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  1. Article: Lecithin and Chitosan as Building Blocks in Anti-

    Hemmingsen, Lisa Myrseth / Panzacchi, Virginia / Kangu, Lloyd Mbugua / Giordani, Barbara / Luppi, Barbara / Škalko-Basnet, Nataša

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 6

    Abstract: The main focus when considering treatment of non-healing and infected wounds is tied to the microbial, particularly bacterial, burden within the wound bed. However, as fungal contributions in these microbial communities become more recognized, the focus ... ...

    Abstract The main focus when considering treatment of non-healing and infected wounds is tied to the microbial, particularly bacterial, burden within the wound bed. However, as fungal contributions in these microbial communities become more recognized, the focus needs to be broadened, and the remaining participants in the complex wound microbiome need to be addressed in the development of new treatment strategies. In this study, lecithin/chitosan nanoparticles loaded with clotrimazole were tailored to eradicate one of the most abundant fungi in the wound environment, namely
    Language English
    Publishing date 2023-05-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16060790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Limosilactobacillus vaginalis

    Giordani, Barbara / Parolin, Carola / Abruzzo, Angela / Foschi, Claudio / Marangoni, Antonella / Luppi, Barbara / Vitali, Beatrice

    Nutrients

    2023  Volume 15, Issue 20

    Abstract: Infant microbiota shaping strictly influences newborns' well-being and long-term health, and babies born by cesarean-section and formula-fed generally show low microbial gut diversity and are more prone to develop various disorders. The supplementation ... ...

    Abstract Infant microbiota shaping strictly influences newborns' well-being and long-term health, and babies born by cesarean-section and formula-fed generally show low microbial gut diversity and are more prone to develop various disorders. The supplementation with beneficial microbes of vaginal origin or derivatives (postbiotics, including heat-inactivated cells) represents a valid strategy to drive the correct gut microbiota shaping. Here, we explored for the first time the bifidogenic activity of a heat-killed vaginal strain (
    MeSH term(s) Pregnancy ; Female ; Humans ; Infant ; Infant, Newborn ; Prebiotics ; Probiotics ; Lactobacillus ; Infant Formula ; Anti-Bacterial Agents/pharmacology
    Chemical Substances Prebiotics ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-10-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15204433
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  3. Article ; Online: When Interactions Between Bile Salts and Cyclodextrin Cause a Negative Food Effect: Dynamic Dissolution/Permeation Studies with Itraconazole (Sporanox®) and Biomimetic Media.

    Cuoco, Arianna / Eriksen, Jonas Borregaard / Luppi, Barbara / Brandl, Martin / Bauer-Brandl, Annette

    Journal of pharmaceutical sciences

    2022  Volume 112, Issue 5, Page(s) 1372–1378

    Abstract: The marketed oral solution of itraconazole (Sporanox®) contains 40% (259.2 mM) of 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). The obvious role of HP-β-CD is to solubilize itraconazole and to overcome its poor aqueous solubility that restricts its ... ...

    Abstract The marketed oral solution of itraconazole (Sporanox®) contains 40% (259.2 mM) of 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). The obvious role of HP-β-CD is to solubilize itraconazole and to overcome its poor aqueous solubility that restricts its absorption. In this study, we investigated the biorelevance of in vitro experiments by the influence of biomimetic media (containing bile salts and phospholipids) on the predicted itraconazole absorption from the commercial HP-β-CD-based Sporanox® solution. We performed phase-solubility studies of itraconazole and dynamic 2-step-dissolution/permeation studies using a biomimetic artificial barrier, Sporanox® solution, and fasted state simulated intestinal fluid (FaSSIF_V1). Both FaSSIF_V1 and HP-β-CD increased the apparent solubility of itraconazole when used individually. In combination, their solubility-enhancing effects were not additive probably due to the competition of bile salts with itraconazole for the hydrophobic cavity of HP-β-CD. Our combined dissolution/permeation experiments indicated the occurrence of a transient supersaturation from Sporanox® upon two-step dissolution. Through systematic variation of bile salt concentrations in the biomimetic media, it was observed that the extent and the duration of supersaturation depend on the concentrations of bile salts: supersaturation was rather stable in the absence of bile salts and phospholipids. The higher the bile salt concentration, the faster the collapse of the transient supersaturation occurred, an effect which is nicely mirrored by reduced in vitro permeation across the barrier. This is an indication of a negative food effect, which in fact correlates well with what earlier had been observed in clinical studies for Sporanox® solution. In essence, we could demonstrate that in vitro two-stage dissolution/permeation experiments using an artificial barrier and selected biomimetic media may predict the negative effects of the latter on cyclodextrin-based drug formulations like Sporanox® Oral Solution and, at the same time, provide a deeper mechanistic insight.
    MeSH term(s) Itraconazole/chemistry ; Cyclodextrins/chemistry ; Solubility ; 2-Hydroxypropyl-beta-cyclodextrin/chemistry ; Bile Acids and Salts ; Biomimetics
    Chemical Substances Itraconazole (304NUG5GF4) ; Cyclodextrins ; 2-Hydroxypropyl-beta-cyclodextrin (1I96OHX6EK) ; Bile Acids and Salts
    Language English
    Publishing date 2022-12-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3151-3
    ISSN 1520-6017 ; 0022-3549
    ISSN (online) 1520-6017
    ISSN 0022-3549
    DOI 10.1016/j.xphs.2022.12.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Modulation of Paracellular-like Drug Transport across an Artificial Biomimetic Barrier by Osmotic Stress-Induced Liposome Shrinking.

    Eriksen, Jonas Borregaard / Barakat, Hesham / Luppi, Barbara / Brandl, Martin / Bauer-Brandl, Annette

    Pharmaceutics

    2022  Volume 14, Issue 4

    Abstract: Various types of artificial biomimetic barriers are widely utilized as in vitro tools to predict the passive "transcellular" transport of drug compounds. The current study investigated if the sandwich barrier ... ...

    Abstract Various types of artificial biomimetic barriers are widely utilized as in vitro tools to predict the passive "transcellular" transport of drug compounds. The current study investigated if the sandwich barrier PermeaPad
    Language English
    Publishing date 2022-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14040721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Prebiotic Activity of Vaginal Lactobacilli on Bifidobacteria: from Concept to Formulation.

    Giordani, Barbara / Abruzzo, Angela / Parolin, Carola / Foschi, Claudio / Laghi, Luca / Marangoni, Antonella / Luppi, Barbara / Vitali, Beatrice

    Microbiology spectrum

    2023  Volume 11, Issue 1, Page(s) e0200922

    Abstract: The gut of babies born vaginally is rapidly colonized ... ...

    Abstract The gut of babies born vaginally is rapidly colonized by
    MeSH term(s) Infant ; Humans ; Infant, Newborn ; Female ; Pregnancy ; Cesarean Section ; Bifidobacterium/metabolism ; Lactation ; Lactobacillus
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.02009-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Lactobacillus crispatus BC1 Biosurfactant Counteracts the Infectivity of Chlamydia trachomatis Elementary Bodies

    Foschi, Claudio / Parolin, Carola / Giordani, Barbara / Morselli, Sara / Luppi, Barbara / Vitali, Beatrice / Marangoni, Antonella

    Microorganisms. 2021 Apr. 30, v. 9, no. 5

    2021  

    Abstract: Lactobacilli-derived biosurfactants (BS) have shown promising effects as antimicrobial molecules. Since Lactobacillus crispatus plays a crucial role in maintaining vaginal eubiosis, BS from this species could represent novel therapeutic agents to ... ...

    Abstract Lactobacilli-derived biosurfactants (BS) have shown promising effects as antimicrobial molecules. Since Lactobacillus crispatus plays a crucial role in maintaining vaginal eubiosis, BS from this species could represent novel therapeutic agents to counteract sexually transmitted pathogens, such as Chlamydia trachomatis (CT). The aim of the present study was to assess the inhibitory effects of a BS produced by the vaginal strain L. crispatus BC1 on the infectivity of CT elementary bodies (EBs). For concentrations ranging between 1 and 0.5 mg/mL at 60-min contact time, L. crispatus BC1 BS displayed a highly significant anti-CT activity, with about 50% reduction of EB infectivity towards HeLa cells. To identify the components responsible for chlamydial inhibition, a panel of selected fatty acids, including those present in BS lipopeptidic structure, was tested against CT EBs. Pentadecanoic acid, myristic acid, β-hydroxy-myristic acid, and β-hydroxy-palmitic acid were able to significantly reduce EBs infectivity up to 5–0.5 µg/mL, concentrations that resulted to be non-toxic for HeLa cells. These data can contribute to the understanding of the biological role of lactobacilli in the vaginal niche, as well as to promote the application of their produced BS as an innovative and antibiotic-sparing anti-chlamydial strategy.
    Keywords Chlamydia trachomatis ; Lactobacillus crispatus ; biosurfactants ; myristic acid ; pathogenicity ; therapeutics
    Language English
    Dates of publication 2021-0430
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9050975
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Transdermal Delivery of Antipsychotics: Rationale and Current Status.

    Abruzzo, Angela / Cerchiara, Teresa / Luppi, Barbara / Bigucci, Federica

    CNS drugs

    2019  Volume 33, Issue 9, Page(s) 849–865

    Abstract: The aim of this article is to provide the rationale for the development of transdermal formulations of antipsychotics by highlighting their main advantages, starting with an overview of the antipsychotic formulations that are currently available on the ... ...

    Abstract The aim of this article is to provide the rationale for the development of transdermal formulations of antipsychotics by highlighting their main advantages, starting with an overview of the antipsychotic formulations that are currently available on the market. Progress regarding transdermal antipsychotic formulations was investigated by performing a search of papers, patents and clinical trials published in the last 10 years. Available data on antipsychotic transdermal formulations are reported and discussed, focusing on the characteristics of the dosage forms and their ability to promote drug absorption. Despite the current availability of a large number of antipsychotics, only a few of these drugs (e.g. aripiprazole, asenapine, blonanserin, chlorpromazine, haloperidol, olanzapine, prochlorperazine, quetiapine, and risperidone) have been developed as transdermal delivery systems. Several papers and patents show that transdermal formulations, such as creams, films, gels, nanosystems, patches, solutions, and sprays, have been evaluated with the aim of expanding the clinical utility of antipsychotic drugs. In particular, the employment of different strategies, such as the use of nanoparticles/vesicles, or permeation enhancers as well as microneedles with iontophoresis, may improve the absorption of antipsychotic drugs through the skin. However, few clinical trials on transdermal delivery of antipsychotic drugs are available and only delivery systems containing asenapine and blonanserin have shown interesting clinical results in terms of pharmacokinetic data, efficacy, and tolerability. Recently, the transdermal patch formulation of blonanserin was approved in Japan for the treatment of schizophrenia.
    MeSH term(s) Administration, Cutaneous ; Animals ; Antipsychotic Agents/pharmacology ; Antipsychotic Agents/therapeutic use ; Clinical Trials as Topic ; Drug Delivery Systems ; Humans
    Chemical Substances Antipsychotic Agents
    Language English
    Publishing date 2019-09-06
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 1203800-3
    ISSN 1179-1934 ; 1172-7047
    ISSN (online) 1179-1934
    ISSN 1172-7047
    DOI 10.1007/s40263-019-00659-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4083: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Lactobacillus crispatus

    Foschi, Claudio / Parolin, Carola / Giordani, Barbara / Morselli, Sara / Luppi, Barbara / Vitali, Beatrice / Marangoni, Antonella

    Microorganisms

    2021  Volume 9, Issue 5

    Abstract: Lactobacilli-derived biosurfactants (BS) have shown promising effects as antimicrobial molecules. ... ...

    Abstract Lactobacilli-derived biosurfactants (BS) have shown promising effects as antimicrobial molecules. Since
    Language English
    Publishing date 2021-04-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9050975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Human

    Corazza, Elisa / Abruzzo, Angela / Giordani, Barbara / Cerchiara, Teresa / Bigucci, Federica / Vitali, Beatrice / di Cagno, Massimiliano Pio / Luppi, Barbara

    Pharmaceutics

    2022  Volume 14, Issue 3

    Abstract: The inclusion of a chemical permeation enhancer in a dosage form is considered an effective approach to improve absorption across the nasal mucosa. Herein we evaluated the possibility of exploiting biosurfactants (BS) produced ... ...

    Abstract The inclusion of a chemical permeation enhancer in a dosage form is considered an effective approach to improve absorption across the nasal mucosa. Herein we evaluated the possibility of exploiting biosurfactants (BS) produced by
    Language English
    Publishing date 2022-02-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14030524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Drug delivery to the brain: In situ gelling formulation enhances carbamazepine diffusion through nasal mucosa models with mucin.

    Corazza, Elisa / di Cagno, Massimiliano Pio / Bauer-Brandl, Annette / Abruzzo, Angela / Cerchiara, Teresa / Bigucci, Federica / Luppi, Barbara

    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

    2022  Volume 179, Page(s) 106294

    Abstract: The objective of this work was to optimize a thermosensitive in situ gelling formulation to improve intranasal and nose-to-brain delivery of the antiepileptic drug carbamazepine (CBZ). A preliminary procedure of vehicles obtained just mixing different ... ...

    Abstract The objective of this work was to optimize a thermosensitive in situ gelling formulation to improve intranasal and nose-to-brain delivery of the antiepileptic drug carbamazepine (CBZ). A preliminary procedure of vehicles obtained just mixing different fractions of poloxamer 407 (P407) and poloxamer 188 (P188) revealed preparations with phase transition temperatures, times to gelation and pH values suitable for nasal delivery. Subsequently, the mucoadhesive properties of the most promising formulations were tuned by adding hydroxypropylmethylcellulose types of different viscosity grades, and the effect of the adhesive polymers was evaluated by testing in vitro time and strength of mucoadhesion on specimens of sheep nasal mucosa. The formulation that showed the greatest mucoadhesive potential in vitro, with a time and force of mucoadhesion equal to 1746,75 s and 3.66 × 10-4 N, respectively, was that composed of 22% P407, 5% P188 and 0.8% HPMC low-viscous and it was further investigated for its ability to increase drug solubility and to control the release of the drug. Lastly, the capability of the candidate vehicle to ensure drug permeation across the biomimetic membrane Permeapad®, an artificial phospholipid-based barrier with a stratified architecture, and the same barrier enriched with a mucin layer was verified. The final formulation was characterized by a pH value of 6.0, underwent gelation at 32.33°C in 37.85 s, thus showing all the features required by in situ gelling thermosensitive preparations designed for nasal delivery and, more notably, it conserved the ability to favor drug permeation in the presence of mucin. These findings suggest that the optimized gelling system could be a promising and easy to realize strategy to improve CBZ delivery to the brain exploiting both a direct and indirect pathway.
    MeSH term(s) Animals ; Sheep ; Mucins ; Gels/chemistry ; Poloxamer/chemistry ; Nasal Mucosa/metabolism ; Administration, Intranasal ; Excipients/metabolism ; Carbamazepine/metabolism ; Temperature ; Brain/metabolism ; Drug Delivery Systems/methods
    Chemical Substances Mucins ; Gels ; Poloxamer (106392-12-5) ; Excipients ; Carbamazepine (33CM23913M)
    Language English
    Publishing date 2022-09-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1154366-8
    ISSN 1879-0720 ; 0928-0987
    ISSN (online) 1879-0720
    ISSN 0928-0987
    DOI 10.1016/j.ejps.2022.106294
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3705: Show issues Location:
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