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  1. AU="Luque-Ballesteros, Laura"
  2. AU="Dondi, Francesco"
  3. AU="McLachlan, Alex"
  4. AU="Krizova, Ludmila"
  5. AU="Balog, Attila"
  6. AU="Faerber, Karin"
  7. AU="Prettner, Klaus"
  8. AU="Ambrožová, I."
  9. AU="William, Doreen"
  10. AU="Gutiérrez-Sánchez, A M"
  11. AU="Bohan, Dana"
  12. AU="Spracklen, D."
  13. AU="Lobo, Brian C"
  14. AU=Zhuang Jianjian AU=Zhuang Jianjian
  15. AU=Pathanki Adithya M
  16. AU="Armando Vilchis-Ordoñez"
  17. AU="Zhongfu Lu"
  18. AU="Lo, Hong-Yip"
  19. AU="Ziman Xiong"
  20. AU="Oakes, Allison H"
  21. AU="Ma, Shaotong"
  22. AU="Zang, Lili"
  23. AU="Adams Brian D"
  24. AU="Maria Papaioannou"
  25. AU="Kollia, Georgia"
  26. AU="Auxiette, Catherine"
  27. AU="Guzmán, Luis"
  28. AU="Alipour, Elnaz"
  29. AU="Queiroz, Dayanna Joyce Marques"
  30. AU="Ramamurthy, Santosh"
  31. AU="Xueying Huang"
  32. AU="Cromwell, Howard C"
  33. AU="Spence, John C H"
  34. AU="Chapinal, Libertad"
  35. AU=Rohaim Mohammed A AU=Rohaim Mohammed A
  36. AU=Hempel Cornelius

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  1. Artikel: Antibody cooperative adsorption onto AuNPs and its exploitation to force natural killer cells to kill HIV-infected T cells.

    Astorga-Gamaza, Antonio / Vitali, Michele / Borrajo, Mireya L / Suárez-López, Rosa / Jaime, Carlos / Bastus, Neus / Serra-Peinado, Carla / Luque-Ballesteros, Laura / Blanch-Lombarte, Oscar / Prado, Julia G / Lorente, Juan / Pumarola, Felix / Pellicer, Marc / Falcó, Vicenç / Genescà, Meritxell / Puntes, Víctor / Buzon, Maria J

    Nano today

    2020  Band 36

    Abstract: HIV represents a persistent infection which negatively alters the immune system. New tools to reinvigorate different immune cell populations to impact HIV are needed. Herein, a novel nanotool for the specific enhancement of the natural killer (NK) immune ...

    Abstract HIV represents a persistent infection which negatively alters the immune system. New tools to reinvigorate different immune cell populations to impact HIV are needed. Herein, a novel nanotool for the specific enhancement of the natural killer (NK) immune response towards HIV-infected T-cells has been developed. Bispecific Au nanoparticles (BiAb-AuNPs), dually conjugated with IgG anti-HIVgp120 and IgG anti-human CD16 antibodies, were generated by a new controlled, linker-free and cooperative conjugation method promoting the ordered distribution and segregation of antibodies in domains. The cooperatively-adsorbed antibodies fully retained the capabilities to recognize their cognate antigen and were able to significantly enhance cell-to-cell contact between HIV-expressing cells and NK cells. As a consequence, the BiAb-AuNPs triggered a potent cytotoxic response against HIV-infected cells in blood and human tonsil explants. Remarkably, the BiAb-AuNPs were able to significantly reduce latent HIV infection after viral reactivation in a primary cell model of HIV latency. This novel molecularly-targeted strategy using a bispecific nanotool to enhance the immune system represents a new approximation with potential applications beyond HIV.
    Sprache Englisch
    Erscheinungsdatum 2020-12-20
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2224882-1
    ISSN 1878-044X ; 1748-0132
    ISSN (online) 1878-044X
    ISSN 1748-0132
    DOI 10.1016/j.nantod.2020.101056
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Latency reversal agents affect differently the latent reservoir present in distinct CD4+ T subpopulations.

    Grau-Expósito, Judith / Luque-Ballesteros, Laura / Navarro, Jordi / Curran, Adrian / Burgos, Joaquin / Ribera, Esteban / Torrella, Ariadna / Planas, Bibiana / Badía, Rosa / Martin-Castillo, Mario / Fernández-Sojo, Jesús / Genescà, Meritxell / Falcó, Vicenç / Buzon, Maria J

    PLoS pathogens

    2019  Band 15, Heft 8, Seite(n) e1007991

    Abstract: Latency reversal agents (LRAs) have proven to induce HIV-1 transcription in vivo but are ineffective at decreasing the size of the latent reservoir in antiretroviral treated patients. The capacity of the LRAs to perturb the viral reservoir present in ... ...

    Abstract Latency reversal agents (LRAs) have proven to induce HIV-1 transcription in vivo but are ineffective at decreasing the size of the latent reservoir in antiretroviral treated patients. The capacity of the LRAs to perturb the viral reservoir present in distinct subpopulations of cells is currently unknown. Here, using a new RNA FISH/flow ex vivo viral reactivation assay, we performed a comprehensive assessment of the viral reactivation capacity of different families of LRAs, and their combinations, in different CD4+ T cell subsets. We observed that a median of 16.28% of the whole HIV-reservoir induced HIV-1 transcripts after viral reactivation, but only 10.10% of these HIV-1 RNA+ cells produced the viral protein p24. Moreover, none of the LRAs were powerful enough to reactivate HIV-1 transcription in all CD4+ T cell subpopulations. For instance, the combination of Romidepsin and Ingenol was identified as the best combination of drugs at increasing the proportion of HIV-1 RNA+ cells, in most, but not all, CD4+ T cell subsets. Importantly, memory stem cells were identified as highly resistant to HIV-1 reactivation, and only the combination of Panobinostat and Bryostatin-1 significantly increased the number of cells transcribing HIV within this subset. Overall, our results validate the use of the RNA FISH/flow technique to assess the potency of LRAs among different CD4+ T cell subsets, manifest the intrinsic differences between cells that encompass the latent HIV reservoir, and highlight the difficulty to significantly impact the latent infection with the currently available drugs. Thus, our results have important implications for the rational design of therapies aimed at reversing HIV latency from diverse cellular reservoirs.
    Mesh-Begriff(e) Anti-HIV Agents/pharmacology ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/virology ; Depsipeptides/pharmacology ; Diterpenes/pharmacology ; HIV Infections/drug therapy ; HIV Infections/immunology ; HIV Infections/virology ; HIV-1/drug effects ; HIV-1/immunology ; Humans ; Viral Load ; Virus Activation/drug effects ; Virus Activation/immunology ; Virus Latency/drug effects ; Virus Latency/immunology
    Chemische Substanzen Anti-HIV Agents ; Depsipeptides ; Diterpenes ; romidepsin (CX3T89XQBK) ; ingenol (IC77UZI9G8)
    Sprache Englisch
    Erscheinungsdatum 2019-08-19
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1007991
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Expression of CD20 after viral reactivation renders HIV-reservoir cells susceptible to Rituximab.

    Serra-Peinado, Carla / Grau-Expósito, Judith / Luque-Ballesteros, Laura / Astorga-Gamaza, Antonio / Navarro, Jordi / Gallego-Rodriguez, Jenny / Martin, Mario / Curran, Adrià / Burgos, Joaquin / Ribera, Esteban / Raventós, Berta / Willekens, Rein / Torrella, Ariadna / Planas, Bibiana / Badía, Rosa / Garcia, Felipe / Castellví, Josep / Genescà, Meritxell / Falcó, Vicenç /
    Buzon, Maria J

    Nature communications

    2019  Band 10, Heft 1, Seite(n) 3705

    Abstract: The identification of exclusive markers to target HIV-reservoir cells will represent a significant advance in the search for therapies to cure HIV. Here, we identify the B lymphocyte antigen CD20 as a marker for HIV-infected cells in vitro and in vivo. ... ...

    Abstract The identification of exclusive markers to target HIV-reservoir cells will represent a significant advance in the search for therapies to cure HIV. Here, we identify the B lymphocyte antigen CD20 as a marker for HIV-infected cells in vitro and in vivo. The CD20 molecule is dimly expressed in a subpopulation of CD4-positive (CD4
    Mesh-Begriff(e) Anti-HIV Agents/therapeutic use ; Antigens, CD20/metabolism ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Flow Cytometry ; HIV Infections/drug therapy ; HIV Infections/immunology ; HIV Infections/metabolism ; HIV-1 ; Humans ; Immunologic Factors/pharmacology ; Immunologic Memory ; Leukocytes, Mononuclear ; Lymph Nodes/cytology ; Lymphocyte Activation/immunology ; RNA, Viral ; Rituximab/pharmacology ; Rituximab/therapeutic use ; Virus Activation ; Virus Latency
    Chemische Substanzen Anti-HIV Agents ; Antigens, CD20 ; Immunologic Factors ; RNA, Viral ; Rituximab (4F4X42SYQ6)
    Sprache Englisch
    Erscheinungsdatum 2019-08-16
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-019-11556-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa.

    Cantero-Pérez, Jon / Grau-Expósito, Judith / Serra-Peinado, Carla / Rosero, Daniela A / Luque-Ballesteros, Laura / Astorga-Gamaza, Antonio / Castellví, Josep / Sanhueza, Tamara / Tapia, Gustavo / Lloveras, Belen / Fernández, Marco A / Prado, Julia G / Solé-Sedeno, Josep M / Tarrats, Antoni / Lecumberri, Carla / Mañalich-Barrachina, Laura / Centeno-Mediavilla, Cristina / Falcó, Vicenç / Buzon, Maria J /
    Genescà, Meritxell

    Nature communications

    2019  Band 10, Heft 1, Seite(n) 4739

    Abstract: HIV viral reservoirs are established very early during infection. Resident memory T cells ( ... ...

    Abstract HIV viral reservoirs are established very early during infection. Resident memory T cells (T
    Mesh-Begriff(e) Adult ; Aged ; Anti-Retroviral Agents/therapeutic use ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/virology ; Cervix Uteri/drug effects ; Cervix Uteri/virology ; Disease Reservoirs/virology ; Female ; HIV Infections/drug therapy ; HIV Infections/immunology ; HIV Infections/virology ; HIV-1/drug effects ; HIV-1/genetics ; HIV-1/immunology ; Humans ; Immunologic Memory/immunology ; Middle Aged ; Mucous Membrane/drug effects ; Mucous Membrane/virology ; Viral Load/drug effects ; Viral Load/genetics ; Viral Load/immunology
    Chemische Substanzen Anti-Retroviral Agents
    Sprache Englisch
    Erscheinungsdatum 2019-10-18
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-019-12732-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Pain Processing in a Social Context and the Link with Psychopathic Personality Traits-An Event-Related Potential Study.

    van Heck, Casper H / Driessen, Josi M A / Amato, Maria / van den Berg, Marnou N / Bhandari, Pritha / Bilbao-Broch, Laura / Farres-Casals, Jordi / Hendriks, Manon / Jodzio, Adrian C / Luque-Ballesteros, Laura / Schöchl, Christina / Velasco-Angeles, Laura R / Weijer, Roel H A / van Rijn, Clementina M / Jongsma, Marijtje L A

    Frontiers in behavioral neuroscience

    2017  Band 11, Seite(n) 180

    Abstract: Empathy describes the ability to understand another person's feelings. Psychopathy is a disorder that is characterized by a lack of empathy. Therefore, empathy and psychopathy are interesting traits to investigate with respect to experiencing and ... ...

    Abstract Empathy describes the ability to understand another person's feelings. Psychopathy is a disorder that is characterized by a lack of empathy. Therefore, empathy and psychopathy are interesting traits to investigate with respect to experiencing and observing pain. The present study aimed to investigate pain empathy and pain sensitivity by measuring event-related potentials (ERPs) extracted from the ongoing EEG in an interactive setup. Each participant fulfilled subsequently the role of "villain" and "victim". In addition, mode of control was modulated resulting in four different conditions; passive villain, active villain, active victim and passive victim. Response-, visual- and pain ERPs were compared between the four conditions. Furthermore, the role of psychopathic traits in these outcomes was investigated. Our findings suggested that people experience more conflict when hurting someone else than hurting themselves. Furthermore, our results indicated that self-controlled pain was experienced as more painful than uncontrolled pain. People that scored high on psychopathic traits seemed to process and experience pain differently. According to the results of the current study, social context, attention and personality traits seem to modulate pain processing and the empathic response to pain in self and others. The within-subject experimental design described here provides an excellent approach to further unravel the influence of social context and personality traits on social cognition.
    Sprache Englisch
    Erscheinungsdatum 2017-09-25
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2452960-6
    ISSN 1662-5153
    ISSN 1662-5153
    DOI 10.3389/fnbeh.2017.00180
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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