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  1. Article ; Online: High production MBL2 polymorphisms protect against COVID-19 complications in critically ill patients

    Lorena Viana de Andrade / Mirela Vanessa de Souza Sá / Beatriz Vasconcelos / Luydson Richardson Silva Vasconcelos / Ricardo Khouri / Carlos Dornels Freire de Souza / Anderson da Costa Armstrong / Rodrigo Feliciano do Carmo

    Heliyon, Vol 10, Iss 1, Pp e23670- (2024)

    A retrospective cohort study

    1481  

    Abstract: Mannose-binding lectin (MBL) binds to SARS-CoV-2, inhibits infection of susceptible cells, and activates the complement system via the lectin pathway. In this study, we investigated the association of MBL2 polymorphisms with the risk of hospitalization ... ...

    Abstract Mannose-binding lectin (MBL) binds to SARS-CoV-2, inhibits infection of susceptible cells, and activates the complement system via the lectin pathway. In this study, we investigated the association of MBL2 polymorphisms with the risk of hospitalization and clinical worsening in patients with COVID-19. A total of 550 patients with COVID-19 were included (94 non-hospitalized and 456 hospitalized). Polymorphisms in MBL2 exon 1 (codons 52, 54 and 57) and promoter region (−550, −221, and +4) were determined by real-time PCR. MBL and complement proteins were measured by Luminex. A higher frequency of the H/H genotype and the HYPA haplotype was observed in non-hospitalized patients when compared to hospitalized. In addition, critically ill patients carrying haplotypes associated with high MBL levels (HYPA/HYPA + HYPA/LYPA + HYPA/LYQA + LYPA/LYQA + LYPA/LYPA + LYQA/LYQA + LXPA/HYPA + LXPA/LYQA + LXPA/LYPA) were protected against lower oxygen saturation levels (P = 0.02), use of invasive ventilation use (P = 0.02, OR 0.38), and shock (P = 0.01, OR 0.40), independent of other potential confounders adjusted by multivariate analysis. Our results suggest that variants in MBL2 associated with high MBL levels may play a protective role in the clinical course of COVID-19.
    Keywords Innate immunity ; Complement system ; Mannose-binding lectin ; Mannan-binding lectin ; Polymorphism ; SARS-CoV-2 ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 616
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Relationship between Cognition, levels of PTX-3, MBL and their polymorphisms

    Tatiana Lins Carvalho / Taciana Furtado de Mendonça Belmont / Andreia Soares da Silva / Kleyton Palmeira do Ó / Lucas de Lucena Simões e Silva / Eline Autran de Lima / Luydson Richardson Silva Vasconcelos / Patrícia Muniz Mendes Freire de Moura / Carolina da Cunha Correia

    Research, Society and Development, Vol 9, Iss

    A systematic review

    2020  Volume 10

    Abstract: Introduction: Studies have suggested that pentraxin 3 (PTX3) and Mannose Binding Lectin (MBL) may interfere with cognitive processes. Objective: Identify data reported in the literature involving cognition, PTX3 and MBL. Materials and Methods: The ... ...

    Abstract Introduction: Studies have suggested that pentraxin 3 (PTX3) and Mannose Binding Lectin (MBL) may interfere with cognitive processes. Objective: Identify data reported in the literature involving cognition, PTX3 and MBL. Materials and Methods: The research was done in five databases and the selection of studies was performed in two stages. The first involved review of titles and abstracts. Then the full articles were read and those that did not meet the eligibility criteria were excluded. Results: A total of 3,097 titles and abstracts were selected, but 3,089 were excluded. Finally, 8 articles were included in the review. The articles pointed out that high levels of PTX-3 could be predictors of cognitive impairment while high levels of MBL could have a protective effect on cognition. Conclusion: The current studies are still contradictory and inconclusive, but they lead us to reflect on possible genetic influences of innate immunity in the Central Nervous System. Further research involving the effects of PTX-3 and MBL and its variants on cognition are necessary.
    Keywords Cognition ; Genotype ; Immunity ; Polymorphism ; Single Nucleotide ; Central Nervous System ; Cognition Disorders ; Special aspects of education ; LC8-6691 ; Science (General) ; Q1-390 ; Social Sciences ; H
    Subject code 120
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Cuidados paliativos em pessoas com carcinoma hepatocelular

    Ana Karla da Silva Freire / Taciana Furtado de Mendonça Belmont / Kleyton Palmeira do Ó / Andreia Soares da Silva / Isabela Cristina Cordeiro Farias / Maria de Fátima Alves Aguiar Carvalho / Edgo Jackson Pinto Santiago / Maria do Socorro de Mendonça Cavalcanti / Zulma Maria de Medeiros / Luydson Richardson Silva Vasconcelos

    Research, Society and Development, Vol 9, Iss 7, Pp e248974125-e

    uma revisão integrativa

    2020  Volume 248974125

    Abstract: Objetivo: analisar as estratégias de cuidado paliativo utilizadas por profissionais de saúde em pessoas com hepatocarcinoma. Método: revisão integrativa da literatura sobre o tema nas bases virtuais de dados Scielo, Lilacs, PubMed, MEDLINE e BDENF, sem ... ...

    Abstract Objetivo: analisar as estratégias de cuidado paliativo utilizadas por profissionais de saúde em pessoas com hepatocarcinoma. Método: revisão integrativa da literatura sobre o tema nas bases virtuais de dados Scielo, Lilacs, PubMed, MEDLINE e BDENF, sem restrição de idioma ou data de publicação. A busca foi realizada nos meses de janeiro e fevereiro de 2020. Resultados: os estudos apontaram escassez na produtividade científica na área, considerando que somente 12 artigos foram selecionados. Percebeu-se que as estratégias de cuidados paliativos utilizadas por profissionais de saúde são variadas e vão desde um tratamento individualizado a cada pessoa até o gerenciamento dos sintomas com abordagem nas necessidades físicas e psicossociais, com valorização da equipe multi/interprofissional. Conclusão: espera-se com este estudo incentivar outros profissionais de saúde a desenvolverem mais publicações para a obtenção de um conhecimento amplo, atualizado e relevante sobre estratégias no cuidado paliativo de pessoas com carcinoma hepatocelular.
    Keywords carcinoma hepatocelular ; cuidados paliativos ; equipe de assistência ao paciente ; Special aspects of education ; LC8-6691 ; Science (General) ; Q1-390 ; Social Sciences ; H
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: MBL2 gene polymorphisms are not related to the occurrence of cerebrovascular disease in sickle cell anemia

    Isabela Cristina Cordeiro Farias / Taciana Furtado Mendonça-Belmont / Patrícia Muniz Mendes Freire Moura / Igor Farias Domingos / Diego Arruda Falcão / Gabriela Silva Arcanjo / Betânia Lucena Domingues Hatzlhofer / Kleyton Palmeira do Ó / João Victor Cordeiro Farias / Andreia Soares da Silva / Luydson Richardson Silva Vasconcelos / Aderson da Silva Araújo / Ana Cláudia Mendonça dos Anjos / Antônio Roberto Lucena-Araújo / Maria do Socorro de Mendonça Cavalcanti / Marcos André Cavalcanti Bezerra

    Research, Society and Development, Vol 9, Iss 7, Pp e439974240-e

    2020  Volume 439974240

    Abstract: Objective: This study has as objective to verify whether MBL2 gene polymorphisms are related to the occurrence of cerebrovascular disease (CD) in sickle cell anemia (SCA) patients. Methods: Overall, 259 unrelated SCA patients were enrolled. The patients ... ...

    Abstract Objective: This study has as objective to verify whether MBL2 gene polymorphisms are related to the occurrence of cerebrovascular disease (CD) in sickle cell anemia (SCA) patients. Methods: Overall, 259 unrelated SCA patients were enrolled. The patients were divided into three groups: control group, stroke group ad range of risk group. Peripheral blood samples were collected and DNA extraction was performed. All patients were genotyped for exon 1, promoter region -221 and promoter region -550 of MBL2 gene, along with β-globin gene haplotypes. Results: Concerning the genotyping of the MBL2, there was no difference in the frequency of allelic and genotypic variants of the exon 1 and the promoter regions -221 and -550 of the MBL2 gene among the studied groups. Conclusion: Despite the small number of patients, and the lack of association between MBL2 polymorphisms and CD, our study represents an effort to understand the impact of MBL2 polymorphisms in the clinical outcome of patients with SCA.
    Keywords sickle cell anemia ; cerebrovascular disease ; mbl2 gene ; polymorphism ; Special aspects of education ; LC8-6691 ; Science (General) ; Q1-390 ; Social Sciences ; H
    Subject code 610
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: LGALS3 +191A and +292C polymorphisms are associated with a reduction in serum gal-3 levels, but not with the clinical events of individuals with sickle cell anemia

    Kleyton Palmeira do Ó / Taciana Furtado de Mendonça-Belmont / Isabela Cristina Cordeiro Farias / Andreia Soares da Silva / Ana Karla da Silva Freire / Patrícia Muniz Mendes Freire de Moura / Luydson Richardson Silva Vasconcelos / Aderson da Silva Araújo / Gabriela da Silva Arcanjo / Diego Arruda Falcão / Betânia Lucena Domingues Hatzlhofer / Antônio Roberto Lucena-Araújo / Marcos André Cavalcanti Bezerra / Maria do Socorro de Mendonça Cavalcanti

    Research, Society and Development, Vol 9, Iss

    2020  Volume 9

    Abstract: Objective: This study aimed to evaluate whether the single nucleotide polymorphisms (SNPs) +191 C>A (rs4644) and +292 A>C (rs4652) of the LGALS3 gene and the serum levels of galectin-3 (gal-3) are associated with clinical events in patients with sickle ... ...

    Abstract Objective: This study aimed to evaluate whether the single nucleotide polymorphisms (SNPs) +191 C>A (rs4644) and +292 A>C (rs4652) of the LGALS3 gene and the serum levels of galectin-3 (gal-3) are associated with clinical events in patients with sickle cell anemia (SCA). Methods: SNP +191 and +292 of the LGALS3 gene were detected by the TaqMan PCR system in real time. Gal-3 levels were measured in serum by ELISA. The study included 322 patients, mean age 36 (21-84). Results: AA and CA genotypes of the +191 region were related to lower levels of gal-3 when compared to CC genotype (p=0.0296). Lower level of gal-3 was also associated with the +191/+292 (AA/CC; CA/CC) diplotypes (p=0.0137) compared to the diplotypes (CC/AA; CC/CC; CC/AC; CA/AC). There was no association between serum levels of galectin-3 and genotype frequencies of the LGALS3 +191 and +292 polymorphisms with clinical events in SCA. Conclusion: The polymorphisms +191 and +292 of the LGALS3 are associated to decrease in serum levels of gal-3. However, no association of polymorphisms and levels of gal-3 with clinical events was observed in patients SCA.
    Keywords Galectin-3 ; LGALS3 ; Polymorphism ; Sickle cell anemia. ; Special aspects of education ; LC8-6691 ; Science (General) ; Q1-390 ; Social Sciences ; H
    Subject code 616
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Single Nucleotide Polymorphisms at +191 and +292 of Galectin-3 Gene (LGALS3) Related to Lower GAL-3 Serum Levels Are Associated with Frequent Respiratory Tract Infection and Vaso-Occlusive Crisis in Children with Sickle Cell Anemia.

    Taciana Furtado de Mendonça Belmont / Kleyton Palmeira do Ó / Andreia Soares da Silva / Kamila de Melo Vilar / Fernanda Silva Medeiros / Luydson Richardson Silva Vasconcelos / Ana Claudia Mendonça Dos Anjos / Betânia Lucena Domingues Hatzlhofer / Maíra Galdino da Rocha Pitta / Marcos André Cavalcanti Bezerra / Aderson da Silva Araújo / Moacyr Jesus Barreto de Melo Rego / Patrícia Moura / Maria do Socorro Mendonça Cavalcanti

    PLoS ONE, Vol 11, Iss 9, p e

    2016  Volume 0162297

    Abstract: INTRODUCTION:Patients with sickle cell anemia (SCA) may present chronic hemolytic anemia, vaso-occlusion and respiratory tract infection (RTI) episodes. Galectin-3 (GAL-3) is a multifunctional protein involved in inflammation, apoptosis, adhesion and ... ...

    Abstract INTRODUCTION:Patients with sickle cell anemia (SCA) may present chronic hemolytic anemia, vaso-occlusion and respiratory tract infection (RTI) episodes. Galectin-3 (GAL-3) is a multifunctional protein involved in inflammation, apoptosis, adhesion and resistance to reactive oxygen species. Studies point to a dual role for GAL-3 as both a circulation damage-associated molecular pattern and a cell membrane associated pattern recognition receptor. OBJECTIVE:To investigate associations between the SNPs of GAL-3 gene (LGALS3) and serum levels with RTI and vaso-occlusive crisis (VOC) in children with SCA. MATERIALS AND METHODS:SNPs +191 and +292 in LGALS3 were studied using the TaqMan real-time PCR system; GAL-3 serum levels were measured by ELISA. The study included 79 children with SCA ranging from 2 to 12 years old. RESULTS:GAL-3 serum levels were associated with LGALS3 +191 and +292 genotypes (p <0.0001; p = 0.0169, respectively). LGALS3 +191, AA genotype was associated with low and CC with higher levels of GAL-3. For LGALS3 +292, the CC genotype was associated with lower GAL-3 and AA with higher levels. Patients with Frequency of RTI (FRTI) ≥1 presented higher frequency of +191AA (p = 0.0263) and +292AC/CC genotypes (p = 0.0320). SNP +292 was associated with Frequency of VOC (FVOC) (p = 0.0347), whereas no association was shown with SNP +191 and FVOC. However, CA/AC and AA/CC genotypes with lower GAL-3 levels showed a higher frequency in patients with FRTI ≥1 (p = 0.0170; p = 0.0138, respectively). Also, patients with FVOC ≥1 presented association with CA/AC (p = 0.0228). LGALS3 +191 and +292 combined genotypes related to low (p = 0.0263) and intermediate expression (p = 0.0245) were associated with FRTI ≥1. Lower GAL-3 serum levels were associated with FRTI ≥1 (p = 0.0426) and FVOC ≥1 (p = 0.0012). CONCLUSION:Variation of GAL-3 serum levels related to SNPs at +191 and +292 may constitute a susceptibility factor for RTI and VOC frequency.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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