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  1. AU="Lukyanov, Sergey"
  2. AU="Baptistella, Amanda"
  3. AU="Dichter, Gabriel S"
  4. AU="D Urbano, Vanessa"
  5. AU="Farhad Shirini"
  6. AU="Wu, Wenming"
  7. AU="Wiedermann, Christian J"
  8. AU="Corradin, Giampietro"
  9. AU="Guan, Xiaodong"
  10. AU=Burmester Gerd R.
  11. AU="Mańczak, Rafał"
  12. AU="Cristina Ceron"
  13. AU=Scardapane Arnaldo
  14. AU="Taylor, Daniel J"
  15. AU="Sabanadzovic, Sead"
  16. AU=Lee Yangsoon AU=Lee Yangsoon
  17. AU="Sahoo, Aditi"
  18. AU="Reyes, Peter Andrew C"
  19. AU="Collobert, Géromine"
  20. AU="Guevara, Katterine"
  21. AU=Ahmadivand Arash

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  1. Artikel ; Online: Digital tools for seaports geo-information support while climate change and Covid-19 pandemic

    Abramov Valery / Lukyanov Sergey / Korinets Ekaterina / Bolshakov Vladimir / Vekshina Tatiana

    E3S Web of Conferences, Vol 258, p

    2021  Band 02020

    Abstract: In article, there are presented digital tools development results for geo-information support to seaports activity within Industry 4.0 period, when while climate change and covid-19 pandemic. In study, there are used methods of data bases constructing, ... ...

    Abstract In article, there are presented digital tools development results for geo-information support to seaports activity within Industry 4.0 period, when while climate change and covid-19 pandemic. In study, there are used methods of data bases constructing, web-technologies and virtual reality tools. Also, there are used Foresight technologies, theory of decision making under uncertainties and risk management. As digital tools, there is proposed to use digital online platforms, which integrate heterogeneous hardware and software resources with the use of web-technologies in distributed networks and wide application of cloud services. In study, there are used data bases and tools of geo-information digital online platform EOS, including its Land Viewer product. As study result, there is demonstrated usage of geo-information support system for Russian seaport Ust-Luga. The research results presented in this article has significant scientific novelty and can be useful for private investors, public environmental organizations of the civil sector and state environmental control bodies.
    Schlagwörter Environmental sciences ; GE1-350
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag EDP Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Digital learning technologies within geo-information management

    Lukyanov Sergey / Popov Nikolay / Sikarev Igor / Rumyantseva Ekaterina / Petrieva Oksana

    E3S Web of Conferences, Vol 258, p

    2021  Band 01004

    Abstract: Recently, there is digital transformation of university education, including new concepts for obtaining and presenting learning materials. In article, there is considered digital learning technologies for geo-information management within Industry 4.0 ... ...

    Abstract Recently, there is digital transformation of university education, including new concepts for obtaining and presenting learning materials. In article, there is considered digital learning technologies for geo-information management within Industry 4.0 while modern global economic crisis in last years. In research, there are used Foresight technologies, theory of decision making under uncertainties and risk management. Also, there are used methods of data bases constructing, web-technologies and virtual reality tools. As base technology, authors propose to use digital educational platforms, which integrate heterogeneous hardware and software resources using web technologies in distributed networks and a wide use of cloud services. Authors propose to use Google Classroom as essential digital educational platform. As study result, there are proposed enlarged groups of didactic works in geo-information management, oriented on practical purposes and adapted to Covid-19 pandemic conditions. There are considered the issues of digital content creation within university education, essentially in practical training. Presented in article results of study have a significant scientific novelty and can be used in educational and training purposes, including the preparation of Master's programs in geo-information management.
    Schlagwörter Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 028
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag EDP Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Temperature dependence of thermodynamic properties of MoS

    Bandura, Andrei V / Lukyanov, Sergey I / Evarestov, Robert A

    Journal of molecular graphics & modelling

    2018  Band 85, Seite(n) 212–222

    Abstract: ... ...

    Abstract MoS
    Mesh-Begriff(e) Density Functional Theory ; Disulfides/chemistry ; Entropy ; Molybdenum/chemistry ; Nanotubes/chemistry ; Temperature ; Thermal Conductivity ; Thermodynamics
    Chemische Substanzen Disulfides ; Molybdenum (81AH48963U) ; molybdenum disulfide (ZC8B4P503V)
    Sprache Englisch
    Erscheinungsdatum 2018-09-04
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1396450-1
    ISSN 1873-4243 ; 1093-3263
    ISSN (online) 1873-4243
    ISSN 1093-3263
    DOI 10.1016/j.jmgm.2018.08.013
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Innovative technologies of geoinformation support for hydraulic structures

    Lukyanov Sergey / Averkiev Alexander / Rybalko Alexander / Tatarenko Yuri / Frolova Natalia / Shevchuk Oleg

    E3S Web of Conferences, Vol 110, p

    2019  Band 01024

    Abstract: The paper presents the technologies of geoinformation support within hydraulic structures construction and exploitation at the stage of engineering-geological, engineering-ecological and engineering-hydrometeorological surveys for environmental economics ...

    Abstract The paper presents the technologies of geoinformation support within hydraulic structures construction and exploitation at the stage of engineering-geological, engineering-ecological and engineering-hydrometeorological surveys for environmental economics during the implementation of major projects in the field of sustainable development of cities and municipalities. The impact of dredging on the natural environment is considered, and a conclusion about the need to study the rate of sedimentation at different stages of exploration, design, construction, and operation of underwater engineering facilities are made. It is shown how the construction of the Marine Facade of St. Petersburg for receiving tourist ferries changed the need for dredging volumes and how this affected the total cost of work. The port of Bronka in Neva Bay is used as an example of sedimentation study during the period of 2005-2007. The developed technologies should help in managing natural risks in the implementation of major projects in the field of construction and operation of hydraulic structures within the framework of the environmental economics in a changing climate.
    Schlagwörter Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 690
    Sprache Englisch
    Erscheinungsdatum 2019-01-01T00:00:00Z
    Verlag EDP Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel: Expanded hexagonal nanohelicenes of zigzag morphology under elastic strain: A quantum chemical study

    Porsev, Vitaly V / Bandura, Andrei V / Evarestov, Robert A / Lukyanov, Sergey I

    Carbon. 2019 Nov., v. 152

    2019  

    Abstract: A new class of carbon 1D structures with symmetry of rod groups P61 and P31 – laterally-extended expanded nanohelicenes (NHs) with zigzag edge morphology – has been thoroughly investigated in the DFT framework. It is shown that these compounds can be ... ...

    Abstract A new class of carbon 1D structures with symmetry of rod groups P61 and P31 – laterally-extended expanded nanohelicenes (NHs) with zigzag edge morphology – has been thoroughly investigated in the DFT framework. It is shown that these compounds can be divided into two groups, with each group having its distinct properties. The spiral ribbons of NHs of the first and second groups have odd and even numbers of carbon hexagons across, respectively. The first group members are semiconductors and their electronic band gap strongly depends on the uniaxial strain. Expanding the “shaft” (the inner hollow region in a NH spiral) results in a smooth decrease of the electronic band gap. If the outer edge of a NH includes fewer than seven hexagons, then the NH is diamagnetic. When the edge includes seven or more hexagons, antiferromagnetic ordering appears. The second group consists of NHs which are diamagnetic metals at equilibrium geometry that, however, undergo a phase transition to antiferromagnetic semiconductors under small (about 10%) elastic stretching. The difference between the electronic and magnetic properties of NHs in the first and second groups stems from the difference in their electronic structure and can be explained using group theory.
    Schlagwörter carbon ; ferrimagnetic materials ; geometry ; magnetic properties ; mathematical theory ; metals ; phase transition ; quantum mechanics ; semiconductors
    Sprache Englisch
    Erscheinungsverlauf 2019-11
    Umfang p. 755-765.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ISSN 0008-6223
    DOI 10.1016/j.carbon.2019.06.036
    Datenquelle NAL Katalog (AGRICOLA)

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  6. Buch: Nucleic acids hybridization

    Buzdin, Anton / Lukyanov, Sergey

    modern applications

    2007  

    Verfasserangabe edited by Anton Buzdin and Sergey Lukyanov
    Schlagwörter Nucleic acid hybridization. ; In situ hybridization.
    Sprache Englisch
    Umfang xix, 314 p. :, ill. ;, 24 cm.
    Verlag Springer
    Erscheinungsort Dordrecht
    Dokumenttyp Buch
    ISBN 9781402060397 ; 1402060394 ; 1402060408 ; 9781402060403
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  7. Artikel ; Online: Tocilizumab, netakimab, and baricitinib in patients with mild-to-moderate COVID-19: An observational study.

    Bryushkova, Ekaterina A / Skatova, Valeria D / Mutovina, Zinaida Y / Zagrebneva, Alena I / Fomina, Daria S / Kruglova, Tatyana S / Akopyan, Anna A / Strazhesko, Irina D / Lukyanov, Sergey A / Tkacheva, Olga N / Lysenko, Maryana A / Chudakov, Dmitry M

    PloS one

    2022  Band 17, Heft 8, Seite(n) e0273340

    Abstract: Objective: The aim of the study was to assess inflammatory markers and clinical outcomes in adult patients admitted to hospital with mild-to-moderate COVID-19 and treated with a combination of standard-of-care (SOC) and targeted immunosuppressive ... ...

    Abstract Objective: The aim of the study was to assess inflammatory markers and clinical outcomes in adult patients admitted to hospital with mild-to-moderate COVID-19 and treated with a combination of standard-of-care (SOC) and targeted immunosuppressive therapy including anti-IL-17A (netakimab), anti-IL-6R (tocilizumab), or JAK1/JAK2 inhibitor (baricitinib) or with a standard-of-care therapy alone.
    Methods: The observational cohort study included 154 adults hospitalized between February and August, 2020 with RT-PCR-confirmed SARS-CoV-2 with National Early Warning Score2 (NEWS2) < 7 and C-reactive protein (CRP) levels ≤ 140 mg/L on the day of the start of the therapy or observation. Patients were divided into the following groups: I) 4 mg baricitinib, 1 or 2 times a day for an average of 5 days (n = 38); II) 120 mg netakimab, one dose (n = 48); III) 400 mg tocilizumab, one dose (n = 34), IV) SOC only: hydroxychloroquine, antiviral, antibacterial, anticoagulant, and dexamethasone (n = 34).
    Results: CRP levels significantly decreased after 72 h in the tocilizumab (p = 1 x 10-5) and netakimab (p = 8 x 10-4) groups and remained low after 120 h. The effect was stronger with tocilizumab compared to other groups (p = 0.028). A significant decrease in lactate dehydrogenase (LDH) levels was observed 72 h after netakimab therapy (p = 0.029). NEWS2 scores significantly improved 72 h after tocilizumab (p = 6.8 x 10-5) and netakimab (p = 0.01) therapy, and 120 h after the start of tocilizumab (p = 8.6 x 10-5), netakimab (p = 0.001), or baricitinib (p = 4.6 x 10-4) therapy, but not in the SOC group. Blood neutrophil counts (p = 6.4 x 10-4) and neutrophil-to-lymphocyte ratios (p = 0.006) significantly increased 72 h after netakimab therapy and remained high after 120 h. The percentage of patients discharged 5-7 days after the start of therapy was higher in the tocilizumab (44.1%) and netakimab (41.7%) groups than in the baricitinib (31.6%) and SOC (23.5%) groups. Compared to SOC (3 of the 34; 8.8%), mortality was lower in netakimab (0 of the 48; 0%, RR = 0.1 (95% CI: 0.0054 to 1.91)), tocilizumab (0 of the 34; 0%, RR = 0.14 (95% CI: 0.0077 to 2.67)), and baricitinib (1 of the 38; 2.6%, RR = 0.3 (95% CI: 0.033 to 2.73)) groups.
    Conclusion: In hospitalized patients with mild-to-moderate COVID-19, the combination of SOC with anti-IL-17A or anti-IL-6R therapy were superior or comparable to the combination with JAK1/JAK2 inhibitor, and all three were superior to SOC alone. Whereas previous studies did not demonstrate significant benefit of anti-IL-17A therapy for severe COVID-19, our data suggest that such therapy could be a rational choice for mild-to-moderate disease, considering the generally high safety profile of IL-17A blockers. The significant increase in blood neutrophil count in the netakimab group may reflect efflux of neutrophils from inflamed tissues. We therefore hypothesize that neutrophil count and neutrophil-to-lymphocyte ratio could serve as markers of therapeutic efficiency for IL-17A-blocking antibodies in the context of active inflammation.
    Mesh-Begriff(e) Adult ; Anti-Inflammatory Agents/therapeutic use ; Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Azetidines ; COVID-19/drug therapy ; Humans ; Purines ; Pyrazoles ; SARS-CoV-2 ; Sulfonamides ; Treatment Outcome
    Chemische Substanzen Anti-Inflammatory Agents ; Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Azetidines ; Purines ; Pyrazoles ; Sulfonamides ; netakimab (D3IAG45DAK) ; tocilizumab (I031V2H011) ; baricitinib (ISP4442I3Y)
    Sprache Englisch
    Erscheinungsdatum 2022-08-24
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0273340
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Pinpointing the tumor-specific T cells via TCR clusters.

    Goncharov, Mikhail M / Bryushkova, Ekaterina A / Sharaev, Nikita I / Skatova, Valeria D / Baryshnikova, Anastasiya M / Sharonov, George V / Karnaukhov, Vadim / Vakhitova, Maria T / Samoylenko, Igor V / Demidov, Lev V / Lukyanov, Sergey / Chudakov, Dmitriy M / Serebrovskaya, Ekaterina O

    eLife

    2022  Band 11

    Abstract: Adoptive cell transfer (ACT) is a promising approach to cancer immunotherapy, but its efficiency fundamentally depends on the extent of tumor-specific T cell enrichment within the graft. This can be estimated via activation with identifiable neoantigens, ...

    Abstract Adoptive cell transfer (ACT) is a promising approach to cancer immunotherapy, but its efficiency fundamentally depends on the extent of tumor-specific T cell enrichment within the graft. This can be estimated via activation with identifiable neoantigens, tumor-associated antigens (TAAs), or living or lysed tumor cells, but these approaches remain laborious, time-consuming, and functionally limited, hampering clinical development of ACT. Here, we demonstrate that homology cluster analysis of T cell receptor (TCR) repertoires efficiently identifies tumor-reactive TCRs allowing to: (1) detect their presence within the pool of tumor-infiltrating lymphocytes (TILs); (2) optimize TIL culturing conditions, with IL-2
    Mesh-Begriff(e) Antigens, Neoplasm/metabolism ; CD8-Positive T-Lymphocytes ; Humans ; Lymphocytes, Tumor-Infiltrating ; Neoplasms/metabolism ; Neoplasms/therapy ; Receptors, Antigen, T-Cell/metabolism
    Chemische Substanzen Antigens, Neoplasm ; Receptors, Antigen, T-Cell
    Sprache Englisch
    Erscheinungsdatum 2022-04-04
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.77274
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Sequencing rare T-cell populations.

    Shugay, Mikhail / Lukyanov, Sergey / Chudakov, Dmitriy M

    Oncotarget

    2015  Band 6, Heft 37, Seite(n) 39393–39394

    Mesh-Begriff(e) Gene Expression Profiling ; High-Throughput Nucleotide Sequencing ; Humans ; Lymphocyte Count ; Lymphocytes/metabolism ; Male
    Sprache Englisch
    Erscheinungsdatum 2015-11-24
    Erscheinungsland United States
    Dokumenttyp Comment ; Editorial
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.6349
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Young's modulus and Poisson's ratio for TiO2-based nanotubes and nanowires: modelling of temperature dependence

    Lukyanov, Sergey I / Bandura, Andrei V / Evarestov, Robert A

    RSC advances. 2016 Feb. 08, v. 6, no. 19

    2016  

    Abstract: In this work molecular mechanics simulations with the help of interatomic potentials were employed to predict the temperature dependence of the Young's modulus and Poisson's ratio of a number of TiO2-based four-facetted nanotubes and nanowires. The ... ...

    Abstract In this work molecular mechanics simulations with the help of interatomic potentials were employed to predict the temperature dependence of the Young's modulus and Poisson's ratio of a number of TiO2-based four-facetted nanotubes and nanowires. The temperature dependence of the Young's modulus was obtained through the calculation of the Helmholtz free energy of the system under isothermal thermodynamic conditions. The Helmholtz free energy simulations were performed in the framework of quasi-harmonic approximation as a result of calculations of the potential energy and the harmonic phonon frequencies of the system under consideration. The Helmholtz free energy calculated for the set of fixed values of the nanoobject translational period allows obtaining the minimal Helmholtz free energy at specified temperatures in the range 0–1000 K. The present simulations demonstrate that the Young's modulus for the TiO2-based nanowires decreases with the increase of the nanowire diameters, and approaches the modulus for the rutile bulk crystal from above. Also, the temperature behavior of the Young's modulus, Poisson's ratio and period for the nanotubes and nanowires are considered. This study reveals that the Poisson's ratios of the nanotubes and nanowires depend on the surface atoms chosen to measure the transverse dimensions of the nanostructures.
    Schlagwörter Gibbs free energy ; Poisson distribution ; mechanics ; models ; modulus of elasticity ; nanotubes ; nanowires ; potential energy ; temperature
    Sprache Englisch
    Erscheinungsverlauf 2016-0208
    Umfang p. 16037-16045.
    Erscheinungsort The Royal Society of Chemistry
    Dokumenttyp Artikel
    ISSN 2046-2069
    DOI 10.1039/c5ra24951a
    Datenquelle NAL Katalog (AGRICOLA)

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