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Article: Identification of

Sun, Aihua / Gou, Xiaoyu / Zhu, Yongze / Lv, Huoyang / Ge, Yumei

2023 Volume 16, Page(s) 5275–5282

Abstract: Disseminated ankle mycosis is a life-threatening systemic infection caused by the emerging opportunistic and lethal fungal ... ...

Abstract	Disseminated ankle mycosis is a life-threatening systemic infection caused by the emerging opportunistic and lethal fungal pathogen
Language	English
Publishing date	2023-08-14
Publishing country	New Zealand
Document type	Case Reports
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S418174
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Serum Interleukin-26 is a Potential Biomarker for the Differential Diagnosis of Neurosyphilis and Syphilis at Other Stages.

Shen, Yuhuan / Dong, Xiaoyan / Liu, Jinlin / Lv, Huoyang / Ge, Yumei

Infection and drug resistance

2022 Volume 15, Page(s) 3693–3702

Abstract: Background: Interleukin-26 (IL-26) is an atypical proinflammatory cytokine due to its binding to circulating double-stranded DNA and direct antibacterial activity. Although IL-26 has been confirmed to be involved in the pathophysiology of cancer, ... ...

Abstract	Background: Interleukin-26 (IL-26) is an atypical proinflammatory cytokine due to its binding to circulating double-stranded DNA and direct antibacterial activity. Although IL-26 has been confirmed to be involved in the pathophysiology of cancer, chronic inflammatory diseases and infections, the diagnostic and prognostic values of IL-26 levels in syphilis patients are not clear. This study aimed to investigate IL-26 levels in different stages of syphilis progression. Methods: A total of 30 healthy controls and 166 patients with syphilis at different stages of disease progression were enrolled. Serum IL-26 levels were quantified in accordance with the protocols of RayBio Results: The levels of serum IL-26 were significantly higher in neurosyphilis patients than in healthy subjects (6.87 (4.36, 12.14) and 1.67 (0.09, 4.89) pg/μL, respectively; **p < 0.0001), latent syphilis (1.48 (0.40, 2.05) pg/μL, p < 0.0001), seroresistant syphilis (0.81 (0.20, 2.91) pg/μL, p < 0.0001) and secondary syphilis (1.66 (0.41, 4.25) pg/μL, p < 0.0001) with data presented as the median with interquartile range. The concentration of serum IL-26 was most sensitive to serum low-density lipoprotein concentration (r = -0.438, p = 0.004) in latent syphilis, urine epithelial cells (r = 0.459, p = 0.003) in seroresistant syphilis, and serum creatinine levels (r = 0.463, p = 0.004) and urea creatinine ratio levels (r = 0.500, p = 0.008) in secondary syphilis patients. There was no significant correlation with the concentration of IL-26 and toluidine red unheated serum test (TRUST) titers in each type of syphilis patient. Conclusion:** Circulating IL-26 in serum displays diagnostic potential in the progression of neurosyphilis and warrants further evaluation in clinical trials.
Language	English
Publishing date	2022-07-14
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S366308
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Article ; Online: Identification of sacrococcygeal and pelvic abscesses infected with invasive Mycoplasma hominis by MALDI-TOF MS.

Su, Fang / Zhang, Junwu / Zhu, Yongze / Lv, Huoyang / Ge, Yumei

Journal of clinical laboratory analysis

2022 Volume 36, Issue 4, Page(s) e24329

Abstract: Background: Mycoplasma hominis is the smallest prokaryotic microorganism with no cell wall, high pleomorphism, and slower reproduction than bacteria. It is difficult for clinical technicians to find M. hominis through the negative Gram staining of ... ...

Abstract	Background: Mycoplasma hominis is the smallest prokaryotic microorganism with no cell wall, high pleomorphism, and slower reproduction than bacteria. It is difficult for clinical technicians to find M. hominis through the negative Gram staining of specimens. Therefore, it is likely to miss detection in routine clinical smear etiological examination. M. hominis is generally considered to be a common colonizing bacterium in urogenital tract with low pathogenicity, and it is usually difficult to invade submucosal tissue and enter the bloodstream. Methods: The abscesses of the patient were examined histopathologically, and the pus in the abscesses was extracted for etiological examination. MALDI-TOF MS was used to identify and confirmed the pathogens in the specimens. The commercial Mycoplasma isolation, culture, and drug sensitivity kit was used to determine antibiotic susceptibility. Results: No pathogens were found after pathological and smear microscopic examination of the puncture fluid from the sacrococcygeal and pelvic abscesses. Until 48 h later, small, translucent, and gray-white colonies were observed in the blood plate culture results. The laboratory physician ultimately determined that the pathogen was M. hominis by MALDI-TOF MS. Conclusion: We report a case of extra-urogenital cystic abscesses infected by M. hominis, in order to improve clinicians' comprehensive understanding of the pathogenicity of Mycoplasma. In addition, the clinical laboratory technician should pay attention to the role of Wright-Giemsa staining of puncture fluid smear in the preliminary detection and the application of MALDI-TOF MS in identification of uncommon pathogenic microorganisms.
MeSH term(s)	Abscess ; Bacteria ; Blood Culture ; Humans ; Mycoplasma hominis ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods
Language	English
Publishing date	2022-03-13
Publishing country	United States
Document type	Case Reports
ZDB-ID	645095-7
ISSN	1098-2825 ; 0887-8013
ISSN (online)	1098-2825
ISSN	0887-8013
DOI	10.1002/jcla.24329
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Article: A Rare Case of a Subcutaneous Abscess Caused by

Lv, Huoyang / Chen, Mengyuan / Ji, Youqi / Pan, Liya / Hong, Xin / Ge, Yumei

Infection and drug resistance

2023 Volume 16, Page(s) 263–268

Abstract: Background: Nocardia cyriacigeorgica: Methods: The clinical data of a patient with cutaneous nocardiosis caused by : Results: Magnetic resonance imaging (MRI) showed that there was a 26 mm × 73 mm abscess under the skin. The pus in the abscess was ...

Abstract	Background: Nocardia cyriacigeorgica Methods: The clinical data of a patient with cutaneous nocardiosis caused by Results: Magnetic resonance imaging (MRI) showed that there was a 26 mm × 73 mm abscess under the skin. The pus in the abscess was green. Gram staining showed positive branched rod-shaped and undivided hyphae. After culture, small wrinkle dry white small colonies were observed, and it was identified as Conclusion: We report the first case of a subcutaneous abscess caused by
Language	English
Publishing date	2023-01-13
Publishing country	New Zealand
Document type	Case Reports
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S395333
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Article ; Online: A Comparison of Candida Detection in Sputum by the Conventional Culture and Fluorescent Polymerase Chain Reaction Methods.

Xu, Xiaoqun / Lv, Huoyang / Zhang, Fengwei / Zhu, Houyong / Cai, Long

Medical science monitor : international medical journal of experimental and clinical research

2021 Volume 27, Page(s) e930293

Abstract: BACKGROUND Candida is a pathogenic fungus. In recent years, the increase in immunosuppressive diseases has led to an increase in Candida infections, with the lungs being the most common site. Therefore, the aim of this study was to compare the positive ... ...

Abstract	BACKGROUND Candida is a pathogenic fungus. In recent years, the increase in immunosuppressive diseases has led to an increase in Candida infections, with the lungs being the most common site. Therefore, the aim of this study was to compare the positive detection rates of Candida in sputum samples by Candida culture and fluorescent polymerase chain reaction (PCR), and to explore a new method for rapid, accurate, and effective detection of Candida in sputum, providing swift evidence of clinical fungal infection. MATERIAL AND METHODS From October 2016 to March 2017, 300 sputum samples were collected and detected by the conventional culture method and fluorescent PCR method. The positive rate of Candida detection was compared between the 2 methods. RESULTS In the 300 sputum samples, the positive detection rate of Candida was 50% by the culture method and 65.67% by the fluorescent PCR method (P<0.001). Therefore, the positive detection rate of Candida was higher by the fluorescent PCR method. CONCLUSIONS The conventional culture method for Candida needs a longer duration (24 h to 48 h) and the positive detection rate is low. However, it takes only 3 h to detect Candida in sputum by the fluorescent PCR method, the positive detection rate is high, and can be used as a screening method for Candida in sputum samples. Additional large-scale clinical trials need to be completed to assess the correlation between fluorescent PCR and pulmonary Candida infection.
MeSH term(s)	Candida/isolation & purification ; Candidiasis ; Culture Techniques/methods ; Fluorescence ; Humans ; Polymerase Chain Reaction/methods ; Reproducibility of Results ; Sensitivity and Specificity ; Sputum/microbiology
Language	English
Publishing date	2021-06-23
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/MSM.930293
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Zs.A 4924: Show issues

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Article ; Online: A rare case of pulmonary nocardiosis comorbid with Sjogren's syndrome.

Peng, Yumeng / Dong, Xiaoyan / Zhu, Yongze / Lv, Huoyang / Ge, Yumei

Journal of clinical laboratory analysis

2021 Volume 35, Issue 9, Page(s) e23902

Abstract: Background: Nocardia is an opportunistic pathogen, which occurs in patients with autoimmune diseases and immune dysfunction, and can cause bacteremia and other life-threatening complications. The clinical manifestations of Nocardia pneumonia are similar ...

Abstract	Background: Nocardia is an opportunistic pathogen, which occurs in patients with autoimmune diseases and immune dysfunction, and can cause bacteremia and other life-threatening complications. The clinical manifestations of Nocardia pneumonia are similar to tuberculous and other clinical common bacterial pneumonia, but its antibacterial treatments are different and detection methods are unique, which may lead patients to suffer for many years due to clinical misdiagnosis and missed diagnosis. Methods: Imaging and laboratory examinations were performed for preliminary diagnosis, and next-generation sequencing was used to identify the exact species type of Nocardia in the bronchoalveolar lavage fluid (BALF) of the patient. Results: Imaging and laboratory parameters preliminarily implied that the patient was infected with Nocardia with Sjogren's syndrome (SS), and NGS showed that the strain was N. terpenica. Conclusions: Accurate etiological diagnosis and corresponding antibiotics are key to improve the prognosis of pulmonary nocardiosis in this case. Nocardia pneumonia is rare in clinical practice; it is of great medical significance to improve the understanding of pulmonary nocardiosis.
MeSH term(s)	Aged ; Anti-Bacterial Agents/therapeutic use ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Male ; Nocardia/isolation & purification ; Nocardia Infections/complications ; Nocardia Infections/diagnosis ; Nocardia Infections/drug therapy ; Nocardia Infections/microbiology ; Sjogren's Syndrome/complications ; Sjogren's Syndrome/diagnosis ; Sjogren's Syndrome/drug therapy
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2021-08-21
Publishing country	United States
Document type	Case Reports
ZDB-ID	645095-7
ISSN	1098-2825 ; 0887-8013
ISSN (online)	1098-2825
ISSN	0887-8013
DOI	10.1002/jcla.23902
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Article: Pacemaker Associated

Chen, Wanyuan / Ji, Youqi / Hong, Xin / Zhu, Yongze / Gou, Xiaoyu / Chen, Mengyuan / Lv, Huoyang / Ge, Yumei

Infection and drug resistance

2023 Volume 16, Page(s) 329–335

Abstract: ... ...

Abstract	Aspergillus
Language	English
Publishing date	2023-01-19
Publishing country	New Zealand
Document type	Case Reports
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S393917
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Article ; Online: Whole genome sequence of an Escherichia coli ST131 strain isolated from a patient with bloodstream infection in China co-harbouring bla

Du, Xiaoxing / Huang, Junwei / Wang, Dairong / Zhu, Yongze / Lv, Huoyang / Li, Xi

Journal of global antimicrobial resistance

2020 Volume 22, Page(s) 700–702

Abstract: Objectives: Escherichia coli sequence type 131 (ST131) is an international multiresistant high-risk clone associated with a large number of clinical infections. Here we report the draft genome sequence of a ST131 clinical isolate (EC538) obtained from a ...

Abstract	Objectives: Escherichia coli sequence type 131 (ST131) is an international multiresistant high-risk clone associated with a large number of clinical infections. Here we report the draft genome sequence of a ST131 clinical isolate (EC538) obtained from a patient with bloodstream infection (BSI) in China co-harbouring the bla Methods: Antimicrobial susceptibility testing of E. coli EC538 was performed. DNA of E. coli EC538 was extracted and was sequenced using an Illumina HiSeq Results: The total number of assembled bases was 5 420 040bp, with 5611 protein-coding sequences. Escherichia coli EC538 belongs to ST131 by multilocus sequence typing (MLST). The presence of bla Conclusion: To our knowledge, this is the first report of an E. coli ST131 strain from a BSI co-harbouring bla
MeSH term(s)	China ; Drug Resistance, Multiple, Bacterial ; Escherichia coli/genetics ; Escherichia coli Infections ; Humans ; Microbial Sensitivity Tests ; Multilocus Sequence Typing ; Sepsis
Language	English
Publishing date	2020-07-07
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2710046-7
ISSN	2213-7173 ; 2213-7165
ISSN (online)	2213-7173
ISSN	2213-7165
DOI	10.1016/j.jgar.2020.06.027
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Article ; Online: Safety of Staphylococcus aureus four-antigen and three-antigen vaccines in healthy adults: A meta-analysis of randomized controlled trials.

Xu, Xiaoqun / Zhu, Houyong / Lv, Huoyang

Human vaccines & immunotherapeutics

2017 Volume 14, Issue 2, Page(s) 314–321

Abstract: Purpose: Two new Staphylococcus aureus vaccines, S. aureus four-antigen (SA4Ag) and three-antigen (SA3Ag) vaccines, have good immunogenicity and tolerance. However, the safety of these vaccines is worth exploring. Here, we performed a meta-analysis to ... ...

Abstract	Purpose: Two new Staphylococcus aureus vaccines, S. aureus four-antigen (SA4Ag) and three-antigen (SA3Ag) vaccines, have good immunogenicity and tolerance. However, the safety of these vaccines is worth exploring. Here, we performed a meta-analysis to investigate the safety of SA3Ag and SA4Ag by evaluating systemic and local adverse events. Methods: The Medline, EMBASE, and Cochrane databases were searched for randomized clinical trials confirming the safety of SA4Ag and SA3Ag. Two investigators independently selected suitable trials, assessed trial quality, and extracted data. Results: Three studies comprising a total of 1,148 participants were included in this review. The two S. aureus vaccines did not increase systemic adverse events (relative ratio 1.1 [95% confidence interval 0.98, 1.24]), but increased the incidence of local adverse events (2.89 [2.15, 3.90]). However, the incidence of severe local adverse events (4.06 [0.78, 21.24]) did not rise significantly. Conclusions: SA4Ag and SA3Ag have acceptable safety in adults.
MeSH term(s)	Adult ; Antigens, Bacterial/immunology ; Humans ; Randomized Controlled Trials as Topic ; Staphylococcal Infections/prevention & control ; Staphylococcal Vaccines/adverse effects ; Staphylococcal Vaccines/immunology ; Staphylococcus aureus/immunology ; Staphylococcus aureus/metabolism
Chemical Substances	Antigens, Bacterial ; Staphylococcal Vaccines
Language	English
Publishing date	2017-12-06
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2017.1395540
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Zs.A 6967: Show issues

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Article ; Online: Emergence of tet(A) and bla

Gu, Danxia / Lv, Huoyang / Sun, Qiaoling / Shu, Lingbin / Zhang, Rong

International journal of antimicrobial agents

2018 Volume 52, Issue 2, Page(s) 307–308

MeSH term(s)	Animals ; Antiporters/genetics ; Bacterial Proteins/genetics ; Carbapenems/pharmacology ; Drug Resistance, Bacterial/drug effects ; Drug Resistance, Bacterial/genetics ; Feces/microbiology ; Humans ; Klebsiella Infections/microbiology ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/genetics ; Klebsiella pneumoniae/isolation & purification ; Klebsiella pneumoniae/pathogenicity ; Male ; Microbial Sensitivity Tests ; Plasmids ; Tigecycline/pharmacology ; beta-Lactamases/genetics
Chemical Substances	Antiporters ; Bacterial Proteins ; Carbapenems ; tetA protein, Bacteria ; Tigecycline (70JE2N95KR) ; beta-Lactamases (EC 3.5.2.6) ; beta-lactamase KPC-2, Klebsiella pneumoniae (EC 3.5.2.6)
Language	English
Publishing date	2018-06-10
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2018.06.003
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Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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