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  1. Article ; Online: Mitochondrial metabolism sustains CD8

    Simula, Luca / Fumagalli, Mattia / Vimeux, Lene / Rajnpreht, Irena / Icard, Philippe / Birsen, Gary / An, Dongjie / Pendino, Frédéric / Rouault, Adrien / Bercovici, Nadège / Damotte, Diane / Lupo-Mansuet, Audrey / Alifano, Marco / Alves-Guerra, Marie-Clotilde / Donnadieu, Emmanuel

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 2203

    Abstract: The ability of ... ...

    Abstract The ability of CD8
    MeSH term(s) Humans ; CD8-Positive T-Lymphocytes/metabolism ; Mitochondria/metabolism ; Neoplasms/pathology ; Metabolic Networks and Pathways ; Cell Movement
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46377-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Impact of sarcopenia indexes on survival and severe immune acute toxicity in metastatic non-small cell lung cancer patients treated with PD-1 immune checkpoint inhibitors.

    Ashton, Elisabeth / Arrondeau, Jennifer / Jouinot, Anne / Boudou-Rouquette, Pascaline / Hirsch, Laure / Huillard, Olivier / Ulmann, Guillaume / Lupo-Mansuet, Audrey / Damotte, Diane / Wislez, Marie / Alifano, Marco / Alexandre, Jérôme / Goldwasser, François

    Clinical nutrition (Edinburgh, Scotland)

    2023  Volume 42, Issue 6, Page(s) 944–953

    Abstract: Background & aims: Sarcopenia has long been associated with higher toxicity induced by anti-cancer treatments and shorter survival in patients with solid tumors. The creatinine-to-cystatin ratio (CC ratio, serum creatinine/cystatin C × 100) and the ... ...

    Abstract Background & aims: Sarcopenia has long been associated with higher toxicity induced by anti-cancer treatments and shorter survival in patients with solid tumors. The creatinine-to-cystatin ratio (CC ratio, serum creatinine/cystatin C × 100) and the sarcopenia index (SI, serum creatinine × cystatin C (CysC)-based glomerular filtration rate (eGFR
    Methods: From the prospective CERTIM cohort, we analyzed retrospectively stage IV NSCLC patients, who received PD-1 inhibitors between June 2015 and November 2020 in Cochin Hospital (Paris, France). We assessed sarcopenia measuring skeletal muscle area (SMA) by computed tomography and handgrip strength (HGS) by a hand dynamometer.
    Results: In total, 200 patients were analyzed. The CC ratio and the IS were significantly correlated with SMA and HGS: r
    Conclusions: In metastatic NSCLC patients treated with PD-1 inhibitors, a lower CC ratio and a lower SI are independent predictors of mortality. However, they are not associated with severe irAEs.
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/complications ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Immune Checkpoint Inhibitors/adverse effects ; Sarcopenia/complications ; Cystatin C ; Programmed Cell Death 1 Receptor/therapeutic use ; Lung Neoplasms/complications ; Lung Neoplasms/drug therapy ; Retrospective Studies ; Creatinine ; Hand Strength ; Prospective Studies
    Chemical Substances Immune Checkpoint Inhibitors ; Cystatin C ; Programmed Cell Death 1 Receptor ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2023-04-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2023.03.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1774: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: EBV-Positive Inflammatory Follicular Dendritic Cell Sarcoma of the Spleen: Report of an Aggressive Form With Molecular Characterization.

    Baber, Alistair / Legendre, Paul / Palmic, Patricia / Lupo-Mansuet, Audrey / Burroni, Barbara / Azoulay, Célia / Szwebel, Tali-Anne / Costedoat-Chalumeau, Nathalie / Leroy, Karen / Blons, Hélène / Blay, Jean-Yves / Boudou-Rouquette, Pascaline / Terrier, Benjamin

    International journal of surgical pathology

    2023  Volume 32, Issue 1, Page(s) 150–154

    Abstract: EBV-positive inflammatory follicular dendritic cell sarcoma (EBV+ inflammatory FDCS) is a rare neoplasm almost exclusively located in the spleen or liver. It is characterized by a proliferation of EBV-positive spindle-shaped cells bearing follicular ... ...

    Abstract EBV-positive inflammatory follicular dendritic cell sarcoma (EBV+ inflammatory FDCS) is a rare neoplasm almost exclusively located in the spleen or liver. It is characterized by a proliferation of EBV-positive spindle-shaped cells bearing follicular dendritic cell markers, associated with an abundant lymphoplasmacytic infiltrate. EBV+ inflammatory FDCS is often asymptomatic or responsible for mild symptoms. It usually displays an indolent course and its prognosis is excellent after tumor removal, although relapsing and metastatic forms exist. Herein, we describe an aggressive form of splenic EBV+ inflammatory FDCS in a 79-year-old woman presenting with abdominal pain, deterioration of general health status, major inflammatory syndrome, and symptomatic hypercalcemia. A splenectomy was performed leading to a rapid improvement in her clinical condition and normalization of laboratory abnormalities. Unfortunately, her symptoms and laboratory abnormalities reappeared 4 months later. Computed tomography showed a mass in the splenectomy site and multiple liver and peritoneal nodules. Further analyses were performed on tumor tissue and showed positive phospho-ERK staining of tumoral cells indicating activation of MAPK pathway. Inactivating mutations were found on
    MeSH term(s) Female ; Humans ; Aged ; Dendritic Cell Sarcoma, Follicular/diagnosis ; Dendritic Cell Sarcoma, Follicular/genetics ; Dendritic Cell Sarcoma, Follicular/metabolism ; Spleen/pathology ; Herpesvirus 4, Human/genetics ; Neoplasm Recurrence, Local/pathology ; Dendritic Cells, Follicular/metabolism ; Dendritic Cells, Follicular/pathology ; Soft Tissue Neoplasms/pathology
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1336393-1
    ISSN 1940-2465 ; 1066-8969
    ISSN (online) 1940-2465
    ISSN 1066-8969
    DOI 10.1177/10668969231168345
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4500: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Impact of sarcopenia indexes on survival and severe immune acute toxicity in metastatic non-small cell lung cancer patients treated with PD-1 immune checkpoint inhibitors

    Ashton, Elisabeth / Arrondeau, Jennifer / Jouinot, Anne / Boudou-Rouquette, Pascaline / Hirsch, Laure / Huillard, Olivier / Ulmann, Guillaume / Lupo-Mansuet, Audrey / Damotte, Diane / Wislez, Marie / Alifano, Marco / Alexandre, Jérôme / Goldwasser, François

    Clinical Nutrition.

    2023  

    Abstract: Sarcopenia has long been associated with higher toxicity induced by anti-cancer treatments and shorter survival in patients with solid tumors. The creatinine-to-cystatin ratio (CC ratio, serum creatinine/cystatin C x 100) and the sarcopenia index (SI, ... ...

    Abstract Sarcopenia has long been associated with higher toxicity induced by anti-cancer treatments and shorter survival in patients with solid tumors. The creatinine-to-cystatin ratio (CC ratio, serum creatinine/cystatin C x 100) and the sarcopenia index (SI, serum creatinine × cystatin C (CysC)-based glomerular filtration rate (eGFRCyₛC)) are have been reported to be correlated with skeletal muscle mass. The aim of this study is to assess primarily whether the CC ratio and the SI could predict mortality in metastatic non-small cell lung cancer (NSCLC) patients treated with PD-1 inhibitors, and secondarily their impact on severe immune-related adverse effects (irAEs). From the prospective CERTIM cohort, we analyzed retrospectively stage IV NSCLC cancer patients, who received PD-1 inhibitors between June 2015 and November 2020 in Cochin Hospital (Paris, France). We assessed sarcopenia measuring skeletal muscle area (SMA) by computed tomography and handgrip strength (HGS) by a hand dynamometer. In total, 200 patients were analyzed. The CC ratio and the IS were significantly correlated with SMA and HGS: rCC/SMA = 0.360, rSI/SMA = 0.407, rCC/HGS = 0.331, rSI/HGS = 0.370. In multivariate analysis of overall survival, a lower CC ratio (HR 1.73, P = 0.033) and a lower SI (HR 1.89, P = 0.019) were independent predictors of poor prognosis. In univariate analysis of severe irAEs, CC ratio (OR 1.01, P = 0.628) and SI (OR 0.99, P = 0.595) were not associated with a higher risk of severe irAEs. In metastatic NSCLC patients treated with PD-1 inhibitors, a lower CC ratio and a lower SI are independent predictors of mortality. However, they are not associated with severe irAEs.
    Keywords acute toxicity ; blood serum ; clinical nutrition ; computed tomography ; creatinine ; glomerular filtration rate ; hand strength ; hospitals ; lung neoplasms ; metastasis ; mortality ; multivariate analysis ; prognosis ; risk ; sarcopenia ; skeletal muscle ; France ; MeSH ; cystatin C ; immune checkpoint inhibitors/toxicity
    Language English
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2023.03.023
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1774: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Resected

    Auliac, Jean-Bernard / Thomas, Pascal-Alexandre / Bylicki, Olivier / Guisier, Florian / Curcio, Hubert / AlainVegnenègre / Swalduz, Aurelie / Wislez, Marie / Le Treut, Jacques / Decroisette, Chantal / Basse, Victor / Falchero, Lionel / De Chabot, Gonzague / Moreau, Diane / Huchot, Eric / Lupo Mansuet, Audrey / Blons, Helene / Chouaïd, Christos / Greillier, Laurent

    Therapeutic advances in medical oncology

    2024  Volume 16, Page(s) 17588359241236451

    Abstract: Background: Few epidemiological data are available on surgically treated Caucasian patients with non-small-cell lung cancers (NSCLCs) harboring epidermal growth factor receptor (: Methods: The participating centers included all consecutive localized ... ...

    Abstract Background: Few epidemiological data are available on surgically treated Caucasian patients with non-small-cell lung cancers (NSCLCs) harboring epidermal growth factor receptor (
    Methods: The participating centers included all consecutive localized non-squamous NSCLC patients undergoing surgery between January 2018 and December 2019 in France.
    Results: The study includes 1391 no squamous NSCLC patients from 16 centers;
    Conclusion: This real-world analysis provides the incidence and outcomes of resected
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2503443-1
    ISSN 1758-8359 ; 1758-8340
    ISSN (online) 1758-8359
    ISSN 1758-8340
    DOI 10.1177/17588359241236451
    Database MEDical Literature Analysis and Retrieval System OnLINE

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