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  1. Book ; Thesis: Lokalisation von Estrogen-bindenden Proteinen im akzessorischen chemosensorischen System des Menschen

    Maximov, Maxim / Jirikowski, Gustav / Lupp, Amelie / Witt, Martin

    2022  

    Institution Friedrich-Schiller-Universität Jena
    Author's details von Maxim Maximov
    Keywords Sinneszelle ; Östrogene ; Pheromon
    Subject Ektohormon ; Follikelhormone ; Estrogene ; Östrogen
    Language German ; English
    Size 64 Blätter, Illustrationen, Diagramme, 64 Blätter
    Publishing place Jena
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Friedrich-Schiller-Universität Jena, 2022
    Note Tag der Verteidigung: 04.01.2022
    HBZ-ID HT021364473
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2022 E 503 order for loan Magazin

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  2. Book ; Thesis: Untersuchungen zum Zusammenhang zwischen Nierenfunktion und renaler 68Ga-DOTATOC- Speicherung unter besonderer Berücksichtigung der Relevanz für die peptidvermittelte Radiorezeptortherapie mit 177Lu-DOTATOC

    Heinzig, Alexander / Busch, Martin / Lupp, Amelie / Kotzerke, Jörg

    2023  

    Title variant achtundsechzig einhundertsiebenundsiebzig
    Institution Friedrich-Schiller-Universität Jena
    Author's details von Alexander Heinzig
    Language German
    Size 80 Seiten, Illustrationen, Diagramme, 30 cm
    Publishing place Jena
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Friedrich-Schiller-Universität Jena, 2023
    Note Tag der Verteidigung: 05.09.2023
    HBZ-ID HT030617162
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    2023 E 148

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  3. Book ; Thesis: Expression von Dopamin-D2-Rezeptoren in gastroenteropankreatischen und bronchopulmonalen neuroendokrinen Neoplasien

    Mandel, Morlin / Lupp, Amelie / Kämmerer, Daniel / Raderer, Markus

    2022  

    Institution Friedrich-Schiller-Universität Jena
    Author's details von Morlin Elna Mandel
    Keywords Neuroendokriner Tumor ; Somatostatin ; Dopaminrezeptor
    Subject Stilamin
    Language German
    Size 90 Blätter, Illustrationen, Diagramme, 29,5 cm
    Publishing place Jena
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Friedrich-Schiller-Universität Jena, 2022
    HBZ-ID HT021571012
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2022 E 1019 order for loan Magazin

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  4. Book ; Thesis: Immunhistochemische Untersuchung der Expression des Corticotropin-Releasing-Hormon-Rezeptors 1 mit Hilfe eines neuen monoklonalen Kaninchen-Antikörpers

    Schlee, Sven / Lupp, Amelie / Jirikowski, Gustav / Franke, Heike

    2022  

    Title variant eins
    Institution Friedrich-Schiller-Universität Jena
    Author's details von Sven Armin Schlee
    Keywords Corticoliberin ; Hormon ; Antikörper ; Kaninchen
    Subject Hauskaninchen ; Stallhase ; Hormone ; Corticotropin-Releasinghormon ; CRH ; CRF ; Corticotropin releasing factor ; Corticotrophin releasing hormone
    Language German
    Size V, 112 Seiten, Illustrationen, Diagramme, 21 cm
    Publishing place Jena
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Friedrich-Schiller-Universität Jena, 2022
    Note Tag der Verteidigung: 05.07.2022
    HBZ-ID HT021687163
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 D 10 order for loan Magazin

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  5. Book ; Thesis: Vergleichende Untersuchung der Expression verschiedener Neuropeptid-Rezeptoren in neuroendokrinen Tumoren und Adenokarzinomen des Pankreas

    Kajtazi, Ylberta / Lupp, Amelie / Kämmerer, Daniel / Kleeff, Jörg H.

    2022  

    Institution Friedrich-Schiller-Universität Jena
    Author's details von Ylberta Kajtazi
    Language German
    Size VIII, 127 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Jena
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Friedrich-Schiller-Universität Jena, 2022
    Note Tag der Verteidigung: 06.12.2022
    HBZ-ID HT030008055
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 703 order for loan Magazin

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  6. Book ; Thesis: Pharmakologische, biochemische und morphologische Charakterisierung fetaler Lebergewebetransplantate in der Milz im Vergleich zur Leber bei der Ratte

    Lupp, Amelie

    2004  

    Author's details von Amelie Irene Lupp
    Language German
    Size 328 Bl., Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Jena, Univ., Habil.-Schr., 2004
    HBZ-ID HT015946275
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 E 868 order for loan Magazin

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  7. Book ; Thesis: Auto- und Heterorezeptoren and serotonergen Nervenendigungen

    Lupp, Amelie

    1991  

    Author's details vorgelegt von Amelie Lupp
    Size 127 Bl. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freiburg im Breisgau Univ., Diss., 1991
    HBZ-ID HT003969531
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    92 E 151 order for loan Magazin

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  8. Book ; Online ; Thesis: Untersuchung der Expression der Arginin-Vasopressin-Rezeptoren 1a und 2 in menschlichen Normal- und Tumorgeweben mit Hilfe von neuen monoklonalen Antikörpern

    Bursian, Kristina [Verfasser] / Lupp, Amelie [Gutachter] / Kämmerer, Daniel [Gutachter] / Franke, Heike [Gutachter]

    2024  

    Author's details Kristina Bursian ; Gutachter: Amelie Lupp, Daniel Kämmerer, Heike Franke
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Friedrich-Schiller-Universität Jena
    Publishing place Jena
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  9. Article: Evaluation of PD-L1 expression in a large set of gastroenteropancreatic neuroendocrine tumours and correlation with clinicopathological data.

    Rösner, Erik / Kaemmerer, Daniel / Sänger, Jörg / Lupp, Amelie

    Translational oncology

    2022  Volume 25, Page(s) 101526

    Abstract: Background: Targeting programmed death protein 1 (PD-1) or its ligand PD-L1 is a promising therapeutic approach for many types of cancer in which PD-L1 is overexpressed. However, data on PD-L1 expression levels in gastroenteropancreatic neuroendocrine ... ...

    Abstract Background: Targeting programmed death protein 1 (PD-1) or its ligand PD-L1 is a promising therapeutic approach for many types of cancer in which PD-L1 is overexpressed. However, data on PD-L1 expression levels in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are limited and contradictory.
    Methods: We evaluated PD-L1 expression in 457 archived, formalin-fixed, paraffin-embedded GEP-NEN samples from 175 patients by immunohistochemistry using the highly sensitive monoclonal anti-PD-L1 antibody 73-10. The immunostaining was semiquantitatively evaluated using a 12-point immunoreactivity score (IRS) taking both PD-L1-positive tumour cells and immune cells into account. Tumour samples with an IRS ≥ 3 were considered PD-L1-positive. Results were correlated with clinicopathological data and with the expression of several typical markers and receptors for neuroendocrine tumours.
    Results: Of the GEP-NEN samples, 73% were PD-L1-positive. The median IRS value across all samples was 4.0, corresponding to low expression. PD-L1 immunostaining was predominantly localised at the plasma membrane of the tumour cells. Positive correlations were observed between PD-L1 expression and tumour grading or Ki-67 index, between PD-L1 expression and the expression of chromogranin A, and between PD-L1 expression and the expression of each of the five somatostatin receptors. PD-L1 expression was lower in tumours with lymph node metastases at diagnosis than in those without regional metastasis and lower in high-stage than in earlier-stage tumours. No association was noted between PD-L1 expression and patient survival.
    Conclusions: PD-L1 expression is common in GEP-NENs and increases with malignancy. Therefore, especially in high-grade GEP-NENs, targeting the PD-1/PD-L1 axis could be a promising additional therapeutic strategy.
    Language English
    Publishing date 2022-09-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2443840-6
    ISSN 1936-5233
    ISSN 1936-5233
    DOI 10.1016/j.tranon.2022.101526
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Co-Expression of Adaptor Protein FAM159B with Different Markers for Neuroendocrine Cells: An Immunocytochemical and Immunohistochemical Study.

    Beyer, Anna-Sophia Liselott / Kaemmerer, Daniel / Sänger, Jörg / Lupp, Amelie

    International journal of molecular sciences

    2022  Volume 23, Issue 21

    Abstract: Little is known about the adaptor protein FAM159B. Recently, FAM159B was shown to be particularly expressed in neuroendocrine cells and tissues, such as pancreatic islets and neuroendocrine cells of the bronchopulmonary and gastrointestinal tracts, as ... ...

    Abstract Little is known about the adaptor protein FAM159B. Recently, FAM159B was shown to be particularly expressed in neuroendocrine cells and tissues, such as pancreatic islets and neuroendocrine cells of the bronchopulmonary and gastrointestinal tracts, as well as in different types of neuroendocrine tumours. To gain insights into possible interactions of FAM159B with other proteins and/or receptors, we analysed the co-expression of FAM159B and various neuroendocrine-specific markers in the cancer cell lines BON-1, PC-3, NCI-h82, OH-1, and A431 and also in human pancreatic tissues and pancreatic neuroendocrine tumours. The markers included prominent markers of neuroendocrine differentiation, such as chromogranin A (CgA), neuron-specific enolase (NSE), synaptophysin (SYP), insulinoma-associated protein 1 (INSM1), neural cell adhesion molecule 1 (NCAM1), serotonin (5-HT), somatostatin-14/28 (SST), and several receptors that are typically expressed by neuroendocrine cells, such as dopamine receptor 2 (D2R), somatostatin receptor (SSTR) 1, 2, 3, 4 and 5, and regulator of G-protein signalling 9 (RGS9). FAM159B was expressed evenly throughout the cytosol in all five cancer cell lines. Immunocytochemical and immunohistochemical analyses revealed co-expression of FAM159B with SYP, INSM1, RGS9, D2R, SSTR2, SSTR3, SSTR4, and SSTR5 and strong overlapping co-localisation with NSE. Double-labelling and co-immunoprecipitation Western blot analyses confirmed a direct association between FAM159B and NSE. These results suggest the involvement of FAM159B in several intracellular signalling pathways and a direct or indirect influence on diverse membrane proteins and receptors.
    MeSH term(s) Humans ; Neuroendocrine Cells/metabolism ; Biomarkers, Tumor/metabolism ; Neuroendocrine Tumors/genetics ; Neuroendocrine Tumors/metabolism ; Chromogranin A/genetics ; Chromogranin A/metabolism ; Adaptor Proteins, Signal Transducing/metabolism ; Pancreatic Neoplasms/pathology ; Repressor Proteins/metabolism
    Chemical Substances Biomarkers, Tumor ; Chromogranin A ; Adaptor Proteins, Signal Transducing ; INSM1 protein, human (147955-03-1) ; Repressor Proteins
    Language English
    Publishing date 2022-11-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232113503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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