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Article ; Online: Feasibility of ultrasound-guided intertruncal approach to supraclavicular brachial plexus block for clavicle surgery.

Luo, Quehua / Wang, Zhipeng

2023 Volume 40, Issue 5, Page(s) 383

MeSH term(s)	Humans ; Brachial Plexus Block ; Clavicle/diagnostic imaging ; Clavicle/surgery ; Feasibility Studies ; Anesthetics, Local ; Ultrasonography, Interventional
Chemical Substances	Anesthetics, Local
Language	English
Publishing date	2023-04-04
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	605770-6
ISSN	1365-2346 ; 0265-0215
ISSN (online)	1365-2346
ISSN	0265-0215
DOI	10.1097/EJA.0000000000001774
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Article ; Online: Modified first-targeted ultrasound window for selective brachial plexus trunk block may reduce the incidence of hemi-diaphragmatic paralysis.

Luo, Quehua / Yao, Weifeng

European journal of anaesthesiology

2023 Volume 40, Issue 6, Page(s) 450–451

MeSH term(s)	Humans ; Respiratory Paralysis/diagnostic imaging ; Respiratory Paralysis/epidemiology ; Respiratory Paralysis/etiology ; Incidence ; Brachial Plexus Block ; Brachial Plexus/diagnostic imaging ; Paralysis/diagnostic imaging ; Paralysis/epidemiology ; Paralysis/etiology ; Ultrasonography, Interventional ; Anesthetics, Local
Chemical Substances	Anesthetics, Local
Language	English
Publishing date	2023-05-01
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	605770-6
ISSN	1365-2346 ; 0265-0215
ISSN (online)	1365-2346
ISSN	0265-0215
DOI	10.1097/EJA.0000000000001825
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Refining the injection technique in the ultrasound-guided intertruncal approach to supraclavicular brachial plexus block for arthroscopic shoulder surgery.

Luo, Quehua / Zheng, Junyi / Yao, Weifeng

Journal of clinical anesthesia

2022 Volume 80, Page(s) 110878

MeSH term(s)	Anesthetics, Local ; Brachial Plexus Block/methods ; Humans ; Ropivacaine ; Shoulder/surgery ; Ultrasonography, Interventional/methods
Chemical Substances	Anesthetics, Local ; Ropivacaine (7IO5LYA57N)
Language	English
Publishing date	2022-05-11
Publishing country	United States
Document type	Letter
ZDB-ID	1011618-7
ISSN	1873-4529 ; 0952-8180
ISSN (online)	1873-4529
ISSN	0952-8180
DOI	10.1016/j.jclinane.2022.110878
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Article ; Online: Benefits of a pre-injection technique to identify the epineurium of individual trunks in the intertruncal approach to supraclavicular brachial plexus block.

Luo, Quehua / Zheng, Junyi / Shu, Haihua / Yao, Weifeng

Journal of clinical anesthesia

2022 Volume 79, Page(s) 110717

MeSH term(s)	Anesthetics, Local ; Brachial Plexus/diagnostic imaging ; Brachial Plexus Block/methods ; Humans ; Torso
Chemical Substances	Anesthetics, Local
Language	English
Publishing date	2022-03-03
Publishing country	United States
Document type	Letter
ZDB-ID	1011618-7
ISSN	1873-4529 ; 0952-8180
ISSN (online)	1873-4529
ISSN	0952-8180
DOI	10.1016/j.jclinane.2022.110717
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Article ; Online: Effects of the costoclavicular block versus interscalene block in patients undergoing arthroscopic shoulder surgery under monitored anesthesia care: a randomized, prospective, non-inferiority study.

Luo, Quehua / Zheng, Junyi / Yang, Caiqi / Wei, Wei / Wang, Kejia / Xiang, Xiaobing / Yao, Weifeng

Korean journal of anesthesiology

2023 Volume 76, Issue 5, Page(s) 413–423

Abstract: Background: Recent studies have reported that costoclavicular blocks (CCBs) can consistently block almost all branches of the brachial plexus while sparing the phrenic nerve and provide effective analgesia after shoulder surgery. We aimed to compare the ...

Abstract	Background: Recent studies have reported that costoclavicular blocks (CCBs) can consistently block almost all branches of the brachial plexus while sparing the phrenic nerve and provide effective analgesia after shoulder surgery. We aimed to compare the efficacy of the CCB with that of the interscalene block (ISB) as the sole blocking technique for shoulder surgery. Methods: A total of 212 patients undergoing elective arthroscopic shoulder surgery were randomized to receive an ISB or CCB based on a non-inferiority design. All patients received titration sedation with propofol under monitored anesthesia during surgery. The primary outcomes were the proportion of patients with complete motor blockade of the suprascapular nerve (SSN) and incidence of hemidiaphragmatic paralysis (HDP). The secondary outcomes included block-related variables, complications, and postoperative pain scores. Results: The proportion of patients with complete motor blockade of the SSN at 20 min between the CCB and ISB groups (53% vs. 66%) exceeded the predefined non-inferiority margin of -5%, but was comparable at 30 min (87% vs. 91%). The CCB resulted in a significantly lower incidence of HDP (7.55% vs. 92.45%), Horner's syndrome (0% vs. 18.87%), and dyspnea (0% vs. 10.38%) than the ISB. None of the patients experienced failed blocks or required conversion to general anesthesia. Pain scores were comparable between the groups. Conclusions: Ultrasound-guided CCBs may be comparable to ISBs, with fewer unfavorable complications in patients with impaired lung function undergoing arthroscopic shoulder surgery.
MeSH term(s)	Humans ; Shoulder/surgery ; Prospective Studies ; Brachial Plexus Block/methods ; Brachial Plexus ; Pain, Postoperative/etiology
Language	English
Publishing date	2023-01-09
Publishing country	Korea (South)
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2557340-8
ISSN	2005-7563 ; 2005-7563
ISSN (online)	2005-7563
ISSN	2005-7563
DOI	10.4097/kja.22638
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Article ; Online: Ultrasound-guided quadratus lumborum block for perioperative analgesia in robot-assisted partial nephrectomy: a randomized controlled trial.

Lai, Renchun / Luo, Quehua / Lai, Jielan / Lu, Xiaoyun / Xu, Mei

Trials

2021 Volume 22, Issue 1, Page(s) 840

Abstract: Background: Recently, several case reports and limited randomized studies have shown that quadratus lumborum blocks (QLB) are effective in providing pain relief after intra-abdominal and retroperitoneal operations. Additionally, robot-assisted partial ... ...

Abstract	Background: Recently, several case reports and limited randomized studies have shown that quadratus lumborum blocks (QLB) are effective in providing pain relief after intra-abdominal and retroperitoneal operations. Additionally, robot-assisted partial nephrectomy (RAPN) has been proposed as a promising operative treatment for renal carcinoma because it enables early recovery and ambulation. Therefore, we aimed to evaluate the analgesic and opioid-sparing effects of a single-injection QLB in patients undergoing RAPN to determine its role in an early recovery program. Methods: Fifty-six patients undergoing elective RAPN under general anesthesia were randomized to two equally sized groups. Patients were randomly allocated to receive either a unilateral QLB (n = 28) with 0.375% bupivacaine 0.5 mL/kg (QLB group) or a conventional scheme (n = 28) (control group). The QLB technique, termed QLB2, was performed as first described by Blanco. The primary outcome was visual analog scale (VAS) scores with movement at 6 h postoperatively. The secondary endpoints were morphine consumption at different time periods after surgery, morphine-related side effects, and assessment of postoperative rehabilitation. Results: Both the VAS pain scores and cumulative opioid consumption were significantly lower in the QLB group at 6 h after surgery as compared with results in the control group (all P < 0.05). There were significant differences in pain scores at all time points except at 4 h with movement and 48 h at rest. However, at 12-24 h no significant differences between the two groups were observed in cumulative opioid consumption or in the duration of PACU and hospital stays. The patient recovery scores were significantly higher in the QLB group. Conclusions: Single-injection pre-emptive QLB applied to RAPN was effective and provided satisfactory analgesia and opioid-sparing effects in combination with typical patient-controlled analgesia. In addition, it may provide an effective technique for early recovery in the perioperative period for RAPN.
MeSH term(s)	Analgesia, Patient-Controlled ; Anesthetics, Local/adverse effects ; Humans ; Nephrectomy/adverse effects ; Pain, Postoperative/diagnosis ; Pain, Postoperative/etiology ; Pain, Postoperative/prevention & control ; Robotics ; Ultrasonography, Interventional
Chemical Substances	Anesthetics, Local
Language	English
Publishing date	2021-11-24
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1468-6708
ISSN (online)	1745-6215 ; 1468-6694
ISSN	1468-6708
DOI	10.1186/s13063-021-05815-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A single dose of ketamine relieves fentanyl-induced-hyperalgesia by reducing inflammation initiated by the TLR4/NF-κB pathway in rat spinal cord neurons.

Zhou, Xin / Li, Qianyi / Luo, Quehua / Wang, Le / Chen, Jiaxin / Xiong, Ying / Wu, Guiyun / Chang, Lu / Liu, Pingping / Shu, Haihua

Drug discoveries & therapeutics

2023 Volume 17, Issue 4, Page(s) 279–288

Abstract: A large amount of clinical evidence has revealed that ketamine can relieve fentanyl-induced hyperalgesia. However, the underlying mechanism is still unclear. In the current study, a single dose of ketamine (5 mg/kg or 10 mg/kg), TAK-242 (3 mg/kg), or ... ...

Abstract	A large amount of clinical evidence has revealed that ketamine can relieve fentanyl-induced hyperalgesia. However, the underlying mechanism is still unclear. In the current study, a single dose of ketamine (5 mg/kg or 10 mg/kg), TAK-242 (3 mg/kg), or saline was intraperitoneally injected into rats 15 min before four subcutaneous injections of fentanyl. Results revealed that pre-administration of ketamine alleviated fentanyl-induced hyperalgesia according to hind paw-pressure and paw-withdrawal tests. High-dose ketamine can reverse the expression of toll-like receptor-dimer (d-TLR4), phospho- nuclear factor kappa-B (p-NF-κB, p-p65), cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) 1 d after fentanyl injection in the spinal cord. Moreover, fentany-linduced-hyperalgesia and changes in the expression of the aforementioned proteins can be attenuated by TAK-242, an inhibitor of TLR4, as well as ketamine. Importantly, TLR4, p-p65, COX-2, and IL-1β were expressed in neurons but not in glial cells in the spinal cord 1 d after fentanyl injection. In conclusion, results suggested that a single dose of ketamine can relieve fentanyl-induced-hyperalgesia via the TLR4/NF-κB pathway in spinal cord neurons.
MeSH term(s)	Rats ; Animals ; NF-kappa B/metabolism ; Fentanyl/adverse effects ; Fentanyl/metabolism ; Hyperalgesia/chemically induced ; Hyperalgesia/drug therapy ; Hyperalgesia/metabolism ; Toll-Like Receptor 4/metabolism ; Ketamine/adverse effects ; Ketamine/metabolism ; Rats, Sprague-Dawley ; Cyclooxygenase 2/adverse effects ; Cyclooxygenase 2/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Neurons/metabolism ; Inflammation ; Spinal Cord/metabolism ; Spinal Cord/pathology
Chemical Substances	NF-kappa B ; Fentanyl (UF599785JZ) ; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate ; Toll-Like Receptor 4 ; Ketamine (690G0D6V8H) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2023-08-09
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2568828-5
ISSN	1881-784X ; 1881-784X
ISSN (online)	1881-784X
ISSN	1881-784X
DOI	10.5582/ddt.2023.01029
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effectiveness of general anaesthesia with remimazolam tosilate on intraoperative haemodynamics and postoperative recovery: study protocol for a randomised, positive-controlled, pragmatic clinical trial (GARTH trial).

Lu, Changyin / Kang, Yin / Luo, Quehua / Zhong, Fei / Cai, Yujing / Zhang, Guangyan / Guo, Zhimin / Zhang, Shaoting / Ma, Jue / Shu, HaiHua

BMJ open

2024 Volume 14, Issue 1, Page(s) e073024

Abstract: Introduction: It is encouraged to estimate the effectiveness of components within the enhanced recovery after surgery (ERAS) protocol through patient-reported outcomes, alongside doctor-reported outcomes and length of hospital stay. At present, studies ... ...

Abstract	Introduction: It is encouraged to estimate the effectiveness of components within the enhanced recovery after surgery (ERAS) protocol through patient-reported outcomes, alongside doctor-reported outcomes and length of hospital stay. At present, studies on the contributions of optimal anaesthetic drugs within the ERAS protocol to patient-reported and doctor-reported outcomes are limited. Therefore, this study aims to pragmatically evaluate the effectiveness and safety of general anaesthesia (GA) with remimazolam tosilate within the ERAS protocol on intraoperative haemodynamics and postoperative recovery in adults undergoing elective surgeries, compared with propofol. Methods and analysis: This study is a single-centre, randomised, blinded, positive-controlled, pragmatic clinical trial. A total of 900 patients, aged ≥18 years old, scheduled for an elective surgical procedure under GA will be included. Patients will be randomised in a 1:1 ratio to the remimazolam group (the GA with remimazolam tosilate within the ERAS protocol group) or propofol group (the GA with propofol within the ERAS protocol group), stratified by general surgery, thoracic surgery and other surgeries (including urological surgery and otolaryngology surgery). The primary outcomes include the 24-hour postoperative quality of recovery-40 score and the rate of intraoperative hypotension. Secondary endpoints include the rate of sedative hypotension requiring treatment, the haemodynamic profiles, the 72-hour postoperative quality of recovery-40 score, the functional anaesthetic capability, adverse events and complications, quality of life within 3 months as well as economic health outcomes. Ethics and dissemination: This study protocol has been approved by the ethics committee of Guangdong Provincial People's Hospital (KY-H-2022-005-03-08). Dissemination plans will be presented at scientific meetings and in scientific publications. Trial registration number: ChiCTR2200062520.
MeSH term(s)	Adolescent ; Adult ; Humans ; Anesthesia, General/adverse effects ; Anesthetics ; Hemodynamics ; Hypotension/etiology ; Postoperative Complications/prevention & control ; Postoperative Complications/etiology ; Propofol ; Quality of Life ; Randomized Controlled Trials as Topic ; Pragmatic Clinical Trials as Topic
Chemical Substances	Anesthetics ; Propofol (YI7VU623SF) ; remimazolam (7V4A8U16MB)
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-073024
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Accidental awareness while under general anaesthesia.

Chang, Lu / Luo, Quehua / Chai, Yunfei / Shu, Haihua

Bioscience trends

2019 Volume 13, Issue 4, Page(s) 364–366

Abstract: Accidental awareness during general anaesthesia may cause many intraoperative discomforts and bring further moderate to severe long-term symptoms including flashbacks, nightmares, hyperarousal or post-traumatic stress disorder. The incidence of awareness ...

Abstract	Accidental awareness during general anaesthesia may cause many intraoperative discomforts and bring further moderate to severe long-term symptoms including flashbacks, nightmares, hyperarousal or post-traumatic stress disorder. The incidence of awareness varied from 0.017% to 4% among studies. The relatively reliable incidence of intraoperative awareness with postoperative recall is 0.02%. The reason causing awareness was unclear. Insufficient anaesthetic dosing was thought as the principal cause. Even awareness was not comprehensively understood, some endeavors have been raised to prevent or reduce it, including i) Reducing the insufficient anaesthetic dosing induced by negligence; ii) Providing close clinical observation and clinical parameters from the monitor such as bispectral index or electroencephalogram, as well as isolated forearm technique and passive brain-computer interface may bring some effects sometimes. Because current studies still have some flaws, further trials with new detecting approach, superior methodology and underlying aetiology are needed to unfasten the possible factors causing awareness.
MeSH term(s)	Anesthesia, General/methods ; Anesthetics, General/administration & dosage ; Consciousness Monitors ; Dose-Response Relationship, Drug ; Female ; Humans ; Incidence ; Intraoperative Awareness/diagnosis ; Intraoperative Awareness/epidemiology ; Intraoperative Awareness/etiology ; Intraoperative Awareness/prevention & control ; Monitoring, Intraoperative/instrumentation ; Monitoring, Intraoperative/methods
Chemical Substances	Anesthetics, General
Language	English
Publishing date	2019-09-13
Publishing country	Japan
Document type	Letter
ZDB-ID	2543899-2
ISSN	1881-7823 ; 1881-7815
ISSN (online)	1881-7823
ISSN	1881-7815
DOI	10.5582/bst.2019.01237
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Article ; Online: Effects of pericapsular nerve group (PENG) block on postoperative recovery in elderly patients with hip fracture: study protocol for a randomised, parallel controlled, double-blind trial.

Luo, Wei / Liang, Jianhui / Wu, Jieting / Luo, Quehua / Wu, Huiyi / Ou, Yanhua / Li, Yuhui / Ma, WuHua

BMJ open

2022 Volume 12, Issue 3, Page(s) e051321

Abstract: Introduction: Hip fracture is a common and serious emergency in the elderly, and it is associated with severe pain, significant morbidity and mortality. The use of peripheral nerve block can relieve pain effectively and reduce opioid requirements, which ...

Abstract	Introduction: Hip fracture is a common and serious emergency in the elderly, and it is associated with severe pain, significant morbidity and mortality. The use of peripheral nerve block can relieve pain effectively and reduce opioid requirements, which may accelerate patient's recovery. The pericapsular nerve group (PENG) block has been found to provide an effective blockade to the hip joint with a potential motor-sparing effect, so we hypothesised that the PENG block may be an effective tool to enhance the recovery in elderly patients after hip fracture surgery. Methods and analysis: This study is a single-centred, randomised, parallel controlled, double-blind trial. A total of 92 elderly patients scheduled for hip fracture surgery will be divided into two groups at random to receive either ultrasound-guided femoral nerve block or ultrasound-guided PENG block. The primary outcome will be to compare the Quality of Recovery-15 scores at 24 hours postoperatively between the two groups. The secondary outcomes will include measuring and comparing the strength of the quadriceps, the visual analogue scale at rest and on movement, the total morphine consumption, the rescue analgesic, the first time of postoperative out-of-bed mobilisation and complications. Ethics and dissemination: This study was approved by the Institutional Review Board of the Ethics Committee of The First Affiliated Hospital of Guangzhou University of Chinese Medicine on 15 December 2020 (reference K2020-110). The results of this study will be published in peer-reviewed international journals. Trial registration number: ChiCTR2100042341.
MeSH term(s)	Aged ; Double-Blind Method ; Femoral Nerve ; Hip Fractures/complications ; Hip Fractures/surgery ; Humans ; Nerve Block/methods ; Pain Measurement ; Pain, Postoperative/drug therapy ; Pain, Postoperative/etiology ; Pain, Postoperative/prevention & control ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2022-03-29
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2021-051321
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