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  1. Article ; Online: Early Detection of Pancreatic Cancer.

    Schwingel, Jérôme / Decker, Miriam / Schneider, Lisa / Stürmer, Carsten Johannes / Lutz, Manfred P

    Oncology research and treatment

    2023  Volume 46, Issue 6, Page(s) 259–267

    Abstract: Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy that is increasingly common. Screening for pancreatic cancer is not well established but might increase the chance of detection in early stages.: Summary: We conducted a ... ...

    Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy that is increasingly common. Screening for pancreatic cancer is not well established but might increase the chance of detection in early stages.
    Summary: We conducted a literature search to summarize current recommendations and to give an overview of patient groups that may benefit from screening. In the general population, screening is not recommended because the low prevalence of PDAC renders any diagnostic tests non-predictive and because there is no direct evidence that links early diagnosis to improved survival. To date, novel approaches like liquid biopsies and molecular markers are not yet able to improve screening in unselected individuals but offer promising potential. Screening efficiency increases considerably with increasing pretest probability. Therefore, the best way to improve early diagnosis is identifying high-risk individuals.
    Key messages: There are well-defined populations with distinct genetic alterations with an increased risk for pancreatic cancer. Those may be screened with common diagnostic methods. In addition, new-onset diabetes is increasingly recognized as an early symptom, especially in elderly patients with weight loss.
    MeSH term(s) Humans ; Aged ; Early Detection of Cancer/methods ; Pancreatic Neoplasms/genetics ; Carcinoma, Pancreatic Ductal/genetics ; Biomarkers, Tumor/genetics ; Pancreatic Neoplasms
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2023-04-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2760274-6
    ISSN 2296-5262 ; 2296-5270
    ISSN (online) 2296-5262
    ISSN 2296-5270
    DOI 10.1159/000530790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Kommentar

    Lutz, Manfred P.

    Gastroenterologie up2date

    2017  Volume 13, Issue 03, Page(s) 208–208

    Language German
    Publishing date 2017-09-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2203033-5
    ISSN 1616-9727 ; 1616-9670
    ISSN (online) 1616-9727
    ISSN 1616-9670
    DOI 10.1055/s-0043-114941
    Database Thieme publisher's database

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  3. Article ; Online: Crizotinib: aseptic abscesses in multiple organs during treatment of EML4-ALK-positive NSCLC.

    Weber, Daniel / Decker, Miriam / Schuster, Michael / Folz, Sara / Stürmer, Carsten Johannes / Lutz, Manfred P

    Journal of cancer research and clinical oncology

    2021  Volume 147, Issue 12, Page(s) 3769–3771

    Abstract: Purpose: We report a novel side effect of Crizotinib, an oral ALK inhibitor used in the treatment of non-small cell lung cancer (NSCLC) with activating rearrangement of EML4-ALK. It expands the known spectrum of complications of Crizotinib.: Methods: ...

    Abstract Purpose: We report a novel side effect of Crizotinib, an oral ALK inhibitor used in the treatment of non-small cell lung cancer (NSCLC) with activating rearrangement of EML4-ALK. It expands the known spectrum of complications of Crizotinib.
    Methods: Clinical case report.
    Results: Multiple aseptic and recurrent abscesses were observed in the liver, thoracic wall as well as in both kidneys in a 75-year-old female patient suffering from NSCLC who had been treated with Crizotinib for almost 2 years. After discontinuation of the treatment the abscesses dissolved spontaneously and did not reoccur.
    Conclusion: Aseptic abscesses under treatment with Crizotinib are not restricted to the kidneys as described before, but can also occur in other abdominal organs as the liver and even in the thoracic wall. We postulate that this finding may point to a yet unknown not tissue-dependent mechanism of action.
    MeSH term(s) Abscess/chemically induced ; Aged ; Antineoplastic Agents/adverse effects ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Crizotinib/adverse effects ; Female ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Oncogene Proteins, Fusion/genetics ; Protein Kinase Inhibitors/adverse effects
    Chemical Substances Antineoplastic Agents ; EML4-ALK fusion protein, human ; Oncogene Proteins, Fusion ; Protein Kinase Inhibitors ; Crizotinib (53AH36668S)
    Language English
    Publishing date 2021-08-09
    Publishing country Germany
    Document type Case Reports ; Letter
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-021-03664-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Targeting Epidermal Growth Factor Receptor-Related Signaling Pathways in Pancreatic Cancer.

    Philip, Philip A / Lutz, Manfred P

    Pancreas

    2015  Volume 44, Issue 7, Page(s) 1046–1052

    Abstract: Pancreatic cancer is aggressive, chemoresistant, and characterized by complex and poorly understood molecular biology. The epidermal growth factor receptor (EGFR) pathway is frequently activated in pancreatic cancer; therefore, it is a rational target ... ...

    Abstract Pancreatic cancer is aggressive, chemoresistant, and characterized by complex and poorly understood molecular biology. The epidermal growth factor receptor (EGFR) pathway is frequently activated in pancreatic cancer; therefore, it is a rational target for new treatments. However, the EGFR tyrosine kinase inhibitor erlotinib is currently the only targeted therapy to demonstrate a very modest survival benefit when added to gemcitabine in the treatment of patients with advanced pancreatic cancer. There is no molecular biomarker to predict the outcome of erlotinib treatment, although rash may be predictive of improved survival; EGFR expression does not predict the biologic activity of anti-EGFR drugs in pancreatic cancer, and no EGFR mutations are identified as enabling the selection of patients likely to benefit from treatment. Here, we review clinical studies of EGFR-targeted therapies in combination with conventional cytotoxic regimens or multitargeted strategies in advanced pancreatic cancer, as well as research directed at molecules downstream of EGFR as alternatives or adjuncts to receptor targeting. Limitations of preclinical models, patient selection, and trial design, as well as the complex mechanisms underlying resistance to EGFR-targeted agents, are discussed. Future clinical trials must incorporate translational research end points to aid patient selection and circumvent resistance to EGFR inhibitors.
    MeSH term(s) Antineoplastic Agents/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Erlotinib Hydrochloride/antagonists & inhibitors ; Erlotinib Hydrochloride/metabolism ; Humans ; Molecular Targeted Therapy/methods ; Pancreatic Neoplasms/drug therapy ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/therapeutic use ; Receptor, Epidermal Growth Factor/antagonists & inhibitors ; Receptor, Epidermal Growth Factor/metabolism ; Signal Transduction/drug effects ; Survival Analysis
    Chemical Substances Antineoplastic Agents ; Protein Kinase Inhibitors ; Erlotinib Hydrochloride (DA87705X9K) ; EGFR protein, human (EC 2.7.10.1) ; Receptor, Epidermal Growth Factor (EC 2.7.10.1)
    Language English
    Publishing date 2015-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 632831-3
    ISSN 1536-4828 ; 0885-3177
    ISSN (online) 1536-4828
    ISSN 0885-3177
    DOI 10.1097/MPA.0000000000000389
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Conference proceedings: Early gastrointestinal cancers

    Otto, Florian / Lutz, Manfred P

    (Recent results in cancer research, ; 196)

    2012  

    Event/congress St. Gallen EORTC Gastrointestinal Cancer Conference (1st, 2012, SaintGallSwitzerland)
    Author's details Florian Otto, Manfred P. Lutz, editors
    Series title Recent results in cancer research, ; 196
    MeSH term(s) Gastrointestinal Neoplasms/diagnosis ; Gastrointestinal Neoplasms/therapy ; Early Detection of Cancer ; Early Medical Intervention
    Language English
    Size xii, 318 p. :, ill.
    Publisher Springer
    Publishing place Heidelberg
    Document type Book ; Conference proceedings
    Note "Contains the majority of the invited expert contributions from the First St. Gallen EORTC Gastrointestinal Cancer Conference, held on 22-24 March 2012 in St. Gallen, Switzerland."--p. [4] of cover.
    ISBN 9783642316289 ; 364231628X ; 9783642316296 ; 3642316298
    Database Catalogue of the US National Library of Medicine (NLM)

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  6. Book ; Online: Early Gastrointestinal Cancers II: Rectal Cancer

    Otto, Florian / Lutz, Manfred P

    (Recent Results in Cancer Research ; 203)

    2014  

    Abstract: This Recent Results in Cancer Research volume provides an up-to-date overview of the multidisciplinary management of locally confined rectal cancer as well as colorectal cancer with synchronous resectable liver metastases. The contents comprise the ... ...

    Author's details edited by Florian Otto, Manfred P. Lutz
    Series title Recent Results in Cancer Research ; 203
    Abstract This Recent Results in Cancer Research volume provides an up-to-date overview of the multidisciplinary management of locally confined rectal cancer as well as colorectal cancer with synchronous resectable liver metastases. The contents comprise the majority of the invited contributions from the Second St. Gallen EORTC Gastrointestinal Cancer Conference, held on 6-8 March 2014 in St. Gallen, Switzerland. Written by some of the world’s leading experts in the imaging, endoscopy, pathology, molecular biology, surgery, radiotherapy, and medical oncology of rectal cancer and liver metastases, the chapters offer a comprehensive view on the latest recommendations in diagnosis and multidisciplinary treatment. Every clinician involved in the care of patients with rectal cancer will find this book interesting and helpful
    Keywords Cancer/Surgery ; Gastroenterology ; Medicine ; Oncology ; Medizin / Gesundheit Chirurgie ; Medizin / Gesundheit Innere Medizin
    Language English
    Size Online-Ressource (VIII, 252 p. 33 illus., 15 illus. in color), online resource
    Publisher Springer International Publishing
    Publishing place Cham ;s.l
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9783319080598 ; 9783319080604 ; 3319080598 ; 3319080601
    DOI 10.1007/978-3-319-08060-4
    Database Former special subject collection: coastal and deep sea fishing

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  7. Book ; Online: Early Gastrointestinal Cancers

    Otto, Florian / Lutz, Manfred P

    (Recent Results in Cancer Research ; 196)

    2012  

    Abstract: This Recent Results in Cancer Research volume contains the majority of the invited expert contributions from the First St. Gallen EORTC Gastrointestinal Cancer Conference, held on 22-24 March 2012 in St. Gallen, Switzerland. Written by some of the world’ ... ...

    Author's details edited by Florian Otto, Manfred P. Lutz
    Series title Recent Results in Cancer Research ; 196
    Abstract This Recent Results in Cancer Research volume contains the majority of the invited expert contributions from the First St. Gallen EORTC Gastrointestinal Cancer Conference, held on 22-24 March 2012 in St. Gallen, Switzerland. Written by some of the world’s leading experts in the field, the volume constitutes a comprehensive update on recent developments in the imaging, molecular biology, pathology, and multidisciplinary management of early cancer of the gastrointestinal tract. The latest recommendations regarding diagnosis and treatment are provided, and areas of consensus and controversy, identified. While the principal focus is on esophageal and gastric cancer, advances in the treatment of colorectal and pancreatic cancer are also discussed in some detail. This book will be of interest to every clinician involved in the care of patients with gastrointestinal malignancies.
    MeSH term(s) Early Detection of Cancer ; Early Medical Intervention ; Gastrointestinal Neoplasms/diagnosis ; Gastrointestinal Neoplasms/therapy
    Keywords Cancer/Surgery ; Gastroenterology ; Medicine ; Oncology ; Pathology ; Radiology, Medical ; Radiotherapy ; Medizin / Gesundheit Biochemie / Labormedizin ; Medizin / Gesundheit Chirurgie ; Medizin / Gesundheit Grundlagen / Nachschlagewerke ; Medizin / Gesundheit Innere Medizin ; Medizin / Gesundheit Radiologie
    Language English
    Size Online-Ressource (XII, 318 p. 36 illus., 33 illus. in color), digital
    Publisher Springer
    Publishing place Berlin ;Heidelberg
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9783642316289 ; 9783642316296 ; 364231628X ; 3642316298
    DOI 10.1007/978-3-642-31629-6
    Database Former special subject collection: coastal and deep sea fishing

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  8. Article ; Online: Correction: Cyclic AMP induces transactivation of the receptors for epidermal growth factor and nerve growth factor, thereby modulating activation of MAP kinase, Akt, and neurite outgrowth in PC12 cells.

    Piiper, Albrecht / Dikic, Ivan / Lutz, Manfred P / Leser, Jürgen / Kronenberger, Bernd / Elez, Robert / Cramer, Henning / Müller-Esterl, Werner / Zeuzem, Stefan

    The Journal of biological chemistry

    2020  Volume 295, Issue 43, Page(s) 14792

    Language English
    Publishing date 2020-10-14
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.AAC120.016177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: Gastrointestinale und endokrine Tumoren

    Lutz, Manfred P

    aktuelle Diagnostik und Therapie

    2003  

    Author's details Herausgeber, Manfred P. Lutz, Guido Adler, Thomas Seufferlein
    MeSH term(s) Gastrointestinal Neoplasms ; Endocrine Gland Neoplasms
    Language German
    Size x, 172 p. :, ill.
    Publisher Zuckschwerdt
    Publishing place München ; New York
    Document type Book
    ISBN 9783886038176 ; 3886038173
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Article ; Online: CXCR4 and hif-1α as prognostic molecular markers for stage 3 colon cancer patients: post hoc analysis of the randomized, multicenter phase 3 PETACC-2 trial dataset.

    Maderer, Annett / Fiteni, Frederic / Tanis, Erik / Mauer, Murielle / Schmitt, Thomas / Aust, Daniela E / Lutz, Manfred P / Roelofson, Felicitas / Gog, Christiane / Weinmann, Arndt / Koehne, Claus H / Moehler, Markus / Thomaidis, Thomas

    Acta oncologica (Stockholm, Sweden)

    2021  Volume 60, Issue 11, Page(s) 1543–1547

    MeSH term(s) Biomarkers, Tumor/genetics ; Colonic Neoplasms/drug therapy ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Neoplasm Staging ; Prognosis ; Receptors, CXCR4/genetics ; Signal Transduction
    Chemical Substances Biomarkers, Tumor ; CXCR4 protein, human ; HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit ; Receptors, CXCR4
    Language English
    Publishing date 2021-08-06
    Publishing country England
    Document type Clinical Trial, Phase III ; Letter ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 896449-x
    ISSN 1651-226X ; 0349-652X ; 0284-186X ; 1100-1704
    ISSN (online) 1651-226X
    ISSN 0349-652X ; 0284-186X ; 1100-1704
    DOI 10.1080/0284186X.2021.1959057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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