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Article ; Online: Drug Reaction with Eosinophilia and Systemic Syndrome in Revision Arthroplasty for a Prosthetic Knee Infection: A Case Report.

Portney, Daniel A / Baker, Hayden P / Boyle, Margaret M / Barbosa, Victoria H / Luu, Hue H

JBJS case connector

2021 Volume 11, Issue 2, Page(s) e20.00805

Abstract: Case: A 51-year-old woman underwent stage I of a 2-stage revision for a prosthetic knee infection with a vancomycin-impregnated articulating cement spacer followed by IV vancomycin and ceftriaxone. Four weeks later, she developed fevers, a diffuse ... ...

Abstract	Case: A 51-year-old woman underwent stage I of a 2-stage revision for a prosthetic knee infection with a vancomycin-impregnated articulating cement spacer followed by IV vancomycin and ceftriaxone. Four weeks later, she developed fevers, a diffuse cutaneous eruption, lymphadenopathy, transaminitis, and acute renal tubular necrosis before being diagnosed with drug reaction with eosinophilia and systemic syndrome (DRESS). Conclusion: DRESS is a rare, potentially life-threatening adverse drug reaction with cutaneous manifestations and multiorgan involvement. Although rare, its incidence in orthopaedic patients is likely to increase with the aging population. It must be recognized early to minimize end-stage organ dysfunction and mortality.
MeSH term(s)	Aged ; Arthroplasty/adverse effects ; Drug-Related Side Effects and Adverse Reactions/complications ; Eosinophilia/chemically induced ; Female ; Humans ; Knee Joint ; Middle Aged ; Vancomycin/adverse effects
Chemical Substances	Vancomycin (6Q205EH1VU)
Language	English
Publishing date	2021-05-26
Publishing country	United States
Document type	Case Reports ; Journal Article
ISSN	2160-3251
ISSN (online)	2160-3251
DOI	10.2106/JBJS.CC.20.00805
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Article ; Online: Efficacy and Safety of Mechanical IVC Filtration for Preventing Pulmonary Embolism in High-Risk Orthopedic Patients Undergoing Total Hip or Knee Arthroplasty.

Ahmed, Osman / Kim, Ye Joon / Patel, Mikin V / Luu, Hue H / Scott, Bryan / Cohen, Kenneth

The Journal of arthroplasty

2021 Volume 36, Issue 7, Page(s) 2586–2590

Abstract: Background: To determine the efficacy and safety of inferior vena cava (IVC) filters in preventing pulmonary embolism (PE) in high-risk patients undergoing hip or knee arthroplasty.: Methods: 2857 hip or knee arthroplasty procedures between January ... ...

Abstract	Background: To determine the efficacy and safety of inferior vena cava (IVC) filters in preventing pulmonary embolism (PE) in high-risk patients undergoing hip or knee arthroplasty. Methods: 2857 hip or knee arthroplasty procedures between January 2013 and December 2018 were retrospectively reviewed. Patients with a preoperative history of venous thromboembolism (VTE), either PE or deep venous thrombosis (DVT), were categorized as high-risk patients. The incidence of overall VTE, PE, and DVT were compared between patients with filters and those without. The subgroup analysis was also performed by patient risk, and filter status and the incidence of VTE, PE, and DVT were compared. Variables such as filter placement, history of hypercoagulability etcetra were evaluated as risk factors for the development of postoperative VTE. Results: In the high-risk group, the use of IVC filters was significantly associated with a lower incidence of pulmonary embolism (0.8% vs 5.5%, P = .028). When compared with the low-risk group, the high-risk group had significantly higher incidence of PE (3.8% vs 2.0%, P = .038), DVT (11.6% vs 5.3%, P < .001), and overall VTE (15.0% vs 6.8%, P < .001). The history of VTE was associated with postoperative VTE (P < .001), PE (P = .042), and DVT (P < .001). There was no significant correlation between filter placement and postoperative VTE, DVT, or PE in the low-risk group. Filter retrieval was successful in 100% (96/96) of attempted patients with no complications. Conclusion: The use of IVC filters is significantly associated with a lower incidence in pulmonary embolism in high-risk arthroplasty patients. High-risk patients demonstrated an incidence of postoperative VTE over two times greater than other patients. Prophylactic placement of IVC filters in hip/knee arthroplasty is safe.
MeSH term(s)	Arthroplasty, Replacement, Knee/adverse effects ; Humans ; Pulmonary Embolism/epidemiology ; Pulmonary Embolism/etiology ; Pulmonary Embolism/prevention & control ; Retrospective Studies ; Risk Factors ; Vena Cava Filters/adverse effects ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/etiology ; Venous Thromboembolism/prevention & control ; Venous Thrombosis/epidemiology ; Venous Thrombosis/etiology ; Venous Thrombosis/prevention & control
Language	English
Publishing date	2021-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	632770-9
ISSN	1532-8406 ; 0883-5403
ISSN (online)	1532-8406
ISSN	0883-5403
DOI	10.1016/j.arth.2021.02.042
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Zs.A 2134: Show issues

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Article ; Online: Do We Need to Wait 3 Months After Corticosteroid Injections to Reduce the Risk of Infection After Total Knee Arthroplasty?

Bhattacharjee, Sarah / Wallace, Sara / Luu, Hue H / Shi, Lewis L / Lee, Michael J / Chen, Antonia F

The Journal of the American Academy of Orthopaedic Surgeons

2020 Volume 29, Issue 14, Page(s) e714–e721

Abstract: Background: Corticosteroid injections administered within 3 months before total knee arthroplasty (TKA) have been linked to increased risk of postoperative infection. However, it would be beneficial to further delineate the timing of injections to ... ...

Abstract	Background: Corticosteroid injections administered within 3 months before total knee arthroplasty (TKA) have been linked to increased risk of postoperative infection. However, it would be beneficial to further delineate the timing of injections to determine whether a narrower window exists for safe administration of corticosteroid injections. The purposes of our study were to (1) determine whether there were a different time frame between corticosteroid injection and primary TKA that increased infection risk and (2) determine risk factors associated with infection after TKA. Methods: TKA patients were identified from a national database from 2007 to 2017 and stratified based on their history of corticosteroid injections within the 6-month preoperative period. Patients who received injections were stratified into biweekly cohorts by the timing of their most recent injection. The 1-year rate of postoperative infection treated by surgical débridement was compared between injection and noninjection cohorts. Univariate logistic regressions of risk factors and a multivariate analysis for patient comorbidities and injection cohorts associated with increased infection risk were conducted. Results: In the 76,090 TKA patients identified, corticosteroid injection within 2 weeks before TKA increased the risk of postoperative infection (P = 0.02) and injections within 2 to 4 weeks trended toward increased infection in univariate regression. No significant differences were observed in any other injection time frames. In the multivariate analysis, injections within 2 weeks before TKA were identified as an independent risk factor (odds ratio: 2.89; P = 0.04) for postoperative infection. Additional risk factors included chronic obstructive pulmonary disease, coronary artery disease, diabetes, ischemic heart disease, obesity, rheumatoid arthritis, and tobacco, whereas female sex and patient aged older than 65 were protective. Discussion: Our results suggest that TKA performed within four weeks of a corticosteroid injection may be associated with a higher risk of postoperative infection; however, delaying surgery more than four weeks may not provide additional infection risk reduction. Further prospective randomized studies are needed to determine the optimal timing of TKA after corticosteroid injections. Level of evidence: Level III.
MeSH term(s)	Adrenal Cortex Hormones/adverse effects ; Aged ; Arthroplasty, Replacement, Knee/adverse effects ; Female ; Humans ; Injections, Intra-Articular ; Male ; Postoperative Complications ; Retrospective Studies ; Risk Factors
Chemical Substances	Adrenal Cortex Hormones
Language	English
Publishing date	2020-10-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200524-1
ISSN	1940-5480 ; 1067-151X
ISSN (online)	1940-5480
ISSN	1067-151X
DOI	10.5435/JAAOS-D-20-00850
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Zs.A 4048: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Osteosarcoma.

Moore, Drew D / Luu, Hue H

Cancer treatment and research

2014 Volume 162, Page(s) 65–92

Abstract: Osteosarcoma is a malignant tumor that primarily affects the long bones but can also involve other bones in the body. It has a bimodal distribution with peaks in the second decade of life and late adulthood. This chapter will highlight the clinical ... ...

Abstract	Osteosarcoma is a malignant tumor that primarily affects the long bones but can also involve other bones in the body. It has a bimodal distribution with peaks in the second decade of life and late adulthood. This chapter will highlight the clinical presentation, diagnosis, and treatment of osteosarcoma.
MeSH term(s)	Antineoplastic Agents/therapeutic use ; Bone Neoplasms/diagnosis ; Bone Neoplasms/epidemiology ; Bone Neoplasms/surgery ; Bone Neoplasms/therapy ; Humans ; Magnetic Resonance Imaging ; Neoplasm Staging ; Osteosarcoma/diagnosis ; Osteosarcoma/epidemiology ; Osteosarcoma/surgery ; Osteosarcoma/therapy ; Prognosis ; Tomography, X-Ray Computed
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2014
Publishing country	United States
Document type	Journal Article ; Review
ISSN	0927-3042
ISSN	0927-3042
DOI	10.1007/978-3-319-07323-1_4
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Article ; Online: A simplified noncryogenic strategy to transport mesenchymal stem cells: Potential applications in cell therapy and regenerative medicine.

Dong, Xiangyu / Gou, Yannian / Guo, Meichun / Zhong, Jiamin / Li, Aohua / Hao, Ailing / Zeng, Wei / Haydon, Rex C / Luu, Hue H / Reid, Russell R / He, Tongchuan / Xu, Yan / Fan, Jiaming

Genes & diseases

2023 Volume 11, Issue 3, Page(s) 101073

Language	English
Publishing date	2023-08-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2821806-1
ISSN	2352-3042 ; 2352-3042
ISSN (online)	2352-3042
ISSN	2352-3042
DOI	10.1016/j.gendis.2023.07.002
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Article ; Online: Glycogen storage disease type I: Genetic etiology, clinical manifestations, and conventional and gene therapies.

Zhong, Jiamin / Gou, Yannian / Zhao, Piao / Dong, Xiangyu / Guo, Meichun / Li, Aohua / Hao, Ailing / Luu, Hue H / He, Tong-Chuan / Reid, Russell R / Fan, Jiaming

Pediatric discovery

2023 Volume 1, Issue 2

Abstract: Glycogen storage disease type I (GSDI) is an inherited metabolic disorder characterized by a deficiency of enzymes or proteins involved in glycogenolysis and gluconeogenesis, resulting in excessive intracellular glycogen accumulation. While GSDI is ... ...

Abstract	Glycogen storage disease type I (GSDI) is an inherited metabolic disorder characterized by a deficiency of enzymes or proteins involved in glycogenolysis and gluconeogenesis, resulting in excessive intracellular glycogen accumulation. While GSDI is classified into four different subtypes based on molecular genetic variants, GSDIa accounts for approximately 80%. GSDIa and GSDIb are autosomal recessive disorders caused by deficiencies in glucose-6-phosphatase (G6Pase-α) and glucose-6-phosphate-transporter (G6PT), respectively. For the past 50 years, the care of patients with GSDI has been improved following elaborate dietary managements. GSDI patients currently receive dietary therapies that enable patients to improve hypoglycemia and alleviate early symptomatic signs of the disease. However, dietary therapies have many limitations with a risk of calcium, vitamin D, and iron deficiency and cannot prevent long-term complications, such as progressive liver and renal failure. With the deepening understanding of the pathogenesis of GSDI and the development of gene therapy technology, there is great progress in the treatment of GSDI. Here, we review the underlying molecular genetics and the current clinical management strategies of GSDI patients with an emphasis on promising experimental gene therapies.
Language	English
Publishing date	2023-07-24
Publishing country	Australia
Document type	Journal Article
ISSN	2835-5598
ISSN (online)	2835-5598
DOI	10.1002/pdi3.3
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Article ; Online: Trends in Deep Vein Thrombosis Prophylaxis and Deep Vein Thrombosis Rates After Total Hip and Knee Arthroplasty.

Bawa, Harpreet / Weick, Jack W / Dirschl, Douglas R / Luu, Hue H

The Journal of the American Academy of Orthopaedic Surgeons

2018 Volume 26, Issue 19, Page(s) 698–705

Abstract: Introduction: Patients undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA) are at high risk of deep vein thrombosis (DVT) postoperatively, necessitating the use of prophylaxis medications. This investigation used a large claims ... ...

Abstract	Introduction: Patients undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA) are at high risk of deep vein thrombosis (DVT) postoperatively, necessitating the use of prophylaxis medications. This investigation used a large claims database to evaluate trends in postoperative DVT prophylaxis and rates of DVT within 6 months after THA or TKA. Methods: Truven Health MarketScan Commercial Claims and Encounters and Medicare Supplemental and Coordination of Benefits databases were reviewed from 2004 to 2013 for patients who underwent THA or TKA. Data were collected on patient age, sex, Charlson Comorbidity Index, and hypercoagulability diagnoses. Postoperative medication claims were reviewed for prescribed aspirin, warfarin, enoxaparin, fondaparinux, rivaroxaban, and dabigatran. Results: A total of 369,483 patients were included in the analysis, of which 239,949 patients had prescription medication claims. Warfarin was the most commonly prescribed anticoagulant. Patients with a hypercoagulable diagnosis had markedly more DVTs within 6 months after THA or TKA. More patients with a hypercoagulable diagnosis were treated with warfarin or lovenox than other types of anticoagulants. A multivariate regression analysis was performed, showing that patients prescribed aspirin, fondaparinux, and rivaroxaban were markedly less likely than those prescribed warfarin or enoxaparin to have a DVT within 6 months after THA or TKA. Conclusion: After THA and TKA, warfarin is the most commonly prescribed prophylaxis. Patients with hypercoagulability diagnoses are at a higher risk of postoperative DVT. The likelihood of DVT within 6 months of THA and TKA was markedly higher in patients treated with warfarin and lovenox and markedly lower in those treated with aspirin, fondaparinux, and rivaroxaban. Level of evidence: Level III.
MeSH term(s)	Aged ; Anticoagulants/therapeutic use ; Arthroplasty, Replacement, Hip/adverse effects ; Arthroplasty, Replacement, Knee/adverse effects ; Aspirin/therapeutic use ; Clinical Decision-Making ; Dabigatran/therapeutic use ; Databases, Factual ; Enoxaparin/therapeutic use ; Female ; Fondaparinux/therapeutic use ; Humans ; Male ; Middle Aged ; Postoperative Complications/prevention & control ; Retrospective Studies ; Rivaroxaban/therapeutic use ; Venous Thrombosis/etiology ; Venous Thrombosis/prevention & control ; Warfarin/therapeutic use
Chemical Substances	Anticoagulants ; Enoxaparin ; Warfarin (5Q7ZVV76EI) ; Rivaroxaban (9NDF7JZ4M3) ; Dabigatran (I0VM4M70GC) ; Fondaparinux (J177FOW5JL) ; Aspirin (R16CO5Y76E)
Language	English
Publishing date	2018-08-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200524-1
ISSN	1940-5480 ; 1067-151X
ISSN (online)	1940-5480
ISSN	1067-151X
DOI	10.5435/JAAOS-D-17-00235
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Zs.A 4048: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 274: Show issues

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Article ; Online: Preoperative Opioid Use Is Associated with Higher Readmission and Revision Rates in Total Knee and Total Hip Arthroplasty.

Weick, Jack / Bawa, Harpreet / Dirschl, Douglas R / Luu, Hue H

The Journal of bone and joint surgery. American volume

2018 Volume 100, Issue 14, Page(s) 1171–1176

Abstract: Background: Prescription opioid use is epidemic in the U.S. Recently, an association was demonstrated between preoperative opioid use and increased health-care utilization following abdominal surgeries. Given that primary total knee arthroplasty (TKA) ... ...

Abstract	Background: Prescription opioid use is epidemic in the U.S. Recently, an association was demonstrated between preoperative opioid use and increased health-care utilization following abdominal surgeries. Given that primary total knee arthroplasty (TKA) and total hip arthroplasty (THA) are 2 of the most common surgical procedures in the U.S., we examined the association of preoperative opioid use with 30-day readmission and early revision rates. Methods: We reviewed 2003 to 2014 data from 2 Truven Health MarketScan databases (commercial insurance and Medicare plus commercial supplemental insurance). Subjects were included if they had a Current Procedural Terminology (CPT) code for primary TKA or THA and were continuously enrolled in the database for at least 6 months prior to the index procedure. Preoperative opioid prescriptions were identified using National Drug Codes (NDCs). Rates of 30-day readmissions and revision arthroplasty were identified and compared among patients with stratified durations of preoperative opioid use in the 6 months preceding TKA or THA. Results: The study included 324,154 patients in the 1-year follow-up group and 159,822 patients in the 3-year follow-up group. Opioid-naive TKA patients had a lower revision rate than did those with >60 days of preoperative opioid use (1-year cohort: 1.07% compared with 2.14%, p < 0.001; 3-year cohort: 2.58% compared with 5.00%, p < 0.001). A similar trend was noted among THA patients (1-year: 0.38% compared with 1.10%, p < 0.001; 3-year: 1.24% compared with 2.99%, p < 0.001). These trends persisted after adjusting for age, sex, and Charlson Comorbidity Index (CCI). The 30-day readmission rate after TKA or THA was significantly lower for patients with no preoperative opioid use compared with those with >60 days of preoperative opioid use (TKA: 4.82% compared with 6.17%, p < 0.001; THA: 3.71% compared with 5.85%, p < 0.001). Again, this association persisted after adjusting for age, sex, and CCI. Conclusions: Preoperative opioid use was associated with significantly increased risk of early revision and significantly increased risk of 30-day readmission after TKA and THA. This study illustrates the increased risk of poor outcomes and increased postoperative health-care utilization for patients with long-term opioid use prior to THA and TKA. Level of evidence: Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.
MeSH term(s)	Aged ; Analgesia/methods ; Analgesics, Opioid/therapeutic use ; Analysis of Variance ; Arthroplasty, Replacement, Hip/statistics & numerical data ; Arthroplasty, Replacement, Knee/statistics & numerical data ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Patient Readmission/statistics & numerical data ; Reoperation/statistics & numerical data ; Retrospective Studies
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2018-07-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	220625-0
ISSN	1535-1386 ; 0021-9355
ISSN (online)	1535-1386
ISSN	0021-9355
DOI	10.2106/JBJS.17.01414
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Zs.MO 464: Show issues

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Article: Review of Osteosarcoma and Current Management.

Durfee, Ryan A / Mohammed, Maryam / Luu, Hue H

Rheumatology and therapy

2016 Volume 3, Issue 2, Page(s) 221–243

Abstract: Osteosarcoma is the most common primary malignancy of bone in children and young adults. This tumor has a very heterogeneous genetic profile and lacks any consistent unifying event that leads to the pathogenesis of osteosarcoma. In this review, some of ... ...

Abstract	Osteosarcoma is the most common primary malignancy of bone in children and young adults. This tumor has a very heterogeneous genetic profile and lacks any consistent unifying event that leads to the pathogenesis of osteosarcoma. In this review, some of the important genetic events involved in osteosarcoma will be highlighted. Additionally, the clinical diagnosis of osteosarcoma will be discussed, as well as contemporary chemotherapeutic and surgical management of this tumor. Finally, the review will discuss some of the novel approaches to treating this disease.
Language	English
Publishing date	2016-10-19
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	2783278-8
ISSN	2198-6584 ; 2198-6576
ISSN (online)	2198-6584
ISSN	2198-6576
DOI	10.1007/s40744-016-0046-y
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Article ; Online: Niclosamide (NA) overcomes cisplatin resistance in human ovarian cancer.

Huang, Linjuan / Zhang, Jing / Deng, Youling / Wang, Hao / Zhao, Piao / Zhao, Guozhi / Zeng, Wei / Wang, Yonghui / Chen, Connie / Wagstaff, William / Haydon, Rex C / Reid, Russell R / He, Tong-Chuan / Shen, Le / Luu, Hue H / Zhao, Ling

Genes & diseases

2023 Volume 10, Issue 4, Page(s) 1687–1701

Abstract: Ovarian cancer (OC) is one of the most lethal malignancies of the female reproductive system. OC patients are usually diagnosed at advanced stages due to the lack of early diagnosis. The standard treatment for OC includes a combination of debulking ... ...

Abstract	Ovarian cancer (OC) is one of the most lethal malignancies of the female reproductive system. OC patients are usually diagnosed at advanced stages due to the lack of early diagnosis. The standard treatment for OC includes a combination of debulking surgery and platinum-taxane chemotherapy, while several targeted therapies have recently been approved for maintenance treatment. The vast majority of OC patients relapse with chemoresistant tumors after an initial response. Thus, there is an unmet clinical need to develop new therapeutic agents to overcome the chemoresistance of OC. The anti-parasite agent niclosamide (NA) has been repurposed as an anti-cancer agent and exerts potent anti-cancer activities in human cancers including OC. Here, we investigated whether NA could be repurposed as a therapeutic agent to overcome cisplatin-resistant (CR) in human OC cells. To this end, we first established two CR lines SKOV3CR and OVCAR8CR that exhibit the essential biological characteristics of cisplatin resistance in human cancer. We showed that NA inhibited cell proliferation, suppressed cell migration, and induced cell apoptosis in both CR lines at a low micromole range. Mechanistically, NA inhibited multiple cancer-related pathways including AP1, ELK/SRF, HIF1, and TCF/LEF, in SKOV3CR and OVCAR8CR cells. NA was further shown to effectively inhibit xenograft tumor growth of SKOV3CR cells. Collectively, our findings strongly suggest that NA may be repurposed as an efficacious agent to combat cisplatin resistance in chemoresistant human OC, and further clinical trials are highly warranted.
Language	English
Publishing date	2023-01-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2821806-1
ISSN	2352-3042 ; 2352-3042
ISSN (online)	2352-3042
ISSN	2352-3042
DOI	10.1016/j.gendis.2022.12.005
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