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Article ; Online: Exploring the role of DLK1 in inducing NLRP3 inflammasome activation in bladder epithelial cells in patients with interstitial cystitis.

Song, Xin / Lv, Tingting / Fang, Weilin / Lv, Jianwei

2024 Volume 47, Issue 4, Page(s) 1907–1908

MeSH term(s)	Humans ; Cystitis, Interstitial ; Urinary Bladder ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Epithelial Cells/metabolism ; Calcium-Binding Proteins ; Membrane Proteins
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; DLK1 protein, human ; Calcium-Binding Proteins ; Membrane Proteins
Language	English
Publishing date	2024-01-06
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2023.12.134
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Zs.B 2831: Show issues

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Article ; Online: Application of an acellular dermal matrix allograft via vaginal natural orifice transluminal endoscopic surgery to treat apical vesicovaginal fistula: The first case report in China.

Song, Xin / Shan, Jiahui / Li, Zeyang / Lv, Jianwei

Asian journal of surgery

2023 Volume 46, Issue 12, Page(s) 6063–6064

MeSH term(s)	Female ; Humans ; Vesicovaginal Fistula/surgery ; Acellular Dermis ; Vagina/surgery ; Natural Orifice Endoscopic Surgery ; Allografts
Language	English
Publishing date	2023-09-27
Publishing country	Netherlands
Document type	Case Reports ; Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2023.09.063
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Article: [Clinical observation on electroacupuncture at "four points of sacral region" on moderate to severe stress urinary incontinence after radical prostatectomy].

Chu, Ting-Ting / Gao, Ming / Wang, Si-You / Lv, Jian-Wei

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

2023 Volume 43, Issue 7, Page(s) 756–761

Abstract: Objective: To compare the clinical therapeutic effect between electroacupuncture at "four points of sacral region" and transurethral Erbium laser in treatment of moderate to severe stress urinary incontinence after radical prostatectomy.: Methods: A ... ...

Abstract	Objective: To compare the clinical therapeutic effect between electroacupuncture at "four points of sacral region" and transurethral Erbium laser in treatment of moderate to severe stress urinary incontinence after radical prostatectomy. Methods: A total of 68 patients of moderate to severe stress urinary incontinence after radical prostatectomy were divided into an electroacupuncture group (34 cases) and an Erbium laser group (34 cases, 3 cases dropped off) according to the settings. In the electroacupuncture group, electroacupuncture was applied at "four points of sacral region", i.e. points of 0.5 Results: Compared with those before treatment, the ICI-Q-SF scores were decreased while the I-QOL scores were increased after 5 courses of treatment and in follow-up after 1, 2 months of treatment completion in the two groups ( Conclusion: Both electroacupuncture at "four points of sacral region" and transurethral Erbium laser can improve the clinical symptoms and the quality of life in patients of moderate to severe stress urinary incontinence after radical prostatectomy. The short-term efficacy and long-term efficacy of electroacupuncture are superior to the Erbium laser technology.
MeSH term(s)	Male ; Humans ; Quality of Life ; Urinary Incontinence, Stress/etiology ; Urinary Incontinence, Stress/therapy ; Sacrococcygeal Region ; Electroacupuncture ; Erbium ; Prostatectomy/adverse effects
Chemical Substances	Erbium (77B218D3YE)
Language	Chinese
Publishing date	2023-07-10
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0255-2930
ISSN	0255-2930
DOI	10.13703/j.0255-2930.20220720-k0006
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Article ; Online: Effect of Myelin Debris on the Phenotypic Transformation of Astrocytes after Spinal Cord Injury in Rats.

Lv, Jianwei / Yu, Hang / Shan, Fangli / Ye, Jianan / Li, Ao / Jing, Juehua / Zheng, Meige / Tian, Dasheng

Neuroscience

2024 Volume 547, Page(s) 1–16

Abstract: After spinal cord injury (SCI), the accumulation of myelin debris can serve as proinflammatory agents, hindering axon regrowth and exacerbating damage. While astrocytes have been implicated in the phagocytosis of myelin debris, the impact of this process ...

Abstract	After spinal cord injury (SCI), the accumulation of myelin debris can serve as proinflammatory agents, hindering axon regrowth and exacerbating damage. While astrocytes have been implicated in the phagocytosis of myelin debris, the impact of this process on the phenotypic transformation of astrocytes and their characteristics following SCI in rats is not well understood. Here, we demonstrated that the conditioned medium of myelin debris can trigger apoptosis in rat primary astrocytes in vitro. Using a compressional SCI model in rats, we observed that astrocytes can engulf myelin debris through ATP-binding cassette transporter sub-family A member 1 (ABCA1), and these engulfed cells tend to transform into A1 astrocytes, as indicated by C3 expression. At 4 days post-injury (dpi), astrocytes rapidly transitioned into A1 astrocytes and maintained this phenotype from 4 to 28 dpi, while A2 astrocytes, characterized by S100, were only detected at 14 and 28 dpi. Reactive astrocytes, identified by Nestin, emerged at 4 and 7 dpi, whereas scar-forming astrocytes, marked by N-cadherin, were evident at 14 and 28 dpi. This study illustrates the distribution patterns of astrocyte subtypes and the potential interplay between astrocytes and myelin debris after SCI in rats. We emphasize that myelin debris can induce astrocyte apoptosis in vitro and promote the transformation of astrocytes into A1 astrocytes in vivo. These two classification methods are not mutually exclusive, but rather complementary.
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	196739-3
ISSN	1873-7544 ; 0306-4522
ISSN (online)	1873-7544
ISSN	0306-4522
DOI	10.1016/j.neuroscience.2024.03.026
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Zs.A 1215: Show issues

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Article ; Online: Unintended dural tears during unilateral biportal endoscopic lumbar surgery: incidence and risk factors.

Yu, Hang / Zhao, Qingzhong / Lv, Jianwei / Liu, Jianjun / Zhu, Bin / Chen, Lei / Jing, Juehua / Tian, Dasheng

Acta neurochirurgica

2024 Volume 166, Issue 1, Page(s) 95

Abstract: Background: An unintended dural tear (DT) is the most common intraoperative complication of lumbar spine surgery. The unilateral biportal endoscopic technique (UBE) has become increasingly popular for treating various degenerative diseases of the lumbar ...

Abstract	Background: An unintended dural tear (DT) is the most common intraoperative complication of lumbar spine surgery. The unilateral biportal endoscopic technique (UBE) has become increasingly popular for treating various degenerative diseases of the lumbar spine; however, the DT incidence and risk factors specific to UBE remain undetermined. Therefore, this study aimed to evaluate the incidence and risk factors of DTs in UBE. Method: Data from all patients who underwent UBE for degenerative lumbar spinal diseases from November 2018 to December 2021 at our institution were used to assess the effects of demographics, diagnosis, and type of surgery on unintended DT risk. Results: Overall, 24/608 patients (3.95%) experienced DTs and were treated with primary suture repair or bed rest. Although several patients experienced mild symptoms of cerebrospinal fluid (CSF) leaks, no serious postoperative sequelae such as nerve root entrapment, meningitis, or intracranial hemorrhage occurred. Additionally, no significant correlations were identified between DT and sex (P = 0.882), body mass index (BMI) (P = 0.758), smoking status (P = 0.506), diabetes (P = 0.672), hypertension (P = 0.187), or surgeon experience (P = 0.442). However, older patients were more likely to experience DT than younger patients (P = 0.034), and patients with lumbar spinal stenosis (LSS) were more likely to experience DT than patients with lumbar disc herniation (LDH) (P = 0.035). Additionally, DT was more common in revision versus primary surgery (P < 0.0001) and in unilateral laminotomy with bilateral decompression (ULBD) versus unilateral decompression (P = 0.031). Univariate logistic regression analysis revealed that age, LSS, ULBD, and revision surgery were significant risk factors for DT. Conclusions: In this UBE cohort, we found that the incidence of DT was 3.95%. Additionally, older age, LSS, ULBD, and revision surgery significantly increased the risk of DT in UBE surgery.
MeSH term(s)	Humans ; Incidence ; Lumbosacral Region ; Risk Factors ; Smoking ; Cerebrospinal Fluid Leak ; Meningitis ; Nerve Compression Syndromes
Language	English
Publishing date	2024-02-21
Publishing country	Austria
Document type	Journal Article
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-024-05965-8
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Uk I Zs.180: Show issues

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Article: Neuromodulation of the Pudendal Nerve Assisted by 3D Printed: A New Method of Neuromodulation for Lower Urinary Tract Dysfunction.

Gu, Yinjun / Lv, Tingting / Jiang, Chen / Lv, Jianwei

Frontiers in neuroscience

2021 Volume 15, Page(s) 619672

Abstract: Electrical stimulation of peripheral nerves by implanted electrodes is an effective treatment for certain pelvic floor diseases. As well as intravesical electrical stimulation, this predominantly includes stimulation of the sacral nerve, tibial nerve, ... ...

Abstract	Electrical stimulation of peripheral nerves by implanted electrodes is an effective treatment for certain pelvic floor diseases. As well as intravesical electrical stimulation, this predominantly includes stimulation of the sacral nerve, tibial nerve, and pudendal nerve. The pudendal nerve is one of the main nerves that stimulate pelvic floor muscles, external urethral meatus, and the anal sphincter and pelvic organs, and it may have effects on frequent urination, urgency, dysuria, and perineal pain. It is difficult to locate because of its anatomical course, however, leading to difficulties fixing the electrode, which increases the difficulty of pudendal nerve electrical stimulation in clinical practice. In the current study 3D printed navigation was used to solve these problems. Combined with autopsy data and patient pelvic and nerve data, a personalized design was generated. Neural modulation of the pudendal nerve was achieved by implanting the lead with the guidance of 3D printed navigation. 3D printed navigation can maximize the phase II conversion rate, reduce the difficulty of surgery, shorten the operation time, reduce damage to additional organs and blood vessels, and increase the accuracy of electrode implantation, and it can be performed while the patient is awake. It is an accurate, reversible, efficient, and minimally invasive surgery.
Language	English
Publishing date	2021-02-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2021.619672
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Article ; Online: A framework for the responsible reform of the 14-day rule in human embryo research.

Peng, Yaojin / Lv, Jianwei / Xiao, Zhenyu / Ding, Lulu / Zhou, Qi

Protein & cell

2022 Volume 13, Issue 8, Page(s) 552–558

MeSH term(s)	Embryo Research ; Humans
Language	English
Publishing date	2022-02-15
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2543451-2
ISSN	1674-8018 ; 1674-800X
ISSN (online)	1674-8018
ISSN	1674-800X
DOI	10.1007/s13238-022-00907-5
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Article ; Online: Responsible governance of human germline genome editing in China†.

Peng, Yaojin / Lv, Jianwei / Ding, Lulu / Gong, Xia / Zhou, Qi

Biology of reproduction

2022 Volume 107, Issue 1, Page(s) 261–268

Abstract: Considerable improvements have been made to gene editing technology, which has been increasingly applied to research involving humans. Nevertheless, human heritable germline genome editing is associated with a series of potential ethical, legal, and ... ...

Abstract	Considerable improvements have been made to gene editing technology, which has been increasingly applied to research involving humans. Nevertheless, human heritable germline genome editing is associated with a series of potential ethical, legal, and social risks, which have generated major controversies and discussions worldwide, especially after the "gene-edited babies" incident. Influenced by this incident, China has realized the importance of ethical governance in the field of life science and technology, has accelerated legislative and policy efforts in this field, and has gradually moved toward the direction of "precautionary" ethical governance. Black letter analysis, big data public opinion analysis, and other research methods are used in this paper. This paper explores the scientific background, ethical debates, and latest developments regarding China's regulatory framework for human germline gene editing after the "gene-edited babies" controversy and provides several recommendations on the future governance system of human germline gene editing in China. This paper argues that in recent years, the ethics governance of germline genome editing in China has been accelerated and great changes have been made. However, the regulatory system for germline genome editing requires further improvement in three aspects: coordination of legislation and agencies, establishment of an ethics review system at high levels, and public participation and education.
MeSH term(s)	China ; Gene Editing ; Genome, Human ; Germ Cells ; Humans
Language	English
Publishing date	2022-05-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1118-6
ISSN	1529-7268 ; 0006-3363
ISSN (online)	1529-7268
ISSN	0006-3363
DOI	10.1093/biolre/ioac114
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Article ; Online: Correlation of serum circulating testosterone levels with stress urinary incontinence in postmenopausal women.

Chen, Yingxiu / Song, Xin / Fang, Weilin / Lv, Tingting / Huang, Jin / Cai, Zhikang / Lv, Jianwei

World journal of urology

2023 Volume 41, Issue 12, Page(s) 3651–3656

Abstract: Objectives: Our study aimed to elucidate the possible relationship between endogenous circulating testosterone and the beginning and development of stress urinary incontinence (SUI) in postmenopausal women.: Patients and methods: The clinical data of ...

Abstract	Objectives: Our study aimed to elucidate the possible relationship between endogenous circulating testosterone and the beginning and development of stress urinary incontinence (SUI) in postmenopausal women. Patients and methods: The clinical data of female patients with SUI who underwent surgery at our hospital from January 2014 to February 2023 and healthy female volunteers recruited during the same period were retrospectively analyzed according to age and body mass index (BMI). Venous blood samples were taken from all subjects, and levels of estradiol, luteinizing hormone, prolactin, follicle-stimulating hormone, progesterone, and testosterone were measured by radioimmunoassay. After adjusting for age, BMI, hypertension, mode of delivery, hysterectomy, and profession, multiple logistic regression analysis was used to determine the relationship between SUI and serum testosterone levels in postmenopausal women. Results: Serum testosterone levels were significantly lower in women with SUI than in healthy control women (0.92 ± 0.67 vs. 1.28 ± 1.10; P < 0.05). Further comparison of testosterone levels between postmenopausal SUI women and healthy postmenopausal women in postmenopausal subjects revealed that testosterone levels were significantly lower in postmenopausal SUI women than in healthy postmenopausal women (0.84 ± 0.64 vs. 1.23 ± 1.10; P < 0.05). This difference in testosterone levels remained significant after controlling for age, BMI, hypertension, mode of delivery, hysterectomy, and profession in postmenopausal women. Conclusion: The results of the present study indicate that low levels of serum testosterone are associated with an increased likelihood of stress urinary incontinence in women. Low serum testosterone levels may be a risk factor for SUI in postmenopausal women.
MeSH term(s)	Female ; Humans ; Urinary Incontinence, Stress ; Postmenopause ; Retrospective Studies ; Testosterone ; Hypertension
Chemical Substances	Testosterone (3XMK78S47O)
Language	English
Publishing date	2023-10-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	380333-8
ISSN	1433-8726 ; 0724-4983
ISSN (online)	1433-8726
ISSN	0724-4983
DOI	10.1007/s00345-023-04681-9
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Article ; Online: Acting on ethics and governance of aging research.

Peng, Yaojin / Ding, Lulu / Song, Moshi / Xiao, Zhenyu / Lv, Jianwei / Liu, Guang-Hui

Trends in molecular medicine

2023 Volume 29, Issue 6, Page(s) 419–421

Abstract: Rapid advances in aging research and clinical translation come with numerous ethical and societal issues that the current regulatory framework may not be sufficient to address. To fill this gap, we propose a responsible and comprehensive governance ... ...

Abstract	Rapid advances in aging research and clinical translation come with numerous ethical and societal issues that the current regulatory framework may not be sufficient to address. To fill this gap, we propose a responsible and comprehensive governance framework to cope with these issues while maximizing the benefits of aging research.
MeSH term(s)	Humans ; Geroscience/ethics ; Geroscience/organization & administration
Language	English
Publishing date	2023-04-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2036490-8
ISSN	1471-499X ; 1471-4914
ISSN (online)	1471-499X
ISSN	1471-4914
DOI	10.1016/j.molmed.2023.03.004
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