Article ; Online: Cancer-associated chromatin variants uncover the oncogenic role of transposable elements.
Current opinion in genetics & development
2022 Volume 74, Page(s) 101911
Abstract: The vast array of cell states found across human tissue arises from chromatin variants, which correspond to segments of the genome, known as DNA elements, adopting a different chromatin state over cell state transitions. Oncogenesis stems from ... ...
Abstract | The vast array of cell states found across human tissue arises from chromatin variants, which correspond to segments of the genome, known as DNA elements, adopting a different chromatin state over cell state transitions. Oncogenesis stems from alterations to the chromatin states over DNA elements that result in cancer-associated chromatin variants. Here, we review how cancer-associated chromatin variants call attention to repetitive DNA elements, and guide the functional characterization of transposable elements to decode their role in oncogenesis. We further discuss prevailing opportunities in the study of repetitive DNA elements to move towards the 'complete cancer genome' goal for precision medicine in oncology. |
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MeSH term(s) | Carcinogenesis/genetics ; Chromatin/genetics ; DNA Methylation ; DNA Transposable Elements/genetics ; Humans ; Neoplasms/genetics |
Chemical Substances | Chromatin ; DNA Transposable Elements |
Language | English |
Publishing date | 2022-04-26 |
Publishing country | England |
Document type | Journal Article ; Review ; Research Support, Non-U.S. Gov't |
ZDB-ID | 1077312-5 |
ISSN | 1879-0380 ; 0959-437X |
ISSN (online) | 1879-0380 |
ISSN | 0959-437X |
DOI | 10.1016/j.gde.2022.101911 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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