (SCO) is a secretory tissue located on the roof of the brain's third ventricle. A new study published in PLOS Biology finds that the SCO responds to glucose by secreting signaling molecules into the cerebrospinal fluid (CSF), thereby decreasing the local ependyma-driven CSF movement.
    MeSH term(s) Humans ; Hyperglycemia ; Glucose ; Biological Transport ; Cell Adhesion Molecules, Neuronal
    Chemical Substances SCO-spondin ; Glucose (IY9XDZ35W2) ; Cell Adhesion Molecules, Neuronal
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2126776-5
    ISSN 1545-7885 ; 1544-9173
    ISSN (online) 1545-7885
    ISSN 1544-9173
    DOI 10.1371/journal.pbio.3002323
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  4. Article ; Online: A new road to STING activation.

    Sulpizio, Ariana / Lairson, Luke L

    Nature chemical biology

    2023  Volume 20, Issue 3, Page(s) 266–267

    MeSH term(s) Protein Serine-Threonine Kinases/metabolism ; Signal Transduction
    Chemical Substances Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2023-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2202962-X
    ISSN 1552-4469 ; 1552-4450
    ISSN (online) 1552-4469
    ISSN 1552-4450
    DOI 10.1038/s41589-023-01455-7
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  5. Article ; Online: Impact of olfactory disorders on personal safety and well-being: a cross-sectional observational study.

    Lee, Liam / Luke, Louis / Boak, Duncan / Philpott, Carl

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2024  

    Abstract: Objectives: Investigate safety perceptions, quantify hazardous events, and analyse their manifestations in individuals with olfactory dysfunction through an online cross-sectional survey.: Methods: An online survey, available from 25th February to ... ...

    Abstract Objectives: Investigate safety perceptions, quantify hazardous events, and analyse their manifestations in individuals with olfactory dysfunction through an online cross-sectional survey.
    Methods: An online survey, available from 25th February to 28th September 2022, captured data on demographics, olfactory disorder causes, safety concerns, and experienced hazardous events. Distributed via Fifth Sense channels, it targeted individuals with self-claimed olfactory dysfunction.
    Results: Of 432 responses, the majority were female (79.6%), aged 41-70, with 20.6% non-UK residents from 21 countries. Leading causes of dysfunction were Covid-19 (22%), idiopathic (20.8%), and congenital (14.4%). Safety concerns were high (85.9%), with gas, smoke, and food as major worries. Over 5 years, 32.2% faced ≥ 1 food incident, 14.8% ≥ 1 gas incident, 34.5% ≥ 1 gas scare, and 18.5% ≥ 1 work incident. Preventative measures were taken by 60.2% at home. Key limitations of this study were self-reported data and sampling bias of charity members.
    Conclusion: This study highlights the significant impact of smell loss on personal safety and emotional well-being. There is an unmet need in mitigating safety concerns/events for individuals with olfactory dysfunction. We suggest collaborate strategies such as educating the public sector and high-risk sectors (e.g. gas companies), and introducing safety 'scratch and sniff' cards as a screening method. Regular assessment of an individual's olfactory ability, similar to routine assessments for other sensory systems (sight, hearing) may allow proactive identification of at-risk people and corrective measures to take place.
    Language English
    Publishing date 2024-02-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-024-08529-9
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  6. Article ; Online: Ependymal cells SCOre sweet cerebrospinal fluid.

    Luke L Liu / Ryann M Fame

    PLoS Biology, Vol 21, Iss 9, p e

    2023  Volume 3002323

    Abstract: The subcommissural organ (SCO) is a secretory tissue located on the roof of the brain's third ventricle. A new study published in PLOS Biology finds that the SCO responds to glucose by secreting signaling molecules into the cerebrospinal fluid (CSF), ... ...

    Abstract The subcommissural organ (SCO) is a secretory tissue located on the roof of the brain's third ventricle. A new study published in PLOS Biology finds that the SCO responds to glucose by secreting signaling molecules into the cerebrospinal fluid (CSF), thereby decreasing the local ependyma-driven CSF movement.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Book ; Online: Personenbezogene Lichtexpositionsmessungen in Feldstudien

    Udovicic, Ljiljana / Janßen, Marco / Nowack, Dennis / Price, Luke L. A.

    eine Handlungsanleitung zur Charakterisierung und Kalibrierung von Lichtexpositionsdetektoren

    (Bericht / Bundesanstalt für Arbeitsschutz und Arbeitsmedizin)

    2016  

    Author's details L. Udovičić, M. Janßen, D. Nowack, L. Price
    Series title Bericht / Bundesanstalt für Arbeitsschutz und Arbeitsmedizin
    Language German
    Size 1 Online-Ressource (47 Seiten), Illustrationen, Diagramme
    Edition 1. Auflage
    Publisher Bundesanstalt für Arbeitsschutz und Arbeitsmedizin (BAuA)
    Publishing place Dortmund ; Berlin ; Dresden
    Publishing country Germany
    Document type Book ; Online
    Note Enthält eine Zusammenfassung in englischer Sprache
    HBZ-ID HT019305033
    DOI 10.21934/baua:bericht20161220
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: Circadian and visual photometry.

    Price, Luke L A / Blattner, Peter

    Progress in brain research

    2022  Volume 273, Issue 1, Page(s) 1–11

    Abstract: Photometry is the metrology of light-optical radiation seen by the human eye due to its action on retinal photoreceptors. Its origins are closely tied to the International Commission on Illumination (CIE), which remains responsible for photometry ... ...

    Abstract Photometry is the metrology of light-optical radiation seen by the human eye due to its action on retinal photoreceptors. Its origins are closely tied to the International Commission on Illumination (CIE), which remains responsible for photometry standards and the language of light used in science and technology. When in 1931 it had become possible to model the response to light of the human eye based on reliable spectroradiometry data, the CIE published standard formulae for predicting the luminance of a stimulus. These and related colorimetry formulae are still in use, having been internationally agreed and adopted. Both fields continue to be the subject of active research and increasing accuracy. CIE S 026:2018 represents another milestone for the metrology of light (CIE, 2018a). It is the first standard where light is considered for its ability to evoke circadian and neurophysiological responses, and includes the spectral sensitivity of melanopsin-a retinal photopigment discovered, and shown to be contributing to and influencing responses from human intrinsically-photosensitive retinal ganglion cells (ipRGCs), only 20 years ago (Berson et al., 2002; Hattar et al., 2002; Provencio et al., 1998). These accessory visual functions also depend to some extent on inputs from the rods and three types of cones; until very recently, rods and cones (or "classical photoreceptors") were the only photoreceptors in visual models. If photometry standards are replaced with modern physiological data, consistent changes should be expected in the photometry of these accessory functions. This chapter outlines the current standards, their definitions and calculations, and how the main elements are related.
    MeSH term(s) Circadian Rhythm/physiology ; Humans ; Photometry ; Photoreceptor Cells, Vertebrate ; Retina/physiology ; Retinal Cone Photoreceptor Cells ; Retinal Ganglion Cells/physiology ; Rod Opsins/physiology
    Chemical Substances Rod Opsins
    Language English
    Publishing date 2022-07-19
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1875-7855 ; 0079-6123
    ISSN (online) 1875-7855
    ISSN 0079-6123
    DOI 10.1016/bs.pbr.2022.02.014
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  9. Article ; Online: Promoting remyelination: A case study in regenerative medicine.

    Beyer, Brittney A / Lairson, Luke L

    Current opinion in chemical biology

    2022  Volume 70, Page(s) 102201

    Abstract: Therapeutics that modulate regenerative mechanisms by targeting the activity of endogenous (adult) stem cell populations have the potential to revolutionize medicine. In many human disease states, capacity to repair damaged tissue underlies progressive ... ...

    Abstract Therapeutics that modulate regenerative mechanisms by targeting the activity of endogenous (adult) stem cell populations have the potential to revolutionize medicine. In many human disease states, capacity to repair damaged tissue underlies progressive decline and disease progression. Recent insights derived from efforts aimed at promoting remyelination for the treatment of multiple sclerosis (MS) highlight the importance of considering the limiting factors and underlying mechanisms associated with all aspects of disease onset, progression and recovery, during both the discovery and clinical stages of developing a regenerative medicine. This perspective presents general considerations for the development of regenerative therapies, using remyelination as a case study.
    MeSH term(s) Humans ; Multiple Sclerosis/drug therapy ; Oligodendroglia ; Regenerative Medicine ; Remyelination
    Language English
    Publishing date 2022-08-27
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1439176-4
    ISSN 1879-0402 ; 1367-5931
    ISSN (online) 1879-0402
    ISSN 1367-5931
    DOI 10.1016/j.cbpa.2022.102201
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  10. Article: Choroid Plexus Modulates Subventricular Zone Adult Neurogenesis and Olfaction Through Secretion of Small Extracellular Vesicles.

    Liu, Luke L / Shannahan, Jonathan / Zheng, Wei

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The choroid plexus (CP) in brain ventricles secrete cerebrospinal fluid (CSF) that bathes the adjacent subventricular zone (SVZ); the latter is the largest neurogenic region in adult brain harboring neural stem/progenitor cells (NSPCs) and supplies ... ...

    Abstract The choroid plexus (CP) in brain ventricles secrete cerebrospinal fluid (CSF) that bathes the adjacent subventricular zone (SVZ); the latter is the largest neurogenic region in adult brain harboring neural stem/progenitor cells (NSPCs) and supplies newborn neurons to the olfactory bulb (OB) for normal olfaction. We discovered the presence of a CP-SVZ regulatory (CSR) axis in which the CP, by secreting small extracellular vesicles (sEVs), regulated adult neurogenesis in the SVZ and maintained olfaction. The proposed CSR axis was supported by 1) differential neurogenesis outcomes in the OB when animals treated with intracerebroventricular (ICV) infusion of sEVs collected from the CP of normal or manganese (Mn)-poisoned mice, 2) progressively diminished SVZ adult neurogenesis in mice following CP-targeted knockdown of SMPD3 to suppress CP sEV secretion, and 3) compromised olfactory performance in these CP-SMPD3-knockdown mice. Collectively, our findings demonstrate the biological and physiological presence of this sEV-dependent CSR axis in adult brains.
    Highlights: CP-secreted sEVs regulate adult neurogenesis in the SVZ.CP-secreted sEVs modulate newborn neurons in the OB.Suppression of sEV secretion from the CP deteriorates olfactory performance.
    Language English
    Publishing date 2023-03-18
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.16.532966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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