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  1. Article ; Online: Modulation of SUR1 K

    Luu, Wing / Bjork, James / Salo, Erin / Entenmann, Nicole / Jurgenson, Taylor / Fisher, Cole / Klein, Amanda H

    International journal of molecular sciences

    2019  Volume 20, Issue 9

    Abstract: The ATP-sensitive ... ...

    Abstract The ATP-sensitive K
    MeSH term(s) Analgesics/pharmacology ; Analgesics/therapeutic use ; Animals ; Diazoxide/pharmacology ; Diazoxide/therapeutic use ; Evoked Potentials ; Female ; Hyperalgesia/drug therapy ; Hyperalgesia/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Potassium Channels, Inwardly Rectifying/metabolism ; Spinal Nerves/drug effects ; Spinal Nerves/metabolism ; Spinal Nerves/physiopathology ; Sulfonylurea Receptors/agonists ; Sulfonylurea Receptors/genetics ; Sulfonylurea Receptors/metabolism ; Touch
    Chemical Substances Abcc8 protein, mouse ; Analgesics ; Kir6.2 channel ; Potassium Channels, Inwardly Rectifying ; Sulfonylurea Receptors ; Diazoxide (O5CB12L4FN)
    Language English
    Publishing date 2019-05-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms20092251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Development of high throughput, high precision synthesis platforms and characterization methodologies for toxicological studies of nanocellulose.

    Pyrgiotakis, Georgios / Luu, Wing / Zhang, Zhenyuan / Vaze, Nachiket / DeLoid, Glen / Rubio, Laura / Graham, W Adam C / Bell, David C / Bousfield, Douglas / Demokritou, Philip

    Cellulose (London, England)

    2019  Volume 25, Page(s) 2303–2319

    Abstract: Cellulose is one of the most abundant natural polymers, is readily available, biodegradable, and inexpensive. Recently, interest is growing around nanoscale cellulose due to the sustainability of these materials, the novel properties, and the overall low ...

    Abstract Cellulose is one of the most abundant natural polymers, is readily available, biodegradable, and inexpensive. Recently, interest is growing around nanoscale cellulose due to the sustainability of these materials, the novel properties, and the overall low environmental impact. The rapid expansion of nanocellulose uses in various applications makes the study of the toxicological properties of these materials of great importance to public health regulators. However, most of the current toxicological studies are highly conflicting, inconclusive, and contradictory. The major reasons for these discrepancies are the lack of standardized methods to produce industry-relevant reference nanocellulose and relevant characterization that will expand beyond the traditional cellulose characterization for applications. In order to address these issues, industry-relevant synthesis platforms were developed to produce nanocellulose of controlled properties that can be used as reference materials in toxicological studies. Herein, two types of nanocellulose were synthesized, cellulose nanofibrils (CNF) and cellulose nanocrystals (CNC) using the friction grinding platform and an acid hydrolysis approach respectively. The nanocellulose structures were characterized extensively regarding their physicochemical properties, including testing for endotoxins and bacteria contamination.
    Language English
    Publishing date 2019-02-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1496831-9
    ISSN 1572-882X ; 0969-0239
    ISSN (online) 1572-882X
    ISSN 0969-0239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Rheology measurements of a biomass slurry: an inter-laboratory study

    Stickel, Jonathan J / Knutsen, Jeffrey S / Liberatore, Matthew W / Luu, Wing / Bousfield, Douglas W / Klingenberg, Daniel J / Scott, C. Tim / Root, Thatcher W / Ehrhardt, Max R / Monz, Thomas O

    Rheologica acta. 2009 Dec., v. 48, no. 9

    2009  

    Abstract: The conversion of biomass, specifically lignocellulosic biomass, into fuels and chemicals has recently gained national attention as an alternative to the use of fossil fuels. Increasing the concentration of the biomass solids during biochemical ... ...

    Abstract The conversion of biomass, specifically lignocellulosic biomass, into fuels and chemicals has recently gained national attention as an alternative to the use of fossil fuels. Increasing the concentration of the biomass solids during biochemical conversion has a large potential to reduce production costs. These concentrated biomass slurries have highly viscous, non-Newtonian behavior that poses several technical challenges to the conversion process. A collaborative effort to measure the rheology of a biomass slurry at four separate laboratories has been undertaken. A comprehensive set of rheological properties were measured using several different rheometers, flow geometries, and experimental methods. The tendency for settling, water evaporation, and wall slip required special care when performing the experiments. The rheological properties were measured at different concentrations up to 30% insoluble solids by mass. The slurry was found to be strongly shear-thinning, to be viscoelastic, and to have a significant concentration-dependent yield stress. The elastic modulus was found to be almost an order of magnitude larger than the loss modulus and weakly dependent on frequency. The techniques and results of this work will be useful to characterize other biomass slurries and in the design of biochemical conversion processing steps that operate at high solids concentrations.
    Keywords biomass ; rheological properties ; rheology ; lignocellulose ; physicochemical properties
    Language English
    Dates of publication 2009-12
    Size p. 1005-1015.
    Document type Article
    ZDB-ID 1463993-2
    ISSN 1435-1528 ; 0035-4511
    ISSN (online) 1435-1528
    ISSN 0035-4511
    DOI 10.1007/s00397-009-0382-8
    Database NAL-Catalogue (AGRICOLA)

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