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  1. Article ; Online: Wet bio-amniotic membrane plugging combined with transplantation in the treatment of small corneal perforations.

    Chen, Yingxin / Lv, Chenxi / Gao, Minghong / Liu, Zhiling / Gao, Ruiyao

    Arquivos brasileiros de oftalmologia

    2024  Volume 87, Issue 2, Page(s) e20220328

    Abstract: Purpose: Wet bio-amniotic membrane plugging combined with transplantation is a novel option that combined amniotic membrane plugging with amniotic membrane transplantation for the treatment of small corneal perforations. This study aimed to evaluate the ...

    Abstract Purpose: Wet bio-amniotic membrane plugging combined with transplantation is a novel option that combined amniotic membrane plugging with amniotic membrane transplantation for the treatment of small corneal perforations. This study aimed to evaluate the efficacy of wet bio-amniotic membrane plugging in the treatment of small corneal perforations and compared it with that of the penetrating keratoplasty procedure.
    Methods: Forty patients (41 eyes) with small corneal perforations <3 mm in diameter treated at our hospital between July 2018 and January 2021 were retrospectively included. Among them, 21 eyes were treated with wet bio-amniotic membrane plugging (wet bio-amniotic membrane plugging group), and 20 eyes were treated with penetrating keratoplasty procedure (penetrating keratoplasty procedure group). The best-corrected visual acuity, anterior chamber formation, corneal thickness, primary disease control, postoperative complications, and graft survival rate were assessed.
    Results: No significant difference in baseline characteristics was found between the wet bio-amniotic membrane plugging and penetrating keratoplasty procedure groups (p>0.05). The postoperative control rates of primary diseases in the wet bio-amniotic membrane plugging and penetrating keratoplasty procedure groups were 95.2% and 90.0%, respectively (p=0.481). Visual acuity was improved 6 months after the operation in the wet bio-amniotic membrane plugging group and was improved at postoperative 1 month in the penetrating keratoplasty procedure group. The formation time of the anterior chamber in the wet bio-amniotic membrane plugging group was significantly shorter than that in the penetrating keratoplasty procedure group (p=0.023). The corneal thickness of the two groups significantly increased 12 months after the operation; however, the degree of thickening in the penetrating keratoplasty procedure group was higher than that in the wet bio-amniotic membrane plugging group (p<0.001). During the follow-up, postoperative complications were not different between the two groups (p>0.999).
    Conclusion: The results suggest that wet bio-amniotic membrane plugging is effective and safe in the treatment of small corneal perforations. Thus, it can be used as an emergency treatment alternative to penetrating keratoplasty procedure for small corneal perforations.
    MeSH term(s) Humans ; Corneal Perforation/surgery ; Amnion ; Retrospective Studies ; Anterior Chamber ; Postoperative Complications
    Language English
    Publishing date 2024-03-04
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 603915-7
    ISSN 1678-2925 ; 0004-2749
    ISSN (online) 1678-2925
    ISSN 0004-2749
    DOI 10.5935/0004-2749.2022-0328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Most suitable plant communities for the slope reclamation of the Zhengzhou-Xinxiang section of the Beijing-Hong Kong-Macao expressway.

    Cao, Wei / Wu, Xiaoqi / Zhu, Niuniu / Meng, Zhenyu / Lv, Chenxi / Li, Xi / Wang, Guojie

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0297004

    Abstract: The construction of expressways in China has produced diverse habitats along slopes characterized by steep gradients, uneven water distribution, poor soil conditions, and no routine maintenance. Manually planting beneficial species is an essential method ...

    Abstract The construction of expressways in China has produced diverse habitats along slopes characterized by steep gradients, uneven water distribution, poor soil conditions, and no routine maintenance. Manually planting beneficial species is an essential method of effectively improving slope soils to prevent soil erosion. However, few studies have evaluated the reclamation effects and plant community composition and structure used to restore slopes along expressways. This study focused on the Zhengzhou-Xinxiang section of the Beijing-Hong Kong-Macao Expressway. A total of 10 representative plant communities were evaluated using the analytic hierarchy process (AHP)-fuzzy integrated evaluation method. The sites were divided into four layers, namely, plant communities, soil nutrients, soil physical properties, and other ecological factors, and 14 indicators were assessed. The evaluation results showed that four of these plant communities (PCs) were excellent, three PCs were good, one PC was normal, two PCs were poor. The four excellent PCs had high Shannon-Wiener index, pielou index, richness index or community productivity. It is worth noting that most excellent plant community structures were tree + shrub + herb. Based on these results, we recommend that fill slopes should be restored using a combination of trees, herbs, and shrubs; also, the vegetation should include native plants, such as B. papyrifera, U. pumila, A. fruticosa, and Cynodon dactylon (L.). This study could provide ideas for plant community composition and structure of new highway slopes in similar climate environment, and provide theoretical support for plant community composition and structure and soil improvement for the existing slope.
    MeSH term(s) Hong Kong ; Macau ; Beijing ; Plants ; Soil/chemistry ; Ecosystem ; China ; Trees
    Chemical Substances Soil
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0297004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Exploring elderly patients' experiences and concerns about early mobilization implemented in postoperative care following lumbar spinal surgery: a qualitative study.

    Huang, Jie / Li, Pan / Wang, Huiting / Lv, Chenxi / Han, Jing / Lu, Xuemei

    BMC nursing

    2023  Volume 22, Issue 1, Page(s) 355

    Abstract: Background: Given its apparent benefits, early mobilization is becoming increasingly important in spinal surgery. However, the time point at which patients first get out of bed for mobilization after spinal surgery varies widely. Beginning in January ... ...

    Abstract Background: Given its apparent benefits, early mobilization is becoming increasingly important in spinal surgery. However, the time point at which patients first get out of bed for mobilization after spinal surgery varies widely. Beginning in January 2022, we conducted a study of early mobilization (mobilization within 4 h postoperatively) following multi-segment lumbar decompression and fusion surgery in elderly patients. The study goal was to better understand elderly patients' perceptions of early mobilization and ultimately contribute to the improvement of elderly patients' perioperative experiences and quality of life.
    Methods: We employed a qualitative descriptive study design involving face-to-face semi-structured interviews. Forty-five consecutive patients were invited, among whom 24 were enrolled and completed the qualitative investigation from February to June 2022. Of these 24 patients, 10 underwent early mobilization (mobilization within 4 h postoperatively) and 14 underwent mobilization at ≥ 24 h postoperatively. Three researchers conducted a 15-question interview the day before each patient's discharge. The interviews were audio-recorded, and content analysis was used to assess the data.
    Results: Six themes regarding the patients' experiences and concerns about early mobilization were identified: worries, benefits, daily routines, pain, education, and support. The study results revealed the obstacles in early mobilization practice and highlighted the importance of perioperative education on early mobilization.
    Conclusions: Clear and explicit guidance on early mobilization and a multidisciplinary mobilization protocol that incorporates a comprehensive pain management plan are essential for effective patient education. These measures may have positive effects on reducing patients' stress and anxiety regarding postoperative early mobilization.
    Language English
    Publishing date 2023-10-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091496-9
    ISSN 1472-6955
    ISSN 1472-6955
    DOI 10.1186/s12912-023-01510-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Vulnerable frequency as an independent prognostic factor for sudden sensorineural hearing loss.

    Liang, Chaoqun / Fang, Qi / Chen, Hongjun / Wang, Zhixian / Qiao, Xiangyun / Liao, Yaqi / Lv, Chenxi / Chen, Mo / Li, Lingxue / Yang, Jianming

    Frontiers in neurology

    2022  Volume 13, Page(s) 962376

    Abstract: Objectives: Sudden sensorineural hearing loss (SSNHL) is a common otology emergency in the practice. Its severe hearing impairment and prognosis impair the quality of life. Given that cochlear hair cell vulnerability is not consistent across frequencies, ...

    Abstract Objectives: Sudden sensorineural hearing loss (SSNHL) is a common otology emergency in the practice. Its severe hearing impairment and prognosis impair the quality of life. Given that cochlear hair cell vulnerability is not consistent across frequencies, this study aims to investigate the impact of frequency-specific hearing loss on prognosis in SSNHL.
    Methods: The study included 255 patients with full-frequency SSNHL. The baseline, clinical, and hearing characteristics, as well as possible cardiovascular predictors in blood, were collected for analysis.
    Results: The 4,000 and 8,000 Hz hearing levels in the responder group were significantly lower than those in the non-responder group (
    Conclusions: Compared with other frequencies, 8,000 Hz hearing level was closely related to prognosis in SSNHL. In an adjusted model, our study did not find an effect of mean hearing on prognosis in SSNHL. However, further multicenter prospective studies are needed for validation.
    Language English
    Publishing date 2022-09-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.962376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Genome-Wide Identification and Characterization of the

    Wu, Huan / Zhu, Ling / Cai, Guiping / Lv, Chenxi / Yang, Huan / Ren, Xiaoli / Hu, Bo / Zhou, Xuemei / Jiang, Tingting / Xiang, Yong / Wei, Rujun / Li, Lujiang / Liu, Hailan / Muhammad, Imran / Xia, Chao / Lan, Hai

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 17

    Abstract: The protein phosphatase 2C (PP2C) constitutes a large gene family that plays crucial roles in regulating stress responses and plant development. A recent study has shown the involvement of ... ...

    Abstract The protein phosphatase 2C (PP2C) constitutes a large gene family that plays crucial roles in regulating stress responses and plant development. A recent study has shown the involvement of an
    Language English
    Publishing date 2023-09-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12173153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Candidate colorectal cancer predisposing gene variants in Chinese early-onset and familial cases.

    Zhang, Jun-Xiao / Fu, Lei / de Voer, Richarda M / Hahn, Marc-Manuel / Jin, Peng / Lv, Chen-Xi / Verwiel, Eugène Tp / Ligtenberg, Marjolijn Jl / Hoogerbrugge, Nicoline / Kuiper, Roland P / Sheng, Jian-Qiu / Geurts van Kessel, Ad

    World journal of gastroenterology

    2015  Volume 21, Issue 14, Page(s) 4136–4149

    Abstract: Aim: To investigate whether whole-exome sequencing may serve as an efficient method to identify known or novel colorectal cancer (CRC) predisposing genes in early-onset or familial CRC cases.: Methods: We performed whole-exome sequencing in 23 ... ...

    Abstract Aim: To investigate whether whole-exome sequencing may serve as an efficient method to identify known or novel colorectal cancer (CRC) predisposing genes in early-onset or familial CRC cases.
    Methods: We performed whole-exome sequencing in 23 Chinese patients from 21 families with non-polyposis CRC diagnosed at ≤ 40 years of age, or from multiple affected CRC families with at least 1 first-degree relative diagnosed with CRC at ≤ 55 years of age. Genomic DNA from blood was enriched for exome sequences using the SureSelect Human All Exon Kit, version 2 (Agilent Technologies) and sequencing was performed on an Illumina HiSeq 2000 platform. Data were processed through an analytical pipeline to search for rare germline variants in known or novel CRC predisposing genes.
    Results: In total, 32 germline variants in 23 genes were identified and confirmed by Sanger sequencing. In 6 of the 21 families (29%), we identified 7 mutations in 3 known CRC predisposing genes including MLH1 (5 patients), MSH2 (1 patient), and MUTYH (biallelic, 1 patient), five of which were reported as pathogenic. In the remaining 15 families, we identified 20 rare and novel potentially deleterious variants in 19 genes, six of which were truncating mutations. One previously unreported variant identified in a conserved region of EIF2AK4 (p.Glu738_Asp739insArgArg) was found to represent a local Chinese variant, which was significantly enriched in our early-onset CRC patient cohort compared to a control cohort of 100 healthy Chinese individuals scored negative by colonoscopy (33.3% vs 7%, P < 0.001).
    Conclusion: Whole-exome sequencing of early-onset or familial CRC cases serves as an efficient method to identify known and potential pathogenic variants in established and novel candidate CRC predisposing genes.
    MeSH term(s) Adult ; Age of Onset ; Asian Continental Ancestry Group/genetics ; Biomarkers, Tumor/genetics ; Case-Control Studies ; China/epidemiology ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/ethnology ; Colorectal Neoplasms/genetics ; Computational Biology ; DNA Mutational Analysis/methods ; Exome ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Germ-Line Mutation ; Heredity ; Humans ; Male ; Middle Aged ; Pedigree ; Phenotype ; Polymorphism, Single Nucleotide ; Predictive Value of Tests ; Risk Factors ; Young Adult
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2015-04-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v21.i14.4136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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