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Article ; Online: EEG alpha activity increased in response to transcutaneous electrical nervous stimulation in young healthy subjects but not in the healthy elderly

Ebru Yıldırım / Bahar Güntekin / Lütfü Hanoğlu / Candan Algun

PeerJ, Vol 8, p e

2020 Volume 8330

Abstract: Transcutaneous Electrical Nerve Stimulation (TENS) is used not only in the treatment of pain but also in the examination of sensory functions. With aging, there is decreased sensitivity to somatosensory stimuli. It is essential to examine the effect of ... ...

Abstract	Transcutaneous Electrical Nerve Stimulation (TENS) is used not only in the treatment of pain but also in the examination of sensory functions. With aging, there is decreased sensitivity to somatosensory stimuli. It is essential to examine the effect of TENS application on the sensory functions in the brain by recording the spontaneous electroencephalogram (EEG) activity and the effect of aging on the sensory functions of the brain during the application. The present study aimed to investigate the effect of the application of TENS on the brain’s electrical activity and the effect of aging on the sensory functions of the brain during application of TENS. A total of 15 young (24.2 ± 3.59) and 14 elderly (65.64 ± 4.92) subjects were included in the study. Spontaneous EEG was recorded from 32 channels during TENS application. Power spectrum analysis was performed by Fast Fourier Transform in the alpha frequency band (8–13 Hz) for all subjects. Repeated measures of analysis of variance was used for statistical analysis (p < 0.05). Young subjects had increased alpha power during the TENS application and had gradually increased alpha power by increasing the current intensity of TENS (p = 0.035). Young subjects had higher alpha power than elderly subjects in the occipital and parietal locations (p = 0.073). We can, therefore, conclude that TENS indicated increased alpha activity in young subjects. Young subjects had higher alpha activity than elderly subjects in the occipital and somatosensory areas. To our knowledge, the present study is one of the first studies examining the effect of TENS on spontaneous EEG in healthy subjects. Based on the results of the present study, TENS may be used as an objective method for the examination of sensory impairments, and in the evaluative efficiency of the treatment of pain conditions.
Keywords	Pain ; TENS ; EEG ; FFT ; Alpha ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	150
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical evaluation and resting state fMRI analysis of virtual reality based training in Parkinson’s disease through a randomized controlled trial

Farzin Hajebrahimi / Halil Aziz Velioglu / Zubeyir Bayraktaroglu / Nesrin Helvaci Yilmaz / Lutfu Hanoglu

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 13

Abstract: Abstract There are few studies investigating the short-term effects of Virtual Reality based Exergaming (EG) on motor and cognition simultaneously and pursue the brain functional activity changes after these interventions in patients with Parkinson’s ... ...

Abstract	Abstract There are few studies investigating the short-term effects of Virtual Reality based Exergaming (EG) on motor and cognition simultaneously and pursue the brain functional activity changes after these interventions in patients with Parkinson’s Disease (PD). The purpose of this study was to investigate the synergistic therapeutic effects of Virtual Reality based EG on motor and cognitive symptoms in PD and its possible effects on neuroplasticity. Eligible patients with the diagnosis of PD were randomly assigned to one of the two study groups: (1) an experimental EG group, (2) an active control Exercise Therapy (ET) group. All patients participated in a 4-week exercise program consisting of 12 treatment sessions. Every session lasted 60 min. Participants underwent a motor evaluation, extensive neuropsychological assessment battery and rs-fMRI before and after the interventions. Thirty patients fulfilled the inclusion criteria and were randomly assigned to the EG and ET groups. After the dropouts, 23 patients completed the assessments and interventions (11 in EG, 13 in ET). Within group analysis showed significant improvements in both groups. Between group comparisons considering the interaction of group × time effect, showed superiority of EG in terms of general cognition, delayed visual recall memory and Boston Naming Test. These results were consistent in the within-group and between-group analysis. Finally, rs-fMRI analysis showed increased activity in the precuneus region in the time × group interaction in the favor of EG group. EG can be an effective alternative in terms of motor and cognitive outcomes in patients with PD. Compared to ET, EG may affect brain functional connectivity and can have beneficial effects on patients’ cognitive functions and motor symptoms. Whenever possible, using EG and ET in combination, may have the better effects on patients daily living and patients can benefit from the advantages of both interventions.
Keywords	Medicine ; R ; Science ; Q
Subject code	796
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Parkinson’s Disease and the COVID-19 Pandemic

Nesrin Helvaci Yilmaz / Basak Bolluk Kilic / Tahsin Ali Zirh / Asile Seval Aslan / Lutfu Hanoglu

Haseki Tıp Bülteni, Vol 60, Iss 3, Pp 204-

Do Quarantine Affect the Motor and Non-Motor Symptoms of Patients with and without Deep Brain Stimulation?

2022 Volume 210

Abstract: Aim:Patients with chronic diseases were forced into lockdown due to the coronavirus disease-2019 pandemic. Extended quarantine could lead to physical inactivity and psychiatric problems. We investigated the effects of quarantine and social isolation ... ...

Abstract	Aim:Patients with chronic diseases were forced into lockdown due to the coronavirus disease-2019 pandemic. Extended quarantine could lead to physical inactivity and psychiatric problems. We investigated the effects of quarantine and social isolation during the pandemic on the motor and non-motor symptoms (NMS) of Parkinson’s disease (PD) patients with and without deep brain stimulation (DBS).Methods:This study included 168 patients with PD who were in quarantine for 2 months (between April 1, 2020 and May 31, 2020). Eighty-three patients had undergone bilateral subthalamic DBS surgery. A questionnaire with three parts was administered via phone: 1) motor symptoms, 2) NMS, and 3) the reasons for impairment.Results:Of the patients, 54.7% reported impairment in at least one motor symptom and 58.9% reported impairment in at least one NMS. Increased tremors, difficulty with turning in bed, and insomnia were significantly more pronounced in patients without DBS. Patients with DBS complained less of being bored due to staying at home and had less deterioration due to lack of exercise and slower disease progression.Conclusion:Half of the symptoms of patients with PD worsened during quarantine, but patients with DBS tolerated the lockdown better. Telemedicine and online physiotherapy programs should be recommended to prevent rapid disease progression.
Keywords	covid-19 ; deep brain stimulation ; parkinson’s disease ; quarantine ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Galenos Yayinevi
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Network Theory and Effects of Transcranial Brain Stimulation Methods on the Brain Networks

Sema Demirci / Lütfü Hanoğlu

Haseki Tıp Bülteni, Vol 52, Iss 4, Pp 238-

2014 Volume 247

Abstract: In recent years, there has been a shift from classic localizational approaches to new approaches where the brain is considered as a complex system. Therefore, there has been an increase in the number of studies involving collaborations with other areas ... ...

Abstract	In recent years, there has been a shift from classic localizational approaches to new approaches where the brain is considered as a complex system. Therefore, there has been an increase in the number of studies involving collaborations with other areas of neurology in order to develop methods to understand the complex systems. One of the new approaches is graphic theory that has principles based on mathematics and physics. According to this theory, the functional-anatomical connections of the brain are defined as a network. Moreover, transcranial brain stimulation techniques are amongst the recent research and treatment methods that have been commonly used in recent years. Changes that occur as a result of applying brain stimulation techniques on physiological and pathological networks help better understand the normal and abnormal functions of the brain, especially when combined with techniques such as neuroimaging and electroencephalography. This review aims to provide an overview of the applications of graphic theory and related parameters, studies conducted on brain functions in neurology and neuroscience, and applications of brain stimulation systems in the changing treatment of brain network models and treatment of pathological networks defined on the basis of this theory.
Keywords	Brain networks ; transcranial magnetic stimulation ; functional connectivity ; graphic theory ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2014-12-01T00:00:00Z
Publisher	Galenos Yayinevi
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Factors Affecting Prognosis in Hypoxic Encephalopathy Patients Followed-up in Intensive Care Unit

Nesrin Helvacı Yılmaz / Cem Erdoğan / Deniz Kızılaslan / Özge Arıcı Düz / Eren Toplutaş / Lütfü Hanoğlu

Ankara Üniversitesi Tıp Fakültesi Mecmuas, Vol 72, Iss 2, Pp 199-

2019 Volume 204

Abstract: Objectives:Hypoxic encephalopathy (HE) after cardiac arrest is a clinical condition that can cause severe neurological sequelae and death. It is important to determine the prognosis in patients with HE for follow up and developing future treatments in ... ...

Abstract	Objectives:Hypoxic encephalopathy (HE) after cardiac arrest is a clinical condition that can cause severe neurological sequelae and death. It is important to determine the prognosis in patients with HE for follow up and developing future treatments in the long term. Our aim was to investigate the effects of age, gender, hypothermia, lesion site in brain magnetic resonance imaging (MRI), seizure and electroencephalography (EEG) findings on prognosis in patients with the diagnosis of HE.Materials and Methods:The data of the adult intensive care unit was evaluated retrospectively. A total of 194 patients with HE were included into the study. One hundred and eighteen (60.8%) of the patients were male and 76 (39.2%) were female. The survivors and those who died were identified. Hypothermia therapy, brain MRI findings (cortical and/or subcortical lesion), presence of seizures (myoclonic, generalized, focal) and EEG findings (epileptic activity, status, generalized slowing) were recorded.Results:The mean age was 59.46±1.71 (18-89). Seventy-six (39.2%) patients underwent hypothermia. One hundred and seven (55.2%) patients died. The rate of exitus in elderly patients was significantly higher (p<0.01). The brain MRI of 88 patients showed hypoxic lesions (cortical in 8 patients, subcortical in 21 patients, cortical + subcortical lesion in 59 patients). The survival rate of the patients with cortical or subcortical pathology is significantly higher than patients with both pathology (p<0.01). As a result of multiple regression analysis, a 1-year increase in age, increased the risk of death by 4%, while the presence of pathological findings in both areas in brain MRI increased the risk of death by 2.62 times. There was no significant difference of gender, hypothermia, seizures and pathological EEG findings on survival (p>0.05).Conclusion:Approximately half of the patients included in our study died. The survival rate of the elderly patients and the patients with multiple lesions in brain MRI was low.
Keywords	Hypoxic Encephalopathy ; Prognosis ; Intensive Care Unit ; Medicine (General) ; R5-920
Subject code	610 ; 616
Language	English
Publishing date	2019-08-01T00:00:00Z
Publisher	Galenos Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Relation of Apathy to Motor and Non-motor Findings in Parkinson’s Disease

Melek Gürbüz / Gönül Akdağ / Özge Arıcı Düz / Feriha Özer / Özlem Çokar / Lütfü Hanoğlu

Haseki Tıp Bülteni, Vol 57, Iss 2, Pp 129-

2019 Volume 134

Abstract: Aim:It has been shown that motor symptoms, as well as non-motor symptoms, significantly affect the quality of life of patients with idiopathic Parkinson’s disease. In our study, the association of apathy, one of the NMS, with motor and non-motor symptoms ...

Abstract	Aim:It has been shown that motor symptoms, as well as non-motor symptoms, significantly affect the quality of life of patients with idiopathic Parkinson’s disease. In our study, the association of apathy, one of the NMS, with motor and non-motor symptoms was investigated.Methods:Patients with stage 1-3 IPH according to the Hoehn-Yahr Scale (H&Y) were included in the study. Patients who received dementia diagnosis according to the DSM IV criteria were excluded from the study. The patients were evaluated using the Unified Parkinson’s Disease Rating Scale (UPDRS), non-motor symptoms Questionnaire (NMSQ), Geriatric Depression Scale (GDS), and the revised diagnostic criteria for apathy.Results:Apathy was found in 26 of 68 patients who were included in the study. Patients with and without apathy were compared in terms of age, clinical and demographic characteristics, L-dopa equivalent doses, depression, and NMSQ scores. The group of patients with apathy consisted of nine females and 17 males and the mean age was 64.3±7.7 years. The non-apathy group included 25 females and 17 males and the mean age was 66.8±9.1 years. There was no statistically significant difference between the groups in terms of age, education, age at onset, duration of illness and L-dopa equivalent doses. The male-to-female ratio was significantly higher in the apathy group. The mean GDS and NMSQ scores in the apathy group were significantly higher than in the non-apathy group. There was a statistically significant difference between the groups in H&Y stage and total UPDRS and subscales scores. It was noteworthy that the rate of stage 3 patients was higher in the group of patients with apathy. The number of patients having bradykinesia in the apathy group and the number of patients having tremor in the group without apathy was higher.Conclusion:Our study showed that apathy, one of the non-motor symptoms, was more prominent in male gender, associated with UPDRS scores, clinical stage and bradykinesia, and accompanied by depression.
Keywords	Parkinson’s disease ; motor symptoms ; non-motor symptoms ; apathy ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2019-06-01T00:00:00Z
Publisher	Galenos Yayinevi
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The effect of rifampicin on the neuronal cell survival in prımary cortical neuron culture after laser axotomy

Mehmet Ozansoy / Ebru Coşkun / Muzaffer Beyza Çeti̇n Ozansoy / Şeyda Çankaya / Mehmet Yalçın Günal / Zübeyir Bayraktaroğlu / Burak Yuluğ / Lütfü Hanoğlu

Acta Medica Alanya, Vol 3, Iss 2, Pp 135-

2019 Volume 140

Abstract: Aim: Neurodegeneration caused by the axonal injury is a widely seen phenomenon in spinal cord and traumatic brain injuries. Due to the disintegration of the synaptic connection neurotrophic factors could not be transported retrogradely towards the cell ... ...

Abstract	Aim: Neurodegeneration caused by the axonal injury is a widely seen phenomenon in spinal cord and traumatic brain injuries. Due to the disintegration of the synaptic connection neurotrophic factors could not be transported retrogradely towards the cell body and the deprivation of the trophic factors lead to the degeneration and death of the injured neuron. Rifampicin is an antibiotic exhibiting several neuroprotective functions in various neurodegenerative conditions. Here we aim to investigate the acute neuroprotective effect of rifampicin in primary cortical neuron culture in which neurons are axotomized by laser axotomy.Methods: Neonatal male mice were used in order to isolate cortical neurons. Isolated primary cortical neurons were cultured. After 24 hours three different rifampicin concentrations (1 μM, 10 μM and 100 μM) were applied to the neurons and after 15 minutes of rifampicin addition, neurons were laser axotomized. Viability of the cells was evaluated by propidium iodide staining after 24 hours of axotomy. Results: Laser axotomy decreases the cortical neuron viability significantly by 80.45%, while rifampicin pre-treatment increases their viability in all three dosages in a statistically significant manner. Conclusion: Rifampicin has an acute neuroprotective effect on the viability of the laser axotomized cortical neurons.
Keywords	laser axotomy ; rifampicin ; neuronal viability ; primary cortical neuron ; neurotrauma ; lazer aksotomi ; rifampisin ; nöronal canlılık ; primer kortikal nöron ; nörotravma ; Medicine ; R
Language	English
Publishing date	2019-08-01T00:00:00Z
Publisher	Alanya Alaaddin Keykubat University
Document type	Article ; Online
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Article ; Online: Combined metabolic activators improve cognitive functions in Alzheimer’s disease patients

Burak Yulug / Ozlem Altay / Xiangyu Li / Lutfu Hanoglu / Seyda Cankaya / Simon Lam / Halil Aziz Velioglu / Hong Yang / Ebru Coskun / Ezgi Idil / Rahim Nogaylar / Ahmet Ozsimsek / Cemil Bayram / Ismail Bolat / Sena Oner / Ozlem Ozdemir Tozlu / Mehmet Enes Arslan / Ahmet Hacimuftuoglu / Serkan Yildirim /

Muhammad Arif / Saeed Shoaie / Cheng Zhang / Jens Nielsen / Hasan Turkez / Jan Borén / Mathias Uhlén / Adil Mardinoglu

Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-

a randomised, double-blinded, placebo-controlled phase-II trial

2023 Volume 23

Abstract: Abstract Background Alzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administered combined metabolic activators (CMA) to the AD rat model and observed that CMA improves the ... ...

Abstract	Abstract Background Alzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administered combined metabolic activators (CMA) to the AD rat model and observed that CMA improves the AD-associated histological parameters in the animals. CMA promotes mitochondrial fatty acid uptake from the cytosol, facilitates fatty acid oxidation in the mitochondria, and alleviates oxidative stress. Methods Here, we designed a randomised, double-blinded, placebo-controlled phase-II clinical trial and studied the effect of CMA administration on the global metabolism of AD patients. One-dose CMA included 12.35 g L-serine (61.75%), 1 g nicotinamide riboside (5%), 2.55 g N-acetyl-L-cysteine (12.75%), and 3.73 g L-carnitine tartrate (18.65%). AD patients received one dose of CMA or placebo daily during the first 28 days and twice daily between day 28 and day 84. The primary endpoint was the difference in the cognitive function and daily living activity scores between the placebo and the treatment arms. The secondary aim of this study was to evaluate the safety and tolerability of CMA. A comprehensive plasma metabolome and proteome analysis was also performed to evaluate the efficacy of the CMA in AD patients. Results We showed a significant decrease of AD Assessment Scale-cognitive subscale (ADAS-Cog) score on day 84 vs day 0 (P = 0.00001, 29% improvement) in the CMA group. Moreover, there was a significant decline (P = 0.0073) in ADAS-Cog scores (improvement of cognitive functions) in the CMA compared to the placebo group in patients with higher ADAS-Cog scores. Improved cognitive functions in AD patients were supported by the relevant alterations in the hippocampal volumes and cortical thickness based on imaging analysis. Moreover, the plasma levels of proteins and metabolites associated with NAD + and glutathione metabolism were significantly improved after CMA treatment. Conclusion Our results indicate that treatment of AD patients with CMA can lead to ...
Keywords	Alzheimer’s disease ; Combined metabolic activators ; Multi-omics ; Systems biology ; Systems medicine ; Neurology. Diseases of the nervous system ; RC346-429
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	BMC
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Article ; Online: Creutzfeldt-Jakob Disease in the Light of Diffusion Magnetic Resonance Imaging Findings

Nesrin Helvacı Yılmaz / Fikret Aysal / Özdil Başkan / Ebru Erbayat Altay / Ahmet Mithat Tavlı / Didem Taşkın / Lütfü Hanoğlu

Türk Nöroloji Dergisi, Vol 21, Iss 1, Pp 37-

2015 Volume 38

Keywords	Creutzfeldt-Jakob disease ; cortical ribboning ; Medicine ; R ; Neurology. Diseases of the nervous system ; RC346-429
Language	English
Publishing date	2015-03-01T00:00:00Z
Publisher	Galenos Yayinevi
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Article ; Online: The Prevalence of Fibromyalgia in Patients with Restless Legs Syndrome

Nesrin Helvacı Yılmaz / Özge Arıcı Düz / Burcu Polat / Sema Demirci / Ahmet Mithat Tavlı / Didem Taşkın / Lütfü Hanoğlu / Fahriye Feriha Özer / Emir Cantürk / Bilge Parlakoğlu / Ayşe Pınar Doğru / Engin Çakar

Türk Nöroloji Dergisi, Vol 22, Iss 4, Pp 161-

2016 Volume 166

Abstract: Objective: To determine the prevalence of fibromyalgia (FM) in patients with Restless legs syndrome (RLS), and to evaluate the relationship of FM and the scales of quality of life. Materials and Methods: Thirty patients aged between 18-65 years (20 ... ...

Abstract	Objective: To determine the prevalence of fibromyalgia (FM) in patients with Restless legs syndrome (RLS), and to evaluate the relationship of FM and the scales of quality of life. Materials and Methods: Thirty patients aged between 18-65 years (20 females, 10 males) with RLS and 30 healthy control subjects (17 female, 13 male) participated in our study. The patients were assessed using the the RLS Severity Rating Scale. The Pittsburg Sleep Quality Index (PSQI), Beck Depression Inventory, Beck Anxiety Questionnaire, and Quality of Life Short form-36 (SF-36) were given to both the patient and control group. The American College of Rheumatology criteria were used to diagnose FM. Results: The average age of the patients was 44.73±11.23 years, the average age of the control group was 46.00±12.23 years. The prevalence of FM was 36.7% in the patient group and 6.7% in the control group (p=0.01). PSQI, depression and anxiety scores were significantly worse in the patient group (p=0.0001; p=0.004; p=0.000). The patients with RLS had higher scores of mental health, social functioning, pain, and general perception of SF-36, and scale for the evaluation of quality of life (p=0.004; p=0.023; p<0.001; p=0.001; p=0.13); the scores for physical and emotional limitations did not differ between the patient and the control group. However, if a patient with RLS had additional FM symptoms, the general perception scores of the body were worse (p=0.029). When we compared the scores of the patients with both RLS and FM with the healthy group, the anxiety scores were the most increased (three times). Conclusion: The prevelance of FM was frequent (36.67%) in patients with moderate and severe RLS. RLS impairs quality of life. However, coexistence of the two diseases only worsened patients’ assessments of their own health score, and affected their anxiety scores the most.
Keywords	Fibromyalgia ; Restless legs syndrome ; Short form-36 ; Medicine ; R ; Neurology. Diseases of the nervous system ; RC346-429
Subject code	796
Language	English
Publishing date	2016-12-01T00:00:00Z
Publisher	Galenos Yayinevi
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