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  1. Article: Utilizing Ceftazidime/Avibactam Therapeutic Drug Monitoring in the Treatment of Neurosurgical Meningitis Caused by Difficult-to-Treat Resistant

    Yasmin, Mohamad / Nutman, Amir / Wang, Lu / Marshall, Steven / Chen, Ke / Wang, Jiping / Yahav, Dafna / Lupinsky, Liad / Hujer, Andrea M / Bhimraj, Adarsh / van Duin, David / Li, Jian / Bonomo, Robert A

    Open forum infectious diseases

    2023  Volume 10, Issue 11, Page(s) ofad507

    Abstract: Background: Central nervous system (CNS) infections caused by : Methods: Therapeutic drug monitoring (TDM) was performed in 3 patients with health care-associated ventriculitis and meningitis (HAVM) using CAZ-AVI 2.5 g infused intravenously every 8 ... ...

    Abstract Background: Central nervous system (CNS) infections caused by
    Methods: Therapeutic drug monitoring (TDM) was performed in 3 patients with health care-associated ventriculitis and meningitis (HAVM) using CAZ-AVI 2.5 g infused intravenously every 8 hours as standard and extended infusion. Simultaneous CSF and plasma samples were obtained throughout the dosing interval in each patient. Concentrations of CAZ and AVI were determined by liquid chromatography/mass spectrometry.
    Results: Bacterial identification revealed KPC-producing
    Conclusions: Postinfusion concentrations of CAZ-AVI were measured in plasma and CSF samples obtained from 3 patients with complicated CNS infections caused by antimicrobial-resistant isolates. The measured concentrations revealed that standard CAZ and AVI exposures sufficiently attained values correlating to 50%
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comparative Plasma Pharmacokinetics of Ceftriaxone and Ertapenem in Normoalbuminemia, Hypoalbuminemia, and Albumin Replacement in a Sheep Model.

    Dhanani, Jayesh A / Ahern, Benjamin / Lupinsky, Liad / Jackson, Karen / Wallis, Steven C / Abdul-Aziz, Mohd H / Lipman, Jeffrey / Roberts, Jason A

    Antimicrobial agents and chemotherapy

    2020  Volume 64, Issue 7

    Abstract: Optimal concentrations of unbound antimicrobials are essential for a maximum microbiological effect. Although hypoalbuminemia and albumin fluid resuscitation are common in critical care, the effects of different albumin concentrations on the unbound ... ...

    Abstract Optimal concentrations of unbound antimicrobials are essential for a maximum microbiological effect. Although hypoalbuminemia and albumin fluid resuscitation are common in critical care, the effects of different albumin concentrations on the unbound concentrations of highly protein-bound antimicrobials are not known. The aim of this study was to compare the effects of different albumin states on total and unbound concentrations of ertapenem and ceftriaxone using an ovine model. The study design was a prospective, three-phase intervention observational study. The subjects were healthy Merino sheep. Eight sheep were subjected to three experimental phases: normoalbuminemia, hypoalbuminemia using plasmapheresis, and albumin replacement using a 25% albumin solution. In each phase, ceftriaxone at 40 mg/kg of body weight and ertapenem at 15 mg/kg were given intravenously. Blood samples were collected at predefined intervals and analyzed using an ultrahigh-performance liquid chromatography-tandem mass spectrometry method. Pharmacokinetic parameters such as the area under the curve from 0 to 24 h (AUC
    MeSH term(s) Animals ; Anti-Bacterial Agents/therapeutic use ; Ceftriaxone ; Ertapenem ; Hypoalbuminemia/drug therapy ; Pharmaceutical Preparations ; Prospective Studies ; Sheep
    Chemical Substances Anti-Bacterial Agents ; Pharmaceutical Preparations ; Ceftriaxone (75J73V1629) ; Ertapenem (G32F6EID2H)
    Language English
    Publishing date 2020-06-23
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.02584-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 809: Show issues Location:
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  3. Article: Comparison between two metabolic monitors in the measurement of resting energy expenditure and oxygen consumption in diabetic and non-diabetic ambulatory and hospitalized patients

    Lupinsky, Liad / Ilya Kagan / Joelle Attal-Singer / Milana Grinev / Miriam Theilla / Pierre Singer / Raphael Hirsh / Shaul Lev

    Nutrition. 2015 Jan., v. 31, no. 1

    2015  

    Abstract: The aim of this study was to assess the validity and reliability of the Fitmate metabolic system in measuring the oxygen consumption and resting metabolic rate (RMR) in ambulatory and hospitalized patients.We conducted a prospective simultaneous clinical ...

    Abstract The aim of this study was to assess the validity and reliability of the Fitmate metabolic system in measuring the oxygen consumption and resting metabolic rate (RMR) in ambulatory and hospitalized patients.We conducted a prospective simultaneous clinical comparison. We enrolled 37 patients (19 women and 18 men) for the four groups of the study. Group 1 (n = 12) included patients receiving home parenteral nutrition. Group 2 (n = 5) included diabetic overweight outpatients with body mass index >30 kg/m2 and hemoglobin A1c > 8 g/dL. Group 3 (n = 10) included hospitalized patients receiving artificial nutrition. Group 4 (n = 10) included patients with congenital heart disease, pulmonary hypertension of any etiology, and other heart disease who have had hemodynamic evaluation during catheterization by the adult congenital team. The patients were tested successively during the same session using the Fitmate metabolic system for 15 min and the Deltatrac II metabolic monitor for 20 min, measuring resting energy expenditure and oxygen consumption. The test was conducted in random order.No significant differences were found between Fit Mate and Deltatrac II for oxygen consumption (238 ± 18 and 240 ± 18 mL/min, respectively, P = 0.72, r = 0.86, mean ± SD absolute difference 22.32 ± 16.99 mL/min) or RMR (1659 ± 122.34 and 1625 ± 118.4 kcal/d, P = 0.28, r = 0.87, mean ± SD absolute difference 152.9 ± 111.95 kcal/d). A degree of limit of agreement (403 kcal) was observed using the Bland-Altman test. When compared with Harris-Benedict predictive equations, Fitmate was found to be superior in accuracy.These data indicate that the Fitmate using a mask provided a fair evaluation of REE despite a large limit of agreement. It remains a reliable and valid system for measuring oxygen consumption and RMR in nonventilated patients.
    Keywords adults ; body mass index ; catheters ; equations ; etiology ; glycohemoglobin ; heart diseases ; hemodynamics ; hypertension ; men ; metabolism ; overweight ; oxygen consumption ; parenteral feeding ; patients ; resting energy expenditure ; resting metabolic rate ; women
    Language English
    Dates of publication 2015-01
    Size p. 176-179.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2014.07.013
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Comparison between two metabolic monitors in the measurement of resting energy expenditure and oxygen consumption in diabetic and non-diabetic ambulatory and hospitalized patients.

    Lupinsky, Liad / Singer, Pierre / Theilla, Miriam / Grinev, Milana / Hirsh, Raphael / Lev, Shaul / Kagan, Ilya / Attal-Singer, Joelle

    Nutrition (Burbank, Los Angeles County, Calif.)

    2015  Volume 31, Issue 1, Page(s) 176–179

    Abstract: Objective: The aim of this study was to assess the validity and reliability of the Fitmate metabolic system in measuring the oxygen consumption and resting metabolic rate (RMR) in ambulatory and hospitalized patients.: Methods: We conducted a ... ...

    Abstract Objective: The aim of this study was to assess the validity and reliability of the Fitmate metabolic system in measuring the oxygen consumption and resting metabolic rate (RMR) in ambulatory and hospitalized patients.
    Methods: We conducted a prospective simultaneous clinical comparison. We enrolled 37 patients (19 women and 18 men) for the four groups of the study. Group 1 (n = 12) included patients receiving home parenteral nutrition. Group 2 (n = 5) included diabetic overweight outpatients with body mass index >30 kg/m(2) and hemoglobin A1c > 8 g/dL. Group 3 (n = 10) included hospitalized patients receiving artificial nutrition. Group 4 (n = 10) included patients with congenital heart disease, pulmonary hypertension of any etiology, and other heart disease who have had hemodynamic evaluation during catheterization by the adult congenital team. The patients were tested successively during the same session using the Fitmate metabolic system for 15 min and the Deltatrac II metabolic monitor for 20 min, measuring resting energy expenditure and oxygen consumption. The test was conducted in random order.
    Results: No significant differences were found between Fit Mate and Deltatrac II for oxygen consumption (238 ± 18 and 240 ± 18 mL/min, respectively, P = 0.72, r = 0.86, mean ± SD absolute difference 22.32 ± 16.99 mL/min) or RMR (1659 ± 122.34 and 1625 ± 118.4 kcal/d, P = 0.28, r = 0.87, mean ± SD absolute difference 152.9 ± 111.95 kcal/d). A degree of limit of agreement (403 kcal) was observed using the Bland-Altman test. When compared with Harris-Benedict predictive equations, Fitmate was found to be superior in accuracy.
    Conclusions: These data indicate that the Fitmate using a mask provided a fair evaluation of REE despite a large limit of agreement. It remains a reliable and valid system for measuring oxygen consumption and RMR in nonventilated patients.
    MeSH term(s) Adolescent ; Adult ; Aged ; Basal Metabolism ; Body Mass Index ; Diabetes Mellitus/metabolism ; Energy Intake ; Female ; Glycated Hemoglobin A/metabolism ; Hospitalization ; Humans ; Male ; Middle Aged ; Oxygen Consumption ; Prospective Studies ; Reproducibility of Results ; Young Adult
    Chemical Substances Glycated Hemoglobin A ; hemoglobin A1c protein, human
    Language English
    Publishing date 2015-01
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2014.07.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2290: Show issues Location:
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  5. Article: Functional significance of using tissue adhesive substance in nephron-sparing surgery: assessment by quantitative SPECT of 99m Tc-Dimercaptosuccinic acid scintigraphy.

    Hidas, Guy / Lupinsky, Liad / Kastin, Alexander / Moskovitz, Boaz / Groshar, David / Nativ, Ofer

    European urology

    2007  Volume 52, Issue 3, Page(s) 785–789

    Abstract: Objectives: To compare changes in renal function following nephron-sparing surgery (NSS) using tissue adhesive only versus NSS using standard suturing technique, as measured by quantitative SPECT of 99m Tc-dimercaptosuccinic acid uptake by the kidney ( ... ...

    Abstract Objectives: To compare changes in renal function following nephron-sparing surgery (NSS) using tissue adhesive only versus NSS using standard suturing technique, as measured by quantitative SPECT of 99m Tc-dimercaptosuccinic acid uptake by the kidney (QDMSA).
    Materials and methods: QDMSA was done before and 3-6 mo after the operation in 32 patients who underwent standard suturing technique and in 24 patients in whom tissue adhesive sealant (19 with albumin glutaraldehyde tissue adhesive [BioGlue]; 5 with CoSeal) was used to close the parenchymal defect. Individual kidney uptake was measured and retrospectively compared between the two groups.
    Results: Average tumor diameter was 3.4cm (range: 2.2-6) in the suture group and 3.56 (range: 1.7-6) in the tissue sealant group. In the tissue sealant group following surgery, we observed an average individual renal function loss of 11.49% compared with the suture group in whom an average individual renal function loss of 20.36% (p = 0.02) was measured by 99m Tc-DMSA.
    Conclusions: The use of tissue sealant to close the parenchymal defect during NSS demonstrated a statistically significant advantage in reducing functioning renal loss as measured by the absolute uptake of QDMSA. Further clinical studies are required to establish the role of tissue sealants in NSS.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Follow-Up Studies ; Humans ; Kidney Neoplasms/diagnostic imaging ; Kidney Neoplasms/metabolism ; Kidney Neoplasms/surgery ; Male ; Middle Aged ; Nephrectomy/methods ; Nephrons/diagnostic imaging ; Nephrons/metabolism ; Nephrons/surgery ; Polyethylene Glycols/pharmacology ; Proteins/pharmacology ; Radiopharmaceuticals/pharmacokinetics ; Retrospective Studies ; Suture Techniques ; Technetium Tc 99m Dimercaptosuccinic Acid/pharmacokinetics ; Time Factors ; Tomography, Emission-Computed, Single-Photon/methods ; Treatment Outcome
    Chemical Substances Bio-glue ; CoSeal ; Proteins ; Radiopharmaceuticals ; Polyethylene Glycols (30IQX730WE) ; Technetium Tc 99m Dimercaptosuccinic Acid (494JNQ8L28)
    Language English
    Publishing date 2007-09
    Publishing country Switzerland
    Document type Comparative Study ; Journal Article
    ZDB-ID 193790-x
    ISSN 1421-993X ; 0302-2838
    ISSN (online) 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2006.12.001
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    Zs.A 1247: Show issues Location:
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    Zs.MO 294: Show issues

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