LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 48

Search options

  1. Article ; Online: Response to De Koster and al. Thuillier P, Benisvy D, Ansquer C, Corvilain B, Mirallie E, Taieb D, et al.: What is the role of functional imaging and isotopic treatment? Ann Endocrinol (Paris) 2022. https://doi.org/10.1016/j.ando.2022.10.008.

    Thuillier, Philippe / Ansquer, Catherine / Borson-Chazot, Françoise / Lussey-Lepoutre, Charlotte

    Annales d'endocrinologie

    2023  Volume 84, Issue 2, Page(s) 327–328

    Language English
    Publishing date 2023-01-17
    Publishing country France
    Document type Letter ; Comment
    ZDB-ID 299-9
    ISSN 2213-3941 ; 0003-4266
    ISSN (online) 2213-3941
    ISSN 0003-4266
    DOI 10.1016/j.ando.2023.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: SFE-AFCE-SFMN 2022 Consensus on the management of thyroid nodules: Introduction to the consensus.

    Borson-Chazot, Françoise / Lussey-Lepoutre, Charlotte / Pattou, François

    Annales d'endocrinologie

    2022  Volume 83, Issue 6, Page(s) 375–377

    Abstract: The SFE-AFCE-SFMN 2022 consensus deals with the management of thyroid nodules, a condition that is a frequent reason for consultation in endocrinology. In more than 90% of cases, patients are euthyroid, with benign non-progressive nodules that do not ... ...

    Abstract The SFE-AFCE-SFMN 2022 consensus deals with the management of thyroid nodules, a condition that is a frequent reason for consultation in endocrinology. In more than 90% of cases, patients are euthyroid, with benign non-progressive nodules that do not warrant specific treatment. The clinician's objective is to detect malignant thyroid nodules at risk of recurrence and death, toxic nodules responsible for hyperthyroidism or compressive nodules warranting treatment. The diagnosis and treatment of thyroid nodules requires close collaboration between endocrinologists, nuclear medicine physicians and surgeons, but also involves other specialists. Therefore, this consensus statement was established jointly by 3 societies: the French Society of Endocrinology (SFE), French Association of Endocrine Surgery (AFCE) and French Society of Nuclear Medicine (SFMN); the various working groups included experts from other specialties (pathologists, radiologists, pediatricians, biologists, etc.). This introductory text explains the reasons for this choice and the methodology used, and gives an overview of the current consensus on the management of the thyroid.
    MeSH term(s) Humans ; Thyroid Nodule/diagnosis ; Thyroid Nodule/therapy ; Thyroid Nodule/pathology ; Nuclear Medicine ; Endocrinology ; Radionuclide Imaging
    Language English
    Publishing date 2022-10-23
    Publishing country France
    Document type Practice Guideline ; Journal Article
    ZDB-ID 299-9
    ISSN 2213-3941 ; 0003-4266
    ISSN (online) 2213-3941
    ISSN 0003-4266
    DOI 10.1016/j.ando.2022.10.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Feasibility of Liver Transplantation after 90Y Radioembolization: Lessons from a Radiation Protection Incident.

    Soret, Marine / Maisonobe, Jacques-Antoine / Maksud, Philippe / Payen, Stéphane / Allaire, Manon / Savier, Eric / Roux, Charles / Lussey-Lepoutre, Charlotte / Kas, Aurélie

    Health physics

    2024  

    Abstract: Abstract: Radioembolization using 90Y is a growing procedure in nuclear medicine for treating hepatocellular carcinoma. Current guidelines suggest postponing liver transplantation or surgical resection for a period of 14 to 30 d after radioembolization ... ...

    Abstract Abstract: Radioembolization using 90Y is a growing procedure in nuclear medicine for treating hepatocellular carcinoma. Current guidelines suggest postponing liver transplantation or surgical resection for a period of 14 to 30 d after radioembolization to minimize surgeons' exposure to ionizing radiation. In light of a radiation protection incident, we reevaluated the minimum delay required between radioembolization and subsequent liver transplantation. A patient with a hepatocellular carcinoma underwent a liver transplantation 44 h after undergoing radioembolization using 90Y (860 MBq SIR-Spheres). No specific radioprotection measures were followed during surgery and pathological analysis. We subsequently (1) evaluated the healthcare professionals' exposure to ionizing radiation by conducting dose rate measurements from removed liver tissue and (2) extrapolated the recommended interval to be observed between radioembolization and surgery/transplantation to ensure compliance with the radiation dose limits for worker safety. The surgeons involved in the transplantation procedure experienced the highest radiation exposure, with whole-body doses of 2.4 mSv and extremity doses of 24 mSv. The recommended delay between radioembolization and liver transplantation was 8 d when using SIR-Spheres and 15 d when injecting TheraSphere. This delay can be reduced further when considering the specific 90Y activity administered during radioembolization. This dosimetric study suggests the feasibility of shortening the delay for liver transplantation/surgery after radioembolization from the 8th or 15th day after using SIR-Spheres or TheraSphere, respectively. This delay can be decreased further when adjusted to the administrated activity while upholding radiation protection standards for healthcare professionals.
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2406-5
    ISSN 1538-5159 ; 0017-9078
    ISSN (online) 1538-5159
    ISSN 0017-9078
    DOI 10.1097/HP.0000000000001814
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Epigenetic and metabolic reprogramming of SDH-deficient paragangliomas.

    Moog, Sophie / Lussey-Lepoutre, Charlotte / Favier, Judith

    Endocrine-related cancer

    2020  Volume 27, Issue 12, Page(s) R451–R463

    Abstract: Pheochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumors arising from the adrenal medulla or extra-adrenal paraganglia. Around 40% of all cases are caused by a germline mutation in a susceptibility gene, half of which being found in an ... ...

    Abstract Pheochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumors arising from the adrenal medulla or extra-adrenal paraganglia. Around 40% of all cases are caused by a germline mutation in a susceptibility gene, half of which being found in an SDHx gene (SDHA, SDHB, SDHC, SDHD or SDHAF2). They encode the four subunits and assembly factor of succinate dehydrogenase (SDH), a mitochondrial enzyme involved both in the tricarboxylic acid cycle and electron transport chain. SDHx mutations lead to the accumulation of succinate, which acts as an oncometabolite by inhibiting iron(II) and alpha-ketoglutarate-dependent dioxygenases thereby regulating the cell's hypoxic response and epigenetic processes. Moreover, SDHx mutations induce cell metabolic reprogramming and redox imbalance. Major discoveries in PPGL pathophysiology have been made since the initial discovery of SDHD gene mutations in 2000, improving the understanding of their biology and patient management. It indeed provides new opportunities for diagnostic tools and innovative therapeutic targets in order to improve the prognosis of patients affected by these rare tumors, in particular in the context of metastatic diseases associated with SDHB mutations. This review first describes an overview of the pathophysiology and then focuses on clinical implications of the epigenetic and metabolic reprogramming of SDH-deficient PPGL.
    MeSH term(s) Epigenomics/methods ; Female ; Humans ; Male ; Paraganglioma/genetics ; Succinate Dehydrogenase/genetics
    Chemical Substances Succinate Dehydrogenase (EC 1.3.99.1)
    Language English
    Publishing date 2020-10-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1218450-0
    ISSN 1479-6821 ; 1351-0088
    ISSN (online) 1479-6821
    ISSN 1351-0088
    DOI 10.1530/ERC-20-0346
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: SFE-AFCE-SFMN 2022 Consensus on the management of thyroid nodules: Initial work-up for thyroid nodules.

    Do Cao, Christine / Haissaguerre, Magalie / Lussey-Lepoutre, Charlotte / Donatini, Gianluca / Raverot, Véronique / Russ, Gilles

    Annales d'endocrinologie

    2022  Volume 83, Issue 6, Page(s) 380–388

    Abstract: The SFE-AFCE-SFMN 2022 consensus deals with the management of thyroid nodules, a condition that is a frequent reason for consultation in endocrinology. In more than 90% of cases, patients are euthyroid, with benign non-progressive nodules that do not ... ...

    Abstract The SFE-AFCE-SFMN 2022 consensus deals with the management of thyroid nodules, a condition that is a frequent reason for consultation in endocrinology. In more than 90% of cases, patients are euthyroid, with benign non-progressive nodules that do not warrant specific treatment. The clinician's objective is to detect malignant thyroid nodules at risk of recurrence and death, toxic nodules responsible for hyperthyroidism or compressive nodules warranting treatment. The diagnosis and treatment of thyroid nodules requires close collaboration between endocrinologists, nuclear medicine physicians and surgeons, but also involves other specialists. Therefore, this consensus statement was established jointly by 3 societies: the French Society of Endocrinology (SFE), French Association of Endocrine Surgery (AFCE) and French Society of Nuclear Medicine (SFMN); the various working groups included experts from other specialties (pathologists, radiologists, pediatricians, biologists, etc.). This section deals with the initial work-up for thyroid nodules in adult patients, including clinical and biological evaluation, standardized ultrasound characterization and EU-TIRADS-based nodule selection for fine-needle aspiration biopsy. Indications for thyroid core-biopsies or open surgical biopsies and for cross-sectional imaging of the neck and upper chest are also mentioned.
    MeSH term(s) Adult ; Humans ; Thyroid Nodule/diagnosis ; Thyroid Nodule/therapy ; Nuclear Medicine ; Biopsy, Fine-Needle/methods ; Radionuclide Imaging ; Endocrinology ; Ultrasonography/methods ; Thyroid Neoplasms/therapy ; Thyroid Neoplasms/diagnostic imaging ; Retrospective Studies
    Language English
    Publishing date 2022-10-21
    Publishing country France
    Document type Practice Guideline ; Journal Article
    ZDB-ID 299-9
    ISSN 2213-3941 ; 0003-4266
    ISSN (online) 2213-3941
    ISSN 0003-4266
    DOI 10.1016/j.ando.2022.10.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Enhanced therapeutic outcomes with atezolizumab-bevacizumab and SIRT combination compared to SIRT alone in unresectable HCC: A promising approach for improved survival.

    Mejait, Amel / Roux, Charles / Soret, Marine / Larrey, Edouard / Wagner, Mathilde / Bijot, Jean Charles / Lussey-Lepoutre, Charlotte / Thabut, Dominique / Goumard, Claire / Maksud, Philippe / Allaire, Manon

    Clinics and research in hepatology and gastroenterology

    2024  Volume 48, Issue 2, Page(s) 102282

    Abstract: Background: Integrating immunotherapy with locoregional therapies marks a significant milestone in the realm of hepatocellular carcinoma (HCC) treatment . This study aimed to assess the impact of addition of Atezolizumab-Bevacizumab (AtezoBev) on the ... ...

    Abstract Background: Integrating immunotherapy with locoregional therapies marks a significant milestone in the realm of hepatocellular carcinoma (HCC) treatment . This study aimed to assess the impact of addition of Atezolizumab-Bevacizumab (AtezoBev) on the outcome patients treated with SIRT.
    Methods: We conducted a study that included all Child-Pugh A HCC treated with SIRT since 2017. We examined the effects of the addition of 3 infusions of AtezoBev before the SIRT procedure and after SIRT on patients outcome (AtezoBev-SIRT group). Time-to-event data were analyzed using Kaplan-Meier with the log-rank test.
    Results: Thirty five HCC patients treated with SIRT were included, of whom 23 % also received AtezoBev infusions. The two groups were similar in terms of liver function and HCC parameters. The median OS was not reached for patients who received AtezoBev in combination with SIRT and 14 months for patients only treated by SIRT. The median PFS was higher in the group treated by SIRT and AtezoBev vs SIRT alone (11.3 months vs 5.8 months). In the global cohort, 8 patients presented a downstaging (23 %), 4 underwent liver surgery (1 in the AtezoBev-SIRT group) and 4 liver transplantation (1 in the AtezoBev-SIRT group) CONCLUSIONS: The administration of AtezoBev, both before and after SIRT, is associated with enhanced OS and PFS outcomes compared to SIRT alone for unresectable HCC.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/drug therapy ; Liver Neoplasms/pathology ; Bevacizumab/therapeutic use ; Treatment Outcome ; Antibodies, Monoclonal, Humanized
    Chemical Substances atezolizumab (52CMI0WC3Y) ; Bevacizumab (2S9ZZM9Q9V) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2024-01-06
    Publishing country France
    Document type Journal Article
    ZDB-ID 2594333-9
    ISSN 2210-741X ; 2210-7401
    ISSN (online) 2210-741X
    ISSN 2210-7401
    DOI 10.1016/j.clinre.2024.102282
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: EPAS1-mutated paragangliomas associated with haemoglobin disorders.

    Mancini, Maxence / Buffet, Alexandre / Porte, Baptiste / Amar, Laurence / Lussey-Lepoutre, Charlotte / Crinière, Lise / Baudin, Eric / Meatchi, Tchao / Gimenez-Roqueplo, Anne-Paule / Favier, Judith / Burnichon, Nelly

    British journal of haematology

    2024  Volume 204, Issue 3, Page(s) 1054–1060

    Abstract: We report a large series of 40 patients presenting EPAS1-mutated paraganglioma (PGL) in whom we investigated a cause underlying chronic hypoxia. Four patients suffered from hypoxaemic heart disease. In patients with available haemoglobin electrophoresis ... ...

    Abstract We report a large series of 40 patients presenting EPAS1-mutated paraganglioma (PGL) in whom we investigated a cause underlying chronic hypoxia. Four patients suffered from hypoxaemic heart disease. In patients with available haemoglobin electrophoresis results, 59% presented with a haemoglobin disorder, including six with sickle cell disease, five with sickle cell trait and two with heterozygous haemoglobin C disease. Histological and transcriptomic characterization of EPAS1 tumours revealed increased angiogenesis and high similarities with pseudohypoxic PGLs caused by VHL gene mutations. Sickle haemoglobinopathy carriers could thus be at increased risk for developing EPAS1-PGLs, which should be taken into account in their management and surveillance.
    MeSH term(s) Humans ; Adrenal Gland Neoplasms ; Hemoglobinopathies ; Hemoglobins/genetics ; Hypoxia/genetics ; Mutation ; Paraganglioma/genetics ; Paraganglioma/pathology
    Chemical Substances Hemoglobins ; endothelial PAS domain-containing protein 1 (1B37H0967P)
    Language English
    Publishing date 2024-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19278
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: SFE-AFCE-SFMN 2022 Consensus on the management of thyroid nodules : What is the role of functional imaging and isotopic treatment?

    Thuillier, Philippe / Benisvy, Danielle / Ansquer, Catherine / Corvilain, Bernard / Mirallié, Eric / Taïeb, David / Borson-Chazot, Françoise / Lussey-Lepoutre, Charlotte

    Annales d'endocrinologie

    2022  Volume 83, Issue 6, Page(s) 401–406

    Abstract: The SFE-AFCE-SFMN 2022 consensus deals with the management of thyroid nodules, a condition that is a frequent reason for consultation in endocrinology. In more than 90% of cases, patients are euthyroid, with benign non-progressive nodules that do not ... ...

    Abstract The SFE-AFCE-SFMN 2022 consensus deals with the management of thyroid nodules, a condition that is a frequent reason for consultation in endocrinology. In more than 90% of cases, patients are euthyroid, with benign non-progressive nodules that do not warrant specific treatment. The clinician's objective is to detect malignant thyroid nodules at risk of recurrence and death, toxic nodules responsible for hyperthyroidism or compressive nodules warranting treatment. The diagnosis and treatment of thyroid nodules requires close collaboration between endocrinologists, nuclear medicine physicians and surgeons, but also involves other specialists. Therefore, this consensus statement was established jointly by 3 societies: the French Society of Endocrinology (SFE), French Association of Endocrine Surgery (AFCE) and French Society of Nuclear Medicine (SFMN); the various working groups included experts from other specialties (pathologists, radiologists, pediatricians, biologists, etc.). This section deals with the role of thyroid scintigraphy in the diagnosis of autonomous thyroid nodules, nuclear medicine in nodules with indeterminate cytology and iodine treatment for autonomous thyroid nodules.
    MeSH term(s) Humans ; Thyroid Nodule/diagnostic imaging ; Thyroid Nodule/therapy ; Technetium Tc 99m Sestamibi ; Nuclear Medicine ; Radionuclide Imaging ; Cytodiagnosis ; Thyroid Neoplasms/pathology
    Chemical Substances Technetium Tc 99m Sestamibi (971Z4W1S09)
    Language English
    Publishing date 2022-10-21
    Publishing country France
    Document type Practice Guideline ; Journal Article
    ZDB-ID 299-9
    ISSN 2213-3941 ; 0003-4266
    ISSN (online) 2213-3941
    ISSN 0003-4266
    DOI 10.1016/j.ando.2022.10.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Solitary Breast Metastasis From Thyroid Papillary Carcinoma Revealed on Whole-Body Radioactive 131I Scan.

    Kharroubi, Dris / Richa, Carine / Saie, Clotilde / Chami, Linda / Lussey-Lepoutre, Charlotte

    Clinical nuclear medicine

    2020  Volume 45, Issue 9, Page(s) 687–688

    Abstract: Breast metastasis from thyroid papillary carcinoma is an exceptional situation. Here, we present the diagnostic approach and the management of a 19-year-old woman with single breast metastasis from thyroid carcinoma. There was no extra thyroidal ... ...

    Abstract Breast metastasis from thyroid papillary carcinoma is an exceptional situation. Here, we present the diagnostic approach and the management of a 19-year-old woman with single breast metastasis from thyroid carcinoma. There was no extra thyroidal extension, neoplastic emboli, or lymph node invasion. The metastasis was revealed by whole-body radioactive I scan, explored by a fine-needle aspiration, and confirmed by elevated thyroglobulin in situ.
    MeSH term(s) Biopsy, Fine-Needle ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Breast Neoplasms/secondary ; Female ; Humans ; Iodine Radioisotopes ; Lymphatic Metastasis ; Thyroid Cancer, Papillary/pathology ; Whole Body Imaging ; Young Adult
    Chemical Substances Iodine Radioisotopes ; Iodine-131
    Language English
    Publishing date 2020-05-21
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000003115
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Novel PET tracers: added value for endocrine disorders.

    Bergeret, Sébastien / Charbit, Judith / Ansquer, Catherine / Bera, Géraldine / Chanson, Philippe / Lussey-Lepoutre, Charlotte

    Endocrine

    2019  Volume 64, Issue 1, Page(s) 14–30

    Abstract: Nuclear medicine has been implicated in the diagnosis and treatment of endocrine disorders for several decades. With recent development of PET tracers, functional imaging now plays a major role in endocrine tumors enabling with high performance to their ... ...

    Abstract Nuclear medicine has been implicated in the diagnosis and treatment of endocrine disorders for several decades. With recent development of PET tracers, functional imaging now plays a major role in endocrine tumors enabling with high performance to their localization, characterization, and staging. Besides
    MeSH term(s) Dihydroxyphenylalanine/analogs & derivatives ; Endocrine System Diseases/diagnostic imaging ; Fluorodeoxyglucose F18 ; Gallium Radioisotopes ; Humans ; Neuroendocrine Tumors/diagnostic imaging ; Positron-Emission Tomography ; Radiopharmaceuticals
    Chemical Substances Gallium Radioisotopes ; Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; fluorodopa F 18 (2C598205QX) ; Dihydroxyphenylalanine (63-84-3) ; Gallium-68 (98B30EPP5S)
    Language English
    Publishing date 2019-03-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-019-01895-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top