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  1. Article ; Online: Ambulatory femoral venovenous extracorporeal membrane oxygenation with a dual-lumen cannula.

    Orozco-Hernandez, Erik J / Muñoz-Largacha, Juan A / Lusby, Megan / Hoopes, Charles W

    JTCVS techniques

    2021  Volume 9, Page(s) 199–201

    Language English
    Publishing date 2021-06-19
    Publishing country United States
    Document type Journal Article
    ISSN 2666-2507
    ISSN (online) 2666-2507
    DOI 10.1016/j.xjtc.2021.06.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Patients Surviving Critical COVID-19 have Impairments in Dual-task Performance Related to Post-intensive Care Syndrome.

    Morelli, Nathan / Parry, Selina M / Steele, Angela / Lusby, Megan / Montgomery-Yates, Ashley A / Morris, Peter E / Mayer, Kirby P

    Journal of intensive care medicine

    2022  Volume 37, Issue 7, Page(s) 890–898

    Abstract: Objective: The purpose was to examine Dual Task (DT) performance in patients surviving severe and critical COVID-19 compared to patients with chronic lung disease (CLD). Secondarily, we aimed to determine the psychometric properties of the Timed Up and ... ...

    Abstract Objective: The purpose was to examine Dual Task (DT) performance in patients surviving severe and critical COVID-19 compared to patients with chronic lung disease (CLD). Secondarily, we aimed to determine the psychometric properties of the Timed Up and Go (TUG) test in patients surviving COVID-19.
    Design: Prospective, cross-sectional, observational study.
    Setting: Academic medical center within United States.
    Patients: Ninety-two patients including 36 survivors of critical COVID-19 that required mechanical ventilation (critical-COVID), 20 patients recovering from COVID-19 that required supplemental oxygen with hospitalization (severe-COVID), and 36 patients with CLD serving as a control group.
    Measurements and main results: Patients completed the TUG, DT-TUG, Short Physical Performance Battery (SPPB), and Six Minute Walk Test (6MWT) 1-month after hospital discharge. A subset of patients returned at 3-months and repeated testing to determine the minimal detectable change (MDC). Critical-COVID group (16.8 ± 7.3) performed the DT-TUG in significantly slower than CLD group (13.9 ± 4.8 s;
    Conclusion: The ability to maintain mobility performance in the presence of a cognitive DT is grossly impaired in patients surviving critical COVID-19. DT performance may subserve the understanding of impairments related to Post-intensive care syndrome (PICS) for survivors of critical illness.
    MeSH term(s) COVID-19/complications ; Critical Illness ; Cross-Sectional Studies ; Gait ; Humans ; Prospective Studies ; Task Performance and Analysis
    Language English
    Publishing date 2022-01-24
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 632828-3
    ISSN 1525-1489 ; 0885-0666
    ISSN (online) 1525-1489
    ISSN 0885-0666
    DOI 10.1177/08850666221075568
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    Zs.A 2158: Show issues Location:
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  3. Article ; Online: Peripheral femoral venoarterial extracorporeal membrane oxygenation as bridge to heart-lung transplant omne iter incipit primus.

    Orozco-Hernandez, Erik J / Melnikoff, Brett / Lusby, Megan / Tallaj, Jose / Hoopes, Charles W

    Journal of cardiac surgery

    2020  Volume 35, Issue 8, Page(s) 2077–2080

    Abstract: Heart-lung transplant (HLT) is a widely accepted modality for certain patients with advanced and refractory cardiopulmonary disease. Some of these patients are critically ill on the transplant waiting list, and venoarterial extracorporeal membrane ... ...

    Abstract Heart-lung transplant (HLT) is a widely accepted modality for certain patients with advanced and refractory cardiopulmonary disease. Some of these patients are critically ill on the transplant waiting list, and venoarterial extracorporeal membrane oxygenation (VA-ECMO) can be used as a bridge to transplantation. Although the experience with ECMO as a bridge to lung transplant is promising, there is limited evidence to use ECMO as a bridge to HLT. Femoral cannulation remains a concern for ambulation given the risk of bleeding and cannula complications despite studies reporting its safety. We present a case of a 56-year-old male with interstitial lung disease and severe secondary pulmonary hypertension, who was successfully bridged to HLT with ambulatory femoral VA-ECMO.
    MeSH term(s) Extracorporeal Membrane Oxygenation/methods ; Femoral Artery ; Heart-Lung Transplantation ; Humans ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/therapy ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/therapy ; Lung Transplantation ; Male ; Middle Aged ; Severity of Illness Index ; Treatment Outcome ; Waiting Lists
    Language English
    Publishing date 2020-07-11
    Publishing country United States
    Document type Case Reports
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.14779
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    Zs.A 2221: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Depressive Symptoms, Exercise Capacity, and Clinical Outcomes After Lung Transplantation.

    Smith, Patrick J / Byrd, Rebecca / Lusby, Megan / Clausen, Emily / Snyder, Laurie D

    Psychosomatic medicine

    2018  Volume 80, Issue 4, Page(s) 403–409

    Abstract: Objective: Depressive symptoms are common among lung transplant recipients and have been associated with worse clinical outcomes. However, few studies have examined the association between depressive symptoms assessed at multiple time points or ... ...

    Abstract Objective: Depressive symptoms are common among lung transplant recipients and have been associated with worse clinical outcomes. However, few studies have examined the association between depressive symptoms assessed at multiple time points or behavioral mechanisms by which posttransplant depressive symptoms may confer greater clinical risk. We therefore examined the associations between depressive symptoms, exercise capacity, chronic lung allograft dysfunction (CLAD), and mortality prospectively in a large sample of lung transplant recipients.
    Methods: Between July 2009 and February 2016, 251 lung transplant recipients were assessed before transplantation and again approximately 3 weeks and 3 months after transplant. Depressive symptoms were assessed using the Centers for Epidemiologic Studies of Depression scale. Functional exercise capacity was assessed using the 6-minute walk test. Cox proportional hazards models were used to examine the associations between depressive symptoms, exercise capacity, CLAD, and mortality.
    Results: During a median (range) follow-up of 4.5 (0.1 to 6.3) years, 53 participants (21%) died. Greater depressive symptoms (hazard ratio [HR] = 1.39 [95% CI = 1.05 to 1.84], p = .021) and poorer exercise capacity (HR = 0.58 [95% CI = 0.38 to 0.90], p = .021) assessed 3 months after transplant were both independently associated with mortality. Although greater depressive symptoms were associated with lower exercise capacity (β = -0.14, p = .039), exercise capacity did not mediate the association between depressive symptoms and mortality. In secondary analyses, depressive symptoms were independently predictive of CLAD (HR = 1.29 [95% CI = 1.01 to 1.65], p = .045) and the composite outcome of CLAD and mortality in a clustered event model (HR = 1.30 [1.09 to 1.56], p = .005).
    Conclusions: Depressive symptoms are associated with mortality and CLAD after lung transplantation, independent of exercise capacity.
    MeSH term(s) Adult ; Aged ; Allografts ; Depression/complications ; Depression/epidemiology ; Depression/physiopathology ; Female ; Follow-Up Studies ; Humans ; Lung Diseases/etiology ; Lung Diseases/mortality ; Lung Diseases/physiopathology ; Lung Diseases/surgery ; Lung Transplantation/adverse effects ; Lung Transplantation/mortality ; Lung Transplantation/psychology ; Male ; Middle Aged ; Outcome Assessment (Health Care)/statistics & numerical data ; Physical Fitness/physiology
    Language English
    Publishing date 2018-03-13
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 3469-1
    ISSN 1534-7796 ; 0033-3174
    ISSN (online) 1534-7796
    ISSN 0033-3174
    DOI 10.1097/PSY.0000000000000573
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  5. Article ; Online: Safety and Feasibility of an Interdisciplinary Treatment Approach to Optimize Recovery From Critical Coronavirus Disease 2019.

    Mayer, Kirby P / Parry, Selina M / Kalema, Anna G / Joshi, Rajan R / Soper, Melissa K / Steele, Angela K / Lusby, Megan L / Dupont-Versteegden, Esther E / Montgomery-Yates, Ashley A / Morris, Peter E

    Critical care explorations

    2021  Volume 3, Issue 8, Page(s) e0516

    Abstract: Objectives: Examine the safety and feasibility of a multimodal in-person or telehealth treatment program, administered in acute recovery phase for patients surviving critical coronavirus disease 2019.: Design: Pragmatic, pre-post, nonrandomized ... ...

    Abstract Objectives: Examine the safety and feasibility of a multimodal in-person or telehealth treatment program, administered in acute recovery phase for patients surviving critical coronavirus disease 2019.
    Design: Pragmatic, pre-post, nonrandomized controlled trial with patients electing enrollment into one of the two recovery pathways.
    Setting: ICU Recovery Clinic in an academic medical center.
    Patients: Adult patients surviving acute respiratory failure due to critical coronavirus disease 2019.
    Interventions: Patients participated in combined ICU Recovery clinic and 8 weeks of physical rehabilitation delivered: 1) in-person or 2) telehealth. Patients received medical care by an ICU Recovery Clinic interdisciplinary team and physical rehabilitation focused on aerobic, resistance, and respiratory muscle training.
    Measurements and main results: Thirty-two patients enrolled with mean age 57 ± 12, 62% were male, and the median Sequential Organ Failure Assessment score was 9.5. There were no differences between the two groups except patients in telehealth pathway (
    Conclusions: A multimodal treatment program combining care from an interdisciplinary team in an ICU Recovery Clinic with physical rehabilitation is safe and feasible in patients surviving the ICU for coronavirus disease 2019 acute respiratory failure.
    Language English
    Publishing date 2021-08-19
    Publishing country United States
    Document type Journal Article
    ISSN 2639-8028
    ISSN (online) 2639-8028
    DOI 10.1097/CCE.0000000000000516
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  6. Article ; Online: Physical Therapy Management of an Individual With Post-COVID Syndrome: A Case Report.

    Mayer, Kirby P / Steele, Angela K / Soper, Melissa K / Branton, Jill D / Lusby, Megan L / Kalema, Anna G / Dupont-Versteegden, Esther E / Montgomery-Yates, Ashley A

    Physical therapy

    2021  Volume 101, Issue 6

    Abstract: Objective: The purpose of this case report is to provide the clinical presentation and physical therapist management for a patient with post-COVID syndrome. Secondarily, the report highlights the importance of assessing cognitive and emotional health in ...

    Abstract Objective: The purpose of this case report is to provide the clinical presentation and physical therapist management for a patient with post-COVID syndrome. Secondarily, the report highlights the importance of assessing cognitive and emotional health in patients with post-COVID syndrome.
    Methods (case description): A 37-year-old woman tested positive for SARS-CoV-2 and developed mild COVID-19 disease but did not require supplemental oxygen or hospitalization. The patient experienced persistent symptoms, including dyspnea, headaches, and cognitive fog. On day 62, they participated in an outpatient physical therapist evaluation that revealed deficits in exercise capacity, obtaining 50% of their age-predicted 6-minute walk distance. They had minor reductions in muscle strength and cognitive function. Self-reported quality of life was 50, and they scored above established cut-off scores for provisional diagnosis of posttraumatic stress disorder (PTSD).
    Results: The patient participated in biweekly physical therapist sessions for 8 weeks, which included aerobic training, strengthening exercises, diaphragmatic breathing techniques, and mindfulness training. Metabolic equivalent for task levels increased with variability over the course of the program. The patient's muscle strength, physical function, and exercise capacity improved. 6-Minute walk distance increased by 199 m, equating to 80% of their age-predicted distance. Quality of life and PTSD scores did not improve. At evaluation after physical therapy, the patient was still experiencing migraines, dyspnea, fatigue, and cognitive dysfunction.
    Conclusion: This case report described the clinical presentation and physical therapist management of a person with post-COVID syndrome, a novel health condition for which little evidence exists to guide rehabilitation examination and interventions. Physical therapists should consider cognitive function and emotional health in their plan of care for patients with post-COVID syndromes.
    Impact: This case alerts physical therapists to post-COVID syndrome-which can include debilitating symptoms of decreased aerobic tolerance, anxiety, PTSD, and cognitive dysfunction-and to the role that therapists can play in assessing these symptoms and managing these patients.
    MeSH term(s) Adult ; COVID-19/complications ; COVID-19/therapy ; Cognitive Dysfunction/therapy ; Cognitive Dysfunction/virology ; Dyspnea/therapy ; Dyspnea/virology ; Female ; Humans ; Pandemics ; Physical Therapy Modalities ; Quality of Life ; SARS-CoV-2 ; Stress Disorders, Post-Traumatic/therapy ; Stress Disorders, Post-Traumatic/virology ; Surveys and Questionnaires ; Syndrome ; Walk Test
    Language English
    Publishing date 2021-03-18
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 415886-6
    ISSN 1538-6724 ; 0031-9023
    ISSN (online) 1538-6724
    ISSN 0031-9023
    DOI 10.1093/ptj/pzab098
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    Ue I Zs.270: Show issues Location:
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