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  1. Article ; Online: Reservoir displacement by an invasive rodent reduces Lassa virus zoonotic spillover risk.

    Eskew, Evan A / Bird, Brian H / Ghersi, Bruno M / Bangura, James / Basinski, Andrew J / Amara, Emmanuel / Bah, Mohamed A / Kanu, Marilyn C / Kanu, Osman T / Lavalie, Edwin G / Lungay, Victor / Robert, Willie / Vandi, Mohamed A / Fichet-Calvet, Elisabeth / Nuismer, Scott L

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 3589

    Abstract: The black rat (Rattus rattus) is a globally invasive species that has been widely introduced across Africa. Within its invasive range in West Africa, R. rattus may compete with the native rodent Mastomys natalensis, the primary reservoir host of Lassa ... ...

    Abstract The black rat (Rattus rattus) is a globally invasive species that has been widely introduced across Africa. Within its invasive range in West Africa, R. rattus may compete with the native rodent Mastomys natalensis, the primary reservoir host of Lassa virus, a zoonotic pathogen that kills thousands annually. Here, we use rodent trapping data from Sierra Leone and Guinea to show that R. rattus presence reduces M. natalensis density within the human dwellings where Lassa virus exposure is most likely to occur. Further, we integrate infection data from M. natalensis to demonstrate that Lassa virus zoonotic spillover risk is lower at sites with R. rattus. While non-native species can have numerous negative effects on ecosystems, our results suggest that R. rattus invasion has the indirect benefit of decreasing zoonotic spillover of an endemic pathogen, with important implications for invasive species control across West Africa.
    MeSH term(s) Animals ; Lassa virus/pathogenicity ; Lassa virus/physiology ; Lassa Fever/transmission ; Lassa Fever/epidemiology ; Lassa Fever/virology ; Lassa Fever/veterinary ; Introduced Species ; Disease Reservoirs/virology ; Humans ; Rats ; Murinae/virology ; Zoonoses/virology ; Zoonoses/transmission ; Zoonoses/epidemiology ; Sierra Leone/epidemiology ; Guinea/epidemiology ; Ecosystem ; Rodent Diseases/virology ; Rodent Diseases/epidemiology ; Rodent Diseases/transmission
    Language English
    Publishing date 2024-04-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-47991-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: HLA-C-restricted viral epitopes are associated with an escape mechanism from KIR2DL2

    Wauquier, Nadia / Petitdemange, Caroline / Tarantino, Nadine / Maucourant, Christopher / Coomber, Moinya / Lungay, Victor / Bangura, James / Debré, Patrice / Vieillard, Vincent

    EBioMedicine

    2019  Volume 40, Page(s) 605–613

    Abstract: Background: Lassa virus (LASV) is the etiologic agent of an acute hemorrhagic fever endemic in West Africa. Natural killer (NK) cells control viral infections in part through the interaction between killer cell immunoglobulin-like receptors (KIRs) and ... ...

    Abstract Background: Lassa virus (LASV) is the etiologic agent of an acute hemorrhagic fever endemic in West Africa. Natural killer (NK) cells control viral infections in part through the interaction between killer cell immunoglobulin-like receptors (KIRs) and their ligands. LASV infection is associated with defective immune responses, including inhibition of NK cell activity in the presence of MHC-class 1
    Methods: We compared individual KIR and HLA-class 1 genotypes of 68 healthy volunteers to 51 patients infected with LASV in Sierra Leone, including 37 survivors and 14 fatalities. Next, potential HLA-C1, HLA-C2, and HLA-Bw4 binding epitopes were in silico screened among LASV nucleoprotein (NP) and envelope glycoprotein (GP). Selected 10-mer peptides were then tested in peptide-HLA stabilization, KIR binding and polyfunction assays.
    Findings: LASV-infected patients were similar to healthy controls, except for the inhibitory KIR2DL2 gene. We found a specific increase in the HLA-C1:KIR2DL2 interaction in fatalities (10/11) as compared to survivors (12/19) and controls (19/29). We also identified that strong of NP and GP viral epitopes was only observed with HLA-C molecules, and associated with strong inhibition of degranulation in the presence of KIR2DL
    Interpretation: Our finding suggests that presentation of specific LASV epitopes by HLA-C alleles to the inhibitory KIR2DL2 receptor on NK cells could potentially prevent the killing of infected cells and provides insights into the mechanisms by which LASV can escape NK-cell-mediated immune pressure.
    MeSH term(s) Antigens, Viral/immunology ; Cell Line ; Cytotoxicity, Immunologic ; Epitope Mapping/methods ; Epitopes/immunology ; Genotype ; HLA-C Antigens/genetics ; HLA-C Antigens/immunology ; Humans ; Immune Tolerance ; Immunomodulation ; Immunophenotyping ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Lassa Fever/genetics ; Lassa Fever/immunology ; Lassa Fever/metabolism ; Lassa Fever/virology ; Lassa virus/immunology ; Protein Binding ; Receptors, KIR2DL2/genetics ; Receptors, KIR2DL2/metabolism
    Chemical Substances Antigens, Viral ; Epitopes ; HLA-C Antigens ; KIR2DL2 protein, human ; Receptors, KIR2DL2
    Language English
    Publishing date 2019-01-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2019.01.048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7090: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: High heart rate at admission as a predictive factor of mortality in hospitalized patients with Lassa fever: An observational cohort study in Sierra Leone.

    Wauquier, Nadia / Couffignal, Camille / Manchon, Pauline / Smith, Elisabeth / Lungay, Victor / Coomber, Moinya / Weisenfluh, Lauren / Bangura, James / Khan, Sheik Humarr / Jambai, Amara / Gbakima, Aiah / Yun, Nadezda / Paessler, Slobodan / Schoepp, Randal / Morse, Stephen S / Gonzalez, Jean-Paul / Fair, Joseph / Mentré, France / Vieillard, Vincent

    The Journal of infection

    2020  Volume 80, Issue 6, Page(s) 671–693

    MeSH term(s) Antibodies, Viral ; Cohort Studies ; Heart Rate ; Humans ; Lassa Fever/diagnosis ; Lassa Fever/epidemiology ; Sierra Leone/epidemiology
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2020-02-03
    Publishing country England
    Document type Letter ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2020.01.021
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1501: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 48: Show issues

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  4. Article ; Online: Genome Sequences of Five Arenaviruses from Pygmy Mice (Mus minutoides) in Sierra Leone.

    Vučak, Matej / Bangura, James / Ghersi, Bruno M / Nichols, Jenna / Hughes, Joseph / da Silva Filipe, Ana / Tremeau-Bravard, Alexandre / Wolking, David J / Amara, Emmanuel / Bangura, Abdulai / Kanu, Marilyn C / Kanu, Osman T / Kargbo, Dickson / Lavalie, Edwin G / Lungay, Victor / Robert, Willie / Turay, Mohamed / Fornie, Steven / Samba, Thomas T /
    Sesay, Bankolay B / Swaray, Patrick / Vandi, Mohamed A / Bah, Mohamed Alpha / Mansaray, Andrew A / Bird, Brian H / Davison, Andrew J

    Microbiology resource announcements

    2022  Volume 11, Issue 5, Page(s) e0009522

    Abstract: The genome sequences of five strains of a mammarenavirus were assembled from metagenomic data from pygmy mice (Mus minutoides) captured in Sierra Leone. The nearest fully sequenced relatives of this virus, which was named Seli virus, are lymphocytic ... ...

    Abstract The genome sequences of five strains of a mammarenavirus were assembled from metagenomic data from pygmy mice (Mus minutoides) captured in Sierra Leone. The nearest fully sequenced relatives of this virus, which was named Seli virus, are lymphocytic choriomeningitis virus, Lunk virus, and Ryukyu virus.
    Language English
    Publishing date 2022-04-07
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.00095-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Serologic evidence of human orthopoxvirus infections in Sierra Leone

    Goba Augustine / Lungay Victor K / Robert Willie / Kanneh Lansana D / Fonnie Richard / Lash RR / Reynolds Mary G / Abel Jason / MacNeil Adam / Moses Lina M / Damon Inger K / Karem Kevin / Bausch Daniel G

    BMC Research Notes, Vol 4, Iss 1, p

    2011  Volume 465

    Abstract: Abstract Background Orthopoxviruses, including variola virus, vaccinia virus, and monkeypox virus, have previously been documented in humans in West Africa, however, no cases of human orthopoxvirus infection have been reported in the region since 1986. ... ...

    Abstract Abstract Background Orthopoxviruses, including variola virus, vaccinia virus, and monkeypox virus, have previously been documented in humans in West Africa, however, no cases of human orthopoxvirus infection have been reported in the region since 1986. We conducted a serosurvey to determine whether human exposure to orthopoxviruses continues to occur in eastern Sierra Leone. Findings To examine evidence of exposure to orthopoxviruses in the Kenema District of Sierra Leone, we collected and tested sera from 1596 persons by IgG ELISA and a subset of 313 by IgM capture ELISA. Eleven persons born after the cessation of smallpox vaccination had high orthopoxvirus-specific IgG values, and an additional 6 persons had positive IgM responses. No geographic clustering was noted. Conclusions These data suggest that orthopoxviruses continue to circulate in Sierra Leone. Studies aimed at obtaining orthopoxvirus isolates and/or genetic sequences from rodents and symptomatic humans in the area are indicated.
    Keywords Medicine ; R ; Biology (General) ; QH301-705.5 ; Science (General) ; Q1-390
    Language English
    Publishing date 2011-10-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Serologic evidence of human orthopoxvirus infections in Sierra Leone.

    Macneil, Adam / Abel, Jason / Reynolds, Mary G / Lash, Rr / Fonnie, Richard / Kanneh, Lansana D / Robert, Willie / Lungay, Victor K / Goba, Augustine / Moses, Lina M / Damon, Inger K / Karem, Kevin / Bausch, Daniel G

    BMC research notes

    2011  Volume 4, Page(s) 465

    Abstract: Background: Orthopoxviruses, including variola virus, vaccinia virus, and monkeypox virus, have previously been documented in humans in West Africa, however, no cases of human orthopoxvirus infection have been reported in the region since 1986. We ... ...

    Abstract Background: Orthopoxviruses, including variola virus, vaccinia virus, and monkeypox virus, have previously been documented in humans in West Africa, however, no cases of human orthopoxvirus infection have been reported in the region since 1986. We conducted a serosurvey to determine whether human exposure to orthopoxviruses continues to occur in eastern Sierra Leone.
    Findings: To examine evidence of exposure to orthopoxviruses in the Kenema District of Sierra Leone, we collected and tested sera from 1596 persons by IgG ELISA and a subset of 313 by IgM capture ELISA. Eleven persons born after the cessation of smallpox vaccination had high orthopoxvirus-specific IgG values, and an additional 6 persons had positive IgM responses. No geographic clustering was noted.
    Conclusions: These data suggest that orthopoxviruses continue to circulate in Sierra Leone. Studies aimed at obtaining orthopoxvirus isolates and/or genetic sequences from rodents and symptomatic humans in the area are indicated.
    Language English
    Publishing date 2011-10-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2413336-X
    ISSN 1756-0500 ; 1756-0500
    ISSN (online) 1756-0500
    ISSN 1756-0500
    DOI 10.1186/1756-0500-4-465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Understanding the emergence of ebola virus disease in sierra leone: stalking the virus in the threatening wake of emergence.

    Wauquier, Nadia / Bangura, James / Moses, Lina / Humarr Khan, Sheik / Coomber, Moinya / Lungay, Victor / Gbakie, Michael / Sesay, Mohammed S K / Gassama, Ibrahim A K / Massally, James L B / Gbakima, Aiah / Squire, James / Lamin, Mohamed / Kanneh, Lansana / Yillah, Mohammed / Kargbo, Kandeh / Roberts, Willie / Vandi, Mohammed / Kargbo, David /
    Vincent, Tom / Jambai, Amara / Guttieri, Mary / Fair, Joseph / Souris, Marc / Gonzalez, Jean Paul

    PLoS currents

    2015  Volume 7

    Abstract: Since Ebola Virus Disease (EVD) was first identified in 1976 in what is now the Democratic Republic of Congo, and despite the numerous outbreaks recorded to date, rarely has an epidemic origin been identified. Indeed, among the twenty-one most documented ...

    Abstract Since Ebola Virus Disease (EVD) was first identified in 1976 in what is now the Democratic Republic of Congo, and despite the numerous outbreaks recorded to date, rarely has an epidemic origin been identified. Indeed, among the twenty-one most documented EVD outbreaks in Africa, an index case has been identified four times, and hypothesized in only two other instances. The initial steps of emergence and spread of a virus are critical in the development of a potential outbreak and need to be thoroughly dissected and understood in order to improve on preventative strategies. In the current West African outbreak of EVD, a unique index case has been identified, pinpointing the geographical origin of the epidemic in Guinea. Herein, we provide an accounting of events that serve as the footprint of EVD emergence in Sierra Leone and a road map for risk mitigation fueled by lessons learned.
    Language English
    Publishing date 2015-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2583641-9
    ISSN 2157-3999 ; 2157-3999
    ISSN (online) 2157-3999
    ISSN 2157-3999
    DOI 10.1371/currents.outbreaks.9a6530ab7bb9096b34143230ab01cdef
    Database MEDical Literature Analysis and Retrieval System OnLINE

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