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  1. Article: Review of the Literature on Partial Resections of the Gallbladder, 1898-2022: The Outline of the Conception of Subtotal Cholecystectomy and a Suggestion to Use the Terms 'Subtotal Open-Tract Cholecystectomy' and 'Subtotal Closed-Tract Cholecystectomy'.

    Lunevicius, Raimundas

    Journal of clinical medicine

    2023  Volume 12, Issue 3

    Abstract: Current descriptions of the history of subtotal cholecystectomy require more details and accuracy. This study presented a narrative review of the articles on partial resections of the gallbladder published between 1898 and 2022. The Scale for the ... ...

    Abstract Current descriptions of the history of subtotal cholecystectomy require more details and accuracy. This study presented a narrative review of the articles on partial resections of the gallbladder published between 1898 and 2022. The Scale for the Assessment of Narrative Review Articles items guided the style and content of this paper. The systematic literature search yielded 165 publications. Of them, 27 were published between 1898 and 1984. The evolution of the partial resections of the gallbladder began in the last decade of the 19th century when Kehr and Mayo performed them. The technique of partial resection of the gallbladder leaving the hepatic wall in situ was well known in the 3rd and 4th decades of the 20th century. In 1931, Estes emphasised the term 'partial cholecystectomy'. In 1947, Morse and Barb introduced the term 'subtotal cholecystectomy'. Madding and Farrow popularised it in 1955-1959. Bornman and Terblanche revitalised it in 1985. This term became dominant in 2014. From a subtotal cholecystectomy technical execution perspective, it is either a single-stage (when it includes only the resectional component) or two-stage (when it also entails closure of the remnant of the gallbladder or cystic duct) operation. Recent papers on classifications of partial resections of the gallbladder indicate the extent of gallbladder resection. Subtotal cholecystectomy is an umbrella term for incomplete cholecystectomies. 'Subtotal open-tract cholecystectomy' and 'subtotal closed-tract cholecystectomy' are terms that characterise the type of completion of subtotal cholecystectomy.
    Language English
    Publishing date 2023-02-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12031230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Gastrointestinal Stromal Tumor

    Lunevicius, Raimundas

    2012  

    Keywords Oncology
    Size 1 electronic resource (132 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021049878
    ISBN 9789535169871 ; 9535169874
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Cholecystectomy: Advances and Issues.

    Lunevicius, Raimundas

    Journal of clinical medicine

    2022  Volume 11, Issue 12

    Abstract: The introduction and rationalization of the terms ' ...

    Abstract The introduction and rationalization of the terms '
    Language English
    Publishing date 2022-06-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11123534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Multiple logistic regression model to predict bile leak associated with subtotal cholecystectomy.

    Lunevicius, Raimundas / Nzenwa, Ikemsinachi C

    Surgical endoscopy

    2023  Volume 37, Issue 7, Page(s) 5405–5413

    Abstract: Background: There are no prediction models for bile leakage associated with subtotal cholecystectomy (STC). Therefore, this study aimed to generate a multivariable prediction model for post-STC bile leakage and evaluate its overall performance.: ... ...

    Abstract Background: There are no prediction models for bile leakage associated with subtotal cholecystectomy (STC). Therefore, this study aimed to generate a multivariable prediction model for post-STC bile leakage and evaluate its overall performance.
    Methods: We analysed prospectively managed data of patients who underwent STC by a single consultant surgeon between 14 May 2013 and 21 December 2021. STC was schematised into four variants with five subvariants and classified broadly as closed-tract or open-tract STC. A contingency table was used to detect independent risk factors for bile leakage. A multiple logistic regression analysis was used to generate a model. Discrimination and calibration statistics were computed to assess the accuracy of the model.
    Results: A total of 81 patients underwent the STC procedure. Twenty-eight patients (35%) developed bile leakage. Of these, 18 patients (64%) required secondary surgical intervention. Multivariable logistic regression revealed two independent predictors of post-STC bile leak: open-tract STC (odds ratio [OR], 7.07; 95% confidence interval [CI], 2.191-25.89; P = 0.0170) and acute cholecystitis (OR, 5.449; 95% CI, 1.584-23.48; P = 0.0121). The area under the receiver-operating characteristic curve was 82.11% (95% CI, 72.87-91.34; P < 0.0001). Tjur's pseudo-R
    Conclusions: Open-tract STC and acute cholecystitis are the most reliable predictors of bile leakage associated with STC. Future prospective, multicentre studies with higher statistical power are needed to generate more specific and externally validated prediction models for post-STC bile leaks.
    MeSH term(s) Humans ; Logistic Models ; Bile ; Cholecystectomy/adverse effects ; Cholecystectomy/methods ; Postoperative Complications/etiology ; Cholecystitis, Acute/etiology ; Cholecystectomy, Laparoscopic/adverse effects ; Retrospective Studies
    Language English
    Publishing date 2023-04-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-023-10049-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A profile of a major trauma centre of North West England between 2011 and 2018.

    Lunevicius, Raimundas / Mesri, Mina

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 5393

    Abstract: This study examined the trends and patterns of major trauma (MT) activities, causes, mortality and survival at the Aintree Major Trauma Centre (MTC), Liverpool, between 2011 and 2018. The number of trauma team activations (TTAs) rose sharply over time (n  ...

    Abstract This study examined the trends and patterns of major trauma (MT) activities, causes, mortality and survival at the Aintree Major Trauma Centre (MTC), Liverpool, between 2011 and 2018. The number of trauma team activations (TTAs) rose sharply over time (n = 699 in 2013; n = 1522 in 2018). The proportion of TTAs that involved MT patients decreased from 75.1% in 2013 to 67.4% in 2018. The leading cause of MT was a fall from less than 2 m (36%). There has been a fivefold increase in the overall number of trauma procedures between 2011 and 2018. Orthopaedic surgeons have performed 80% of operations (n = 7732), followed by neurosurgeons, oral and maxillofacial surgeons, and general trauma surgeons. Both types of fall (> 2 m and < 2 m) and road traffic accidents were the three leading causes of death during the study period. The observed mortality rates exceeded that of expected rates in years 2012, 2014, 2016 and 2017. The all-cause observed to expected mortality ratio was 1.08 between 2012 and 2018. A change in care for MT patients was not directly associated with improved survival, although the marginally ascending trend line in survival rates between 2012 and 2018 reflects a gradual positive change.
    MeSH term(s) Adult ; Disease-Free Survival ; England/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Survival Rate ; Trauma Centers ; Wounds and Injuries/mortality
    Language English
    Publishing date 2021-03-08
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-84266-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Subtotal Cholecystectomy: Results of a Single-Center, Registry-Based Retrospective Cohort Study of 180 Adults in 2011-2018.

    Lunevicius, Raimundas / Haagsma, Juanita A

    Journal of laparoendoscopic & advanced surgical techniques. Part A

    2020  Volume 31, Issue 9, Page(s) 1019–1033

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Adult ; Cholecystectomy ; Cholecystectomy, Laparoscopic/adverse effects ; Gallstones ; Humans ; Registries ; Retrospective Studies
    Language English
    Publishing date 2020-10-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1381909-4
    ISSN 1557-9034 ; 1092-6429
    ISSN (online) 1557-9034
    ISSN 1092-6429
    DOI 10.1089/lap.2020.0713
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Post-COVID-19 vaccination occurrence of splenic infarction due to arterial thrombosis.

    Anderson, Alexander / Seddon, Mary / Shahzad, Khalid / Lunevicius, Raimundas

    BMJ case reports

    2021  Volume 14, Issue 12

    Abstract: We present the case of an 82-year-old woman admitted to a regional emergency general surgery centre with severe left upper quadrant abdominal pain and tenderness within 21 days of receiving the first dose of the ChAdOx1 nCov-19 vaccine (Vaxzevria, ... ...

    Abstract We present the case of an 82-year-old woman admitted to a regional emergency general surgery centre with severe left upper quadrant abdominal pain and tenderness within 21 days of receiving the first dose of the ChAdOx1 nCov-19 vaccine (Vaxzevria, AstraZeneca). Following further investigation through CT imaging, a thrombus was discovered in the patient's splenic artery resulting in a large splenic infarct. Splenic infarcts are rare and it is important to note the association between time of administration of the first dose of vaccine and the occurrence of thromboembolic complications in the noted absence of other risk factors for this condition. We hypothesise a link between Vaxzevria vaccine injection and a rare form of thromboembolic complication: thrombosis of the splenic artery.
    MeSH term(s) Aged, 80 and over ; COVID-19 ; COVID-19 Vaccines ; ChAdOx1 nCoV-19 ; Female ; Humans ; SARS-CoV-2 ; Splenic Infarction/diagnostic imaging ; Splenic Infarction/etiology ; Thrombosis/diagnostic imaging ; Thrombosis/etiology ; Vaccination
    Chemical Substances COVID-19 Vaccines ; ChAdOx1 nCoV-19 (B5S3K2V0G8)
    Language English
    Publishing date 2021-12-07
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-243846
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Rising incidence of colorectal cancer in individuals younger than 50 years and increasing mortality from rectosigmoid cancer in England.

    Ng, Oon-Hui / Lunevicius, Raimundas / Arthur, James D

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2021  Volume 23, Issue 10, Page(s) 2637–2646

    Abstract: Aim: The aim was to describe changes in incidence and mortality from colorectal cancer (CRC) in England by analysing data available from the National Cancer Registration and Analysis Service (NCRAS, 2001-2017).: Methods: Data analysis was undertaken ... ...

    Abstract Aim: The aim was to describe changes in incidence and mortality from colorectal cancer (CRC) in England by analysing data available from the National Cancer Registration and Analysis Service (NCRAS, 2001-2017).
    Methods: Data analysis was undertaken to interpret trends and patterns in age-standardized incidence and death rates from CRC, including sub-analyses by six age groups (0-24, 25-49, 50-59, 60-69, 70-79, 80+) and three sites of cancer-colonic, rectosigmoid and rectal.
    Results: Overall CRC incidence remained relatively stable-70.1 cases per 100 000 individuals (95% CI 69.3-71.0) in 2001 and 68.8 cases (95% CI 68.0-69.5) in 2017. Sub-analysis demonstrates a quarter fewer incidence of rectosigmoid cancer (-27%). This is counterbalanced by a 3% rise in colon cancers. The age-standardized incidence rate of CRC increased by 59% in the 25-49 age group. In the over 50s, CRC incidence remained stable, with reductions seen in rectosigmoid cancer (50-59 years, -19%; 60-69, -26%; 70-79, -39%; 80+, -27%). Overall, mortality improved (-18.7%), primarily as a result of the reduction in deaths from colon (-31.6%) and rectal cancers (-25.1%). Deaths from the small incident number of rectosigmoid cancers, however, demonstrated a significant increase overall (+166.7%). Grouped age-standardized death rate analyses showed increasing death rates in the under 50s (+28.3%) compared to declining rates in the over 50s (-15.8%).
    Conclusions: There is a clear trend in increased incidence and mortality in individuals under 50 years old. There is also a trend to increased mortality from rectosigmoid cancer. These findings should have implications for national screening programme extension to under 50s and a call to arms for appropriate identification, staging and treatment of rectosigmoid cancers.
    MeSH term(s) Colorectal Neoplasms/epidemiology ; Humans ; Incidence ; Mass Screening ; Middle Aged ; Rectal Neoplasms/epidemiology ; Sigmoid Neoplasms/epidemiology
    Language English
    Publishing date 2021-08-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.15819
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Risks associated with subtotal cholecystectomy and the factors influencing them: A systematic review and meta-analysis of 85 studies published between 1985 and 2020.

    Nzenwa, Ikemsinachi C / Mesri, Mina / Lunevicius, Raimundas

    Surgery

    2021  Volume 170, Issue 4, Page(s) 1014–1023

    Abstract: Background: Subtotal cholecystectomy is recognized as a rescue procedure performed in grossly suboptimal circumstances that would deem a total cholecystectomy too risky to execute. An earlier systematic review based on 30 studies published between 1985 ... ...

    Abstract Background: Subtotal cholecystectomy is recognized as a rescue procedure performed in grossly suboptimal circumstances that would deem a total cholecystectomy too risky to execute. An earlier systematic review based on 30 studies published between 1985 and 2013 concluded that subtotal cholecystectomy had a morbidity rate comparable to that of total cholecystectomy. This systematic review appraises 17 clinical outcomes in patients undergoing subtotal cholecystectomy.
    Methods: The study protocol was registered with the International Prospective Register for Systematic Reviews (CRD42020172808). MEDLINE, Embase, Cochrane bibliographic databases, and Google Scholar were used to identify papers published between 1985 and June 2020. Data related to the surgical setting, approach, intervention on the hepatic wall of the gallbladder, type of completion of subtotal cholecystectomy, year of study, and study design were collected. Seventeen clinical outcomes were considered. Meta-analyses were performed using a random-effects model, and the effect size was presented as risk ratios with 95% confidence intervals.
    Results: From 1,017 records, 85 eligible studies were identified and included. These included 3,645 patients who underwent subtotal cholecystectomy. Laparoscopic (80.1%, n = 2,918) and reconstituting (74.6%, n = 2,719) approaches represented the majority of all subtotal cholecystectomy cases. Seven (0.2%) cases of injury to the bile duct were reported. Bile leak was reported in 506 (13.9%) patients. Reconstituting subtotal cholecystectomy was associated with a lower risk for 11 clinical outcomes. Open subtotal cholecystectomy was associated with an increased rate of 30-day mortality and wound infections.
    Conclusion: Subtotal cholecystectomy is associated with significant morbidity. Laparoscopic and reconstituting surgery may reduce the risks of some perioperative complications and long-term sequelae after subtotal cholecystectomy.
    MeSH term(s) Cholecystectomy, Laparoscopic/adverse effects ; Cholecystectomy, Laparoscopic/methods ; Cholecystolithiasis/surgery ; Gallbladder/surgery ; Global Health ; Humans ; Morbidity/trends ; Periodicals as Topic ; Postoperative Complications/epidemiology ; Retrospective Studies ; Survival Rate/trends
    Language English
    Publishing date 2021-04-27
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2021.03.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A nationwide analysis of gallbladder surgery in England between 2000 and 2019.

    Lunevicius, Raimundas / Nzenwa, Ikemsinachi C / Mesri, Mina

    Surgery

    2021  Volume 171, Issue 2, Page(s) 276–284

    Abstract: Background: There are no reports on nationwide trends in subtotal cholecystectomy (STC) and cholecystostomy in England. We hypothesized that, as in the United States, a substantial increase in the utilization of these surgical procedures, over time, may ...

    Abstract Background: There are no reports on nationwide trends in subtotal cholecystectomy (STC) and cholecystostomy in England. We hypothesized that, as in the United States, a substantial increase in the utilization of these surgical procedures, over time, may be observed. We aimed to generate a reliable report on 4 of the most common gallbladder surgical procedures in England to allow cross-procedure comparisons and highlight significant changes in the management of benign gallbladder disease over time.
    Methods: We obtained data from NHS Digital and extracted population estimates from the Office of National Statistics. We examined the trends in the use of STC, cholecystostomy, cholecystolithotomy and total cholecystectomy (TC) between 2000 and 2019.
    Results: Of the 1,234,319 gallbladder surgeries performed, TC accounted for 96.8% (n = 1,194,786) and the other 3 surgeries for 3.2% (n = 39,533). The total number of gallbladder surgeries performed annually increased by 80.4% from 2000 to 2019. We detected increases in the counts of cholecystostomies by 723.1% (n = 290 in 2000 vs n = 2,387 in 2019) and STCs by 716.6% (n = 217 in 2000 vs n = 1,772 in 2019). Consequently, there was a decrease in the ratio of TC to STC (180:1 in 2000 vs 38:1 in 2019). A similar decrease was observed in the ratio of cholecystectomy to cholecystostomy (135:1 in 2000 vs 29:1 in 2019).
    Conclusion: Increased utilization of STC and cholecystostomy was detected in England. These findings highlight the importance of regular monitoring of nationwide trends in gallbladder surgery and the associated clinical outcomes.
    MeSH term(s) Adolescent ; Adult ; Age Distribution ; Aged ; Child ; Child, Preschool ; Cholecystectomy/statistics & numerical data ; Cholecystectomy/trends ; Cholecystostomy/statistics & numerical data ; Cholecystostomy/trends ; England ; Female ; Gallbladder/surgery ; Gallbladder Diseases/surgery ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Procedures and Techniques Utilization ; Retrospective Studies ; Sex Distribution ; Young Adult
    Language English
    Publishing date 2021-11-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2021.10.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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